Major trial aims to boost survival for Tough-to-Treat blood cancer

NCT ID NCT04529772

Ongoing Disease control Sponsor: Acerta Pharma BV Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding a newer targeted drug called acalabrutinib to a standard chemotherapy regimen (R-CHOP) works better for people under 75 with a specific, harder-to-treat type of aggressive lymphoma. The main goal is to see if the new combination helps patients live longer without their cancer getting worse. About 611 participants will be randomly assigned to get either the new combination or the standard treatment plus a placebo.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Tucson, Arizona, 85711, United States
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Little Rock, Arkansas, 72205, United States
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Irvine, California, 92618, United States
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Aurora, Colorado, 80012, United States
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Norwich, Connecticut, 06360, United States
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Fort Myers, Florida, 33901, United States
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Orlando, Florida, 32804, United States
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St. Petersburg, Florida, 33705-1449, United States
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Tallahassee, Florida, 32308-5304, United States
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West Palm Beach, Florida, 33401, United States
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Fort Wayne, Indiana, 46845, United States
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Des Moines, Iowa, 50309, United States
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Wichita, Kansas, 67214, United States
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Louisville, Kentucky, 40207, United States
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Baltimore, Maryland, 21201, United States
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Grand Rapids, Michigan, 49503, United States
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Minneapolis, Minnesota, 55407, United States
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St Louis, Missouri, 63129, United States
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Albany, New York, 12208, United States
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New York, New York, 10028, United States
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New York, New York, 10065, United States
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Stony Brook, New York, 11795, United States
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Charlotte, North Carolina, 28204, United States
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Winston-Salem, North Carolina, 27103, United States
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Eugene, Oregon, 97401, United States
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Portland, Oregon, 97239, United States
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Philadelphia, Pennsylvania, 19111, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Nashville, Tennessee, 37203, United States
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Fort Sam Houston, Texas, 78234, United States
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Lubbock, Texas, 79410, United States
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Salem, Virginia, 24153, United States
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Adelaide, 5000, Australia
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Camperdown, 2050, Australia
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Clayton, 3168, Australia
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Darlinghurst, 2010, Australia
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Heidelberg, 3084, Australia
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Hobart, 7000, Australia
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Kogarah, 2217, Australia
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Liverpool, 2170, Australia
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Nedlands, 6009, Australia
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Westmead, 2145, Australia
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Linz, 4021, Austria
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Salzburg, 5020, Austria
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Wels, 4600, Austria
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Antwerp, 2060, Belgium
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Bruges, 8000, Belgium
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La Louvière, 7100, Belgium
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Curitiba, 81520-060, Brazil
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Florianópolis, 88034-000, Brazil
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Goiânia, 74605-020, Brazil
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Passo Fundo, 99010-260, Brazil
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Porto Alegre, 90035-003, Brazil
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Porto Alegre, 90110-270, Brazil
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Porto Alegre, 90619-900, Brazil
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Ribeirão Preto, 14051-140, Brazil
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Rio de Janeiro, 22793-080, Brazil
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São Paulo, 01236-030, Brazil
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São Paulo, 01323-001, Brazil
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São Paulo, 01509-900, Brazil
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São Paulo, 04029-000, Brazil
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São Paulo, 05652-900, Brazil
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São Paulo, 08270-070, Brazil
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São Paulo, 13083-878, Brazil
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São Paulo, 5403, Brazil
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Vancouver, British Columbia, V5Z 4E6, Canada
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Toronto, CA, M5G 2M9, Canada
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Winnipeg, Manitoba, R3E 0V9, Canada
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London, Ontario, N6A 5W9, Canada
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Lévis, Quebec, G6V 0B8, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Ottawa, K1H 8L6, Canada
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Toronto, M4N 3M5, Canada
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Beijing, 100044, China
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Beijing, 100191, China
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Changchun, 130021, China
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Chengdu, 610041, China
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Guangzhou, 510060, China
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Guangzhou, 510080, China
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Guangzhou, 510120, China
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Hangzhou, 310003, China
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Hangzhou, 310009, China
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Harbin, 150081, China
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Jinan, 250117, China
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Luoyang, 471003, China
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Nanchang, 330006, China
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Nanning, 530021, China
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Shanghai, 200032, China
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Shanghai, China
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Shenyang, 110004, China
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Shenyang, 110042, China
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Shijiazhuang, 050020, China
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Suzhou, 215006, China
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Tianjin, 300020, China
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Tianjin, 300060, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Xiamen, 361003, China
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Zhengzhou, 450008, China
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Ostrava - Poruba, 708 52, Czechia
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Pilsen, 304 60, Czechia
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Prague, 100 34, Czechia
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Prague, 128 08, Czechia
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Brest, 29609, France
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Caen, 14033, France
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Marseille, 13385, France
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Montpellier, 34295, France
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Nantes, 44093, France
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Pessac, 33604, France
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Pierre-Bénite, 69495, France
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Rennes, 35033, France
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Toulouse, 31100, France
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Bamberg, 96049, Germany
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Berlin, 10967, Germany
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Dresden, 01307, Germany
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Homburg, 66421, Germany
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Neumünster, 24534, Germany
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Bangalore, 560064, India
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Delhi, 110029, India
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Kochi, 682041, India
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Mumbai, 400 012, India
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Nashik, 422004, India
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Nashik, 422009, India
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Pune, 411001, India
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Afula, 18101, Israel
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Ashdod, 7747629, Israel
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Beersheba, 8410101, Israel
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Haifa, 31048, Israel
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Haifa, 31096, Israel
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Haifa, 34362, Israel
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Holon, 58100, Israel
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Jerusalem, 91031, Israel
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Jerusalem, 91120, Israel
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Nahariya, 22100, Israel
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Petah Tikva, 4941492, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 6423906, Israel
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Ẕerifin, 70300, Israel
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Bari, 70124, Italy
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Bergamo, 24127, Italy
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Bologna, 40138, Italy
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Florence, 50134, Italy
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Genova, 16132, Italy
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Meldola, 47014, Italy
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Milan, 20141, Italy
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Milan, 20162, Italy
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Novara, 28100, Italy
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Palermo, 90146, Italy
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Pavia, 27100, Italy
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Pisa, 56126, Italy
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Ravenna, 48121, Italy
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Reggio Emilia, 42123, Italy
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Roma, 00144, Italy
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Roma, 00152, Italy
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Siena, 53100, Italy
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Torino, 10126, Italy
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Tricase, 73039, Italy
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Venezia, 30174, Italy
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Chiba, 260-8717, Japan
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Chūōku, 104-0045, Japan
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Fukuoka, 812-8582, Japan
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Itabashi-ku, 173-8610, Japan
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Kahoku-gun, 920-0293, Japan
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Kashiwa, 277-8577, Japan
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Kobe, 650-0047, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-0008, Japan
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Kumamoto, 860-8556, Japan
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Kyoto, 602-8026, Japan
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Matsuyama, 791-0280, Japan
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Nagasaki, 852-8501, Japan
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Nagoya, 460-0001, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 466-8560, Japan
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Niigata, 951-8520, Japan
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Okayama, 700-8558, Japan
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Osaka, 545-8586, Japan
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Sapporo, 003-0006, Japan
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Sendai, 980-8574, Japan
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Shimotsuke-shi, 329-0498, Japan
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Tsu, 514-8507, Japan
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Chihuahua City, 31000, Mexico
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Monterrey, 64460, Mexico
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Gdansk, 80-952, Poland
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Krakow, 30-510, Poland
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Lodz, 93-513, Poland
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Lublin, 20-081, Poland
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Warsaw, 02-776, Poland
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Wroclaw, 50-367, Poland
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Braga, 4710, Portugal
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Lisbon, 1400-038, Portugal
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Lisbon, 1649-035, Portugal
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Lisbon, 1998-018, Portugal
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Matosinhos Municipality, 4454-509, Portugal
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Porto, 4099-001, Portugal
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Porto, 4200-319, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Chelyabinsk, 454087, Russia
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Moscow, 125284, Russia
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Saint Petersburg, 194291, Russia
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Saint Petersburg, 197022, Russia
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Busan, 49201, South Korea
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Busan, 49241, South Korea
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Goyang-si, 10408, South Korea
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Jeonju, 54907, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06591, South Korea
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Seoul, 5505, South Korea
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Seoul, 6351, South Korea
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Suwon, 16499, South Korea
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Alcalá de Henares, 28805, Spain
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Barcelona, 08003, Spain
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Barcelona, 08035, Spain
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Gijón, 33394, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28007, Spain
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Madrid, 28033, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28046, Spain
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Palma, 07198, Spain
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Pamplona, 31008, Spain
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Pozuelo de Alarcón, 28223, Spain
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Salamanca, 37007, Spain
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Seville, 41013, Spain
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Valencia, 46026, Spain
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Kaohsiung City, 833, Taiwan
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Tainan, 70403, Taiwan
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Tainan, 736, Taiwan
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Taipei, 100, Taiwan
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Taipei, 235, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Ankara, 06700, Turkey (Türkiye)
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Ankara, 6200, Turkey (Türkiye)
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Ankara, 6500, Turkey (Türkiye)
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Balçova, 35340, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)
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Kayseri, 38030, Turkey (Türkiye)
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Mersin, 33079, Turkey (Türkiye)
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Samsun, 55139, Turkey (Türkiye)
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Trabzon, 61080, Turkey (Türkiye)
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Cherkasy, 18009, Ukraine
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Khmelnytskyi, 29000, Ukraine
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Kyiv, 03022, Ukraine
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Kyiv, 04112, Ukraine
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Lviv, 79044, Ukraine
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Mykolayiv, 54058, Ukraine
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Zaporizhzhia, 69600, Ukraine

Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B-CELL LYMPHOMA