Breathing battle: which oxygen method saves more lives after ICU extubation?
NCT ID NCT05686850
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at two ways to help ICU patients who struggle to breathe after their breathing tube is taken out. About 670 adults will be randomly assigned to receive either a non-invasive ventilation mask alternating with high-flow nasal oxygen, or high-flow nasal oxygen alone. The goal is to see which approach lowers the chance of death within 28 days.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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André Mignot Hospital
RECRUITINGLe Chesnay, France
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Angers University Hospital
RECRUITINGAngers, France
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Bordeaux University Hospital
WITHDRAWNBordeaux, France
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Brest University Hospital
RECRUITINGBrest, France
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Clermont-Ferrand University Hospital
RECRUITINGClermont-Ferrand, France
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Complejo Hospitalario Universitario de Toledo
TERMINATEDToledo, Spain
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Cèdres Clinic
RECRUITINGCornebarrieu, France
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Dax Hospital
WITHDRAWNDax, France
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Emile Muller Hospital
RECRUITINGMulhouse, France
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Erasme Hospital
RECRUITINGBrussels, Belgium
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Felix Guyon Hospital
TERMINATEDSaint-Denis, Reunion
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Fleyriat Hospital
RECRUITINGBourg-en-Bresse, France
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Foch Hospital
RECRUITINGSuresnes, France
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Francois Mitterrand Hospital
RECRUITINGDijon, France
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Grenoble University Hospital
RECRUITINGGrenoble, France
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Henri Duffaut Hospital
RECRUITINGAvignon, France
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Henri Mondor Hospital
RECRUITINGAurillac, France
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Henri Mondor Hospital
RECRUITINGCréteil, France
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Hospital Universitari de Bellvitge
NOT_YET_RECRUITINGL'Hospitalet de Llobregat, Spain
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Hospital Universitario Central de Asturias
NOT_YET_RECRUITINGOviedo, Spain
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Hospital de La Santa Creu I Sant Pau
NOT_YET_RECRUITINGBarcelona, Spain
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La Pitié Salpêtrière Hospital
RECRUITINGParis, France
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La Rochelle Hospital
RECRUITINGLa Rochelle, France
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La Timone Hospital
RECRUITINGMarseille, France
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Le Mans Hospital
RECRUITINGLe Mans, France
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Lens Hospital
RECRUITINGLens, France
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Lille University Hospital
RECRUITINGLille, France
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Limoges University Hospital
RECRUITINGLimoges, France
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Louis Mourier Hospital
RECRUITINGColombes, France
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Mont de Marsan Hospital
WITHDRAWNMont-de-Marsan, France
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Moulins-Yzeure Hospital
RECRUITINGMoulins, France
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Nantes University Hospital
RECRUITINGNantes, France
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Nice University Hospital
RECRUITINGNice, France
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Nord-Franche-Comté Hospital
RECRUITINGBelfort, France
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Orléans University Hospital
RECRUITINGOrléans, France
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Pau Hospital
RECRUITINGPau, France
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Pierre Zobda Quitman Hospital
RECRUITINGFort-de-France, Martinique
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Poitiers University Hospital
RECRUITINGPoitiers, France
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Rennes University Hospital
RECRUITINGRennes, France
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Rouen University Hospital
RECRUITINGRouen, France
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Saint Joseph Saint Luc Hospital
RECRUITINGLyon, France
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Saint Nazaire Hospital
RECRUITINGSaint-Nazaire, France
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Saintes Hospital
RECRUITINGSaintes, France
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Tours University Hospital
RECRUITINGTours, France
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Vannes Hospital
RECRUITINGVannes, France
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Vendée Hospital
RECRUITINGLa Roche-sur-Yon, France
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Victor Dupouy Hospital
RECRUITINGArgenteuil, France