Breakthrough trial targets genetic weakness in aggressive lung cancer

NCT ID NCT07063745

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding an experimental drug called BMS-986504 to standard immunotherapy and chemotherapy works better than standard treatment alone for people with advanced lung cancer that has spread and has a specific genetic deletion called MTAP. The trial will involve about 590 participants who haven't received previous treatment for their metastatic cancer. Researchers will compare how long patients live without their cancer getting worse and overall survival between the two treatment groups.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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AZ Delta vzw
RECRUITING

Roeselare, West-Vlaanderen, 8800, Belgium

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Alaska Oncology and Hematology
RECRUITING

Anchorage, Alaska, 99508, United States

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Alexandra General Hospital of Athens
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Athens, Attikí, 115 28, Greece

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Antwerp University Hospital
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Edegem, Antwerpen, 2650, Belgium

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Asan Medical Center
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Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea

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Azienda Ospedaliero-Universitaria San Luigi Gonzaga
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Orbassano, Torino, 10043, Italy

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Baptist Health Lexington
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Lexington, Kentucky, 40503, United States

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CHRU de Brest
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Brest, Finistère, 29200, France

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CHU Bordeaux Haut-Leveque
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Pessac, Aquitaine, 33600, France

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CHU de Toulouse - Hopital Larrey
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Toulouse, Haute-Garonne, 31059, France

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Centre François Baclesse
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Caen, Calvados, 14076, France

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Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
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Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54511, France

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Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
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Tours, 37032, France

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Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
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Rennes, Ille-et-Vilaine, 35033, France

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Centrul de Diagnostic si Tratament Provita
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Bucharest, 020335, Romania

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Centrul de Oncologie "Sfântul Nectarie"
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Craiova, Dolj, 200542, Romania

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Centrum Medyczne Pratia Poznań
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Poznan, Greater Poland Voivodeship, 60-192, Poland

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Centrum Onkologii im. Prof. Franciszka Lukaszczyka
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Bydgoszcz, 85796, Poland

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Chang Gung Medical Foundation-Linkou Branch
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Taoyuan District, 333, Taiwan

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Chi Mei Hospital - Liouying Branch
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Tainan, Tainan, 73657, Taiwan

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Chu Gabriel Montpied
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Clermont-Ferrand, Puy-de-Dôme, 63000, France

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Chu Jean Minjoz
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Besançon, Doubs, 25000, France

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Complex Oncology Center - Ruse EOOD
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Rousse, 7002, Bulgaria

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Cro-Irccs
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Aviano, Friuli Venezia Giulia, 33081, Italy

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Dana-Farber Cancer Institute
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Boston, Massachusetts, 02215, United States

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Fakultni nemocnice Hradec Kralove
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Hradec Králové, Hradec Králové, 500 05, Czechia

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Fred Hutchinson Cancer Center
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Seattle, Washington, 98109, United States

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Guangdong Provincial People's Hospital
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Guangzhou, Guangdong, 510000, China

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Guangxi Medical University Affiliated Cancer Hospital
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Nanning, Guangxi, 530021, China

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H.R.U Málaga - Hospital General
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Málaga, 29011, Spain

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Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States

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Hospices Civils de Lyon - Hopital Louis Pradel
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Bron, Rhône, 69677, France

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Hospital Universitari Vall d'Hebron
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Barcelona, Barcelona [Barcelona], 08035, Spain

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Hospital Universitario 12 de Octubre
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Madrid, Madrid, Comunidad de, 28041, Spain

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Hospital Universitario Puerta de Hierro Majadahonda
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Majadahonda, Madrid, Comunidad de, 28222, Spain

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Hospital Universitario Virgen Del Rocio
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Seville, 41013, Spain

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IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
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Bologna, 40138, Italy

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Institut Curie
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Paris, 75248, France

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Institut Paoli-Calmettes
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Marseille, Provence-Alpes-Côte d'Azur Region, 13273, France

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Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
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Bucharest, București, 022338, Romania

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Institutul Oncologic Cluj
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Cluj-Napoca, 400015, Romania
Institutul Oncologic Cluj
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Cluj-Napoca, 400015, Romania

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Institutul Regional de Oncologie
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Iași, 700483, Romania

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Kaiser Permanente Interstate Medical Office Central
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Portland, Oregon, 97227, United States

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Klinik Löwenstein
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Löwenstein, 74245, Germany

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Krankenhaus Barmherzige Brüder Regensburg
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Regensburg, Bavaria, 93049, Germany

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Landeskrankenhaus Rankweil
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Rankweil, 6830, Austria

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Leicester Royal Infirmary
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Leicester, Leicestershire, LE1 5WW, United Kingdom

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Liaoning Cancer Hospital
RECRUITING

Shenyang, Liaoning, 110042, China

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Local Institution - 0005
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Athens, Attikí, 115 26, Greece

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Local Institution - 0006
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Thessaloniki, Kentrikí Makedonía, 540 07, Greece

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Local Institution - 0010
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Kfar Saba, Central District, 4428164, Israel

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Local Institution - 0011
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Ramat Gan, Central District, 5265601, Israel

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Local Institution - 0013
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Jerusalem, Jerusalem, 9112001, Israel

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Local Institution - 0014
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Haifa, Northern District, 3109601, Israel

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Local Institution - 0016
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Afula, Northern District, 1834111, Israel

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Local Institution - 0017
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Jerusalem, Jerusalem, 9013102, Israel
Local Institution - 0039
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Milan, 20133, Italy

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Local Institution - 0044
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Perugia, Umbria, 06132, Italy

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Fuzhou, Fujian, 350014, China

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Local Institution - 0047
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Zhengzhou, 450008, China

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Local Institution - 0049
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Beijing, Beijing Municipality, 100142, China

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Local Institution - 0050
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Changsha, Hunan, 410013, China

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Local Institution - 0051
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Jinan, Shandong, 250117, China

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Local Institution - 0054
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Hangzhou, Zhejiang, 310022, China

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Local Institution - 0059
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Wuhan, Hubei, 430079, China

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Xi'an, Shaanxi, 710038, China

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Guangzhou, Guangdong, 510515, China

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Local Institution - 0066
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Linyi, Shandong, 276001, China

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Qingdao, Shandong, 266003, China

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Local Institution - 0069
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Hangzhou, Zhejiang, 310016, China

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Local Institution - 0072
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Hefei, Anhui, 230031, China

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Local Institution - 0074
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Beijing, Beijing Municipality, 100034, China

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Local Institution - 0076
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Bauru, São Paulo, 17033-490, Brazil

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Local Institution - 0078
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São Paulo, 01246-000, Brazil

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Local Institution - 0079
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Natal, Rio Grande do Norte, 59062-000, Brazil

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Local Institution - 0081
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Barretos, São Paulo, 14784400, Brazil

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Local Institution - 0085
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Blumenau, Santa Catarina, 89010-340, Brazil

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Local Institution - 0088
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Vitória, Espírito Santo, 29055450, Brazil

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Local Institution - 0091
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Rio de Janeiro, 20231-050, Brazil

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Local Institution - 0094
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Campinas, São Paulo, 13060-803, Brazil

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Local Institution - 0095
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São Paulo, São Paulo, 01509-010, Brazil

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Local Institution - 0096
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Drammen, Buskerud, 3004, Norway

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Local Institution - 0099
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Guangzhou, Guangdong, 0, China

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Xiamen, Fujian, 361003, China

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Local Institution - 0104
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Shenyang, Liaoning, 110004, China

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Local Institution - 0105
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Napoli, Campania, 80131, Italy

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Local Institution - 0106
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Harbin, Heilongjiang, 150081, China

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Local Institution - 0107
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Zhengzhou, Henan, 450000, China

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Local Institution - 0110
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Nanchang, Jiangxi, 330209, China

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Local Institution - 0118
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Madrid, Madrid, Comunidad de, 28009, Spain

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Local Institution - 0120
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Tucson, Arizona, 85724, United States

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Local Institution - 0127
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Scarborough, Maine, 04074, United States

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Local Institution - 0128
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Rochester, New York, 14642, United States

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Local Institution - 0129
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Columbus, Ohio, 43210, United States

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Local Institution - 0131
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Fairfax, Virginia, 22031, United States
Local Institution - 0152
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Fort Lauderdale, Florida, 33316, United States

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Local Institution - 0163
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Cleveland, Ohio, 44195, United States

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Local Institution - 0179
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Hawthorne, New York, 10532, United States

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Local Institution - 0186
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Richmond, Virginia, 23298, United States

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Local Institution - 0202
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München, Bavaria, 81675, Germany

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Local Institution - 0207
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Vienna, 1210, Austria

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Local Institution - 0212
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Dijon, Côte-d'Or, 21079, France

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Local Institution - 0213
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Créteil, Val-de-Marne, 94010, France

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Local Institution - 0215
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Saint-Herblain, Loire-Atlantique, 44800, France

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Local Institution - 0220
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Montpellier, Hérault, 34298, France

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Local Institution - 0225
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Yvoir, Namur, 5530, Belgium

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Local Institution - 0226
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Hasselt, Limburg, 3500, Belgium

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Local Institution - 0230
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Arnhem, 6815 AD, Netherlands
Local Institution - 0232
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Sendai, Miyagi, 9810914, Japan

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Local Institution - 0233
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Sapporo, Hokkaido, 0608648, Japan

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Local Institution - 0234
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Bunkyo-ku, Tokyo, 1138603, Japan

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Local Institution - 0235
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Shimotsuga, Tochigi, 321-0293, Japan

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Local Institution - 0236
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Kashiwa, Chiba, 277-8577, Japan

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Local Institution - 0237
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Matsusaka, Mie-ken, 515-8544, Japan

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Local Institution - 0238
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Yokohama, Kanagawa, 2418515, Japan

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Local Institution - 0239
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Osaka, 534-0021, Japan

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Local Institution - 0240
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Hirakata, Osaka, 573-1191, Japan

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Local Institution - 0241
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Nankoku, Kochi, 783-8505, Japan

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Local Institution - 0242
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Ube, Yamaguchi, 755-0241, Japan

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Local Institution - 0243
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Nagoya, Aichi-ken, 460-0001, Japan

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Local Institution - 0244
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Okayama, 701-1192, Japan

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Local Institution - 0245
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Hidaka, Saitama, 350-1298, Japan

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Local Institution - 0246
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Fukuoka, 811-1395, Japan

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Local Institution - 0247
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Kobe, Hyōgo, 650-0047, Japan

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Local Institution - 0248
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Hospitalet, Barcelona [Barcelona], 08907, Spain

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Local Institution - 0250
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Olomouc, 779 00, Czechia

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Local Institution - 0253
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Barcelona, Catalunya [Cataluña], 08036, Spain
Local Institution - 0255
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Valencia, 46026, Spain

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Kawasaki, Kanagawa, 216-8511, Japan

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Krakow, Lesser Poland Voivodeship, 30-727, Poland

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Warsaw, Masovian Voivodeship, 04-125, Poland

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Bangalore, Karnataka, 560092, India

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Varanasi, Uttar Pradesh, 221002, India

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Hyderabad, Telangana, 500033, India

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Local Institution - 0266
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Mumbai, Maharashtra, 400012, India

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Local Institution - 0267
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New Delhi, National Capital Territory of Delhi, 110029, India

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Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea

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Cheongju-si, Chungcheongbuk-do [Chungbuk], 28644, South Korea

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Shanghai, Shanghai Municipality, 200030, China

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Local Institution - 0279
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Nanjing, Jiangsu, 210009, China

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Local Institution - 0280
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Hangzhou, Zhejiang, 310003, China

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Local Institution - 0281
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Shenzhen, Guangdong, 518020, China

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Local Institution - 0283
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Taiyuan, Shanxi, 030000, China

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Local Institution - 0284
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Shenyang, Liaoning, 110001, China

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Local Institution - 0286
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Beijing, Beijing Municipality, 100142, China

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Local Institution - 0287
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Farkasgyepű, Veszprém megye, 8582, Hungary

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Local Institution - 0288
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Budapest, 1083, Hungary

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Local Institution - 0290
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Gyula, Bekes County, 5700, Hungary

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Local Institution - 0291
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Gyöngyös, Heves County, 3200, Hungary

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Local Institution - 0293
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Mexico City, Mexico City, 03100, Mexico

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Local Institution - 0294
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Mexico City, Mexico City, 06760, Mexico
Local Institution - 0296
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Guadalajara, Jalisco, 44260, Mexico

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Local Institution - 0297
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Oaxaca City, Oaxaca, 68020, Mexico

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Local Institution - 0298
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Monterrey, Nuevo León, 66460, Mexico

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Local Institution - 0305
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Bogotá, Cundinamarca, 111511, Colombia

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Local Institution - 0306
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Montería, Departamento de Córdoba, 230002, Colombia

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Local Institution - 0307
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Stara Zagora, 6000, Bulgaria

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Local Institution - 0309
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Haskovo, 6300, Bulgaria

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Local Institution - 0315
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Panagyurishte, Pazardzhik, 4500, Bulgaria

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Local Institution - 0317
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Adana, 01370, Turkey (Türkiye)

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Local Institution - 0318
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Adana, 01140, Turkey (Türkiye)

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Local Institution - 0319
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Edirne, 22030, Turkey (Türkiye)

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Local Institution - 0320
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Bursa, 16059, Turkey (Türkiye)

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Local Institution - 0321
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Ankara, 06680, Turkey (Türkiye)

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Local Institution - 0323
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Shatin, 0, Hong Kong

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Local Institution - 0326
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Guadalajara, Jalisco, 44680, Mexico

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Local Institution - 0327
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Chihuahua City, 31203, Mexico

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Local Institution - 0328
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Querétaro, 76000, Mexico

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Local Institution - 0330
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Medellín, Antioquia, 050030, Colombia

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Local Institution - 0331
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Puebla City, 72530, Mexico

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Local Institution - 0334
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Otashi, Gunma, 373-8550, Japan

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Local Institution - 0335
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Shiwa-gun Yahaba-cho, Iwate, 028-3695, Japan

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Local Institution - 0336
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Himeji, Hyōgo, 670-8520, Japan

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Local Institution - 0340
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Liège, 4000, Belgium

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Local Institution - 0344
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Bengaluru, Karnataka, 560017, India

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Local Institution - 0345
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Mumbai, Maharashtra, 400004, India

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Local Institution - 0346
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Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

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Local Institution - 0349
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Izmir, Karsiyaka, İzmir, 009035575, Turkey (Türkiye)

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Local Institution - 0350
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Antalya, 07059, Turkey (Türkiye)

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Local Institution - 0351
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São José do Rio Preto, São Paulo, 15090000, Brazil

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Local Institution - 0352
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Nanjing, Jiangsu, 210000, China

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Local Institution - 0353
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Shijiazhuang, Hebei, 050035, China

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Local Institution - 0354
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Salt Lake City, Utah, 84112, United States

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Local Institution - 0355
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São Caetano do Sul, São Paulo, 09541-270, Brazil

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Local Institution - 0356
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Copenhagen, Capital Region, 2100, Denmark

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Local Institution - 0367
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Ballarat Central, Victoria, 3350, Australia

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Local Institution - 0368
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Garran, ACT 2605, Australia

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Local Institution - 0373
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Woolloongabba, QLD 4102, Australia

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Local Institution - 0374
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El Paso, Texas, 79915, United States

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Local Institution - 0377
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The Woodlands, Texas, 77380, United States
Local Institution - 0387
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Changsha, Hunan, 410008, China

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Local Institution - 0390
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Kuching, Sarawak, 93590, Malaysia

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Local Institution - 0405
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Detroit, Michigan, 48201, United States

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Local Institution - 0408
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Guiyang, Guizhou, 550002, China

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Local Institution - 0411
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Bangkok, 10330, Thailand

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Local Institution - 0412
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Bangkok, 10700, Thailand

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Local Institution - 0413
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Kuala Lumpur, Kuala Lumpur, 59100, Malaysia

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Local Institution - 0418
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Ann Arbor, Michigan, 48109, United States

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Local Institution - 0420
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Traverse City, Michigan, 49684, United States

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Local Institution - 0429
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Paris, Île-de-France Region, 75014, France

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Local Institution - 0430
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St. Petersburg, Florida, 33709, United States
Local Institution - 0431
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Hobart, Tasmania, 7000, Australia

Contact
Local Institution - 0432
NOT_YET_RECRUITING

Liverpool, New South Wales, 2170, Australia

Contact
Local Institution - 0433
NOT_YET_RECRUITING

Dallas, Texas, 75390, United States

Contact
Local Institution - 0444
NOT_YET_RECRUITING

Los Angeles, California, 90067, United States

Contact
Local Institution - 0445
NOT_YET_RECRUITING

Veldhoven, North Brabant, 5504 DB, Netherlands

Contact
Local Institution - 0446
NOT_YET_RECRUITING

Buenos Aires, C1280AEB, Argentina

Contact
Local Institution - 0447
NOT_YET_RECRUITING

Buenos Aires, 1426, Argentina

Contact
Local Institution - 0458
NOT_YET_RECRUITING

Wieliszew, Masovian Voivodeship, 05-135, Poland

Contact
Local Institution - 0459
NOT_YET_RECRUITING

Sofia, Sofia, 1431, Bulgaria

Contact
Local Institution - 0460
NOT_YET_RECRUITING

Sofia, 1527, Bulgaria

Contact
Local Institution - 0461
NOT_YET_RECRUITING

Göppingen, Baden-Wurttemberg, 73035, Germany

Contact
Local Institution - 0462
NOT_YET_RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany

Contact
Local Institution - 0463
NOT_YET_RECRUITING

Rosario, Santa Fe Province, 2000, Argentina

Contact
Local Institution - 0465
NOT_YET_RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

Contact
Local Institution - 0467
NOT_YET_RECRUITING

Lebanon, New Hampshire, 03756, United States

Contact
Local Institution - 0468
NOT_YET_RECRUITING

Verona, 37126, Italy

Contact
Local Institution - 0471
NOT_YET_RECRUITING

Seoul, 06591, South Korea

Contact
LungenClinic Grosshansdorf
RECRUITING

Großhansdorf, 22927, Germany

Contact Phone: •••-•••-••••
Lungenfachklinik Immenhausen
RECRUITING

Immenhausen, 34376, Germany

Contact Phone: •••-•••-••••
Lyell McEwin Hospital
RECRUITING

Elizabeth Vale, South Australia, 5112, Australia

Contact Phone: •••-•••-••••
Mayo Clinic in Arizona - Phoenix
RECRUITING

Phoenix, Arizona, 85054, United States

Contact Phone: •••-•••-••••
Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224, United States

Contact Phone: •••-•••-••••
Mayo Clinic in Rochester, Minnesota
RECRUITING

Rochester, Minnesota, 55905, United States

Contact Phone: •••-•••-••••
Nanjing First Hospital
RECRUITING

Nanjing, Jiangsu, 210012, China

Contact Phone: •••-•••-••••
National Cancer Center
RECRUITING

Goyang-si, Kyǒnggi-do, 10408, South Korea

Contact Phone: •••-•••-••••
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan

Contact Phone: •••-•••-••••
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan

Contact Phone: •••-•••-••••
Oncology Hematology West P.C. dba Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States

Contact Phone: •••-•••-••••
Ordensklinikum Linz GmbH Elisabethinen
RECRUITING

Linz, Upper Austria, 4020, Austria

Contact Phone: •••-•••-••••
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy

Contact Phone: •••-•••-••••
Ospedale Santa Maria delle Croci
RECRUITING

Ravenna, Emilia-Romagna, 48121, Italy

Contact Phone: •••-•••-••••
Pius Hospital Oldenburg
RECRUITING

Oldenburg, Lower Saxony, 26121, Germany

Contact Phone: •••-•••-••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Phone: •••-•••-••••
Queen Mary Hospital
RECRUITING

Hksar, 0, Hong Kong

Contact Phone: •••-•••-••••
Radiology Therapeutic Center
RECRUITING

Otopeni, Ilfov, 075100, Romania

Contact Phone: •••-•••-••••
Robert Bosch Krankenhaus GmbH
RECRUITING

Stuttgart, Baden-Wurttemberg, 70376, Germany

Contact Phone: •••-•••-••••
S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING

Iași, 700106, Romania

Contact Phone: •••-•••-••••
SC Radiotherapy Center Cluj SRL
RECRUITING

Florești, Cluj, 407280, Romania

Contact Phone: •••-•••-••••
Sahlgrenska Universitetssjukhuset
RECRUITING

Gothenburg, Västra Götalands Län [se-14], 413 45, Sweden

Contact Phone: •••-•••-••••
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

Contact Phone: •••-•••-••••
Sarah Cannon Research Institute UK
RECRUITING

London, London, City of, w1g 6ad, United Kingdom

Contact Phone: •••-•••-••••
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Kyǒnggi-do, 13620, South Korea

Contact Phone: •••-•••-••••
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea

Contact Phone: •••-•••-••••
Sichuan Cancer hospital
RECRUITING

Chengdu, Sichuan, 610041, China

Contact Phone: •••-•••-••••
Spitalul Municipal Schuller Ploiești
RECRUITING

Ploieşti, 100337, Romania

Contact Phone: •••-•••-••••
St. Luke's Cancer Institute: Boise
RECRUITING

Boise, Idaho, 83712, United States

Contact Phone: •••-•••-••••
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia

Contact Phone: •••-•••-••••
Szpital Specjalistyczny w Prabutach Spolka z o.o.
RECRUITING

Prabuty, Pomeranian Voivodeship, 82-550, Poland

Contact Phone: •••-•••-••••
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan

Contact Phone: •••-•••-••••
Thoracic General Hospital of Athens "I Sotiria"
RECRUITING

Athens, Attikí, 115 27, Greece

Contact Phone: •••-•••-••••
USC/Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

Contact Phone: •••-•••-••••
UZ Brussel
RECRUITING

Brussels, 1090, Belgium

Contact Phone: •••-•••-••••
University General Hospital of Larissa
RECRUITING

Larissa, Thessalía, 41110, Greece

Contact Phone: •••-•••-••••
University Hospital of Patras
RECRUITING

Pátrai, Achaḯa, 26504, Greece

Contact Phone: •••-•••-••••
University Medical Center Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands

Contact Phone: •••-•••-••••
University of Kentucky Chandler Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States

Contact Phone: •••-•••-••••
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-••••
West China Hospital Sichuan University
RECRUITING

Chengdu, Sichuan, 611135, China

Contact Phone: •••-•••-••••
Wuhan Union Hospital Cancer Center
RECRUITING

Wuhan, Hubei, 430023, China

Contact Phone: •••-•••-••••
Zhongshan Hospital,Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200032, China

Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.

METASTATIC NON-SMALL CELL LUNG CANCER WITH MTAP DELETION