New hope for aggressive lymphoma: drug duo takes on relapsed cancer
NCT ID NCT06508658
First seen Oct 31, 2025 · Last updated Apr 24, 2026 · Updated 26 times
Summary
This study tests a new combination of drugs (epcoritamab plus lenalidomide) against a standard chemotherapy regimen for adults with diffuse large B-cell lymphoma that has come back or not responded to prior treatment. About 360 participants will be randomly assigned to one of three groups to compare safety and effectiveness. The goal is to see if the new combo can delay cancer growth better than current options.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AZ-Delta. /ID# 264740
Roeselare, West-Vlaanderen, 8800, Belgium
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Adnan Menderes University /ID# 242418
Aydin, 09100, Turkey (Türkiye)
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Aidport sp z o.o. /ID# 262766
Poznan, Greater Poland Voivodeship, 60-175, Poland
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Albert Schweitzer Ziekenhuis, locatie Dordwijk /ID# 263361
Dordrecht, South Holland, 3318 AT, Netherlands
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Alberts Cellular Therapy /ID# 262720
Pretoria, Gauteng, 0044, South Africa
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Ankara Universitesi Fakultesi /ID# 242410
Ankara, 06620, Turkey (Türkiye)
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Asan Medical Center /ID# 242409
Seoul, Seoul Teugbyeolsi, 05505, South Korea
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Bradford Hill /ID# 262795
Santiago, Santiago Metropolitan, 8420383, Chile
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CHRU Tours - Hopital Bretonneau /ID# 244580
Tours, Indre-et-Loire, 37044, France
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CHU Poitiers - La miletrie /ID# 243074
Poitiers, Vienne, 86000, France
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CHU de CAEN - Hopital de la Cote de Nacre /ID# 243075
Caen, Calvados, 14033, France
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CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 262751
Montreal, Quebec, H1T 2M4, Canada
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Canberra Hospital /ID# 265312
Garran, Australian Capital Territory, 2605, Australia
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Cancer Center of Kansas - Wichita /ID# 270117
Wichita, Kansas, 67214, United States
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Centre Hospitalier D'Avignon /ID# 243072
Avignon, Provence-Alpes-Côte d'Azur Region, 84000, France
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Centre Hospitalier Epicura - Hornu /ID# 265148
Boussu, Hainaut, 7301, Belgium
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Centre Hospitalier de la Cote Basque /ID# 243065
Bayonne, Pyrenees-Atlantiques, 64100, France
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Centro De Investigación Clinica Chapultepec /ID# 243959
Mexico City, Mexico City, 04100, Mexico
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Centro de Quimioterapia E Investigacion Sas de Cv /Id# 263293
Jalisco, 45645, Mexico
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China Medical University Hospital /ID# 242931
Taichung, 40447, Taiwan
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Chonnam National University Hwasun Hospital /ID# 262843
Hwasun-gun, Jeonranamdo, 58128, South Korea
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City Of Hope - Atlanta. /ID# 273092
Newnan, Georgia, 30265, United States
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City Of Hope - Chicago /ID# 274430
Zion, Illinois, 60099, United States
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City of Hope National Medical Center /ID# 273338
Duarte, California, 91010, United States
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Clinica Alemana de Santiago /ID# 244139
Santiago, 7650568, Chile
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Clinical Hospital Center - Bežanijska Kosa /ID# 263053
Belgrade, Beograd, 11080, Serbia
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Clinical Hospital Center Zvezdara /ID# 263059
Belgrade, Beograd, 11000, Serbia
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Community Cancer Trials Of Utah /ID# 271715
Ogden, Utah, 84405, United States
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Constantiaberg Haematology /ID# 273041
Cape Town, Western Cape, 7800, South Africa
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Debreceni Egyetem-Klinikai Kozpont /ID# 242451
Debrecen, Hajdú-Bihar, 4032, Hungary
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Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 262923
Budapest, 1097, Hungary
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Desert Regional Medical Center /ID# 272437
Palm Springs, California, 92262, United States
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Dong-A University Medical Center /ID# 262841
Busan, Busan Gwang Yeogsi, 49201, South Korea
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Duplicate_Saitama Cancer Center /ID# 265277
Kitaadachi-gun, Saitama, 362-0806, Japan
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East Carolina University - Brody School of Medicine /ID# 242227
Greenville, North Carolina, 27834, United States
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Ege University Medical Faculty /ID# 242417
Izmir, 35040, Turkey (Türkiye)
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Fakultni nemocnice Motol a Homolka /ID# 272378
Prague, Praha 5, 150 06, Czechia
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Fakultni nemocnice Olomouc /ID# 262832
Olomouc, 779 00, Czechia
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Fakultní nemocnice Hradec Králové - Sokolská /ID# 264071
Hradec Králové, Hradec Kralove, 500 05, Czechia
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First Affiliated Hospital of China Medical University /ID# 242701
Shenyang, Liaoning, 110001, China
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Fujian Province Cancer Hospital /ID# 265075
Fuzhou, Fujian, 350014, China
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Fujita Health University Hospital /ID# 265968
Toyoake, Aichi-ken, 470-1192, Japan
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Fukushima Medical University Hospital /ID# 264667
Fukushima, Fukushima, 960-1295, Japan
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Fundacion Arturo Lopez Perez /ID# 242421
Providencia, Santiago Metropolitan, 7500921, Chile
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Fundaleu /Id# 242789
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1114, Argentina
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Fundeni Clinical Institute /ID# 266734
Bucharest, Bucharest, 022328, Romania
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General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 242039
Athens, 10676, Greece
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General Hospital of Athens Laiko /ID# 262809
Athens, Attica, 11527, Greece
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General University Hospital of Thessaloniki AXEPA /ID# 242038
Thessaloniki, 54636, Greece
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Guangdong Provincial Peoples Hospital /ID# 242942
Guangzhou, Guangdong, 510080, China
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Gulfport Memorial Hospital /ID# 268104
Gulfport, Mississippi, 39501, United States
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Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 262901
Győr, Győr-Moson-Sopron, 9024, Hungary
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Haemalife Inc. /ID# 262719
Kuils River, Western Cape, 7580, South Africa
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Harbin Medical University Cancer Hospital /Id# 242961
Harbin, Heilongjiang, 150081, China
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Henan Cancer Hospital /ID# 242700
Zhengzhou, Henan, 450008, China
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Henry Ford Hospital /ID# 266446
Detroit, Michigan, 48202, United States
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Hopital Saint Vincent de Paul /ID# 243070
Lille, 59020, France
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Hospital Alemao Oswaldo Cruz /ID# 247418
São Paulo, 01323-020, Brazil
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Hospital Erasto Gaertner /ID# 264049
Curitiba, Puerto Rico, 81520-060, Brazil
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Hospital Sao Rafael /ID# 262949
Salvador, Estado de Bahia, 41253-190, Brazil
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Hospital Universitario Austral /ID# 242791
Pilar, Buenos Aires, 1629, Argentina
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Hospital da Luz /ID# 262965
Lisbon, Lisbon District, 1500-650, Portugal
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Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 242425
São Paulo, 05403-000, Brazil
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Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 264045
Ribeirão Preto, São Paulo, 14049-900, Brazil
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Hubei Cancer Hospital /ID# 242963
Wuhan, Hubei, 430079, China
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Hyogo Prefectural Amagasaki General Medical Center /ID# 277258
Amagasaki, Hyōgo, 660-8550, Japan
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Inje University - Busan Paik Hospital /ID# 262842
Busan, Busan Gwang Yeogsi, 47392, South Korea
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Institute for Oncology and Radiology of Serbia /ID# 263055
Belgrade, Beograd, 11000, Serbia
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Institute for Oncology of Vojvodina /ID# 263052
Kamenitz, Vojvodina, 21208, Serbia
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Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 243139
Tianjin, Tianjin Municipality, 300020, China
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Instituto Alexander Fleming /ID# 263804
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1426, Argentina
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Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 263944
São Paulo, 01401-002, Brazil
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Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE /ID# 262961
Porto, 4200-072, Portugal
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Institutul Oncologic Prof Dr. Ion Chiricuta Cluj Napoca /ID# 243753
Cluj-Napoca, Cluj, 400015, Romania
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Institutul Regional de Oncologie /ID# 244367
Iași, Iaşi, 700483, Romania
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Istanbul Florence Nightingale Hospital /ID# 271544
Şişli, 34381, Turkey (Türkiye)
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Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi /ID# 242414
Istanbul, 34098, Turkey (Türkiye)
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Jeonbuk National University Hospital /ID# 242958
Jeonju, Jeonrabugdo, 54907, South Korea
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Jeroen Bosch Ziekenhuis, locatie 's-Hertogenbosch /ID# 265204
's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands
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Jiangsu Peoples Hospital /ID# 271924
Nanjing, Jiangsu, 210029, China
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Jiangxi Provincial Cancer Hospital /ID# 242968
Nanchang, Jiangxi, 330029, China
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Kagoshima University Hospital /ID# 248259
Kagoshima, Kagoshima-ken, 890-8520, Japan
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Kansai Medical University Hospital /ID# 266018
Hirakata-shi, Osaka, 573-1191, Japan
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Karadeniz Technical University Farabi Hospital /ID# 264694
Trabzon, 61080, Turkey (Türkiye)
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Keimyung University Dongsan Hospital /ID# 262840
Daegu, Gyeongsangbuk-do, 42601, South Korea
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Kindai University Hospital /ID# 265474
Sakai-shi, Osaka, 590-0197, Japan
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Klinicka bolnica Merkur /ID# 262619
Zagreb, City of Zagreb, 10000, Croatia
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Klinicki Bolnicki Centar (KBC) Split /ID# 262618
Split, Split-Dalmatia County, 21000, Croatia
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Klinicki bolnicki centar Osijek /ID# 262621
Osijek, County of Osijek-Baranja, 31000, Croatia
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Klinicki bolnicki centar Sestre milosrdnice /ID# 262620
Zagreb, City of Zagreb, 10000, Croatia
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Klinicki bolnicki centar Zagreb /ID# 262617
Zagreb, City of Zagreb, 10000, Croatia
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Klinički Bolnički Centar Rijeka /ID# 266004
Rijeka, Primorje-Gorski Kotar County, 51000, Croatia
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Kyushu University Hospital /ID# 267624
Fukuoka, Fukuoka, 812-8582, Japan
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Les Hôpitaux Universitaires de Strasbourg - Hôpital de Hautepierre /ID# 264068
Strasbourg, Alsace, 67200, France
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Lutheran Medical Center- Cancer Centers of Colorado /ID# 265823
Golden, Colorado, 80401, United States
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Medisch Centrum Leeuwarden /ID# 245501
Leeuwarden, Provincie Friesland, 8934 AD, Netherlands
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Monash Health - Monash Medical Centre /ID# 262783
Clayton, Victoria, 3168, Australia
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NHS Lanarkshire /ID# 272332
Airdrie, North Lanarkshire, ML6 0JS, United Kingdom
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 263314
Warsaw, Masovian Voivodeship, 02-781, Poland
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National Cancer Centre Singapore /ID# 267015
Singapore, Central Singapore, 169611, Singapore
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National Cheng Kung University Hospital /ID# 243301
Tainan, 704, Taiwan
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National Hospital Organization Shikoku Cancer Center /ID# 265977
Matsuyama, Ehime, 791-0280, Japan
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National Taiwan University Hospital /ID# 243300
Taipei City, Taipei, 100, Taiwan
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National University Hospital /ID# 264016
Singapore, 119074, Singapore
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New York Medical College /ID# 265799
Valhalla, New York, 10595, United States
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North Shore Hospital /ID# 266060
Auckland, 0622, New Zealand
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Northwest Cancer Center - Dyer Clinic /ID# 269787
Dyer, Indiana, 46311, United States
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Nottingham City Hospital /ID# 265129
Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
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OLVG - Locatie Oost /ID# 263355
Amsterdam, North Holland, 1091 AC, Netherlands
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Ondokuz mayis University Facul /ID# 242412
Samsun, 55200, Turkey (Türkiye)
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Orszagos Onkologiai Intezet /ID# 242457
Budapest, 1122, Hungary
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Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 262924
Pécs, Baranya, 7624, Hungary
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Peking University Third Hospital /ID# 242941
Beijing, Beijing Municipality, 100191, China
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Pratia MCM Krakow /ID# 262882
Krakow, Lesser Poland Voivodeship, 30-727, Poland
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Royal Cornwall Hospital /ID# 265130
Truro, Cornwall, TR1 3LQ, United Kingdom
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Royal Perth Hospital /ID# 243790
Perth, Western Australia, 6000, Australia
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Royal Prince Alfred Hospital /ID# 263242
Sydney, New South Wales, 2050, Australia
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Rush University Medical Center /ID# 242103
Chicago, Illinois, 60612, United States
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SHAT Hematologic Diseases /ID# 242708
Sofia, 1797, Bulgaria
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Samsung Medical Center /ID# 242408
Seoul, Seoul Teugbyeolsi, 06351, South Korea
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Sapporo Medical University Hospital /ID# 264928
Sapporo, Hokkaido, 060-8543, Japan
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Second Affiliated Hospital, Zhejiang University - Binjiang Campus /ID# 243137
Hangzhou, Zhejiang, 310052, China
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Semmelweis Egyetem /ID# 242455
Budapest, 1085, Hungary
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Seoul National University Bundang Hospital /ID# 242405
Seongnam-si, Gyeonggido, 13620, South Korea
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Seoul National University Hospital /ID# 242407
Seoul, Seoul Teugbyeolsi, 03080, South Korea
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Shandong Cancer Hospital /ID# 264036
Jinan, Shandong, 250117, China
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Shanghai Tongji Hospital /ID# 263952
Shanghai, Shanghai Municipality, 200065, China
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Shonankamakura General Hospital /ID# 277671
Kamakura, Kanagawa, 247-8533, Japan
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Spitalul Clinic Coltea /ID# 243694
Bucharest, 030171, Romania
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St. Antonius Ziekenhuis /ID# 245197
Nieuwegein, Utrecht, 3435 CM, Netherlands
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Sun Yat-Sen University Cancer Center /ID# 242712
Guangzhou, Guangdong, 510060, China
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Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 242436
Kielce, Świętokrzyskie Voivodeship, 25-734, Poland
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Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 242468
Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
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Taichung Veterans General Hospital /ID# 242937
Taichung, 40705, Taiwan
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Tan Tock Seng Hospital /ID# 266061
Singapore, Central Singapore, 308433, Singapore
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The Affiliated Cancer Hospital of Xinjiang Medical University /ID# 242966
Ürümqi, Xinjiang, 830000, China
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The Catholic University of Korea, Seoul St. Marys Hospital /ID# 242406
Seoul, Seoul Teugbyeolsi, 06591, South Korea
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The First Affiliated Hospital of Nanchang University /ID# 242703
Nanchang, Jiangxi, 330006, China
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The First Affiliated Hospital of Soochow University /ID# 242939
Suzhou, Jiangsu, 215006, China
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The First Affiliated Hospital of Wenzhou Medical University /ID# 263951
Wenzhou, Zhejiang, 325000, China
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The First Affiliated Hospital of Xiamen /ID# 264305
Xiamen, Fujian, 361003, China
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The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 242960
Hangzhou, Zhejiang, 310003, China
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The First Hospital of Jilin University /ID# 242940
Changchun, Jilin, 130021, China
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 242923
Newcastle upon Tyne, NE3 3HD, United Kingdom
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The Second Hospital of Hebei Medical University /ID# 242944
Shijiazhuang, Hebei, 050000, China
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Theageneio Anticancer Hospital /ID# 242036
Thessaloniki, 54639, Greece
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Thompson Cancer Survival Ctr /ID# 242149
Knoxville, Tennessee, 37916, United States
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Tianjin Cancer Hospital /ID# 243940
Tianjin, Tianjin Municipality, 300000, China
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Tokai University Hospital /ID# 265433
Isehara, Kanagawa, 259-1193, Japan
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Toowoomba Hospital /ID# 263243
Toowoomba, Queensland, 4350, Australia
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Trakya University Medical Facu /ID# 242419
Edirne, Istanbul, 22030, Turkey (Türkiye)
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UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 262761
Varna, 9009, Bulgaria
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UMHAT Sveti Georgi /ID# 242905
Plovdiv, 4002, Bulgaria
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UMHAT Sveti Ivan Rilski /ID# 242389
Sofia, 1431, Bulgaria
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Ulsan University Hospital /ID# 242956
Ulsan, Ulsan Gwang Yeogsi, 44033, South Korea
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Unidade Local de Saude Sao Joao, EPE /ID# 262962
Porto, 4200-319, Portugal
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Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 242702
Wuhan, Hubei, 430048, China
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Universitair Ziekenhuis Brussel /ID# 242574
Jette, Brussels Capital, 1090, Belgium
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Universitair Ziekenhuis Leuven /ID# 246671
Leuven, Vlaams-Brabant, 3000, Belgium
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Universite Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 242565
Yvoir, Namur, 5530, Belgium
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University Clinical Center Nis /ID# 263701
Niš, Nisavski Okrug, 18300, Serbia
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University Clinical Center Serbia /ID# 263057
Belgrade, Beograd, 11000, Serbia
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University Clinical Center Vojvodina /ID# 264138
Novi Sad, 21000, Serbia
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University General Hospital Attikon /ID# 242041
Athens, Attica, 12462, Greece
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University of Kentucky Chandler Medical Center. /ID# 242087
Lexington, Kentucky, 40536, United States
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University of Maryland, Baltimore /ID# 242216
Baltimore, Maryland, 21201, United States
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University of Yamanashi Hospital /ID# 264671
Chuo-shi, Yamanashi, 409-3898, Japan
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Utah Cancer Specialists - Salt Lake City /ID# 268603
Salt Lake City, Utah, 84106, United States
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Valkyrie Clinical Trials /ID# 269935
Los Angeles, California, 90067, United States
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Vehbi Koc vakfi Amerikan Hasta /ID# 242415
Istanbul, 34365, Turkey (Türkiye)
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Veterans Affairs Medical Center - Salt Lake City /ID# 265329
Salt Lake City, Utah, 84108, United States
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Wellington Hospital /ID# 265966
Wellington, 6021, New Zealand
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Wits Clinical Research /ID# 264656
Johannesburg, Gauteng, 1864, South Africa
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Wollongong Hospital /ID# 244646
Wollongong, New South Wales, 2500, Australia
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Yunnan Province Cancer Hospital /ID# 264057
Kunming, Yunnan, 650106, China
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Zhejiang Cancer hospital /ID# 242711
Hangzhou, Zhejiang, 310022, China
Conditions
Explore the condition pages connected to this study.