New stuttering drug shows promise in early trial

NCT ID NCT05583955

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called NOE-105 in 75 adult men who have stuttered since childhood. The goal was to see if it could improve speech fluency without the side effects of older treatments. Participants took the drug or a placebo for 10 weeks, and researchers measured changes in stuttering severity and daily functioning.

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Conditions

The condition(s) this trial relates to.

Childhood-Onset Fluency Disorder stutter disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Noema Investigator site

    Bellflower, California, 90706, United States

  • Noema Investigator site

    Jacksonville, Florida, 32256, United States

  • Noema Investigator site

    Orlando, Florida, 32801, United States

  • Noema Investigator site

    Overland Park, Kansas, 66210, United States

  • Noema Investigator site

    Berlin, New Jersey, 08009, United States

  • Noema Investigator site

    Memphis, Tennessee, 38119, United States

  • Noema Investigator site

    Brookvale, New South Wales, 2100, Australia

  • Noema Investigator site

    Miranda, New South Wales, 2228, Australia

  • Noema Investigator site

    Sydney, New South Wales, 2109, Australia