New drug trial aims to tame rare Muscle-Attacking disease

NCT ID NCT05379634

Ongoing Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an experimental drug called nipocalimab can help control symptoms of active idiopathic inflammatory myopathies (IIM), a group of rare autoimmune diseases that cause muscle inflammation and weakness. About 36 adults with active IIM will receive either nipocalimab or a placebo for 52 weeks to see if the drug improves their symptoms and allows them to reduce their steroid medication. The main goal is to see if participants achieve at least minimal improvement in their overall disease activity while taking very low doses of steroids.

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Contacts and locations

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Locations

A.O. Universitaria Ospedali Riuniti di Ancona

Ancona, 60126, Italy
ACME Research Arthritis and Osteoporosis Center

Orangeburg, South Carolina, 29118, United States
AMIR Research

Montreal, Quebec, H4A 3T2, Canada
Ajou University Hospital

Suwon, 16499, South Korea
Arizona Arthritis and Rheumatology Research PLLC

Phoenix, Arizona, 85032, United States
Attune Health Autoimmune and Inflamation Care and Research

Beverly Hills, California, 90211, United States
Augusta University

Augusta, Georgia, 30912, United States
CITER Centro de Investigacion y Tratamiento de las Enfermedades Reumaticas S A de C V

México, 06700, Mexico
Centro Integral en Reumatologia S A de C V

Guadalajara, 44160, Mexico
Centro de Estudios de Investigacion Basica y Clinica, S.C.

Guadalajara, 44690, Mexico
Charite Universitaetsmedizin Berlin

Berlin, 10117, Germany
Clinical Research Institute of Michigan, LLC

Saint Clair Shores, Michigan, 48081, United States
Debreceni Egyetem

Debrecen, 4032, Hungary
FM Clinical Research, LLC South Florida Neurology Associates, P. A.

Boca Raton, Florida, 33487, United States
Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy
Fondazione Policlinico Universitario A Gemelli IRCCS

Roma, 00168, Italy
Fukushima Medical University Hospital

Fukushima, 960 1295, Japan
HonorHealth Neurology

Scottsdale, Arizona, 85251, United States
Hosp. Univ. Marques de Valdecilla

Santander, 39008, Spain
Hosp. Univ. de Bellvitge

Barcelona, 08907, Spain
Hosp. Univ. de La Paz

Madrid, 28046, Spain
Hospital Pasteur

Nice, 06000, France
Hôpital Pitié-Salpétrière

Paris, 75013, France
IRCSS Ospedale San Raffaele Turro

Milan, 20127, Italy
Immanuel Klinik Rüdersdorf

Rüdersdorf Bei Berlin, 15562, Germany
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Mexico City, 14080, Mexico
Integral Rheumatology And Immunology Specialists

Plantation, Florida, 33324, United States
Johns Hopkins University

Baltimore, Maryland, 21224, United States
Klinikum der Universitaet Muenchen

München, 80336, Germany
Lawson Health Research / London Health Sciences Center Research

London, Ontario, N6C 2R5, Canada
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Torrance, California, 90502, United States
Narodowy Instytut Geriatrii Reumatologii i Rehabilitacji im prof dr hab med Eleonory Reicher

Warsaw, 02 637, Poland
National Hospital Organization Kyushu Medical Center

Fukuoka, 810 8563, Japan
National Hospital Organization Osaka Minami Medical Center

Kawachi-Nagano, 586 8521, Japan
Nervie and Muscle Center of Texas

Houston, Texas, 77030, United States
Nippon Medical School Hospital

Tokyo, 113 8603, Japan
Nouvel Hopital Civil

Strasbourg, 67091, France
Oregon Health and Science University

Portland, Oregon, 97239, United States
Orszagos Mozgasszervi Intezet ORFI Campus

Budapest, 1023, Hungary
Revmatologicky ustav

Prague, 128 50, Czechia
Salford Royal Hospital

Salford, M6 8HD, United Kingdom
Seoul National University Hospital

Seoul, 03080, South Korea
Shinshu University Hospital

Matsumoto, 390-8621, Japan
St Marianna University Hospital

Kanagawa, 216 8511, Japan
St. Luke's International Hospital

Tokyo, 104 8560, Japan
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy

Bydgoszcz, 85 168, Poland
The Brigham and Women's Hospital, Inc.

Boston, Massachusetts, 02115, United States
Tohoku University Hospital

Sendai, 980 8574, Japan
Tokushukai Chiba-Nishi General Hospital

Matsudo-shi, 270-2251, Japan
University College London Hospitals NHSFT

London, WC1N 3BG, United Kingdom
University of California Irvine Medical Center

Orange, California, 92868, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Pennsylvania - Perelman School of Medicine

Philadelphia, Pennsylvania, 19104, United States
University of South Florida

Tampa, Florida, 33612, United States
University of Texas at Houston Medical School

Houston, Texas, 77030, United States
Western General Hospital

Edinburgh, EH4 2XU, United Kingdom
Wexner Medical Center at the Ohio State University

Columbus, Ohio, 43203, United States

Conditions

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MYOSITIS