Can women with BRCA mutations safely keep their nipples during preventive mastectomy?
NCT ID NCT06888388
First seen Dec 26, 2025 · Last updated May 13, 2026 · Updated 20 times
Summary
This study follows 4700 women with high-risk gene mutations (like BRCA1/2) who choose preventive mastectomy to see if keeping the nipple is safe over the long term. Researchers will track how many develop breast cancer years after surgery. The goal is to provide clear evidence so guidelines can be updated.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Brigham and Women's Hospital - Dana-Farber Brigham Cancer Center
NOT_YET_RECRUITINGBoston, Massachusetts, 02115, United States
Contact Email: •••••@•••••
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CHU de Quebec Université laval
RECRUITINGQuébec, Quebec, G1S 4L8, Canada
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Champalimaud Foundation, University of Lisbon
NOT_YET_RECRUITINGLisbon, Portugal
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Hamilton Health Sciences
RECRUITINGHamilton, Ontario, L8L 2X2, Canada
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Jewish General Hospital
RECRUITINGMontreal, Quebec, H3T1E2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memorial Sloan Kettering Cancer Center (MSKCC)
NOT_YET_RECRUITINGNew York, New York, 10065, United States
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University of Calgary
RECRUITINGCalgary, Alberta, T2N 4N1, Canada
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University of Melbourne, Peter MacCallum Cancer Center
NOT_YET_RECRUITINGMelbourne, Australia
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104-6205, United States
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Women's College Hospital, University of Toronto
NOT_YET_RECRUITINGToronto, Ontario, Canada
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Contact Email: •••••@•••••
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Yale University
RECRUITINGNew Haven, Connecticut, 06510, United States
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Ziekenhuis Aan de Stroom
ACTIVE_NOT_RECRUITINGAntwerp, 2030, Belgium
Conditions
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