Promising drug targets rare ovarian tumor growth

NCT ID NCT05348356

First seen Jan 11, 2026 · Last updated May 16, 2026 · Updated 21 times

Summary

This study tested a drug called nirogacestat in 53 people with a rare type of ovarian cancer that had come back after treatment. The goal was to see if the drug could shrink tumors or stop them from growing. Researchers measured how many patients had their tumors shrink and how long they lived without the cancer getting worse.

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Contacts and locations

Locations

  • AdventHealth Orlando

    Orlando, Florida, 32804, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • David C. Pratt Cancer Center

    St Louis, Missouri, 63141, United States

  • Froedtert and Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Greater Baltimore Medical Center

    Baltimore, Maryland, 21204, United States

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States

  • Jagiellonian Innovation Centre Clinical Research Centre

    Krakow, 30-348, Poland

  • Maria Sklodowska-Curie Bialystok Oncology Center

    Bialystok, 15-027, Poland

  • Maria Sklodowska-Curie National Institute of Oncology-National Research Institute, Clinic of Oncological Gynecology

    Warsaw, 02-781, Poland

  • Memorial Sloan Kettering Cancer Institute

    New York, New York, 10065, United States

  • OU Health Stephenson Cancer Center

    Oklahoma City, Oklahoma, 73104, United States

  • Orlando Health Cancer Institute

    Orlando, Florida, 32806, United States

  • UCLA-JCCC Dept. of OBGYN - Women's Health Clinical Research Unit

    Los Angeles, California, 90095, United States

  • USC/Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • UW/Fred Hutch Cancer Center

    Seattle, Washington, 98109, United States

  • University Teaching Hospital Poznan, Department of Oncological Gynaecology

    Poznan, 60-569, Poland

  • University of New Mexico Comprehensive Cancer Center

    Albuquerque, New Mexico, 87102, United States

  • Women's Cancer Care

    Covington, Louisiana, 70433, United States

  • Women's Cancer Center at Kettering

    Kettering, Ohio, 45429, United States

Conditions

Explore the condition pages connected to this study.