Could a pill tame muscle weakness in myasthenia gravis?
NCT ID NCT06463587
First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 3 times
Summary
This phase 3 trial is testing a new oral form of cladribine, a drug that calms the immune system, in 264 adults with generalized myasthenia gravis. Participants receive either low-dose cladribine, high-dose cladribine, or a placebo in two courses four weeks apart. The main goal is to see if cladribine improves daily activities and muscle strength compared to placebo after 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cladribine (oral tablet)
What this could lead to
If it works, this could offer a new oral treatment option to control symptoms and improve daily living for people with generalized myasthenia gravis.
What could go wrong
This is a phase 3 trial, but cladribine is an immune-suppressing drug with known risks like infections and low blood counts. It may not work better than placebo, and long-term safety is still being studied.
Disclaimer
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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AHEPA General Hospital of Thessaloniki
RECRUITINGThessaloniki, 54636, Greece
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ANESC Research
RECRUITINGEl Paso, Texas, 79912, United States
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Advanced Neurosciences Research LLC
RECRUITINGLongmont, Colorado, 80501, United States
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Affiliated Hospital of Zunyi Medical University
RECRUITINGZunyi, Guizhou, 563099, China
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Arizona Neuroscience Research, LLC
RECRUITINGPhoenix, Arizona, 85032, United States
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Asan Medical Center
RECRUITINGSeoul, 138-736, South Korea
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Atrium Health Wake Forest Baptist
RECRUITINGWinston-Salem, North Carolina, 27157-1078, United States
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Aversi Clinic Ltd
RECRUITINGTbilisi, 0160, Georgia
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Azienda Ospedaliera Universitaria Policlinico Tor Vergata - U.O.C. Neurologia
RECRUITINGRoma, 00133, Italy
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Azienda Socio Sanitaria Territoriale Papa Giovanni
RECRUITINGBergamo, 24127, Italy
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Bangalore Medical College and Victoria Hospital - 300148268
RECRUITINGBangalore, Karnataka, 560002, India
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Baylor Scott & White Neurology - McKinney
RECRUITINGMcKinney, Texas, 75071, United States
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Baylor Scott & White Research Institute - Baylor Scott & White Research Institute
RECRUITINGDallas, Texas, 75246, United States
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Box Hill Hospital - PARENT
RECRUITINGBox Hill, Victoria, 3128, Australia
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Brain and Mind Research Institute
RECRUITINGCamperdown, New South Wales, 2050, Australia
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Brainaxy Clinic S.R.L.
RECRUITINGConstanța, 900591, Romania
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Burnaby Hospital - Fraser Health Multiple Sclerosis Clinic
RECRUITINGBurnaby, British Columbia, V5G 2X6, Canada
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C. H. R. de la Citadelle - Account 1
RECRUITINGLiège, 4000, Belgium
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CER San Juan Centro Polivalente de Asistencia e Inv. Clinica
RECRUITINGSan Juan, 5400, Argentina
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CHU Clermont Ferrand - Hopital Gabriel Montpied - service de neurologie B
RECRUITINGClermont-Ferrand, Puy De Dome, 63003, France
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CHU Nice - Hôpital Pasteur - Cardiology
RECRUITINGNice, Alpes Maritimes, 06002, France
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CHU Strasbourg - Hopital Hautepierre - Service Anesthesie-Reanimation&Medecine Peri-Opera
RECRUITINGStrasbourg, Bas Rhin, 67098, France
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CHU de Grenoble - Hôpital Albert Michallon - Centre de Références des Maladies Neuromusculaires
RECRUITINGLa Tronche, Isere, 38700, France
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Centralsjukhuset Karlstad
RECRUITINGKarlstad, 65230, Sweden
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Centro de Investigaciones Medicas Tucuman
RECRUITINGSan Miguel de Tucumán, Argentina
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Charité Universitaetsmedizin Berlin - Campus Charité Mitte - Klinik fuer Neurologie
RECRUITINGBerlin, 10117, Germany
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Chiba University Hospital - Dept of Neurology
RECRUITINGChiba, Chiba, 260-8677, Japan
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China Medical University Hospital
RECRUITINGTaichung, 404327, Taiwan
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China-Japan Union Hospital of Jilin University - 300173736
RECRUITINGChangchun, Jilin, 130033, China
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Chonnam National University Hospital
RECRUITINGGwangju, 61469, South Korea
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Chopda Medicare & Research Centre - 300188248
RECRUITINGNashik, Maharashtra, 422005, India
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Clinical Trials of South Carolina - Charleston
RECRUITINGCharleston, South Carolina, 29406, United States
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Danderyd Sjukhus - 300147691
RECRUITINGStockholm, 18288, Sweden
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Deenanath Mangeshkar Hospital and Research Centre - Department of Neurology
RECRUITINGPune, Maharashtra, 411030, India
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Erlanger Health, Inc. - 1123255
RECRUITINGChattanooga, Tennessee, 37403, United States
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Expertia S.A- Mautalen Salud e Investigación
RECRUITINGCiudad Autonoma Buenos Aires, 1427, Argentina
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Fondation Ophtalmologique Adolphe de Rothschild - Service de neurologie
RECRUITINGParis, Paris, 75940, France
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Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITINGMilan, 20133, Italy
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Fondazione Istituto Neurologico Casimiro Mondino - Neurology
RECRUITINGPavia, 27100, Italy
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Fukuoka University Hospital - Dept of Neurology/Health Care
RECRUITINGFukuoka, Fukuoka, 814-0180, Japan
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Fundacion Rosarina de Neurorehabilitacion
RECRUITINGRosario, Argentina
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General Hanamaki Hospital - Dept of Neurology
RECRUITINGHanamaki-shi, Iwate, 025-0082, Japan
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Gold Coast University Hospital - PARENT
RECRUITINGSouthport, Australia
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Groupe Hospitalier Pitie-Salpetriere - Centre Référent Maladies Rares SLA - Neurologie
RECRUITINGParis, 75013, France
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Hacettepe University Medical Faculty - Neurology Department
RECRUITINGAnkara, 06100, Turkey (Türkiye)
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Hakodate Municipal Hospital - Dept of Neurology
RECRUITINGHakodate-shi, Hokkaido, 392006, Japan
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Henan Provincial People's Hospital
RECRUITINGZhengzhou, Henan, 450003, China
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Hopital Neurologique Pierre Wertheimer - Pathologies neuro-musculaires. Electromyographie
RECRUITINGBron, Rhone, 69677, France
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Hospital Cordoba
RECRUITINGCórdoba, Argentina
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Hospital Universitari Germans Trias i Pujol - Servicio de Neurologia
RECRUITINGBadalona, Barcelona, 08916, Spain
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Hospital Universitari Vall d'Hebron - Neurology Dept
RECRUITINGBarcelona, 08035, Spain
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Hospital Universitari i Politecnic La Fe - Pediatry Department
RECRUITINGValencia, 46026, Spain
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Hospital Universitario Central de Asturias - Servicio de Neurologia
RECRUITINGOviedo, Principality of Asturias, 33011, Spain
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Hospital Universitario Reina Sofia - Neurology Dept
RECRUITINGCórdoba, Córdoba, 14004, Spain
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Huashan Hospital, Fudan University - Neurology
RECRUITINGShanghai, Shanghai Municipality, 200040, China
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Hôpital Henri Mondor - Service de Neurologie
RECRUITINGCréteil, Val De Marne, 94010, France
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INECO Neurociencias Oroño
RECRUITINGRosario, Argentina
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IRCCS Istituto delle Scienze Neurologiche di Bologna - Unità Operativa Complessa Clinica Neurologica
RECRUITINGBologna, 40139, Italy
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IRCCS Ospedale Policlinico San Martino - Neuroradiologia
RECRUITINGGenova, 16132, Italy
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IUHW Narita Hospital - Dept of Neurology
RECRUITINGNarita-shi, Chiba, 286-8520, Japan
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Inselspital - Universitaetsspital Bern - Neuropsychologische Rehabilitation, Neurologie
RECRUITINGBern, 3010, Switzerland
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Instituto de Investigaciones Metabolicas (IDIM)
RECRUITINGCiudad Autonoma Buenos Aires, C1012AAR, Argentina
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Instituto de Investigaciones Neurologicas Raul Carrea, FLENI - de Investigaciones Clinicas del área de Cardiología y enfermedades metabólicas asociadas
RECRUITINGCiudad Autonoma Buenos Aires, 1428, Argentina
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Institutul Clinic Fundeni - parent
RECRUITINGBucharest, 022328, Romania
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Integrated Neurology Services - Dr. Simon Fishman's Office
ACTIVE_NOT_RECRUITINGFalls Church, Virginia, 22043, United States
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John Hunter Hospital - PARENT
RECRUITINGCity of Burnside, South Australia, SA 5072, Australia
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Kagawa University Hospital - Dept of Neurology
RECRUITINGKita-gun, Kagawa-ken, 7610793, Japan
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Kaohsiung Chang Gung Memorial Hospital
RECRUITINGKaohsiung City, 83301, Taiwan
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Karadeniz Tecnical Uni. Med. Fac. - Neurology Departmen
RECRUITINGTrabzon, 61080, Turkey (Türkiye)
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Keimyung University Dongsan Hospital
WITHDRAWNSeoul, South Korea
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Korea University Anam Hospital
RECRUITINGSeoul, 136-705, South Korea
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Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii Klinicznej
RECRUITINGKrakow, 31-505, Poland
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Kyungpook National University Chilgok Hospital
RECRUITINGDaegu, 41404, South Korea
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Ltd. Pineo Medical Ecosystem
RECRUITINGTbilisi, 0114, Georgia
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MHATNP "Sv.Naum", EAD - Third Neurology Clinic
RECRUITINGSofia, 1113, Bulgaria
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MTZ Clinical Research Powered By Pratia
RECRUITINGWarsaw, 02-091, Poland
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Mallikatta Neurocentre
RECRUITINGMangalore, Karnataka, 575001, India
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Medical Center Hera - branch Montana
RECRUITINGMontana, 3400, Bulgaria
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Medizinische Hochschule Hannover - Klinik fur Neurologie mit Klinischer Neurophysiol
RECRUITINGHanover, Lower Saxony, 30625, Germany
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Mersin University Medical Faculty - Neurology Department
RECRUITINGMersin, 33079, Turkey (Türkiye)
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Miami Valley Hospital South
RECRUITINGCenterville, Ohio, 45459, United States
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Nagasaki University Hospital - Dept of Neurology
RECRUITINGNagasaki, Nagasaki, 852-8501, Japan
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Neurology Associates, P. A.
RECRUITINGMaitland, Florida, 32751, United States
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Neurology of Central Florida Research Center, LLC
RECRUITINGAltamonte Springs, Florida, 32714, United States
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New Hospitals LLC
RECRUITINGTbilisi, 0114, Georgia
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Nizam's Institute of Medical Sciences
RECRUITINGHyderabad, Andhra Pradesh, 500082, India
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Nottingham University Hospitals NHS Trust
RECRUITINGNottingham, Nottinghamshire, NG7 2UH, United Kingdom
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Ondokuz Mayis Univ. Med. Fac. - Neurology
RECRUITINGAtakum/SAMSUN, 55270, Turkey (Türkiye)
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Osaka University Hospital - Dept of Neurology/Stroke Care Unit
RECRUITINGSuita-shi, Japan
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Ospedale ca' Foncello - Neurology
RECRUITINGTreviso, 31100, Italy
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Peking Union Medical College Hospital
RECRUITINGBeijing, Beijing Municipality, 100730, China
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Policlinico Universitario Agostino Gemelli - UOC Neurologia
RECRUITINGRome, Roma, 00168, Italy
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Princess Alexandra Hospital - PARENT
RECRUITINGSouth Brisbane, Queensland, 4101, Australia
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Royal Hallamshire Hospital - Dept of Neurology
RECRUITINGSheffield, South Yorkshire, S10 2JF, United Kingdom
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S.C Neurocity S.R.L
RECRUITINGBucharest, 040215, Romania
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SFM Clinical Research, LLC
RECRUITINGBoca Raton, Florida, 33487, United States
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SP ZOZ Szpital Uniwersytecki w Krakowie - Zespó
RECRUITINGKrakow, 30-688, Poland
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Sahlgrenska Sjukhuset
RECRUITINGGöteborg, 41345, Sweden
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Saitama Medical University Hospital - Dept of Neurology/Stroke Care Unit
RECRUITINGIruma-gun, Saitama, 350-0495, Japan
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Seoul Metropolitan Government Seoul National University Boramae Medical Center
RECRUITINGSeoul, 156707, South Korea
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Shengjing Hospital of China Medical University
RECRUITINGShenyang, Liaoning, 110004, China
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Shijiazhuang People's Hospital
RECRUITINGShijiazhuang, Hebei, 050000, China
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Shin Kong Wu Ho-Su Memorial Hospital
RECRUITINGTaipei, 111, Taiwan
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Southern Tohoku Medical Clinic - Dept of Neurology
RECRUITINGKoriyama-shi, Fukushima, 963-8563, Japan
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Spitalul Clinic Judetean de Urgenta Targu Mures - Sectia Clinica Neurologie I
RECRUITINGTârgu Mureş, 540136, Romania
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St John's Medical College Hospital
RECRUITINGBangalore, Karnataka, 560034, India
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St. Joseph Hospital - St. Joseph Hospital Haan
RECRUITINGBochum, North Rhine-Westphalia, 44791, Germany
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Sunshine Coast University Hospital
RECRUITINGBirtinya, Queensland, 4575, Australia
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Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont - Neurologiai Klinika
RECRUITINGSzeged, 6725, Hungary
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Taipei Veterans General Hospital
RECRUITINGTaipei, 11217, Taiwan
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The First Affiliated Hospital of Bengbu Medical College
RECRUITINGAnhui Sheng, Anhui, 233000, China
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The First Affiliated Hospital of Guangzhou University of Chinese Medicine - 300164595
RECRUITINGGuangzhou, Guangdong, 510405, China
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The First Hospital of Jilin University - The First Hospital of Jilin University
RECRUITINGChangchun, Jilin, 130021, China
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The George Washington University Medical Faculty Associates Foggy Bottom South Pavilion
RECRUITINGWashington D.C., District of Columbia, 20037, United States
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The University of Vermont Medical Center
RECRUITINGBurlington, Vermont, 05401, United States
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Toho University Ohashi Medical Center - Dept of Neurology
RECRUITINGMeguro-ku, Tokyo-To, 153-8515, Japan
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Tokyo Medical University Hospital - Dept of Neurology
RECRUITINGShinjuku-ku, Tokyo-To, 160-0023, Japan
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Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
RECRUITINGWuhan, Hubei, 430030, China
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UMHAT "Sv. Georgi", EAD
RECRUITINGPlovdiv, 4000, Bulgaria
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UMHAT 'Dr. Georgi Stranski', EAD
RECRUITINGPleven, 5800, Bulgaria
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UMHATEM 'N.I. Pirogov', EAD
RECRUITINGSofia, 1606, Bulgaria
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UNC Hospitals - PARENT
RECRUITINGChapel Hill, North Carolina, 27599, United States
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UZ Leuven
RECRUITINGLeuven, 3000, Belgium
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Universitaetsklinikum Carl Gustav Carus TU Dresden - Medizinische Klinik I
RECRUITINGDresden, Saxony, 01307, Germany
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Universitaetsklinikum Duesseldorf AoeR - Klinik fuer Neurologie
RECRUITINGDüsseldorf, North Rhine-Westphalia, 40225, Germany
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Universitaetsklinikum Leipzig AoeR - Klinik und Poliklinik fuer Neurologie
RECRUITINGLeipzig, Saxony, 04103, Germany
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Universitaetsklinikum Schleswig-Holstein - Campus Luebeck - Neurologie
RECRUITINGLübeck, Schleswig-Holstein, 23562, Germany
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Universitaetsklinikum Ulm - Klinik fuer Neurologie
RECRUITINGUlm, Baden-Wurttemberg, 89081, Germany
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Universitaetsmedizin Goettingen - Abteilung fuer Nephrologie und Rheumatologie
RECRUITINGGöttingen, Lower Saxony, 37075, Germany
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University General Hospital of Larissa - Rheumatology Clinic
RECRUITINGLarissa, 41500, Greece
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University Hospital of Patra
RECRUITINGPátrai, 26504, Greece
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45219, United States
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University of Connecticut Health Center - Department of Medicine
RECRUITINGFarmington, Connecticut, 06030-5550, United States
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University of Florida Health Science Center - 300120311
RECRUITINGJacksonville, Florida, 32209, United States
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University of Kansas Medical Center Research Institute, Inc. - 3901 Rainbow (MAIN)
RECRUITINGKansas City, Kansas, 66160, United States
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University of South Florida - PARENT - PARENT
RECRUITINGTampa, Florida, 33612, United States
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Uniwersyteckie Centrum Kliniczne - Dept of Neurology
RECRUITINGGdansk, 80-214, Poland
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West China Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, 610041, China
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Wielospecjalistyczne Centrum Medyczne Ibismed - Dept of Neurology
RECRUITINGZabrze, Poland
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Xi 'an International Medical Center
RECRUITINGXi’an, Shanxi, 710038, China
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Xiangya Hospital, Central South University
RECRUITINGChangsha, Hu'nan, 410008, China
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Xuanwu Hospital Capital Medical University
RECRUITINGBeijing, Beijing Municipality, 100053, China
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Yashoda Super Speciality Hospital - 300158817
RECRUITINGHyderabad, Andhra Pradesh, 500082, India
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