New drug showdown: can nipocalimab beat efgartigimod for muscle weakness?

NCT ID NCT07217587

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests whether nipocalimab works better than efgartigimod for people with generalized myasthenia gravis, a condition where the immune system attacks nerve-muscle connections, causing weakness. About 115 adults will receive one of the two drugs to see which reduces harmful antibodies and improves daily activities. The goal is better symptom control, not a cure.

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Conditions

The condition(s) this trial relates to.

myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYASTHENIA GRAVIS

Contacts and locations

Locations

Advanced Neurology of Colorado
RECRUITING

Fort Collins, Colorado, 80528, United States
Atrium Health Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Equity Medical
RECRUITING

New York, New York, 10023, United States
HOCH Health Ostschweiz Kantonsspital St.Gallen
RECRUITING

Sankt Gallen, 9007, Switzerland
HSHS St. Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Josephson Wallack Munshower Neurology, PC
RECRUITING

Indianapolis, Indiana, 46256, United States
Neurology Center of North Orange County
RECRUITING

Fullerton, California, 92835, United States
Neurology Clinic, PC
RECRUITING

Cordova, Tennessee, 38018, United States
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
SFM Clinical Research LLC
RECRUITING

Boca Raton, Florida, 33487, United States
Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Texas Neurology
RECRUITING

Dallas, Texas, 75206, United States
The Neurology Group
RECRUITING

Pomona, California, 91767, United States
Tulane Center for Clinical Research
RECRUITING

New Orleans, Louisiana, 70112, United States
University of Connecticut
RECRUITING

Farmington, Connecticut, 06030, United States
Velocity Clinical Research, Inc.
RECRUITING

Raleigh, North Carolina, 27607 6010, United States

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