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Pee and blood may spare patients painful bone marrow needles

NCT ID NCT03521596

Completed Knowledge-focused Sponsor: Fondazione Italiana Linfomi - ETS Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at 300 people with Waldenström's macroglobulinemia or a related condition to see if blood or urine tests could detect key genetic mutations as accurately as bone marrow biopsies. The goal is to find a less invasive way to monitor the disease over time. Researchers compared mutation rates in blood and urine samples to those from bone marrow to check for agreement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a less invasive way to monitor Waldenström's macroglobulinemia using blood or urine instead of bone marrow biopsies.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve outcomes. The blood/urine tests may not be accurate enough to replace bone marrow biopsies in all cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

monoclonal gammopathy of uncertain significance Neoplasm, Residual Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WALDENSTROM MACROGLOBULINEMIA

Contacts and locations

Locations

  • A.O. Città della Salute e della Scienza Ematologia Universitaria

    Torino, Italy

  • A.O. Universitaria Di Parma

    Parma, 43126, Italy

  • AO Arcispedale Santa Maria Nuova - IRCCS

    Reggio Emilia, 42123, Italy

  • AOU Università degli Studi della Campania Luigi Vanvitelli

    Naples, 80131, Italy

  • Azienda Sanitaria Universitaria Integrata di Udine (A.S.U.I. Udine) - PO S. Maria della Misericordia

    Udine, 33100, Italy

  • Divisione di Ematologia Ospedale Niguarda

    Milan, MI, Italy

  • Ematologia - OSPEDALE DI CIRCOLO E FONDAZIONE MACCHI

    Varese, 21100, Italy

  • Ematologia Policlinico San Matteo

    Pavia, 27100, Italy

  • I.R.C.C.S. Istituto Oncologico Veneto - Oncologia 1

    Padova, 35128, Italy

  • IRCCS Istituto Tumori Giovanni Paolo II - UOC Ematologia

    Bari, 70124, Italy

  • Ospedale degli Infermi di Rimini

    Rimini, 47924, Italy

  • Policlinico A. Gemelli Università Cattolica del Sacro Cuore

    Roma, 00168, Italy

  • SOS Ematologia Ospedale C. Massaia

    Asti, 14100, Italy

  • UOC Ematologia, AOU Senese

    Siena, 53100, Italy

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