New hope for aggressive lymphoma: drug duo takes on relapsed cancer

NCT ID NCT06508658

First seen Oct 31, 2025 · Last updated Apr 24, 2026 · Updated 26 times

Summary

This study tests a new combination of drugs (epcoritamab plus lenalidomide) against a standard chemotherapy regimen for adults with diffuse large B-cell lymphoma that has come back or not responded to prior treatment. About 360 participants will be randomly assigned to one of three groups to compare safety and effectiveness. The goal is to see if the new combo can delay cancer growth better than current options.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DIFFUSE LARGE B-CELL LYMPHOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • AZ-Delta. /ID# 264740

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Adnan Menderes University /ID# 242418

    Aydin, 09100, Turkey (Türkiye)

  • Aidport sp z o.o. /ID# 262766

    Poznan, Greater Poland Voivodeship, 60-175, Poland

  • Albert Schweitzer Ziekenhuis, locatie Dordwijk /ID# 263361

    Dordrecht, South Holland, 3318 AT, Netherlands

  • Alberts Cellular Therapy /ID# 262720

    Pretoria, Gauteng, 0044, South Africa

  • Ankara Universitesi Fakultesi /ID# 242410

    Ankara, 06620, Turkey (Türkiye)

  • Asan Medical Center /ID# 242409

    Seoul, Seoul Teugbyeolsi, 05505, South Korea

  • Bradford Hill /ID# 262795

    Santiago, Santiago Metropolitan, 8420383, Chile

  • CHRU Tours - Hopital Bretonneau /ID# 244580

    Tours, Indre-et-Loire, 37044, France

  • CHU Poitiers - La miletrie /ID# 243074

    Poitiers, Vienne, 86000, France

  • CHU de CAEN - Hopital de la Cote de Nacre /ID# 243075

    Caen, Calvados, 14033, France

  • CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 262751

    Montreal, Quebec, H1T 2M4, Canada

  • Canberra Hospital /ID# 265312

    Garran, Australian Capital Territory, 2605, Australia

  • Cancer Center of Kansas - Wichita /ID# 270117

    Wichita, Kansas, 67214, United States

  • Centre Hospitalier D'Avignon /ID# 243072

    Avignon, Provence-Alpes-Côte d'Azur Region, 84000, France

  • Centre Hospitalier Epicura - Hornu /ID# 265148

    Boussu, Hainaut, 7301, Belgium

  • Centre Hospitalier de la Cote Basque /ID# 243065

    Bayonne, Pyrenees-Atlantiques, 64100, France

  • Centro De Investigación Clinica Chapultepec /ID# 243959

    Mexico City, Mexico City, 04100, Mexico

  • Centro de Quimioterapia E Investigacion Sas de Cv /Id# 263293

    Jalisco, 45645, Mexico

  • China Medical University Hospital /ID# 242931

    Taichung, 40447, Taiwan

  • Chonnam National University Hwasun Hospital /ID# 262843

    Hwasun-gun, Jeonranamdo, 58128, South Korea

  • City Of Hope - Atlanta. /ID# 273092

    Newnan, Georgia, 30265, United States

  • City Of Hope - Chicago /ID# 274430

    Zion, Illinois, 60099, United States

  • City of Hope National Medical Center /ID# 273338

    Duarte, California, 91010, United States

  • Clinica Alemana de Santiago /ID# 244139

    Santiago, 7650568, Chile

  • Clinical Hospital Center - Bežanijska Kosa /ID# 263053

    Belgrade, Beograd, 11080, Serbia

  • Clinical Hospital Center Zvezdara /ID# 263059

    Belgrade, Beograd, 11000, Serbia

  • Community Cancer Trials Of Utah /ID# 271715

    Ogden, Utah, 84405, United States

  • Constantiaberg Haematology /ID# 273041

    Cape Town, Western Cape, 7800, South Africa

  • Debreceni Egyetem-Klinikai Kozpont /ID# 242451

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 262923

    Budapest, 1097, Hungary

  • Desert Regional Medical Center /ID# 272437

    Palm Springs, California, 92262, United States

  • Dong-A University Medical Center /ID# 262841

    Busan, Busan Gwang Yeogsi, 49201, South Korea

  • Duplicate_Saitama Cancer Center /ID# 265277

    Kitaadachi-gun, Saitama, 362-0806, Japan

  • East Carolina University - Brody School of Medicine /ID# 242227

    Greenville, North Carolina, 27834, United States

  • Ege University Medical Faculty /ID# 242417

    Izmir, 35040, Turkey (Türkiye)

  • Fakultni nemocnice Motol a Homolka /ID# 272378

    Prague, Praha 5, 150 06, Czechia

  • Fakultni nemocnice Olomouc /ID# 262832

    Olomouc, 779 00, Czechia

  • Fakultní nemocnice Hradec Králové - Sokolská /ID# 264071

    Hradec Králové, Hradec Kralove, 500 05, Czechia

  • First Affiliated Hospital of China Medical University /ID# 242701

    Shenyang, Liaoning, 110001, China

  • Fujian Province Cancer Hospital /ID# 265075

    Fuzhou, Fujian, 350014, China

  • Fujita Health University Hospital /ID# 265968

    Toyoake, Aichi-ken, 470-1192, Japan

  • Fukushima Medical University Hospital /ID# 264667

    Fukushima, Fukushima, 960-1295, Japan

  • Fundacion Arturo Lopez Perez /ID# 242421

    Providencia, Santiago Metropolitan, 7500921, Chile

  • Fundaleu /Id# 242789

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1114, Argentina

  • Fundeni Clinical Institute /ID# 266734

    Bucharest, Bucharest, 022328, Romania

  • General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 242039

    Athens, 10676, Greece

  • General Hospital of Athens Laiko /ID# 262809

    Athens, Attica, 11527, Greece

  • General University Hospital of Thessaloniki AXEPA /ID# 242038

    Thessaloniki, 54636, Greece

  • Guangdong Provincial Peoples Hospital /ID# 242942

    Guangzhou, Guangdong, 510080, China

  • Gulfport Memorial Hospital /ID# 268104

    Gulfport, Mississippi, 39501, United States

  • Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 262901

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Haemalife Inc. /ID# 262719

    Kuils River, Western Cape, 7580, South Africa

  • Harbin Medical University Cancer Hospital /Id# 242961

    Harbin, Heilongjiang, 150081, China

  • Henan Cancer Hospital /ID# 242700

    Zhengzhou, Henan, 450008, China

  • Henry Ford Hospital /ID# 266446

    Detroit, Michigan, 48202, United States

  • Hopital Saint Vincent de Paul /ID# 243070

    Lille, 59020, France

  • Hospital Alemao Oswaldo Cruz /ID# 247418

    São Paulo, 01323-020, Brazil

  • Hospital Erasto Gaertner /ID# 264049

    Curitiba, Puerto Rico, 81520-060, Brazil

  • Hospital Sao Rafael /ID# 262949

    Salvador, Estado de Bahia, 41253-190, Brazil

  • Hospital Universitario Austral /ID# 242791

    Pilar, Buenos Aires, 1629, Argentina

  • Hospital da Luz /ID# 262965

    Lisbon, Lisbon District, 1500-650, Portugal

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 242425

    São Paulo, 05403-000, Brazil

  • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 264045

    Ribeirão Preto, São Paulo, 14049-900, Brazil

  • Hubei Cancer Hospital /ID# 242963

    Wuhan, Hubei, 430079, China

  • Hyogo Prefectural Amagasaki General Medical Center /ID# 277258

    Amagasaki, Hyōgo, 660-8550, Japan

  • Inje University - Busan Paik Hospital /ID# 262842

    Busan, Busan Gwang Yeogsi, 47392, South Korea

  • Institute for Oncology and Radiology of Serbia /ID# 263055

    Belgrade, Beograd, 11000, Serbia

  • Institute for Oncology of Vojvodina /ID# 263052

    Kamenitz, Vojvodina, 21208, Serbia

  • Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 243139

    Tianjin, Tianjin Municipality, 300020, China

  • Instituto Alexander Fleming /ID# 263804

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1426, Argentina

  • Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 263944

    São Paulo, 01401-002, Brazil

  • Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE /ID# 262961

    Porto, 4200-072, Portugal

  • Institutul Oncologic Prof Dr. Ion Chiricuta Cluj Napoca /ID# 243753

    Cluj-Napoca, Cluj, 400015, Romania

  • Institutul Regional de Oncologie /ID# 244367

    Iași, Iaşi, 700483, Romania

  • Istanbul Florence Nightingale Hospital /ID# 271544

    Şişli, 34381, Turkey (Türkiye)

  • Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi /ID# 242414

    Istanbul, 34098, Turkey (Türkiye)

  • Jeonbuk National University Hospital /ID# 242958

    Jeonju, Jeonrabugdo, 54907, South Korea

  • Jeroen Bosch Ziekenhuis, locatie 's-Hertogenbosch /ID# 265204

    's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands

  • Jiangsu Peoples Hospital /ID# 271924

    Nanjing, Jiangsu, 210029, China

  • Jiangxi Provincial Cancer Hospital /ID# 242968

    Nanchang, Jiangxi, 330029, China

  • Kagoshima University Hospital /ID# 248259

    Kagoshima, Kagoshima-ken, 890-8520, Japan

  • Kansai Medical University Hospital /ID# 266018

    Hirakata-shi, Osaka, 573-1191, Japan

  • Karadeniz Technical University Farabi Hospital /ID# 264694

    Trabzon, 61080, Turkey (Türkiye)

  • Keimyung University Dongsan Hospital /ID# 262840

    Daegu, Gyeongsangbuk-do, 42601, South Korea

  • Kindai University Hospital /ID# 265474

    Sakai-shi, Osaka, 590-0197, Japan

  • Klinicka bolnica Merkur /ID# 262619

    Zagreb, City of Zagreb, 10000, Croatia

  • Klinicki Bolnicki Centar (KBC) Split /ID# 262618

    Split, Split-Dalmatia County, 21000, Croatia

  • Klinicki bolnicki centar Osijek /ID# 262621

    Osijek, County of Osijek-Baranja, 31000, Croatia

  • Klinicki bolnicki centar Sestre milosrdnice /ID# 262620

    Zagreb, City of Zagreb, 10000, Croatia

  • Klinicki bolnicki centar Zagreb /ID# 262617

    Zagreb, City of Zagreb, 10000, Croatia

  • Klinički Bolnički Centar Rijeka /ID# 266004

    Rijeka, Primorje-Gorski Kotar County, 51000, Croatia

  • Kyushu University Hospital /ID# 267624

    Fukuoka, Fukuoka, 812-8582, Japan

  • Les Hôpitaux Universitaires de Strasbourg - Hôpital de Hautepierre /ID# 264068

    Strasbourg, Alsace, 67200, France

  • Lutheran Medical Center- Cancer Centers of Colorado /ID# 265823

    Golden, Colorado, 80401, United States

  • Medisch Centrum Leeuwarden /ID# 245501

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

  • Monash Health - Monash Medical Centre /ID# 262783

    Clayton, Victoria, 3168, Australia

  • NHS Lanarkshire /ID# 272332

    Airdrie, North Lanarkshire, ML6 0JS, United Kingdom

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 263314

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • National Cancer Centre Singapore /ID# 267015

    Singapore, Central Singapore, 169611, Singapore

  • National Cheng Kung University Hospital /ID# 243301

    Tainan, 704, Taiwan

  • National Hospital Organization Shikoku Cancer Center /ID# 265977

    Matsuyama, Ehime, 791-0280, Japan

  • National Taiwan University Hospital /ID# 243300

    Taipei City, Taipei, 100, Taiwan

  • National University Hospital /ID# 264016

    Singapore, 119074, Singapore

  • New York Medical College /ID# 265799

    Valhalla, New York, 10595, United States

  • North Shore Hospital /ID# 266060

    Auckland, 0622, New Zealand

  • Northwest Cancer Center - Dyer Clinic /ID# 269787

    Dyer, Indiana, 46311, United States

  • Nottingham City Hospital /ID# 265129

    Nottingham, Nottinghamshire, NG5 1PB, United Kingdom

  • OLVG - Locatie Oost /ID# 263355

    Amsterdam, North Holland, 1091 AC, Netherlands

  • Ondokuz mayis University Facul /ID# 242412

    Samsun, 55200, Turkey (Türkiye)

  • Orszagos Onkologiai Intezet /ID# 242457

    Budapest, 1122, Hungary

  • Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 262924

    Pécs, Baranya, 7624, Hungary

  • Peking University Third Hospital /ID# 242941

    Beijing, Beijing Municipality, 100191, China

  • Pratia MCM Krakow /ID# 262882

    Krakow, Lesser Poland Voivodeship, 30-727, Poland

  • Royal Cornwall Hospital /ID# 265130

    Truro, Cornwall, TR1 3LQ, United Kingdom

  • Royal Perth Hospital /ID# 243790

    Perth, Western Australia, 6000, Australia

  • Royal Prince Alfred Hospital /ID# 263242

    Sydney, New South Wales, 2050, Australia

  • Rush University Medical Center /ID# 242103

    Chicago, Illinois, 60612, United States

  • SHAT Hematologic Diseases /ID# 242708

    Sofia, 1797, Bulgaria

  • Samsung Medical Center /ID# 242408

    Seoul, Seoul Teugbyeolsi, 06351, South Korea

  • Sapporo Medical University Hospital /ID# 264928

    Sapporo, Hokkaido, 060-8543, Japan

  • Second Affiliated Hospital, Zhejiang University - Binjiang Campus /ID# 243137

    Hangzhou, Zhejiang, 310052, China

  • Semmelweis Egyetem /ID# 242455

    Budapest, 1085, Hungary

  • Seoul National University Bundang Hospital /ID# 242405

    Seongnam-si, Gyeonggido, 13620, South Korea

  • Seoul National University Hospital /ID# 242407

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Shandong Cancer Hospital /ID# 264036

    Jinan, Shandong, 250117, China

  • Shanghai Tongji Hospital /ID# 263952

    Shanghai, Shanghai Municipality, 200065, China

  • Shonankamakura General Hospital /ID# 277671

    Kamakura, Kanagawa, 247-8533, Japan

  • Spitalul Clinic Coltea /ID# 243694

    Bucharest, 030171, Romania

  • St. Antonius Ziekenhuis /ID# 245197

    Nieuwegein, Utrecht, 3435 CM, Netherlands

  • Sun Yat-Sen University Cancer Center /ID# 242712

    Guangzhou, Guangdong, 510060, China

  • Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 242436

    Kielce, Świętokrzyskie Voivodeship, 25-734, Poland

  • Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 242468

    Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary

  • Taichung Veterans General Hospital /ID# 242937

    Taichung, 40705, Taiwan

  • Tan Tock Seng Hospital /ID# 266061

    Singapore, Central Singapore, 308433, Singapore

  • The Affiliated Cancer Hospital of Xinjiang Medical University /ID# 242966

    Ürümqi, Xinjiang, 830000, China

  • The Catholic University of Korea, Seoul St. Marys Hospital /ID# 242406

    Seoul, Seoul Teugbyeolsi, 06591, South Korea

  • The First Affiliated Hospital of Nanchang University /ID# 242703

    Nanchang, Jiangxi, 330006, China

  • The First Affiliated Hospital of Soochow University /ID# 242939

    Suzhou, Jiangsu, 215006, China

  • The First Affiliated Hospital of Wenzhou Medical University /ID# 263951

    Wenzhou, Zhejiang, 325000, China

  • The First Affiliated Hospital of Xiamen /ID# 264305

    Xiamen, Fujian, 361003, China

  • The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 242960

    Hangzhou, Zhejiang, 310003, China

  • The First Hospital of Jilin University /ID# 242940

    Changchun, Jilin, 130021, China

  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 242923

    Newcastle upon Tyne, NE3 3HD, United Kingdom

  • The Second Hospital of Hebei Medical University /ID# 242944

    Shijiazhuang, Hebei, 050000, China

  • Theageneio Anticancer Hospital /ID# 242036

    Thessaloniki, 54639, Greece

  • Thompson Cancer Survival Ctr /ID# 242149

    Knoxville, Tennessee, 37916, United States

  • Tianjin Cancer Hospital /ID# 243940

    Tianjin, Tianjin Municipality, 300000, China

  • Tokai University Hospital /ID# 265433

    Isehara, Kanagawa, 259-1193, Japan

  • Toowoomba Hospital /ID# 263243

    Toowoomba, Queensland, 4350, Australia

  • Trakya University Medical Facu /ID# 242419

    Edirne, Istanbul, 22030, Turkey (Türkiye)

  • UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 262761

    Varna, 9009, Bulgaria

  • UMHAT Sveti Georgi /ID# 242905

    Plovdiv, 4002, Bulgaria

  • UMHAT Sveti Ivan Rilski /ID# 242389

    Sofia, 1431, Bulgaria

  • Ulsan University Hospital /ID# 242956

    Ulsan, Ulsan Gwang Yeogsi, 44033, South Korea

  • Unidade Local de Saude Sao Joao, EPE /ID# 262962

    Porto, 4200-319, Portugal

  • Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 242702

    Wuhan, Hubei, 430048, China

  • Universitair Ziekenhuis Brussel /ID# 242574

    Jette, Brussels Capital, 1090, Belgium

  • Universitair Ziekenhuis Leuven /ID# 246671

    Leuven, Vlaams-Brabant, 3000, Belgium

  • Universite Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 242565

    Yvoir, Namur, 5530, Belgium

  • University Clinical Center Nis /ID# 263701

    Niš, Nisavski Okrug, 18300, Serbia

  • University Clinical Center Serbia /ID# 263057

    Belgrade, Beograd, 11000, Serbia

  • University Clinical Center Vojvodina /ID# 264138

    Novi Sad, 21000, Serbia

  • University General Hospital Attikon /ID# 242041

    Athens, Attica, 12462, Greece

  • University of Kentucky Chandler Medical Center. /ID# 242087

    Lexington, Kentucky, 40536, United States

  • University of Maryland, Baltimore /ID# 242216

    Baltimore, Maryland, 21201, United States

  • University of Yamanashi Hospital /ID# 264671

    Chuo-shi, Yamanashi, 409-3898, Japan

  • Utah Cancer Specialists - Salt Lake City /ID# 268603

    Salt Lake City, Utah, 84106, United States

  • Valkyrie Clinical Trials /ID# 269935

    Los Angeles, California, 90067, United States

  • Vehbi Koc vakfi Amerikan Hasta /ID# 242415

    Istanbul, 34365, Turkey (Türkiye)

  • Veterans Affairs Medical Center - Salt Lake City /ID# 265329

    Salt Lake City, Utah, 84108, United States

  • Wellington Hospital /ID# 265966

    Wellington, 6021, New Zealand

  • Wits Clinical Research /ID# 264656

    Johannesburg, Gauteng, 1864, South Africa

  • Wollongong Hospital /ID# 244646

    Wollongong, New South Wales, 2500, Australia

  • Yunnan Province Cancer Hospital /ID# 264057

    Kunming, Yunnan, 650106, China

  • Zhejiang Cancer hospital /ID# 242711

    Hangzhou, Zhejiang, 310022, China

Conditions

Explore the condition pages connected to this study.