Could a pill tame muscle weakness in myasthenia gravis?

NCT ID NCT06463587

Recruiting now Disease control Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 13, 2026 · Updated 7 times

Summary

This phase 3 trial is testing a new oral form of cladribine, a drug that calms the immune system, in 264 adults with generalized myasthenia gravis. Participants receive either low-dose cladribine, high-dose cladribine, or a placebo in two courses four weeks apart. The main goal is to see if cladribine improves daily activities and muscle strength compared to placebo after 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cladribine (oral tablet)
What this could lead to: If it works, this could offer a new oral treatment option to control symptoms and improve daily living for people with generalized myasthenia gravis.
What could go wrong: This is a phase 3 trial, but cladribine is an immune-suppressing drug with known risks like infections and low blood counts. It may not work better than placebo, and long-term safety is still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALIZED MYASTHENIA GRAVIS

Contacts and locations

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Locations

AHEPA General Hospital of Thessaloniki
RECRUITING

Thessaloniki, 54636, Greece
ANESC Research
RECRUITING

El Paso, Texas, 79912, United States

Contact Email: •••••@•••••
Advanced Neurosciences Research LLC
ACTIVE_NOT_RECRUITING

Longmont, Colorado, 80501, United States
Affiliated Hospital of Zunyi Medical University
RECRUITING

Zunyi, Guizhou, 563099, China
Arizona Neuroscience Research, LLC
RECRUITING

Phoenix, Arizona, 85032, United States
Asan Medical Center
RECRUITING

Seoul, 138-736, South Korea
Atrium Health Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157-1078, United States
Aversi Clinic Ltd
RECRUITING

Tbilisi, 0160, Georgia
Azienda Ospedaliera Universitaria Policlinico Tor Vergata - U.O.C. Neurologia
RECRUITING

Rome, 00133, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni
RECRUITING

Bergamo, 24127, Italy
Bangalore Medical College and Victoria Hospital - 300148268
RECRUITING

Bangalore, Karnataka, 560002, India
Baylor Scott & White Neurology - McKinney
RECRUITING

McKinney, Texas, 75071, United States
Baylor Scott & White Research Institute - Baylor Scott & White Research Institute
RECRUITING

Dallas, Texas, 75246, United States
Box Hill Hospital - PARENT
RECRUITING

Box Hill, Victoria, 3128, Australia
Brain and Mind Research Institute
RECRUITING

Camperdown, New South Wales, 2050, Australia
Brainaxy Clinic S.R.L.
RECRUITING

Constanța, 900591, Romania
Burnaby Hospital - Fraser Health Multiple Sclerosis Clinic
RECRUITING

Burnaby, British Columbia, V5G 2X6, Canada
C. H. R. de la Citadelle - Account 1
RECRUITING

Liège, 4000, Belgium
CER San Juan Centro Polivalente de Asistencia e Inv. Clinica
RECRUITING

San Juan, 5400, Argentina
CHU Clermont Ferrand - Hopital Gabriel Montpied - service de neurologie B
RECRUITING

Clermont-Ferrand, Puy De Dome, 63003, France
CHU Nice - Hôpital Pasteur - Cardiology
RECRUITING

Nice, Alpes Maritimes, 06002, France
CHU Strasbourg - Hopital Hautepierre - Service Anesthesie-Reanimation&Medecine Peri-Opera
RECRUITING

Strasbourg, Bas Rhin, 67098, France
CHU de Grenoble - Hôpital Albert Michallon - Centre de Références des Maladies Neuromusculaires
RECRUITING

La Tronche, Isere, 38700, France
Centralsjukhuset Karlstad
RECRUITING

Karlstad, 65230, Sweden
Centro de Investigaciones Medicas Tucuman
RECRUITING

San Miguel de Tucumán, Argentina
Charité Universitaetsmedizin Berlin - Campus Charité Mitte - Klinik fuer Neurologie
RECRUITING

Berlin, 10117, Germany
Chiba University Hospital - Dept of Neurology
RECRUITING

Chiba, Chiba, 260-8677, Japan
China Medical University Hospital
RECRUITING

Taichung, 404327, Taiwan
China-Japan Union Hospital of Jilin University - 300173736
RECRUITING

Changchun, Jilin, 130033, China
Chonnam National University Hospital
RECRUITING

Gwangju, 61469, South Korea
Chopda Medicare & Research Centre - 300188248
RECRUITING

Nashik, Maharashtra, 422005, India
Clinical Trials of South Carolina - Charleston
RECRUITING

Charleston, South Carolina, 29406, United States
Danderyd Sjukhus - 300147691
RECRUITING

Stockholm, 18288, Sweden
Deenanath Mangeshkar Hospital and Research Centre - Department of Neurology
RECRUITING

Pune, Maharashtra, 411030, India
Dokuz Eylul University Faculty of Medicine - Neurology Department
RECRUITING

Izmir, 35340, Turkey (Türkiye)
Erlanger Health, Inc. - 1123255
RECRUITING

Chattanooga, Tennessee, 37403, United States
Expertia S.A- Mautalen Salud e Investigación
RECRUITING

Ciudad Autonoma Buenos Aires, 1427, Argentina
Fondation Ophtalmologique Adolphe de Rothschild - Service de neurologie
RECRUITING

Paris, Paris, 75940, France
Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, 20133, Italy
Fondazione Istituto Neurologico Casimiro Mondino - Neurology
RECRUITING

Pavia, 27100, Italy
Fukuoka University Hospital - Dept of Neurology/Health Care
RECRUITING

Fukuoka, Fukuoka, 814-0180, Japan
Fundacion Rosarina de Neurorehabilitacion
RECRUITING

Rosario, Argentina
General Hanamaki Hospital - Dept of Neurology
RECRUITING

Hanamaki-shi, Iwate, 025-0082, Japan
Gold Coast University Hospital - PARENT
RECRUITING

Southport, Australia
Groupe Hospitalier Pitie-Salpetriere - Centre Référent Maladies Rares SLA - Neurologie
RECRUITING

Paris, 75013, France
Hacettepe University Medical Faculty - Neurology Department
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Hakodate Municipal Hospital - Dept of Neurology
RECRUITING

Hakodate-shi, Hokkaido, 392006, Japan
Henan Provincial People's Hospital
RECRUITING

Zhengzhou, Henan, 450003, China
Hopital Neurologique Pierre Wertheimer - Pathologies neuro-musculaires. Electromyographie
RECRUITING

Bron, Rhone, 69677, France
Hospital Cordoba
RECRUITING

Córdoba, Argentina
Hospital Universitari Germans Trias i Pujol - Servicio de Neurologia
RECRUITING

Badalona, Barcelona, 08916, Spain
Hospital Universitari Vall d'Hebron - Neurology Dept
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politecnic La Fe - Pediatry Department
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Central de Asturias - Servicio de Neurologia
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Reina Sofia - Neurology Dept
RECRUITING

Córdoba, CÃ³rdoba, 14004, Spain
Huashan Hospital, Fudan University - Neurology
RECRUITING

Shanghai, Shanghai Municipality, 200040, China
Hôpital Henri Mondor - Service de Neurologie
RECRUITING

Créteil, Val De Marne, 94010, France
INECO Neurociencias Oroño
RECRUITING

Rosario, Argentina
IRCCS Istituto delle Scienze Neurologiche di Bologna - Unità Operativa Complessa Clinica Neurologica
RECRUITING

Bologna, 40139, Italy
IRCCS Ospedale Policlinico San Martino - Neuroradiologia
RECRUITING

Genova, 16132, Italy
IUHW Narita Hospital - Dept of Neurology
RECRUITING

Narita-shi, Chiba, 286-8520, Japan
Inselspital - Universitaetsspital Bern - Neuropsychologische Rehabilitation, Neurologie
RECRUITING

Bern, 3010, Switzerland
Instituto de Investigaciones Metabolicas (IDIM)
RECRUITING

Ciudad Autonoma Buenos Aires, C1012AAR, Argentina
Instituto de Investigaciones Neurologicas Raul Carrea, FLENI - de Investigaciones Clinicas del área de Cardiología y enfermedades metabólicas asociadas
RECRUITING

Ciudad Autonoma Buenos Aires, 1428, Argentina
Institutul Clinic Fundeni - parent
RECRUITING

Bucharest, 022328, Romania
Integrated Neurology Services - Dr. Simon Fishman's Office
ACTIVE_NOT_RECRUITING

Falls Church, Virginia, 22043, United States
John Hunter Hospital - PARENT
RECRUITING

City of Burnside, South Australia, SA 5072, Australia
Kagawa University Hospital - Dept of Neurology
RECRUITING

Kita-gun, Kagawa-ken, 7610793, Japan
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 83301, Taiwan
Karadeniz Tecnical Uni. Med. Fac. - Neurology Departmen
RECRUITING

Trabzon, 61080, Turkey (Türkiye)
Keimyung University Dongsan Hospital
WITHDRAWN

Seoul, South Korea
Kocaeli University Medical Faculty - Neurology Department
RECRUITING

Kocaeli, 41380, Turkey (Türkiye)
Korea University Anam Hospital
RECRUITING

Seoul, 136-705, South Korea
Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii Klinicznej
RECRUITING

Krakow, 31-505, Poland
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, 41404, South Korea

Contact Email: •••••@•••••
Ltd. Pineo Medical Ecosystem
RECRUITING

Tbilisi, 0114, Georgia
MHATNP "Sv.Naum", EAD - Third Neurology Clinic
RECRUITING

Sofia, 1113, Bulgaria
MTZ Clinical Research Powered By Pratia
RECRUITING

Warsaw, 02-091, Poland
Mallikatta Neurocentre
RECRUITING

Mangalore, Karnataka, 575001, India
Medical Center Hera - branch Montana
RECRUITING

Montana, 3400, Bulgaria
Medizinische Hochschule Hannover - Klinik fur Neurologie mit Klinischer Neurophysiol
RECRUITING

Hanover, Lower Saxony, 30625, Germany
Mersin University Medical Faculty - Neurology Department
RECRUITING

Mersin, 33079, Turkey (Türkiye)

Contact Email: •••••@•••••
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States
Nagasaki University Hospital - Dept of Neurology
RECRUITING

Nagasaki, Nagasaki, 852-8501, Japan
Neurology Associates, P. A.
RECRUITING

Maitland, Florida, 32751, United States
Neurology of Central Florida Research Center, LLC
RECRUITING

Altamonte Springs, Florida, 32714, United States

Contact Email: •••••@•••••
New Hospitals LLC
RECRUITING

Tbilisi, 0114, Georgia
Nizam's Institute of Medical Sciences
RECRUITING

Hyderabad, Andhra Pradesh, 500082, India
Nottingham University Hospitals NHS Trust
RECRUITING

Nottingham, Nottinghamshire, NG7 2UH, United Kingdom
Ondokuz Mayis Univ. Med. Fac. - Neurology
RECRUITING

Atakum/SAMSUN, 55270, Turkey (Türkiye)
Osaka University Hospital - Dept of Neurology/Stroke Care Unit
RECRUITING

Suita-shi, Japan
Ospedale ca' Foncello - Neurology
RECRUITING

Treviso, 31100, Italy
Peking Union Medical College Hospital
RECRUITING

Beijing, Beijing Municipality, 100730, China
Policlinico Universitario Agostino Gemelli - UOC Neurologia
RECRUITING

Rome, 00168, Italy
Princess Alexandra Hospital - PARENT
RECRUITING

South Brisbane, Queensland, 4101, Australia
Queen Square Centre for Neuromuscular Diseases
RECRUITING

London, Greater London, SE1 9RT, United Kingdom
Royal Hallamshire Hospital - Dept of Neurology
RECRUITING

Sheffield, South Yorkshire, S10 2JF, United Kingdom
S.C Neurocity S.R.L
RECRUITING

Bucharest, 040215, Romania
SFM Clinical Research, LLC
RECRUITING

Boca Raton, Florida, 33487, United States
SP ZOZ Szpital Uniwersytecki w Krakowie - Zespó
RECRUITING

Krakow, 30-688, Poland
Sahlgrenska Sjukhuset
RECRUITING

GÃ¶teborg, 41345, Sweden
Saitama Medical University Hospital - Dept of Neurology/Stroke Care Unit
RECRUITING

Iruma-gun, Saitama, 350-0495, Japan
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul Metropolitan Government Seoul National University Boramae Medical Center
RECRUITING

Seoul, 156707, South Korea
Shengjing Hospital of China Medical University
RECRUITING

Shenyang, Liaoning, 110004, China
Shijiazhuang People's Hospital
RECRUITING

Shijiazhuang, Hebei, 050000, China
Shin Kong Wu Ho-Su Memorial Hospital
RECRUITING

Taipei, 111, Taiwan
Southern Tohoku Medical Clinic - Dept of Neurology
RECRUITING

Koriyama-shi, Fukushima, 963-8563, Japan
Spitalul Clinic Judetean de Urgenta Targu Mures - Sectia Clinica Neurologie I
RECRUITING

Târgu Mureş, 540136, Romania
St John's Medical College Hospital
RECRUITING

Bangalore, Karnataka, 560034, India
St. Joseph Hospital - St. Joseph Hospital Haan
RECRUITING

Bochum, North Rhine-Westphalia, 44791, Germany
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont - Neurologiai Klinika
RECRUITING

Szeged, 6725, Hungary
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
The First Affiliated Hospital of Bengbu Medical College
RECRUITING

Anhui Sheng, Anhui, 233000, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine - 300164595
RECRUITING

Guangzhou, Guangdong, 510405, China
The First Hospital of Jilin University - The First Hospital of Jilin University
RECRUITING

Changchun, Jilin, 130021, China
The George Washington University Medical Faculty Associates Foggy Bottom South Pavilion
RECRUITING

Washington D.C., District of Columbia, 20037, United States
The University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
Toho University Ohashi Medical Center - Dept of Neurology
RECRUITING

Meguro-ku, Tokyo-To, 153-8515, Japan
Tokyo Medical University Hospital - Dept of Neurology
RECRUITING

Shinjuku-ku, Tokyo-To, 160-0023, Japan
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
RECRUITING

Wuhan, Hubei, 430030, China
UMHAT "Sv. Georgi", EAD
RECRUITING

Plovdiv, 4000, Bulgaria
UMHAT 'Dr. Georgi Stranski', EAD
RECRUITING

Pleven, 5800, Bulgaria
UMHATEM 'N.I. Pirogov', EAD
RECRUITING

Sofia, 1606, Bulgaria
UNC Hospitals - PARENT
RECRUITING

Chapel Hill, North Carolina, 27599, United States
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Universitaetsklinikum Carl Gustav Carus TU Dresden - Medizinische Klinik I
RECRUITING

Dresden, Saxony, 01307, Germany
Universitaetsklinikum Duesseldorf AoeR - Klinik fuer Neurologie
RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Universitaetsklinikum Leipzig AoeR - Klinik und Poliklinik fuer Neurologie
RECRUITING

Leipzig, Saxony, 04103, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck - Neurologie
RECRUITING

Lübeck, Schleswig-Holstein, 23562, Germany
Universitaetsklinikum Ulm - Klinik fuer Neurologie
RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
Universitaetsmedizin Goettingen - Abteilung fuer Nephrologie und Rheumatologie
RECRUITING

Göttingen, Lower Saxony, 37075, Germany
University Clinical Center Kragujevac - Department of Neurology
RECRUITING

Kragujevac, 34000, Serbia
University General Hospital of Larissa - Rheumatology Clinic
RECRUITING

Larissa, 41500, Greece
University Hospital of Patra
RECRUITING

Pátrai, 26504, Greece
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Connecticut Health Center - Department of Medicine
RECRUITING

Farmington, Connecticut, 06030-5550, United States
University of Florida Health Science Center - 300120311
RECRUITING

Jacksonville, Florida, 32209, United States
University of Kansas Medical Center Research Institute, Inc. - 3901 Rainbow (MAIN)
RECRUITING

Kansas City, Kansas, 66160, United States
University of South Florida - PARENT - PARENT
RECRUITING

Tampa, Florida, 33612, United States
Uniwersyteckie Centrum Kliniczne - Dept of Neurology
RECRUITING

Gdansk, 80-214, Poland
West China Hospital, Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Wielospecjalistyczne Centrum Medyczne Ibismed - Dept of Neurology
RECRUITING

Zabrze, Poland
Xi 'an International Medical Center
RECRUITING

Xi’an, Shanxi, 710038, China
Xiangya Hospital, Central South University
RECRUITING

Changsha, Hu'nan, 410008, China
Xuanwu Hospital Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100053, China
Yashoda Super Speciality Hospital - 300158817
RECRUITING

Hyderabad, Andhra Pradesh, 500082, India

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