Major trial aims to boost chemo power against aggressive blood cancer

NCT ID NCT06356129

Ongoing Disease control Sponsor: Celgene Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding an experimental drug called golcadomide to standard chemotherapy (R-CHOP) works better and is safe for people newly diagnosed with high-risk large B-cell lymphoma. It will involve about 850 participants who will be randomly assigned to receive either the new combination or the standard chemo plus a placebo. The main goal is to see if the new combination helps patients live longer without their cancer getting worse.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO

Palermo, Sicily, 90146, Italy
Faculty of Medicine Siriraj Hospital

Bangkok, Bangkok, 10700, Thailand
Local Institution - 0004

Sherbrooke, Quebec, J1H 5N4, Canada
Local Institution - 0009

Pittsburgh, Pennsylvania, 15232, United States
Local Institution - 0012

Pensacola, Florida, 32504, United States
Local Institution - 0014

Mobile, Alabama, 36604, United States
Local Institution - 0031

Westwood, Kansas, 66205, United States
Local Institution - 0045

Miami Beach, Florida, 33140, United States
Local Institution - 0046

Houston, Texas, 77030, United States
Local Institution - 0048

Skokie, Illinois, 60077, United States
Local Institution - 0049

Morristown, New Jersey, 07960, United States
Local Institution - 0066

Massillon, Ohio, 44646, United States
Local Institution - 0067

Minneapolis, Minnesota, 55407, United States
Local Institution - 0068

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea
Local Institution - 0069

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea
Local Institution - 0070

Seoul, Seoul-teukbyeolsi [Seoul], 06591, South Korea
Local Institution - 0071

L'Hospitalet Del Llobregat, Barcelona [Barcelona], 08908, Spain
Local Institution - 0072

Madrid, 28006, Spain
Local Institution - 0073

Montreal, Quebec, H4J 1C5, Canada
Local Institution - 0074

Montpellier, Languedoc-Roussillon, 34295, France
Local Institution - 0076

Villejuif, Val-de-Marne, 94800, France
Local Institution - 0077

Paris, 75010, France
Local Institution - 0079

Tours, Indre-et-Loire, 37032, France
Local Institution - 0081

Lille, Nord, 59000, France
Local Institution - 0083

Nice, Alpes-Maritimes, 06202, France
Local Institution - 0084

Strasbourg, Alsace, 67033, France
Local Institution - 0087

Marseille, Bouches-du-Rhône, 13273, France
Local Institution - 0089

Pierre-Bénite, Rhône, 69310, France
Local Institution - 0090

Bordeaux, Aquitaine, 33076, France
Local Institution - 0091

Victoria, British Columbia, V8R 6V5, Canada
Local Institution - 0092

Málaga, Málaga, 29010, Spain
Local Institution - 0093

Salamanca, 37007, Spain
Local Institution - 0095

Cáceres, 10003, Spain
Local Institution - 0096

Majadahonda, Madrid, Comunidad de, 28222, Spain
Local Institution - 0098

Porto, 4200-072, Portugal
Local Institution - 0100

Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea
Local Institution - 0102

Olomouc, Olomoucký kraj, 779 00, Czechia
Local Institution - 0103

Prague, Praha 10, 100 34, Czechia
Local Institution - 0104

Hradec Králové, Hradec Králové, 500 05, Czechia
Local Institution - 0105

Brno, Brno-město, 625 00, Czechia
Local Institution - 0106

Santiago, Santiago Metropolitan, 7500921, Chile
Local Institution - 0107

Santiago, Santiago Metropolitan, 7580206, Chile
Local Institution - 0108

Santiago, Santiago Metropolitan, 7620002, Chile
Local Institution - 0110

Santiago, Santiago Metropolitan, 8320325, Chile
Local Institution - 0111

Córdoba, 5016, Argentina
Local Institution - 0112

Buenos Aires, 1426, Argentina
Local Institution - 0113

Buenos Aires, Buenos Aires F.D., C1118AAT, Argentina
Local Institution - 0114

Busan, Pusan-Kwangyǒkshi, 49241, South Korea
Local Institution - 0115

Busan, Pusan-Kwangyǒkshi, 49201, South Korea
Local Institution - 0118

Seoul, 07345, South Korea
Local Institution - 0119

Buenos Aires, C1426ANZ, Argentina
Local Institution - 0120

Pilsen, Plzeň Region, 305 99, Czechia
Local Institution - 0121

Mexico City, DIF, 14080, Mexico
Local Institution - 0122

Mexico City, DIF, 03100, Mexico
Local Institution - 0124

Puebla City, 72424, Mexico
Local Institution - 0125

Oaxaca City, Oaxaca, 68020, Mexico
Local Institution - 0126

Mexico City, Mexico City, 14080, Mexico
Local Institution - 0127

Morelia, Michoacán, 58260, Mexico
Local Institution - 0128

Mexico City, Mexico City, 06720, Mexico
Local Institution - 0129

Bogotá, Bogota D.C., 110131, Colombia
Local Institution - 0130

Bogota, Cundinamarca, 111151, Colombia
Local Institution - 0131

Busan, Pusan-Kwangyǒkshi, 49267, South Korea
Local Institution - 0132

Shanghai, Shanghai Municipality, 200025, China
Local Institution - 0133

Guangzhou, Guangdong, 510515, China
Local Institution - 0134

Taipei, 10002, Taiwan
Local Institution - 0135

Taichung, 40447, Taiwan
Local Institution - 0136

Buenos Aires, C1431FWO, Argentina
Local Institution - 0139

Monterrey, Nuevo León, 66460, Mexico
Local Institution - 0141

Chengdu, Sichuan, 610041, China
Local Institution - 0142

Chiayi City, Chiayi, 613, Taiwan
Local Institution - 0143

Seoul, Seoul-teukbyeolsi [Seoul], 02841, South Korea
Local Institution - 0145

Taichung, 407, Taiwan
Local Institution - 0146

Tainan, Tainan, 71004, Taiwan
Local Institution - 0147

Taipei, 112, Taiwan
Local Institution - 0149

Goyang-si, Kyǒnggi-do, 10408, South Korea
Local Institution - 0153

Montreal, Quebec, H3T 1M5, Canada
Local Institution - 0154

Mumbai, Maharashtra, 400012, India
Local Institution - 0156

Suzhou, Jiangsu, 215006, China
Local Institution - 0157

Xiamen, Fujian, 361003, China
Local Institution - 0158

Taoyuan District, 333, Taiwan
Local Institution - 0159

Kaohsiung City, 83301, Taiwan
Local Institution - 0160

Budapest, 1122, Hungary
Local Institution - 0161

Szombathely, Vas County, 9700, Hungary
Local Institution - 0162

Kaposvár, Somogy County, 7400, Hungary
Local Institution - 0163

Budapest, 1088, Hungary
Local Institution - 0164

Viña del Mar, Región de Valparaíso, 0, Chile
Local Institution - 0166

Sakai, Osaka, 590-0197, Japan
Local Institution - 0167

Yamagata, 990-9585, Japan
Local Institution - 0168

Kashiwa, Chiba, 277-8577, Japan
Local Institution - 0169

Shenyang, Liaoning, 110015, China
Local Institution - 0170

Isehara, Kanagawa, 259-1193, Japan
Local Institution - 0171

Kumamoto, 860-0008, Japan
Local Institution - 0172

Santa Cruz de Tenerife, Canary Islands, 38010, Spain
Local Institution - 0174

Chapel Hill, North Carolina, 27599, United States
Local Institution - 0175

New Brunswick, New Jersey, 08901, United States
Local Institution - 0176

New York, New York, 10029, United States
Local Institution - 0179

Portland, Oregon, 97239, United States
Local Institution - 0182

Chicago, Illinois, 60611, United States
Local Institution - 0190

Buffalo, New York, 14263, United States
Local Institution - 0192

West Palm Beach, Florida, 33401, United States
Local Institution - 0195

Beijing, Beijing Municipality, 100091, China
Local Institution - 0196

Chongqing, Chongqing Municipality, 400030, China
Local Institution - 0197

Hangzhou, Zhejiang, 310003, China
Local Institution - 0200

Créteil, Val-de-Marne, 94010, France
Local Institution - 0201

Krakow, Lesser Poland Voivodeship, 30-727, Poland
Local Institution - 0202

Lille, Hauts-de-France, 59020, France
Local Institution - 0203

Rochester, Minnesota, 55905, United States
Local Institution - 0204

Bratislava, 83101, Slovakia
Local Institution - 0214

Wuhan, Hubei, 430030, China
Local Institution - 0215

Kyoto, 602-8566, Japan
Local Institution - 0223

La Tronche, Isère, 38700, France
Local Institution - 0233

Suwon, Kyǒnggi-do, 16499, South Korea
Local Institution - 0234

Taiyuan, Shanxi, 030032, China
Local Institution - 0236

Chongqing, Chongqing Municipality, 400016, China
Local Institution - 0237

Nanchang, Jiangxi, 330006, China
Local Institution - 0238

Zhengzhou, Henan, 450008, China
Local Institution - 0239

Harbin, Heilongjiang, 150081, China
Local Institution - 0240

Guangzhou, Guangdong, 510555, China
Local Institution - 0241

Nanchang, Jiangxi, 330029, China
Local Institution - 0242

Jinan, Shandong, 250012, China
Local Institution - 0243

Prague, 12808, Czechia
Local Institution - 0244

Bayonne, 64109, France
Local Institution - 0246

Chapecó, Santa Catarina, 89812-210, Brazil
Local Institution - 0247

Joinville, Santa Catarina, 89201260, Brazil
Local Institution - 0248

São Paulo, São Paulo, 01323-903, Brazil
Local Institution - 0249

Jaú, São Paulo, 17210-120, Brazil
Local Institution - 0250

Barretos, São Paulo, 14784400, Brazil
Local Institution - 0251

São Paulo, 05652-900, Brazil
Local Institution - 0252

São Paulo, 04543-000, Brazil
Local Institution - 0253

Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
Local Institution - 0255

Fortaleza, Ceará, 60115-281, Brazil
Local Institution - 0256

Goiânia, Goiás, 74605-020, Brazil
Local Institution - 0266

Debrecen, Hajdú-Bihar, 4032, Hungary
Local Institution - 0268

Itabashiku, Tokyo, 173-8610, Japan
Local Institution - 0269

Hidaka, Saitama, 350-1298, Japan
Local Institution - 0270

Kanazawa, Ishikawa-ken, 920-8530, Japan
Local Institution - 0271

Ōgaki, Gifu, 503-8502, Japan
Local Institution - 0272

Hiroshima, 7348551, Japan
Local Institution - 0273

Amagasaki, Hyōgo, 660-8550, Japan
Local Institution - 0274

Fuzhou, Fujian, 350014, China
Local Institution - 0275

Changsha, Hunan, 410013, China
Local Institution - 0277

Uppsala, Uppsala Län [se-03], 751 85, Sweden
Local Institution - 0278

Linköping, Östergötlands Län [se-05], 581 85, Sweden
Local Institution - 0279

Lund, Skåne Län [se-12], 22185, Sweden
Local Institution - 0280

Helsinki, 00029, Finland
Local Institution - 0281

Oulu, North Ostrobothnia, 90220, Finland
Local Institution - 0282

Turku, Southwest Finland, 20521, Finland
Local Institution - 0283

Kuopio, Northern Savonia, 70210, Finland
Local Institution - 0284

Odense, Region Syddanmark, 5000, Denmark
Local Institution - 0285

Aarhus, Central Jutland, 8200, Denmark
Local Institution - 0286

Lisbon, 1500-650, Portugal
Local Institution - 0287

Jacksonville, Florida, 32224, United States
Local Institution - 0288

Nagaizumi-cho,Sunto-gun, Shizuoka, 411-8777, Japan
Local Institution - 0291

Changchun, Jilin, 130021, China
Local Institution - 0292

Dijon, Côte-d'Or, 21000, France
Local Institution - 0293

Richmond, Virginia, 23298, United States
Local Institution - 0294

São Paulo, 01409-901, Brazil
Local Institution - 0296

Niterói, Rio de Janeiro, 24020-096, Brazil
Local Institution - 0297

Lago Sul, Federal District, 71635580, Brazil
Local Institution - 0298

Rio de Janeiro, 22061-080, Brazil
Local Institution - 0301

São José do Rio Preto, São Paulo, 15090000, Brazil
Local Institution - 0302

Curitiba, Paraná, 81520-060, Brazil
Local Institution - 0303

Atlanta, Georgia, 30322, United States
Local Institution - 0304

Natal, Rio Grande do Norte, 59075-740, Brazil
Local Institution - 0306

Poitiers, Vienne, 86021, France
Local Institution - 0313

Fukuoka, 812-8582, Japan
Local Institution - 0314

Donostia / San Sebastian, Gipuzkoa, 20014, Spain
Local Institution - 0315

Caen, 14033, France
Local Institution - 0316

São Paulo, São Paulo, 01509-010, Brazil
Local Institution - 0317

São Paulo, 05403-000, Brazil
Local Institution - 0319

Fukuoka, 811-1395, Japan
Local Institution - 0320

Sendai, Miyagi, 980-8574, Japan
Local Institution - 0321

Saint Priest En Jarez, Pays de la Loire Region, 42271, France
Local Institution - 0322

Osaka, 543-8555, Japan
Local Institution - 0323

Saint-Pierre, La Réunion, 97448, France
Local Institution - 0324

Pessac, Aquitaine, 33600, France
Local Institution - 0325

Nantes, Pays de la Loire Region, 44000, France
Local Institution - 0327

Sapporo, Hokkaido, 064-0804, Japan
Local Institution - 0328

Himeji, Hyōgo, 670-8540, Japan
Local Institution - 0329

Okayama, 700-8558, Japan
Local Institution - 0330

Katowice, Silesian Voivodeship, 40-027, Poland
Local Institution - 0331

Chūō, Yamanashi, 409-3898, Japan
Local Institution - 0332

Brest, Finistère, 29200, France
Local Institution - 0333

Yokohama, Kanagawa, 221-0855, Japan
Local Institution - 0334

Shenyang, Liaoning, 110004, China
Local Institution - 0335

Saint-Cloud, Hauts-de-Seine, 92210, France
Local Institution - 0336

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland
Local Institution - 0337

Lublin, Lublin Voivodeship, 20-090, Poland
Local Institution - 0338

Nanning, Guangxi, 530021, China
Local Institution - 0339

Shanghai, Shanghai Municipality, 200032, China
Local Institution - 0342

San Francisco, California, 94143, United States
Local Institution - 0343

Morioka, Iwate, 020-0066, Japan
Local Institution - 0344

Jinan, Shandong, 250117, China
Local Institution - 0346

Wuhan, Hubei, 430022, China
Local Institution - 0347

Osaka, 545-8586, Japan
Local Institution - 0348

Fukuoka, 810-8563, Japan
Local Institution - 0350

Bunkyo-ku, Tokyo, 113-8431, Japan
Local Institution - 0353

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
Local Institution - 0356

Birtinya, Queensland, 4575, Australia
Local Institution - 0357

Gosford, New South Wales, 2250, Australia
Local Institution - 0358

Westmead, New South Wales, 2145, Australia
Local Institution - 0359

St Albans, Victoria, 3021, Australia
Local Institution - 0360

Southport, Queensland, 4215, Australia
Local Institution - 0361

Sydney, New South Wales, 2560, Australia
Local Institution - 0362

Heidelberg, Victoria, 3084, Australia
Local Institution - 0363

Tiwi, Northern Territory, 0810, Australia
Local Institution - 0364

Warrnambool, Victoria, 3280, Australia
Local Institution - 0365

Frankston, Victoria, 3195, Australia
Local Institution - 0366

Hamilton, Waikato Region, 3240, New Zealand
Local Institution - 0367

Dunedin, Otago, 9016, New Zealand
Local Institution - 0368

Sapporo, Hokkaido, 0608648, Japan
Local Institution - 0369

New York, New York, 10028, United States
Local Institution - 0370

Essen, 45122, Germany
Local Institution - 0371

Nagoya, Aichi-ken, 466-8560, Japan
Local Institution - 0372

San Juan, 00909, Puerto Rico
Local Institution - 0374

Bucharest, 022328, Romania
Local Institution - 0376

Sibiu, 557260, Romania
Local Institution - 0377

Bucharest, 030171, Romania
Local Institution - 0378

Bucharest, 050098, Romania
Local Institution - 0379

Iași, 700483, Romania
Local Institution - 0380

Brasov, 500052, Romania
Local Institution - 0381

Bucharest, București, 022328, Romania
Local Institution - 0382

Bucharest, 030171, Romania
Local Institution - 0383

Augsburg, Bavaria, 86156, Germany
Local Institution - 0384

Koblenz, Rhineland-Palatinate, 56068, Germany
Local Institution - 0385

Wels, Upper Austria, 4600, Austria
Local Institution - 0386

Vienna, 1140, Austria
Local Institution - 0387

Linz, 4020, Austria
Local Institution - 0388

Skórzewo, Greater Poland Voivodeship, 60-185, Poland
Local Institution - 0389

Barakaldo, Bizkaia, 48903, Spain
Local Institution - 0391

Oslo, 0310, Norway
Local Institution - 0392

Sofia, 1407, Bulgaria
Local Institution - 0393

Plovdiv, 4002, Bulgaria
Local Institution - 0394

Sofia, 1431, Bulgaria
Local Institution - 0395

Ioannina, Ípeiros, 455 00, Greece
Local Institution - 0396

Athens, Attikí, 11527, Greece
Local Institution - 0397

Chaïdári, Attikí, 12462, Greece
Local Institution - 0398

Alexandroupoli, Anatolikí Makedonía Kai Thráki, 681 00, Greece
Local Institution - 0399

Athens, Attikí, 106 76, Greece
Local Institution - 0400

Ankara, 06100, Turkey (Türkiye)
Local Institution - 0401

Ankara, 06200, Turkey (Türkiye)
Local Institution - 0402

Trabzon, 61080, Turkey (Türkiye)
Local Institution - 0403

Mersin, 33440, Turkey (Türkiye)
Local Institution - 0405

Ankara, 06100, Turkey (Türkiye)
Local Institution - 0406

Izmir, 35100, Turkey (Türkiye)
Local Institution - 0407

Samsun, 55270, Turkey (Türkiye)
Local Institution - 0408

Baton Rouge, Louisiana, 70809, United States
Local Institution - 0409

El Palmar, Murcia, Murcia, Región de, 30120, Spain
Local Institution - 0410

New Town, West Bengal, 700160, India
Local Institution - 0411

Belagavi, Karnataka, 590010, India
Local Institution - 0412

A Coruña, A Coruña [La Coruña], 15006, Spain
Local Institution - 0413

Howrah, West Bengal, 711103, India
Local Institution - 0414

Tampa, Florida, 33612, United States
Local Institution - 0415

Margate, Florida, 33063, United States
Local Institution - 0416

Riyadh, 12713, Saudi Arabia
Local Institution - 0417

Tg.Mures, Mureș County, 540136, Romania
Local Institution - 0419

York, Pennsylvania, 17403, United States
Local Institution - 0421

Buenos Aires, Buenos Aires F.D., C1417DTB, Argentina
Local Institution - 0422

Ankara, 06170, Turkey (Türkiye)
Local Institution - 0423

Cluj-Napoca, 400015, Romania
Local Institution - 0424

Houston, Texas, 77030, United States
Local Institution - 0427

Singapore, Central Singapore, 168583, Singapore
Local Institution - 0428

Chiang Mai, 50200, Thailand
Local Institution - 0430

Kochi, Kerala, 682027, India
Local Institution - 0431

Kuching, Sarawak, 93586, Malaysia
Local Institution - 0432

George Town, Pulau Pinang, 10990, Malaysia
Local Institution - 0433

New Delhi, National Capital Territory of Delhi, 110029, India
Local Institution - 0434

Bangkok, Bangkok, 10330, Thailand
Local Institution - 0435

Fort Sam Houston, Texas, 78234, United States
Local Institution - 0436

Edgewood, Kentucky, 41017, United States
Local Institution - 0437

Kansas City, Missouri, 64132, United States
Local Institution - 0438

Jeddah, 22384, Saudi Arabia
Local Institution - 0439

Dammam, Eastern Province, 31444, Saudi Arabia
Local Institution - 0441

Deagu, Taegu-Kwangyǒkshi, 41404, South Korea
Local Institution - 0443

Warsaw, Masovian Voivodeship, 02-781, Poland
Local Institution - 0445

Riyadh, Riyadh Region, 11426, Saudi Arabia
Local Institution - 0449

Ampang, Selangor, 68000, Malaysia
Local Institution - 0450

Tulsa, Oklahoma, 74146, United States
Local Institution - 0451

East Syracuse, New York, 13057, United States
Local Institution - 0452

Phoenix, Arizona, 85054, United States
Local Institution - 0453

Lembah Pantai, Kuala Lumpur, 59100, Malaysia
Local Institution - 0456

Seongnam, Kyǒnggi-do, 13620, South Korea
Local Institution - 0457

Wenzhou, Zhejiang, 325000, China
Local Institution - 0459

Santiago, Santiago Metropolitan, 8420383, Chile
Local Institution - 0461

Waukee, Iowa, 50309, United States
Local Institution - 0462

Auckland, 1023, New Zealand
Local Institution - 0466

Reno, Nevada, 89511, United States
Local Institution - 0467

Ürümqi, Xinjiang, 830000, China
Local Institution - 0469

New Delhi, National Capital Territory of Delhi, 110085, India
Local Institution - 0470

Tianjin, Tianjin Municipality, 300060, China
Local Institution - 0475

Eiheiji-cho,Yoshida-gun, Fukui, 910-1193, Japan
Local Institution - 0477

Anchorage, Alaska, 99508, United States
Local Institution - 0478

Ann Arbor, Michigan, 48109, United States
Local Institution - 0480

Hackensack, New Jersey, 07601, United States
Local Institution - 0483

Hangzhou, Zhejiang, 310052, China
Local Institution - 0484

New York, New York, 10016, United States
Local Institution - 0485

Weston, Florida, 33331, United States
Local Institution - 0486

Besançon, Doubs, 25000, France
Local Institution - 0487

Solna, Stockholms Län [se-01], 171 64, Sweden
Local Institution - 0488

Madrid, 28040, Spain
Local Institution - 0489

Seville, 41013, Spain
Local Institution - 0490

Madrid, 28007, Spain
Local Institution - 0491

Badalona, Barcelona [Barcelona], 08916, Spain
Local Institution - 0493

Rome, Lazio, 00168, Italy
Local Institution - 0495

Ravenna, Emilia-Romagna, 48121, Italy
Local Institution - 0496

Novara, 28100, Italy
Local Institution - 0497

Fort Myers, Florida, 33901, United States
Local Institution - 0498

East Brunswick, New Jersey, 08816, United States
Local Institution - 0499

Groningen, 9713 GZ, Netherlands
Local Institution - 0500

Leiden, South Holland, 2333 ZA, Netherlands
Local Institution - 0502

St. Petersburg, Florida, 33705, United States
Local Institution - 0503

Cottbus, 03048, Germany
Local Institution - 0504

Halle, Saxony-Anhalt, 06120, Germany
Local Institution - 0505

Erlangen, Bavaria, 91054, Germany
Local Institution - 0506

Lübeck, Schleswig-Holstein, 23538, Germany
Local Institution - 0507

Langen, Hesse, 63225, Germany
Local Institution - 0508

Berlin, 10967, Germany
Local Institution - 0510

Dresden, 01307, Germany
Local Institution - 0511

Ulm, Baden-Wurttemberg, 89081, Germany
Local Institution - 0512

Bayreuth, Bavaria, 95445, Germany
Local Institution - 0513

Hanover, Lower Saxony, 30459, Germany
Local Institution - 0514

Taipei, 11217, Taiwan
Local Institution - 0515

Atlanta, Georgia, 30303, United States
Local Institution - 0516

Houston, Texas, 77026, United States
Ramathibodi Hospital

Bangkok, Bangkok, 10400, Thailand

Conditions

Explore the condition pages connected to this study.

LARGE B-CELL LYMPHOMA