New hope for blood cancer patients: Two-Drug combo aims to tame disease

NCT ID NCT04603495

Summary

This large, late-stage trial is testing whether adding a new drug called pelabresib to the standard treatment (ruxolitinib) works better for people newly diagnosed with myelofibrosis, a serious bone marrow cancer. The study will see if the combination shrinks enlarged spleens more effectively and better relieves symptoms like fatigue and pain. It involves 430 patients who have not yet received this type of targeted therapy.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • : Pecs University, 1st Department of Medicine

    Pécs, Pecs, 7624, Hungary

  • :Hospital Ampang

    Ampang, Selangor, 68000, Malaysia

  • A.O.U. Policlinico S. Orsola-Malpighi

    Bologna, 40138, Italy

  • AOU S.Luigi Gonzaga

    Orbassano, Italy

  • Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust

    Cambridge, CB2 0QQ, United Kingdom

  • Amiens South Hospital univerisy - Hopital Sud

    Amiens, 80054, France

  • Amsterdam UMC

    Amsterdam, 1081, Netherlands

  • Ankara University Faculty of Medicine Cebeci Research and Application Hospital

    Ankara, Turkey (Türkiye)

  • Antalya Medstar Hospital

    Antalya, Turkey (Türkiye)

  • Azienda Ospedaliera San Gerardo di Monza

    Monza, Italy

  • Azienda Ospedaliera Universitaria Arcispedale Sant'Anna

    Ferrara, Italy

  • Azienda Ospedaliera Universitaria Careggi

    Florence, Italy

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

    Bergamo, 24127, Italy

  • Center for Blood Disorders and Cellular Therapy, Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • Centre Hospitalier

    Le Mans, 72000, France

  • Centre Hospitalier Lyon Sud Secteur 1G

    Pierre-Bénite, 69310, France

  • Centrum Medyczne Pratia

    Skorzewo, 60-185, Poland

  • Chang Gung Memorial Hospital Chiayi

    Chiayi City, Taiwan

  • China Medical University Hospital

    Chiayi City, Taiwan

  • Chru Brabois

    Vandœuvre-lès-Nancy, 54500, France

  • Chu Pontchaillou - Service Hematologie

    Rennes, 35033, France

  • Chulabhorn Hospital

    Bangkok, Lak Si, 10210, Thailand

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio, 44195, United States

  • Cliniques universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Daegu Catholic University Medical Center

    Daegu, South Korea

  • Decatur Memorial Hospital Cancer Care Center of Decatur/Cancer Care Specialists of IL

    Decatur, Illinois, 62526, United States

  • Domaine Universitaire du Sart Tilman

    Liège, 4000, Belgium

  • Dr. Abdurrahman Yurtaslan Oncology Health Application and Research Center

    Ankara, Turkey (Türkiye)

  • Edirne Trakya University Faculty of Medicine Hospital

    Edirne, Turkey (Türkiye)

  • Erciyes University Faculty of Medicine Hospital

    Kayseri, 8039, Turkey (Türkiye)

  • Fakultni nemocnice Hradec Kralove

    Hradec Králové, 500 05, Czechia

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, Italy

  • Franciscan Health/Indiana blood and Marrow Transplantation

    Indianapolis, Indiana, 46237, United States

  • Gachon University Gil Medical Center

    Incheon, South Korea

  • Gard Cancer Institute

    Nîmes, 30029, France

  • Gaziantep University Sahinbey Research and Application Center Hospital

    Gaziantep, Turkey (Türkiye)

  • Guy's & St Thomas NHS Foundation Trust

    London, SE1 9RT, United Kingdom

  • Gyeongsang National University Hospital

    Jinju, Gyeongsangnam-do, South Korea

  • Hadassah University Hospital-Ein Kerem

    Jerusalem, 9590300, Israel

  • Hospital Clinic de Barcelona

    Barcelona, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Ordine Mauriziano of Turin

    Turin, 10128, Italy

  • Hospital Pulau Pinang

    George Town, Pulau Pinang, 10450, Malaysia

  • Hospital Queen Elizabeth

    Kota Kinabalu, 88586, Malaysia

  • Hospital San Pedro de Alcantara

    Cáceres, 10003, Spain

  • Hospital Sultanah Aminah

    Johor Bahru, Johor, 80100, Malaysia

  • Hospital Sultanah Bahiyah

    Alor Star, Kedah, 05460, Malaysia

  • Hospital Universitario Central de Asturias

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Universitario de Gran Canaria Dr. Negrin

    Las Palmas de Gran Canaria, 35010, Spain

  • Hospital Universitario de Salamanc

    Salamanca, 37007, Spain

  • Hospital Virgen Macarena

    Seville, Spain

  • Hämatologisch-Onkologische Praxis Augsburg

    Augsburg, Bavaria, 86151, Germany

  • Hôpital Bretonneau

    Tours, 37044, France

  • Hôpital de Jolimont

    La Louvière, 7100, Belgium

  • Hôpital l'Archet 1

    Nice, 06202, France

  • ICO Badalona - Hospital Universitari Germans Trias i Pujol

    Badalona, 8916, Spain

  • IRCCS Istituto Romagnolo per lo studio dei tumori "Dino Amadori"

    Meldola, Italy

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Icon Cancer Centre

    Brisbane, Queensland, 4101, Australia

  • Imperial College Healthcare NHS Trust, Hammersmith Hospital

    London, W12 0HS, United Kingdom

  • Inje University Busan Paik Hospital

    Busan, South Korea

  • Inje University Haeundae Paik Hospital

    Busan, 48108, South Korea

  • Institut de Cancérologie Lucien Neuwirth

    Saint-Priest-en-Jarez, 42271, France

  • Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers

    Chandler, Arizona, 85224, United States

  • Izmir Ege University Faculty of Medicine Hospital

    Izmir, Turkey (Türkiye)

  • Jeonbuk National University Hospital

    Jeonju, 54907, South Korea

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Kepler University Hospital

    Linz, 4021, Austria

  • King Chulalongkorn Memorial Hospital

    Bangkok, Pathumwan, 10330, Thailand

  • Kocaeli University Application

    Kocaeli, Turkey (Türkiye)

  • Korea University Anam Hospital

    Seoul, South Korea

  • Krankenhaus der Elisabethinen Linz

    Linz, 4020, Austria

  • Kyungpook National University Hospital

    Daegu, 41944, South Korea

  • LKH - Universitätsklinikum Graz; Abteilung für Hämatologie

    Graz, A-8036, Austria

  • Lady Davis Carmel Medical Center

    Haifa, 3436212, Israel

  • Laiko General Hospital

    Athens, Greece

  • London Health Sciences Center - Victoria Hospital

    London, Ontario, N6A 5W9, Canada

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Maastricht University Medical Center

    Maastricht, 6229 HX, Netherlands

  • Mayo Clinic

    Jacksonville, Florida, 32224, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Mersin University

    Mersin, Turkey (Türkiye)

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Monash Health

    Clayton, Victoria, 3168, Australia

  • Morales Meseguer General University Hospital

    Murcia, 30008, Spain

  • Nasz Lekarz Przychodnie Medyczne

    Torun, 87-100, Poland

  • National Taiwan University Hospital

    Taipei, Taiwan

  • Norton Cancer Institute, St. Matthews Campus

    Louisville, Kentucky, 40207, United States

  • One Clinical Research PTY LTD

    Nedlands, 6009, Australia

  • Ospedale Sant'Eugenio

    Rome, Italy

  • Ospedale di Circolo e Fondazione Macchi - ASST Sette Laghi

    Varese, Italy

  • Oxford University Hospitals NHS Foundation Trust, Department of Haematology, Cancer and Haematology Centre, Churchill Hospital

    Oxford, United Kingdom

  • Peninsula Private Hospital Clinical Trials Unit

    Frankston, Victoria, 3199, Australia

  • Pilgrim Hospital

    Boston, PE21 9QS, United Kingdom

  • Pratia Onkologia Katowice

    Katowice, Poland

  • Prince of Wales Hospital

    Hong Kong, New Territories, Hong Kong

  • Princess Margaret Cancer Center

    Toronto, Ontario, M5G 2M9, Canada

  • Princess Margaret Hospital

    Hong Kong, Kowloon, Hong Kong

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Quirónsalud Madrid University Hospital

    Madrid, 28223, Spain

  • Rabin Medical Center - Beilinson Campus,

    Petah Tikva, 49100, Israel

  • Rajavithi Hospital

    Bangkok, Ratchathewi District, 10400, Thailand

  • Rambam Health Corporation

    Haifa, 3109601, Israel

  • Regional Hospital Spedali Civili di Brescia

    Brescia, 25123, Italy

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Samsun 19 Mayıs University Health Application Research Hospital

    Samsun, Turkey (Türkiye)

  • Samsung Medical Center

    Seoul, 135-710, South Korea

  • Seoul National University Hospital

    Seoul, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • Shaarei Zedek

    Nahariya, 2210001, Israel

  • Shamir Medical Center

    Be’er Ya‘aqov, 60930000, Israel

  • Songklanagarind Hospital

    Songkhla, Hat Yai District, 90110, Thailand

  • Soroka Medical Center

    Beersheba, 84101, Israel

  • Srinagarind hospital,Khon Kaen University

    Khon Kaen, Mueang Khon Kaen District, 40002, Thailand

  • Sunway Medical Centre

    Petaling Jaya, Selangor, 47500, Malaysia

  • Szabolcs Szatmár Bereg Megyei Kórházak és Egyetemi Oktatókórház; Jósa András Oktatókórház, Hematológia

    Nyíregyháza, Hungary

  • Taichung Veterans General Hospital

    Taichung, Taiwan

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • The Catholic University Of Korea St. Vincent Hospital

    Gyeonggi-do, South Korea

  • The Catholic University of Korea

    Seoul, South Korea

  • The Catholic University of South Korea Seoul St. Mary's Hospital

    Seoul, South Korea

  • The Clatterbridge Cancer Centre

    Liverpool, L7 8YA, United Kingdom

  • Tom Baker Cancer Centre

    Calgary, Alberta, T2N 4N2, Canada

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCLA Medical Center

    Los Angeles, California, 90095, United States

  • UGH of Ioannina

    Ioannina, 455 00, Greece

  • USC Clinical Trials Centre Sunshine Coast Haematology and Oncology Clinic

    Buderim, QLD 4556, Australia

  • USC/Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • UZ Leuven

    Leuven, Belgium

  • Ulsan University Hospital

    Ulsan, South Korea

  • University College London Hospitals

    London, United Kingdom

  • University General Hospital of Patras

    Rio, 26504, Greece

  • University Hospital 'Paolo Giaccone' Polyclinic

    Palermo, 90127, Italy

  • University Hospital Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • University Hospital Maggiore della Carità

    Novara, 28100, Italy

  • University Hospital Olomouc

    Olomouc, 779 00, Czechia

  • University Hospital Salzburg

    Salzburg, 5020, Austria

  • University Hospital of Padova

    Padua, 35128, Italy

  • University Hospital of Toledo

    Toledo, 45007, Spain

  • University Hospital of Wales

    Cardiff, Wales, CF14 4XW, United Kingdom

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294-3300, United States

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Michigan Medical Center

    Ann Arbor, Michigan, 48109, United States

  • University of Texas Health Science Center - San Antonio

    San Antonio, Texas, 78229, United States

  • Universitätsklinikum Halle (Saale), Krukenberg-Krebszentrum Halle (KKH)

    Halle, Saxony, 06120, Germany

  • Universitätsklinikum Jena, Klinik für Innere Medizin II

    Jena, Thuringia, 07747, Germany

  • Universitätsklinikum Ulm

    Ulm, Baden-Wurttemberg, 89081, Germany

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-293, Poland

  • Vall d'Hebron Institute of Oncology

    Barcelona, Spain

  • Washington University

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medical College- New York Presbyterian Hospital

    New York, New York, 10065, United States

  • Western General Hospital

    Edinburgh, Scotland, EH4 2XU, United Kingdom

  • Wojewódzki Szpital Specjalistyczny w Bialej Podlaskiej

    Biała Podlaska, 21-50, Poland

  • Wolfson Medical Center

    Holon, Israel

  • Yale University School of Medicine

    New Haven, Connecticut, 06510, United States

  • ZNA

    Antwerp, Belgium

Conditions

Explore the condition pages connected to this study.