New hope for patients with Hard-to-Treat blood cancer

NCT ID NCT05144841

Summary

This study is testing an experimental drug called zilovertamab vedotin for people with an aggressive type of blood cancer called diffuse large B-cell lymphoma that has returned or hasn't responded to at least two prior treatments. The main goals are to see if the drug shrinks tumors and for how long, while closely monitoring side effects. It is for patients who have already tried other major therapies, including stem cell transplants or CAR-T cell therapy, or who are not eligible for them.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AHN West Penn Hospital ( Site 0212)

    Pittsburgh, Pennsylvania, 15224, United States

  • Ankara University Hospital Cebeci-hematology ( Site 2300)

    Ankara, 06100, Turkey (Türkiye)

  • Atlantic Health System Morristown Medical Center ( Site 0213)

    Morristown, New Jersey, 07960, United States

  • Avera Cancer Institute- Research ( Site 0233)

    Sioux Falls, South Dakota, 57105, United States

  • Beijing Cancer hospital ( Site 2900)

    Beijing, Beijing Municipality, 100142, China

  • Centre Hospitalier de la Côte Basque ( Site 1002)

    Bayonne, Aquitaine, 64109, France

  • Clínica Alemana de Santiago ( Site 2704)

    Santiago, Region M. de Santiago, 7650568, Chile

  • Dokuz Eylül Üniversitesi-Hematology ( Site 2304)

    Izmir, 35340, Turkey (Türkiye)

  • Evangelismos General Hospital of Athens ( Site 1214)

    Athens, Attica, 106 76, Greece

  • Faculty of Medicine Siriraj Hospital ( Site 0701)

    Bangkok, Bangkok, 10700, Thailand

  • Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0800)

    Brno, Brno-mesto, 625 00, Czechia

  • Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa di Ematologia ( Site 1501)

    Milan, Lombardy, 20133, Italy

  • Franciscan St. Francis Health ( Site 0225)

    Indianapolis, Indiana, 46237, United States

  • Fudan University Shanghai Cancer Center ( Site 2908)

    Shanghai, Shanghai Municipality, 200032, China

  • General Hospital of Athens "Laiko"-Hematology Department ( Site 1213)

    Athens, Attica, 115 27, Greece

  • Georgetown University Medical Center ( Site 0204)

    Washington D.C., District of Columbia, 20007, United States

  • Hacettepe Universitesi-Department of Hematology ( Site 2302)

    Ankara, 06230, Turkey (Türkiye)

  • Hadassah Medical Center ( Site 1402)

    Jerusalem, 9112001, Israel

  • Haukeland Universitetssjukehus ( Site 1601)

    Bergen, Hordaland, 5021, Norway

  • Henan Cancer Hospital-hematology department ( Site 2903)

    Zhengzhou, Henan, 450008, China

  • Hospital Universitari Vall d'Hebron ( Site 2005)

    Barcelona, 08035, Spain

  • Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 2000)

    Madrid, 28040, Spain

  • Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca ( Site 2003)

    Salamanca, 37007, Spain

  • Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1503)

    Rozzano, Milano, 20089, Italy

  • Hunan Cancer Hospital ( Site 2905)

    Changsha, Hunan, 410013, China

  • IRCCS - AOU di Bologna-Istituto di Ematologia "L. e A. Seragnoli" ( Site 1500)

    Bologna, 40138, Italy

  • Innovative Clinical Research Institute ( Site 0202)

    Whittier, California, 90603, United States

  • Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 2002)

    L'Hospitalet Del Llobregat, Barcelona, 08908, Spain

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1502)

    Naples, 80131, Italy

  • James Lind Centro de Investigación del Cáncer ( Site 2705)

    Temuco, Región de la Araucanía, 4800827, Chile

  • Karadeniz Teknik Universitesi Tip Fakultesi-Hematology ( Site 2307)

    Trabzon, 61080, Turkey (Türkiye)

  • Karmanos Cancer Institute ( Site 0216)

    Detroit, Michigan, 48201, United States

  • Karolinska Universitetssjukhuset Solna ( Site 2102)

    Solna, Stockholm County, 171 64, Sweden

  • MEDICAL COLLEGE OF WISCONSIN ( Site 0234)

    Milwaukee, Wisconsin, 53226, United States

  • Maharaj Nakorn Chiang Mai Hospital ( Site 0702)

    Muang, Chiang Mai, 50200, Thailand

  • Massachusetts General Hospital-Cancer Center Protocol Office ( Site 0203)

    Boston, Massachusetts, 02114, United States

  • Mega Medipol-Hematology ( Site 2308)

    Istanbul, 34214, Turkey (Türkiye)

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( S

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • New York Medical College ( Site 0215)

    Valhalla, New York, 10595, United States

  • North Estonia Medical Centre Foundation ( Site 0900)

    Tallinn, Harju, 13419, Estonia

  • Northside Hospital ( Site 0206)

    Atlanta, Georgia, 30342, United States

  • Ondokuz Mayıs Universitesi ( Site 2306)

    Samsun, 55139, Turkey (Türkiye)

  • Oslo universitetssykehus, Radiumhospitalet ( Site 1600)

    Oslo, 0310, Norway

  • Pitie Salpetriere University Hospital-Clinical haematology ( Site 1000)

    Paris, 75013, France

  • Pratia Onkologia ( Site 1701)

    Katowice, Silesian Voivodeship, 40-519, Poland

  • Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0100)

    Toronto, Ontario, M5G 2M9, Canada

  • SUN YAT-SEN UNIVERSITY CANCER CENTRE-Internal Medicine ( Site 2907)

    Guangzhou, Guangdong, 510030, China

  • Saint Louis University Cancer Center ( Site 0209)

    St Louis, Missouri, 63110, United States

  • Samsung Medical Center ( Site 0600)

    Seoul, 06351, South Korea

  • Severance Hospital, Yonsei University Health System-Medical oncology ( Site 0601)

    Seoul, 03722, South Korea

  • Shaare Zedek Medical Center ( Site 1404)

    Jerusalem, 9103102, Israel

  • Shanghai East Hospital ( Site 2902)

    Shanghai, Shanghai Municipality, 200120, China

  • Skånes Universitetssjukhus Lund ( Site 2100)

    Lund, Skåne County, 22185, Sweden

  • Soroka Medical Center-Hematology Department ( Site 1403)

    Beersheba, 8410101, Israel

  • Sourasky Medical Center ( Site 1400)

    Tel Aviv, 64239, Israel

  • St. Joseph Hospital-The Center for Cancer Prevention and Treatment ( Site 0229)

    Orange, California, 92868, United States

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1707)

    Krakow, Lesser Poland Voivodeship, 31-826, Poland

  • Szpitale Pomorskie Sp. z o. o.-Hematology and Bone Marrow Transplantation Department ( Site 1702)

    Gdynia, Pomeranian Voivodeship, 81-519, Poland

  • The First Affiliated Hospital, Zhejiang University-Bone marrow transplant centre ( Site 2912)

    Hangzhou, Zhejiang, 310003, China

  • The First Hospital of Jilin University-Hematology ( Site 2910)

    Changchun, Jilin, 130021, China

  • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C

    Columbus, Ohio, 43210, United States

  • Tianjin Medical University Cancer Institute and Hospital-lymphoma ( Site 2901)

    Tianjin, Tianjin Municipality, 300060, China

  • University Hospitals Cleveland Medical Center ( Site 0222)

    Cleveland, Ohio, 44106, United States

  • University of Chicago Medical Center ( Site 0207)

    Chicago, Illinois, 60637, United States

  • University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0217)

    Cincinnati, Ohio, 45219, United States

  • University of Maryland-Greenebaum Comprehensive Cancer Center ( Site 0211)

    Baltimore, Maryland, 21201, United States

  • University of Michigan ( Site 0200)

    Ann Arbor, Michigan, 48109, United States

  • Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku ( Site

    Wroclaw, Lower Silesian Voivodeship, 50-367, Poland

  • Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0801)

    Prague, 12808, Czechia

  • West China Hospital of Sichuan University-Head and Neck Oncology ( Site 2911)

    Chengdu, Sichuan, 610041, China

  • Wuhan Union Hospital ( Site 2906)

    Wuhan, Hubei, 430022, China

Conditions

Explore the condition pages connected to this study.