New hope for tough lung cancers: targeted pill challenges chemo

NCT ID NCT06881784

Recruiting now Disease control Sponsor: Revolution Medicines, Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new oral drug called daraxonrasib works better than standard chemotherapy (docetaxel) for people with advanced non-small cell lung cancer that has a specific genetic change (RAS mutation) and has stopped responding to initial treatments. About 420 participants will be randomly assigned to receive either the new drug or chemotherapy. The main goals are to see if the new drug helps people live longer or live longer without their cancer getting worse.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AZ Delta
RECRUITING

Roeselare, 8800, Belgium

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AZ Groeninge
RECRUITING

Kortrijk, 8500, Belgium

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Aichi Cancer Center Hospital
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan

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Aidport Sp. z o.o.
RECRUITING

Skorzewo, 60-185, Poland

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Ajou University Hospital
RECRUITING

Gyeonggi-do, Suwon-si, 16499, South Korea

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Alabama Oncology
RECRUITING

Birmingham, Alabama, 35243, United States

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Amsterdam UMC, Locatie VUMC
RECRUITING

Amsterdam, Netherlands, 1081BT, Netherlands

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Antoni van Leeuwenhoek
RECRUITING

Amsterdam, 1066 CX, Netherlands

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Auckland City Hospital - Cancer and Blood Research
RECRUITING

Grafton, Auckland, 1023, New Zealand

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Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States

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Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello)
RECRUITING

Pisa, Pisa, 56124, Italy

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Azienda Socio Sanitaria Territoriale Niguarda
RECRUITING

Milan, Milano, 21206, Italy

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BRCR Global
RECRUITING

Plantation, Florida, 33322, United States

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Beaumont Hospital Cancer Clinical
RECRUITING

Dublin, D09 V2N0, Ireland

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Blacktown Medical Oncology Research
RECRUITING

Blacktown, New South Wales, 2148, Australia

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CHU Brest - Hôpital Morvan
RECRUITING

Brest, 29200, France

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CHU Nantes - Hôpital Guillaume et René Laënnec
RECRUITING

Saint-Herblain, Loire Atlantique, 44805, France

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CHU Rennes Hôpital Pontchaillou
RECRUITING

Rennes, Ille et Vilaine, 35033, France

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CHU Strasbourg - Nouvel Hôpital Civil
RECRUITING

Strasbourg, Bas Rhin, 67091, France

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CHU de Grenoble - Hôpital Albert Michallon
RECRUITING

La Tronche, Isere, 38700, France

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CHU de Toulouse - Hopital Larrey
RECRUITING

Toulouse, 31059, France

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Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia

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Cancer Care Centers of Breevard
RECRUITING

Rockledge, Florida, 32955, United States

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Cancer Institute Hospital of JFCR
RECRUITING

Koto-Ku, Tokyo, 135-8550, Japan

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Center for Care and Discovery
RECRUITING

Chicago, Illinois, 60637, United States

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Centre Hospitalier Intercommunal de Créteil
RECRUITING

Créteil, Val de Marne, 94000, France

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Centre Leon Berard
RECRUITING

Léon, Lyon, 69008, France

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Chang Gung Medical Foundation Linkou
RECRUITING

Taoyuan District, 333, Taiwan

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Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, 58128, South Korea

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Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia

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Chungbuk National University Hospital
RECRUITING

Cheongju-si, 28644, South Korea

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Cleveland Clinic Martin North
RECRUITING

Stuart, Florida, 34994, United States

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Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, A Coruña, 15006, Spain

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Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States

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Erasmus Medisch Centrum
RECRUITING

Rotterdam, Netherlands, 3015AA, Netherlands

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Evangelische Lungenklinik Berlin
RECRUITING

Berlin, 13125, Germany

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Florida Cancer Specialists & Research Institute - East
RECRUITING

West Palm Beach, Florida, 33401, United States

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Florida Cancer Specialists & Research Institute - North
RECRUITING

St. Petersburg, Florida, 33705, United States

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Florida Cancer Specialists & Research Institute - South
RECRUITING

Fort Myers, Florida, 33901, United States

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Fondazione IRCCS San Gerardo dei Tintori
RECRUITING

Monza, Milan, 20900, Italy

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, 00168, Italy

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Fujita Health University Hospital
RECRUITING

Toyoake-shi, Aichi-ken, 470-1192, Japan

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Grand Hôpital de Charleroi - Les Viviers
RECRUITING

Gilly, 6060, Belgium

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HFR Fribourg/Kantonsspital Fribourg
RECRUITING

Fribourg, 1708, Switzerland

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Henry Ford Health
RECRUITING

Detroit, Michigan, 48202, United States

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Hong Kong United Oncology Centre
RECRUITING

Hong Kong, Hong Kong

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Hopital Albert Calmette - CHU Lille
RECRUITING

Lille, Nord, 59037, France

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Hopital Louis Pradel
RECRUITING

Bron, Rhone, 69677, France

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Hopital Nord - CHU Marseille
RECRUITING

Marseille, Bouches-du-Rhône, 13915, France

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Hospital Universitari Dexeus
RECRUITING

Barcelona, Barcelona, 08028, Spain

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Hospital Universitario HM Madrid Sanchinarro
RECRUITING

Madrid, Madrid, 28050, Spain

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Hospital Universitario La Paz
RECRUITING

Fuencarral-El Pardo, Madrid, 28046, Spain

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Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain

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Hyogo Cancer Center
RECRUITING

Akashi, Hyōgo, 673-8558, Japan

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Hôpital Bichat - Claude Bernard
RECRUITING

Paris, Paris, 75018, France

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IEO Istituto Europeo di Oncologia
RECRUITING

Milan, Milano, 20141, Italy

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INSTYTUT GENETYKI I IMMMUNOLOGII GENIM sp. z o.o.
RECRUITING

Lublin, 29-609, Poland

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Institut Bergonie
RECRUITING

Gironde, 33076, France

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Institut Gustave Roussy
RECRUITING

Vaillant, Villejuif, 94800, France

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Institut Jules Bordet
RECRUITING

Anderlecht, Belgium, 1070, Belgium

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Institut de Cancerologie de l Ouest
RECRUITING

Saint-Herblain, Loire Atlantique, 44805, France

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Institut régional du Cancer de Montpellier
RECRUITING

Montpellier, Herault, 34298, France

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Istituto Clinico Humanitas
RECRUITING

Rossano, Milano, 20089, Italy

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Istituto Nazionale Tumori Fondazione G. Pascale
RECRUITING

Naples, Napoli, 80131, Italy

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Istituto Nazionale dei Tumori Regina Elena IRCCS
RECRUITING

Roma, Roma, 00144, Italy

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Johns Hopkins University of Medicine
RECRUITING

Baltimore, Maryland, 21224, United States

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Kanagawa Cancer Center
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan

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Kanazawa University Hospital
RECRUITING

Kanazawa, Ishikawa-ken, 920-8641, Japan

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Kansai Medical University Hospital
RECRUITING

Hirakata-shi, Osaka, 573-1191, Japan

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Kantonsspital St. Gallen
RECRUITING

Sankt Gallen, 9000, Switzerland

Contact Email: •••••@•••••

Contact
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung, Taiwan, 100, Taiwan

Contact Phone: •••-•••-•••• Email: •••••@•••••
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Kindai University Hospital
RECRUITING

Osakasayama-shi, Osaka, 589-8511, Japan

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Klinikum Esslingen GmbH
RECRUITING

Baden, 73730, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Korea University Anam Hospital
RECRUITING

Seoul, 02841, South Korea

Contact Phone: •••-•••-•••• Email: •••••@•••••
LKI Lungenfachklinik Immenhausen
RECRUITING

Immenhausen, Hesse, 34376, Germany

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Contact
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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Maastricht University Medical Center P. Debyelaan 25
RECRUITING

Maastricht, 6229, Netherlands

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Mater Misericordiae Limited
RECRUITING

South Brisbane, Queensland, 4101, Australia

Contact Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mater Private Hospital
RECRUITING

Dublin, Dublin, 7, Ireland

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Contact
Med-Polonia Sp. z o.o.
RECRUITING

Poznan, 60-693, Poland

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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MemorialCare Long Beach Medical Center
RECRUITING

Long Beach, California, 90806, United States

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Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Morristown Medical Center (MMCORC)
RECRUITING

Morristown, New Jersey, 07960, United States

Contact Email: •••••@•••••
NHO Shikoku Cancer Center
RECRUITING

Matsuyama, Ehime, 791-0280, Japan

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Nara Medical University Hospital
RECRUITING

Kashihara-shi, Nara, 634-8522, Japan

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National Cancer Center Hospital
RECRUITING

Chuo Ku, Tokyo, 104-0045, Japan

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National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan

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National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore

Contact Phone: •••-•••-•••• Email: •••••@•••••
National Cheng Kung University Hospital
RECRUITING

Tainan, Taiwan, 704, Taiwan

Contact Phone: •••-•••-•••• Email: •••••@•••••
National Hospital Organization Hokkaido Cancer Center
RECRUITING

Sapporo, Hokkaido, 003-0804, Japan

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National Taiwan University Hospital
RECRUITING

Taipei, Taiwan, 10002, Taiwan

Contact Phone: •••-•••-•••• Email: •••••@•••••
National University Hospital
RECRUITING

Singapore, Singapore, 119074, Singapore

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Niigata Cancer Center
RECRUITING

Niigata, Niigata, 951-8566, Japan

Contact Phone: •••-•••-••••
Oncology Associates of Oregon PC
RECRUITING

Eugene, Oregon, 97401, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Pan American Center for Oncology Trials
RECRUITING

San Juan, Puerto Rico, 00909, Puerto Rico

Contact Phone: •••-•••-•••• Email: •••••@•••••
Queen Mary Hospital
RECRUITING

Hong Kong, Hong Kong

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Radboudumc
RECRUITING

Nijmegen, 6525 GA, Netherlands

Contact Email: •••••@•••••
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
SCRI Oncology Partners - Tennessee
RECRUITING

Nashville, Tennessee, 37203, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea

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Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea

Contact Phone: •••-•••-•••• Email: •••••@•••••
Shizuoka Cancer Center
RECRUITING

Nagaizumi-chō, Shizuoka, 411-8777, Japan

Contact Phone: •••-•••-••••
Sir Charles Gairdner Hospital
RECRUITING

Perth, Western Australia, 6009, Australia

Contact Phone: •••-•••-•••• Email: •••••@•••••
St. Vincent Frontier Cancer Center
RECRUITING

Billings, Montana, 59102, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan

Contact Phone: •••-•••-•••• Email: •••••@•••••
Taylor Cancer Research Center
RECRUITING

Maumee, Ohio, 43537, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Texas Oncology - Gulf Coast
RECRUITING

The Woodlands, Texas, 77380, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Texas Oncology - South Austin
RECRUITING

Austin, Texas, 78745, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Texas Oncology Dallas
RECRUITING

Dallas, Texas, 75251, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••
The University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Thoraxklinik Heidelberg gGmbH
RECRUITING

Baden, Wuerttemberg, 69469, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Tohoku University Hospital
RECRUITING

Sendai, Miyagi, 980-8574, Japan

Contact Phone: •••-•••-••••
TriHealth Cancer & Blood Institute Research
RECRUITING

Cincinnati, Ohio, 45220, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
UNC Lineberger Comprehensive Cancer Center at University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
UZ Leuven-Campus Gasthuisberg
RECRUITING

Leuven, 3000, Belgium

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, Saxony, 01307, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitaetsklinikum Essen
RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
University Cancer and Blood Center
RECRUITING

Athens, Georgia, 30607, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University Hospital Limerick
RECRUITING

Cork, Limerick, V94 F858, Ireland

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitätsspital Basel
RECRUITING

Basel, 4031, Switzerland

Contact Email: •••••@•••••

Contact
Utah Cancer Specialists
RECRUITING

Salt Lake City, Utah, 84106, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Wakayama Medical University Hospital
RECRUITING

Wakayama, Wakayama, 641-8510, Japan

Contact Phone: •••-•••-••••
Washington University School of Medicine - Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Yale University, Smillow Cancer Center
RECRUITING

New Haven, Connecticut, 06519, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

NON SMALL CELL LUNG CANCER NSCLC NSCLC (ADVANCED NON-SMALL CELL LUNG CANCER) NSCLC (NON-SMALL CELL LUNG CARCINOMA) NSCLC NON-SMALL CELL LUNG CANCER