New hope for Tough-to-Treat lung cancer: experimental combo enters final testing

NCT ID NCT06635824

Summary

This trial is testing whether a new drug called acasunlimab, when combined with pembrolizumab, works better than standard chemotherapy (docetaxel) for people with advanced non-small cell lung cancer. It is for patients whose cancer has spread, is PD-L1 positive, and has gotten worse after trying a PD-1/PD-L1 inhibitor and platinum chemotherapy. The main goal is to see if the new combination helps people live longer and controls the cancer better.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AOU San Luigi Gonzaga

    Orbassano, Torino, Italy

  • AOU Università degli Studi della Campania "Luigi Vanvitelli"

    Naples, Napoli, Italy

  • ASST Papa Giovanni XXIII

    Bergamo, Italy

  • AZ Delta

    Roeselare, Belgium

  • AZ Sint-Maarten

    Mechelen, Belgium

  • Adana City Hospital

    Adana, Turkey (Türkiye)

  • Aichi Cancer Center Hospital

    Nagoya, Japan

  • Aidport sp z o.o.

    Skorzewo, Poland

  • Ajou University Hospital

    Suwon, Gyeonggi-do, South Korea

  • Alexandra General Hospital

    Athens, Greece

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania, 15212, United States

  • Amsterdam UMC Locatie VUMC

    Amsterdam, Netherlands

  • Ankara City Hospital

    Ankara, Turkey (Türkiye)

  • Antoni van Leeuwenhoek

    Amsterdam, Netherlands

  • Arizona Blood and Cancer Specialists

    Tucson, Arizona, 85712, United States

  • Asan Medical Center

    Seoul, South Korea

  • Asklepios Klinik Harburg

    Hamburg, Germany

  • Assistance Publique-Hôpitaux de Marseille

    Marseille, France

  • Auxilio Mutuo Cancer Center

    San Juan, 917, Puerto Rico

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105, United States

  • BP A Beneficencia Portuguesa de Sao Paulo

    São Paulo, São Paulo, Brazil

  • Ballarat Oncology & Haematology Service

    Wendouree, Australia

  • Baptist Health Lexington

    Lexington, Kentucky, 40503, United States

  • Barts Hospital

    London, United Kingdom

  • Beatson West of Scotland Cancer Care

    Glasgow, Strathclyde, United Kingdom

  • Beaumont Hospital

    Dublin, Ireland

  • Bioclinic Thessaloniki

    Thessaloniki, Greece

  • Bács-Kiskun County Hospital BKMK

    Kecskemét, Hungary

  • C. H. U. St-Pierre

    Brussels, Belgium

  • CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia

    Santo André, Brazil

  • CH de Mulhouse - Hôpital Emile Muller

    Mulhouse, France

  • CHU Angers - Hôpital Larrey

    Angers, France

  • CHU Rennes - Hopital Pontchaillou

    Rennes, France

  • CHU de Liège

    Liège, Belgium

  • CRC - Centro Ricerche Cliniche di Verona S.r.l.

    Verona, Italy

  • Cancer Institute At Swedish Med Ctr

    Seattle, Washington, 98104, United States

  • Cancer Institute Hospital of JFCR

    Kōtō City, Japan

  • Centre Hospitalier Intercommunal de Creteil (CHIC)

    Créteil, France

  • Centre Hospitalier de la côte Basque

    Bayonne, France

  • Centre Léon Bérard

    Lyon, France

  • Centro Gaucho Integrado - Mae de Deus Center

    Porto Alegre, Rio Grande do Sul, Brazil

  • Centro Paulista de Oncologia S.A.

    São Paulo, São Paulo, Brazil

  • Centro de Investigacion Clinica Bradford Hill

    Santiago, Chile

  • Centro de Investigacion Pergamino S.A.

    Pergamino, Buenos Aires, Argentina

  • Chang Gung Memorial Hospital,Linkou

    Taoyuan, Taiwan

  • Chris OBrien LifeHouse

    Camperdown, New South Wales, Australia

  • Chungbuk National University Hospital

    Cheongju-si, South Korea

  • Clinica Universidad de Navarra

    Pamplona, Navarre, Spain

  • Clinique Belharra

    Bayonne, Pyrenees Atlantiques, France

  • Cliniques Universitaires Saint-Luc

    Brussels, Belgium

  • Clínica de Neoplasias Litoral Ltda.

    Itajaí, Santa Catarina, Brazil

  • Community Cancer Center East Medical Oncology Hematology

    Indianapolis, Indiana, 46219, United States

  • Complejo Hospitalario Universitario Insular Materno-Infantil

    Las Palmas de Gran Canaria, Las Palmas, Spain

  • Complejo Hospitalario Universitario de Santiago CHUS

    Santiago de Compostela, La Coruña, Spain

  • Complex Oncology Center - Plovdiv, EOOD

    Plovdiv, Bulgaria

  • Cork University Hospital

    Cork, Ireland

  • Department for Pulmonary Diseases University Hospital Centre Zagreb

    Zagreb, Croatia

  • Derriford Hospital

    Plymouth, United Kingdom

  • Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

    Ankara, Turkey (Türkiye)

  • Erasmus Medisch Centrum

    Rotterdam, Netherlands

  • Evangelische Lungenklinik Berlin

    Berlin, Germany

  • FALP - Fundación Arturo López Pérez

    Providencia, Chile

  • Facility name: Clínica Universidad de Navarra

    Madrid, Spain

  • Flinders Medical Centre

    Bedford Park, South Australia, Australia

  • Fondazione IRCCS San Gerardo dei Tintori

    Monza, Milano, Italy

  • General Hospital Dubrovnik

    Dubrovnik, Croatia

  • Gold Coast Hospital

    Southport, Queensland, Australia

  • Goztepe Prof. Dr. Suleyman Yalcin City Hospital

    Istanbul, Turkey (Türkiye)

  • Grand Hôpital de Charleroi

    Gilly, Belgium

  • Gulhane Training and Research Hospital

    Ankara, Turkey (Türkiye)

  • Gunma Prefectural Cancer Center

    Ota-shi, Japan

  • Guy's Hospital

    London, United Kingdom

  • H.C. Hospitales S.L.

    Marbella, Málaga, Spain

  • Henry Dunant Hospital Center

    Athens, Greece

  • Hiroshima University Hospital

    Hiroshima, Hiroshima, Japan

  • Hopital Albert Calmette - CHU Lille

    Lille, France

  • Hopital Saint Joseph - Paris

    Paris, France

  • Hospital CUF Porto

    Porto, Portugal

  • Hospital Erasto Gaertner

    Curitiba, Paraná, Brazil

  • Hospital Ernesto Dornelles

    Porto Alegre, Brazil

  • Hospital General Universitario Dr. Balmis

    Alicante, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, Spain

  • Hospital Italiano de Buenos Aires

    Ciudad Autonoma Buenos Aires, Argentina

  • Hospital Italiano de La Plata

    La Plata, Buenos Aires, Argentina

  • Hospital Quironsalud Malaga

    Málaga, Spain

  • Hospital Sirio-Libanes

    São Paulo, São Paulo, Brazil

  • Hospital São Lucas da PUCRS

    Porto Alegre, Rio Grande Do Su, Brazil

  • Hospital Universitari Vall d'Hebron

    Barcelona, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Spain

  • Hospital Universitario HM Sanchinarro

    Madrid, Spain

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcón, Madrid, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, Córdoba, Spain

  • Hospital Universitario Virgen Macarena

    Seville, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, Spain

  • Hospital de Clinicas de Ijui

    Ijuí, Rio Grande do Sul, Brazil

  • Hôpital Ambroise Paré

    Boulogne-Billancourt, France

  • Hôpital Privé du Confluent

    Nantes, France

  • Hôpital Sainte Musse

    Toulon, France

  • ICO - Site René Gauducheau

    Saint-Herblain, France

  • ICO Girona

    Girona, Spain

  • ICO l'Hospitalet

    L'Hospitalet de Llobregat, Barcelona, Spain

  • IRAM - Instituto de Radio Medicina

    Santiago, Chile

  • IRCCS Centro di Riferimento Oncologico

    Aviano, Pordenone, Italy

  • IRCCS Istituto Nazionale dei Tumori

    Milan, Italy

  • IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST

    Meldola, Italy

  • IRCCS Policlinico Universitario Agostino Gemelli

    Rome, Roma, Italy

  • IVO - Instituto Valenciano de Oncologia

    Valencia, Spain

  • Institut Bergonié

    Bordeaux, Gironde, France

  • Institut Curie

    Paris, France

  • Institut Gustave Roussy

    Villejuif, Val De Marne, France

  • Institut Paoli Calmettes

    Marseille, Bouches-du-Rhône, France

  • Institut Sainte Catherine

    Avignon, Vaculuse, France

  • Instituto D'Or Pesquisa e Ensino - Rio de Janeiro

    Rio de Janeiro, Rio Do Janeiro, Brazil

  • Instituto Medico Especializado Alexander Fleming

    Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina

  • Instytut Gruzlicy i Chorob Pluc w Warszawie

    Warsaw, Poland

  • Interbalkan Hospital of Thessaloniki

    Thessaloniki, Greece

  • Investigaciones CORI S.R.L.

    La Rioja, Argentina

  • Isala Zwolle

    Zwolle, Netherlands

  • Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty

    Istanbul, Turkey (Türkiye)

  • Istituto Clinico Humanitas

    Rozzano, Milano, Italy

  • Istituto Nazionale per la Ricerca sul Cancro di Genova

    Genova, Italy

  • Istituto di Candiolo

    Candiolo, Italy

  • JCHO Kyushu Hospital

    Kitakyushu-shi, Fukuoka, Japan

  • Jessa Ziekenhuis Hospital

    Hasselt, Belgium

  • Johannes Gutenberg University Mainz

    Mainz, Rhineland-Palatinate, Germany

  • Juntendo University Hospital

    Bunkyō City, Tokyo-To, Japan

  • Kaiser Foundation Hospitals

    Honolulu, Hawaii, 96817, United States

  • Kaiser Permanente Vallejo Medical Center

    Vallejo, California, 94589, United States

  • Kanagawa Cancer Center

    Yokohama, Japan

  • Keimyung University Dongsan Hospital

    Daegu, South Korea

  • Kepler Universitatsklinikum Med Campus III

    Linz, Austria

  • Kindai University Hospital

    Osakasayama-shi, Osaka, Japan

  • Kingston Health Sciences Centre

    Kingston, Ontario, Canada

  • Klinikum Esslingen GmbH

    Esslingen am Neckar, Baden-Wurttemberg, Germany

  • Kobe Minimally Invasive Cancer Center

    Kobe, Hyōgo, Japan

  • Kurashiki Central Hospital

    Kurashiki-shi, Japan

  • Kurume University Hospital

    Kurume-shi, Japan

  • LKH - Rankweil

    Rankweil, Austria

  • Leiden University Medical Center

    Leiden, Netherlands

  • Liv Hospital Ankara

    Ankara, Turkey (Türkiye)

  • LungenClinic Grosshansdorf GmbH

    Großhansdorf, Schleswig-Holstein, Germany

  • MHAT "Serdika", EOOD

    Sofia, Bulgaria

  • MHAT Heart and Brain - Pleven

    Pleven, Bulgaria

  • MHAT for women's health - Nadezhda, OOD

    Sofia, Bulgaria

  • MHH Medizinische Hochschule Hannover

    Hanover, Lower Saxony, Germany

  • MUHC - Jewish General Hospital

    Montreal, Quebec, Canada

  • MVZ Martha-Maria Halle-Doelau

    Halle, Saxony-Anhalt, Germany

  • Maria Sklodowska-Curie National Research Institute of Oncology (Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie)

    Warsaw, Poland

  • Medical Park Seyhan Hospital

    Adana, Turkey (Türkiye)

  • Midtown Tennessee Oncology

    Nashville, Tennessee, 37203, United States

  • Miyagi Cancer Center

    Natori-shi, Japan

  • MultiHemo Servicos Medicos

    Recife, Pernambuco, Brazil

  • NHO Hokkaido Cancer Center

    Hokkaido, Japan

  • NHO Kyushu Cancer Center

    Fukuoka, Japan

  • NHO Nagoya Medical Center

    Nagoya, Japan

  • National Cancer Center Hospital

    Chūōku, Japan

  • National Cancer Center Korea

    Goyang-si, South Korea

  • National Cheng Kung University Hospital

    Tainan, Taiwan

  • National Taiwan University Cancer Center

    Taipei, Taiwan

  • National Taiwan University Hospital Yunlin Branch

    Douliu, Taiwan

  • Nippon Medical School Hospital

    Bunkyō City, Japan

  • North Estonia Medical Centre Foundation

    Tallinn, Estonia

  • Norton Cancer Institute

    Louisville, Kentucky, 40202, United States

  • Nottingham University Hospitals City Campus

    Nottingham, United Kingdom

  • Novant Health Oncology Specialists

    Winston-Salem, North Carolina, 27103, United States

  • Novant Health Pharmacy

    Charlotte, North Carolina, 28204, United States

  • Ocala Oncology Center P.L.

    Ocala, Florida, 34474, United States

  • Okayama University Hospital

    Okayama, Japan

  • Oncocentro APYS

    Viña del Mar, Chile

  • Oncoclínicas Rio de Janeiro

    Rio de Janeiro, Brazil

  • Oncoclínicas do Brasil Serviços Médicos SA

    Belo Horizonte, Brazil

  • Oncology Hematology West

    Omaha, Nebraska, 68124, United States

  • Oncology Hematology West, PC dba Nebraska Cancer Specialists

    Omaha, Nebraska, 68130, United States

  • Orlando Regional Medical Center

    Orlando, Florida, 32806, United States

  • Orszagos Koranyi Pulmonologiai Intezet

    Budapest, Hungary

  • Osaka International Cancer Institute

    Osaka, Japan

  • Osaka Medical and Pharmaceutical University Hospital

    Osaka, Japan

  • Ospedale Santa Maria delle Croci

    Ravenna, Italy

  • Pan American Oncology Trials, LLC

    San Juan, 902, Puerto Rico

  • Parkridge Medical Center

    Chattanooga, Tennessee, 37404, United States

  • Piedmont Cancer Institute - Fayetteville Office

    Fayetteville, Georgia, 30214, United States

  • Piedmont Cancer Institute - Newnan Office

    Newnan, Georgia, 30265, United States

  • Piedmont Cancer Institute - Sandy Springs (Atlanta) Office

    Atlanta, Georgia, 30328, United States

  • Piedmont Cancer Institute - Stockbridge Office

    Stockbridge, Georgia, 30281, United States

  • Piedmont Cancer Institute Atlanta

    Atlanta, Georgia, 30318, United States

  • Pikeville Medical Center

    Pikeville, Kentucky, 41501, United States

  • Polish Mother's Memorial Hospital (Instytut Centrum Zdrowia Matki Polki)

    Lodz, Poland

  • Princess Margaret Cancer Centre - University Health Network

    Toronto, Ontario, Canada

  • Radboudumc

    Nijmegen, Netherlands

  • Regina Elena National Cancer Institute

    Roma, Italy

  • Saiseikai Kumamoto Hospital

    Kumamoto, Kumamoto, Japan

  • Samsung Medical Center

    Seoul, South Korea

  • Sanatorio Parque S.A.

    Rosario, Santa Fe Province, Argentina

  • Sestre milosrdnice University Hospital Center

    Zagreb, Croatia

  • Severance Hospital, Yonsei University Health System

    Seoul, South Korea

  • Shikoku Cancer Center

    Matsuyama, Ehime, Japan

  • Sir Charles Gairdner Hospital

    Perth, Western Australia, Australia

  • South Austin Cancer Ctr

    Austin, Texas, 78745, United States

  • Specialty Hospital Medico

    Rijeka, Croatia

  • St James's Hospital

    Dublin, Ireland

  • St John of God Subiaco Hospital

    Subiaco, Western Australia, Australia

  • St Vincent's Hospital Melbourne

    Fitzroy, Australia

  • St Vincent's University Hospital

    Dublin, Ireland

  • St. Francis Hospital - Grand Island

    Grand Island, Nebraska, 68803, United States

  • St. Jansdal Ziekenhuis

    Harderwijk, Netherlands

  • Standort Penzing der Klinik Ottakring

    Vienna, Austria

  • Stony Brook University Medical Center|University Medical Center

    Stony Brook, New York, 11790, United States

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

    Krakow, Poland

  • Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie

    Koszalin, Poland

  • Taipei Veterans General Hospital

    Taipei, Taiwan

  • Tartu University Hospital

    Tartu, Estonia

  • Tennessee Oncology

    Nashville, Tennessee, 37205, United States

  • Texas Oncology-Austin Central

    Austin, Texas, 78731, United States

  • Texas Oncology-Austin Midtown

    Austin, Texas, 78705, United States

  • The Christie Hospital

    Manchester, United Kingdom

  • Thoraxklinik Heidelberg gGmbH

    Heidelberg, Baden-Wurttemberg, Germany

  • UMHAT "Sv. Ivan Rilski", EAD

    Sofia, Bulgaria

  • UMHAT 'SofiaMed', OOD

    Sofia, Bulgaria

  • Unidade Local de Saude da Arrabida E. P. E

    Setúbal, Portugal

  • Unidade Local de Saude de Coimbra E P E

    Coimbra, Portugal

  • Unidade Local de Saúde de Matosinhos, E.P.E. - Hospital Pedro Hispano

    Matosinhos Municipality, Portugal

  • Universitaetsmedizin Goettingen

    Göttingen, Lower Saxony, Germany

  • Universitair Medisch Centrum Utrecht

    Utrecht, Netherlands

  • Universitair Ziekenhuis Bruxelles

    Brussels, Belgium

  • Universitatsklinikum Carl Gustav Carus Dresden

    Dresden, Saxony, Germany

  • University Cancer & Blood Center, LLC

    Athens, Georgia, 30607, United States

  • University General Hospital Attikon

    Athens, Greece

  • University General Hospital of Heraklion

    Heraklion, Greece

  • University General Hospital of Larissa

    Larissa, Greece

  • University Hospital Limerick

    Limerick, Ireland

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Pennsylvania Health System

    Philadelphia, Pennsylvania, 19104, United States

  • University of Tennessee Medical Center Cancer Institute

    Knoxville, Tennessee, 37920, United States

  • University of Virginia Hematology and Oncology

    Charlottesville, Virginia, 22903, United States

  • Usc Norris Comprehensive Cancer Center

    Los Angeles, California, 90089, United States

  • Vivantes Klinikum Neukoelln

    Berlin, Germany

  • Vivantes Klinikum Spandau

    Berlin, Germany

  • Vivantes Klinikum im Friedrichshain

    Berlin, Germany

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Waterford Regional Hospital

    Waterford, Ireland

  • Westmead Hospital

    Sydney, New South Wales, Australia

  • Wiener Gesundheitsverbund - Klinik Floridsdorf

    Vienna, Austria

  • William Osler Health System-Brampton Civic Hospital|William Osler Health System

    Brampton, Ontario, Canada

  • Zuyderland Medisch Centrum - Heerlen

    Heerlen, Netherlands

  • İ.E.Ü. Medicalpoint İzmir Hastanesi

    Izmir, Turkey (Türkiye)

Conditions

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