Can a 3-Day drug beat the standard for amoeba diarrhea in kids?
NCT ID NCT07790926
First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This trial tests two medicines, nitazoxanide and metronidazole, to see which works better for diarrhea caused by Entamoeba histolytica in children. About 90 children aged 2 to 15 with confirmed amoeba infection will be randomly assigned to one of the two drugs. Nitazoxanide is given for 3 days, while metronidazole is given for 5 days. Researchers will compare how quickly diarrhea resolves, stool consistency, and hospital stay length to determine the more effective treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Nitazoxanide and metronidazole, two oral antiparasitic drugs
- What this could lead to
- If nitazoxanide works better, it could become a shorter, more effective treatment for amoeba diarrhea in children, reducing hospital stays.
- What could go wrong
- This is a small, phase 2 trial, so results may not apply to all children. Both drugs can cause side effects like nausea or stomach upset.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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90 people
The number who actually took part.
- Started
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Apr 2024
- Finished
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Apr 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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2 to 15 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children of both genders aged between 2 to 15 years having diarrhea (frequency of stools greater than 3 or stools softer than normal consistency with nausea, abdominal cramps. Children having Entamoema infection proven on microscopic examination by presence of cyst and trophozite of entamoeba Exclusion Criteria: * Patient with severe dehydration. Patient with any serious concomitant illness that needs antibiotic treatment. If severe adverse events occur at any time. Cytotoxic drugs, food \& chemical poisoning Those who were not able to attend follow-up examinations Children suffering from any other systemic disorders like PEM, certain Immunodeficiencies and Cystic Fibrosis. Microscopic stool examination positive to cyst of Entamoeba histolytica.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Pediatric Medicine
Lahore, Punjab Province, 54100, Pakistan