New drug shows promise in keeping rare nerve disease at bay

NCT ID NCT05327114

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 03, 2026 · Updated 27 times

Summary

This study tests a drug called nipocalimab in adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a condition where the immune system attacks nerves, causing weakness and numbness. The goal is to see if nipocalimab can delay relapses compared to a placebo. About 201 participants will first receive nipocalimab, and those who improve will be randomly assigned to continue the drug or switch to placebo. The main focus is how long it takes for a relapse to occur.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Advocate Health - Aurora St. Luke's Medical Center
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Ahepa Hospital Aristotle University of Thessaloniki
RECRUITING

Thessaloniki, 54636, Greece
Attikon General Hospital of Athens
RECRUITING

Athens, 12462, Greece
Austin Neuromuscular Center
RECRUITING

Austin, Texas, 78756, United States
Azienda Ospedaliera Universitaria San Martino di Genova
RECRUITING

Genova, 16132, Italy
Azienda Ospedaliera di Rilievo Nazionale A Cardarelli
RECRUITING

Naples, 80131, Italy
Beaumont Hospital Royal Oak
COMPLETED

Royal Oak, Michigan, 48073, United States
Beijing Tiantan Hospital, Capital Medical University
RECRUITING

Beijing, 100070, China
Boston Clinical Trials
RECRUITING

Boston, Massachusetts, 02111, United States
CHRU Strasbourg
RECRUITING

Strasbourg, 67200, France
CHU Bordeaux
RECRUITING

Bordeaux, 33000, France
Centro Hospitalar de Sao Joao Epe
RECRUITING

Porto, 4200 319, Portugal
Centrum Medyczne
COMPLETED

Chorzów, 41 500, Poland
Chiba University Hospital
RECRUITING

Chiba, 260-8677, Japan
Chifeng Municipal Hospital
RECRUITING

Chifeng, 024000, China
Chubu Rosai Hospital
RECRUITING

Nagoya, 455-8530, Japan
Cleveland Clinic Main Campus
RECRUITING

Cleveland, Ohio, 44195, United States
Clinical Research Center sp z o o MEDIC R s k
RECRUITING

Poznan, 61 731, Poland
Clinical Research Institute S.C.
RECRUITING

Tlalnepantla, 54055, Mexico
Dokkyo Medical University Hospital
RECRUITING

Shimotsuga Gun, 321 0293, Japan
Ehime University Hospital
RECRUITING

Toon-shi, 791-0295, Japan
Fakultni Nemocnice Ostrava
COMPLETED

Ostrava, 708 52, Czechia
Fakultni nemocnice Hradec Kralove
RECRUITING

Hradec Králové, 500 05, Czechia
Fondation Adolphe de Rothschild Hospital
RECRUITING

Paris, 75019, France
Fondazione Policlinico Universitario A Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, 350001, China
Fundación Cardiovascular de Colombia - Instituto del Corazón Floridablanca
RECRUITING

Floridablanca, 681004, Colombia
Gold Coast University Hospital
RECRUITING

Parkwood, 4215, Australia
Healthcare Innovations Institute Inc
RECRUITING

Coral Springs, Florida, 33067, United States
Hopital PASTEUR
RECRUITING

Nice, 06000, France
Hopital de Bicetre
RECRUITING

Le Kremlin-Bicêtre, 94270, France
Hopital de la Pitie Salpetriere
RECRUITING

Paris, 75013, France
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 8035, Spain
Hosp. Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hosp. Gral. Univ. de Alicante
RECRUITING

Alicante, 03010, Spain
Hosp. Univ. Donostia
RECRUITING

Donostia / San Sebastian, 20014, Spain
Hosp. Univ. de Basurto
RECRUITING

Bilbao, 48013, Spain
Hosp. Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospices Civils de Lyon HCL
RECRUITING

Bron, 69699, France
Hospital Garcia de Orta
RECRUITING

Almada, 2805-267, Portugal
Hospital Gral Agudos Ignacio Pirovano
RECRUITING

Buenos Aires, C1428, Argentina
Hospital Italiano de Buenos Aires
RECRUITING

Buenos Aires, C1199ABB, Argentina
Hospital de Braga
RECRUITING

Braga, 4710-243, Portugal
Huashan Hospital Fudan University
RECRUITING

Shanghai, 200040, China
IMMUNOe Health and Research Centers
RECRUITING

Centennial, Colorado, 80112, United States
IRCCS Istituto Clinico Humanitas
RECRUITING

Rozzano, 20086, Italy
Institute of Science Tokyo Hospital
RECRUITING

Bunkyō City, 113 8519, Japan
Instituto Neurológico de Colombia
RECRUITING

Medellín, 50021, Colombia
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Judisches Krankenhaus Berlin
RECRUITING

Berlin, 13347, Germany
Kansas City Veterans Affairs Medical Center
RECRUITING

Kansas City, Missouri, 64128, United States
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 88301, Taiwan
Kindai University Hospital
RECRUITING

Osaka Sayama Shi, 589 8511, Japan
Kobe City Medical Center General Hospital
COMPLETED

Kobe, 650 0047, Japan
Konkuk University Medical Center
COMPLETED

Seoul, 05030, South Korea
Kumamoto University Hospital
RECRUITING

Kumamoto, 860-8556, Japan
Kyunghee University Medical Center
RECRUITING

Seoul, 02447, South Korea
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
NHS Greater Glasgow and Clyde
RECRUITING

Glasgow, G514TF, United Kingdom
Nagoya University Hospital
RECRUITING

Nagoya, 466-8560, Japan
National Center of Neurology and Psychiatry
RECRUITING

Kodaira-shi, 187-8551, Japan
National Hospital Organization Asahikawa Medical Center
RECRUITING

Asahikawa, 070-0901, Japan
National Hospital Organization Sendai Medical Center
RECRUITING

Sendai, 983-8520, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
Neurology Associates PA
COMPLETED

Maitland, Florida, 32751, United States
Papageorgiou General Hospital Of Thessaloniki
RECRUITING

Thessaloniki, 56429, Greece
Pardubicka krajska nemocnice a s
COMPLETED

Pardubice, 53203, Czechia
Patras University Hospital
COMPLETED

Pátrai, 26504, Greece
Peking University First Hospital
RECRUITING

Beijing, 100034, China
Peking University Third Hospital
RECRUITING

Beijing, 100191, China
Prywatny Gabinet Lekarski
RECRUITING

Lublin, 20 093, Poland
Qianfoshan hospital of Shandong Province
RECRUITING

Jinan, 250014, China
Qilu Hospital of Shandong University
RECRUITING

Jinan, 250012, China
Renmin Hospital of Wuhan University
RECRUITING

Wuhan, 430023, China
Royal Devon & Exeter Hospital
RECRUITING

Devon, EX2 5DW, United Kingdom
Royal Free Hospital
SUSPENDED

London, NW3 2QG, United Kingdom
Saitama Medical Center
RECRUITING

Koshigaya, 343-8555, Japan
Samsung Medical Center
RECRUITING

Seoul, 135-710, South Korea
Seirei Hamamatsu General Hospital
RECRUITING

Hamamatsu, 430-8558, Japan
Sheffield Teaching Hospitals NHS Foundation Trust
RECRUITING

Sheffield, S10 2 JF, United Kingdom
Shin Kong Wu Ho Su Memorial Hospital
RECRUITING

Taipei, 111, Taiwan
Sichuan Provincial Peoples Hospital
RECRUITING

Chengdu, 610072, China
South Shore Neurologic Associates - Patchogue
RECRUITING

Patchogue, New York, 11772, United States
Specjalistyczne Gabinety Lekarskie
COMPLETED

Krakow, 30 539, Poland
St Josefs Krankenhaus Potsdam Sanssouci
RECRUITING

Potsdam, 14471, Germany
St. Josef-Hospital, Ruhr-Universität Bochum
RECRUITING

Bochum, 44791, Germany
Tangdu hospital the Fourth Military Medical
RECRUITING

Xi'an, 710032, China
Tenri Hospital
RECRUITING

Tenri, 632-0015, Japan
The Alfred Hospital
RECRUITING

Melbourne, 3004, Australia
The First Affiliated Hospital Sun Yat sen University
RECRUITING

Guangzhou, 510080, China
The First Affiliated Hospital of NanChang University
RECRUITING

Nanchang, 330006, China
The First Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The Neurological Institute of New York
COMPLETED

New York, New York, 10032, United States
The Neurological Institute, PA
RECRUITING

Charlotte, North Carolina, 28204, United States
The Ottawa Hospital Ottawa NeuroMuscular Centre
RECRUITING

Ottawa, K1N 6N5, Canada
The Third Xiangya Hospital of Central Sourth University
RECRUITING

Changsha, 410008, China
Tokai University Hospital
RECRUITING

Isehara, 259-1193, Japan
Tokyo Women's Medical University Hospital
COMPLETED

Shinjuku-ku, 162-8666, Japan
Tong Ren Hospital Shanghai Jiao Tong University school of medicine
COMPLETED

Shanghai, 200336, China
Toyama University Hospital
RECRUITING

Toyama, 930-0194, Japan
Universitaetsklinikum Leipzig
RECRUITING

Leipzig, 4103, Germany
University Hospitals Birmingham NHS Foundation Trust
RECRUITING

Birmingham, B15 2TH, United Kingdom
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
Xi 'an GaoXin Hospital
RECRUITING

Xi'an, 710075, China
Xiangya Hospital Central South University
RECRUITING

Changsha, 410008, China
Xuanwu Hospital ,Capital Medical University
RECRUITING

Beijing, 100053, China
Yamaguchi University Hospital
RECRUITING

Ube, 755-8505, Japan
i Can Oncology Center
SUSPENDED

Monterrey, 64710, Mexico

Conditions

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POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING