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Breakthrough trial targets 'Undruggable' lung cancer mutations

NCT ID NCT06162221

Recruiting now Disease control Sponsor: Revolution Medicines, Inc. Source: ClinicalTrials.gov ↗

Summary

This clinical trial is testing several new experimental drugs designed to target specific genetic mutations (called RAS mutations) found in advanced non-small cell lung cancer. The study will involve 616 adults whose cancer has progressed despite standard treatments. Researchers aim to determine safe doses and see if these drugs, given alone or with standard therapies, can help control the cancer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • A.O.U. San Luigi Gonzaga-Orbassano - SCDU Oncologia Medica

    RECRUITING

    Orbassano, 10043, Italy

  • ASST Grande Ospedale Metropolitano Niguarda

    RECRUITING

    Milan, 20162, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Ambroise-Paré Hospital

    RECRUITING

    Boulogne, 92104, France

  • Banner MD Anderson Cancer Center

    RECRUITING

    Gilbert, Arizona, 85234, United States

  • Baptist Medical Center

    RECRUITING

    Memphis, Tennessee, 38120, United States

  • Boca Raton Clinical Research Associates

    RECRUITING

    Plantation, Florida, 33322, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU de Lille Institut Cœur Poumon

    RECRUITING

    Lille, Hauts-de-France, 59037, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU de Nantes

    RECRUITING

    Nantes, Hauts-de-France, 44093, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cancer Specialists of North Florida

    RECRUITING

    Saint Augustine, Florida, 32086, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre François Baclesse

    RECRUITING

    Caen, 14076, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre Georges François Leclerc

    RECRUITING

    Dijon, Bourgogne-Franche-Comté, 21079, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Charite-Universitaetsmedizin Berlin - Campus Charite Mitte

    RECRUITING

    Berlin, 12203, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Chi Mei Hospital, Liouying

    RECRUITING

    Tainan, 73657, Taiwan

  • City of Hope - Duarte

    RECRUITING

    Duarte, California, 91010, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • City of Hope - Lennar

    RECRUITING

    Irvine, California, 92618, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Clinica Universidad de Navarra

    RECRUITING

    Pamplona, Navarre, 31008, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Clinical Research Alliance

    RECRUITING

    Westbury, New York, 11590, United States

    Contact Phone: •••-•••-••••

  • Columbia University Medical Center

    RECRUITING

    New York, New York, 10032, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Complejo Hospitalario Universitario A Coruña

    RECRUITING

    A Coruña, 15006, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dana Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • EDOG - Institut Bergonié

    RECRUITING

    Bordeaux, Nouvelle-Aquitaine, 33000, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Fondazione IRCCS Istituto Nazionale dei tumori

    RECRUITING

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario A Gemelli-Rome

    RECRUITING

    Rome, 00168, Italy

    Contact Email: •••••@•••••

  • Fundacion Instituto Valenciano de Oncologia

    RECRUITING

    Valencia, 46009, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Georgetown University Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • H Lee Moffitt Cancer Center and Research Institute

    RECRUITING

    Tampa, Florida, 33612, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Henry Dunant Hospital Center

    RECRUITING

    Athens, 115 26, Greece

  • Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion)

    RECRUITING

    Detroit, Michigan, 48202, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hopital Foch

    RECRUITING

    Suresnes, 92150, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hopital Tenon - AP-HP

    RECRUITING

    Paris, 75020, France

  • Hospices Civils de Lyon - Hôpital Louis Pradel

    RECRUITING

    Bron, Auvergne-Rhône-Alpes, 69500, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Clinico San Carlos

    RECRUITING

    Madrid, Madrid, 28040, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Regional Universitario de Malaga - Hospital Civil

    RECRUITING

    Málaga, 29011, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Universitari Vall D' Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitari i Politecnic La Fe de Valencia

    RECRUITING

    Valencia, Valencia, 46026, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, Madrid, 28041, Spain

    Contact Email: •••••@•••••

  • Hospital Universitario Fundacion Jimenez Diaz

    RECRUITING

    Madrid, 28040, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Universitario Ramon y Cajal

    RECRUITING

    Madrid, 28034, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Virgen del Rocio - PPDS

    RECRUITING

    Seville, 41014, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hôpital Cochin

    RECRUITING

    Paris, 75014, France

  • ICO Badalona - H.U. Germans Trias i Pujol

    RECRUITING

    Barcelona, 08916, Spain

  • IRCCS Instituto Nazionale tumori Ragina Elena

    RECRUITING

    Rome, 00144, Italy

    Contact Email: •••••@•••••

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut Curie

    RECRUITING

    Paris, Île-de-France Region, 75005, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut Gustave Roussy

    RECRUITING

    Villejuif, 94805, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut de Cancerologie de Ouest (ICO) - Angers

    RECRUITING

    Angers, 49055, France

  • Intermountain Health - St. Vincent Frontier Cancer Center

    RECRUITING

    Billings, Montana, 59102, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l

    RECRUITING

    Meldola, Emilia-Romagna, 47014, Italy

    Contact Email: •••••@•••••

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, 807, Taiwan

  • Krankenhaus Bethanien Moers

    RECRUITING

    Moers, 47441, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Leiden University Medical Center

    RECRUITING

    Leiden, 2333 ZA, Netherlands

  • Linear Clinical Research

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • Liverpool Hospital

    RECRUITING

    Liverpool, New South Wales, 2170, Australia

  • Lungenfachklinik Immenhausen

    RECRUITING

    Immenhausen, 34376, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Monash Health

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • NEXT Oncology Dallas

    RECRUITING

    Irving, Texas, 75039, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • NEXT Oncology Virginia

    RECRUITING

    Fairfax, Virginia, 22031, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • National Cancer Center

    RECRUITING

    Goyang-si, Gyeonggi-do, 10408, South Korea

  • Nebraska Cancer Specialist

    RECRUITING

    Grand Island, Nebraska, 68803, United States

  • New York University Langone Health

    RECRUITING

    New York, New York, 10016, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Odense University Hospital, Department of Oncology

    RECRUITING

    Odense, 5000, Denmark

  • Oncopole Claudius Regaud

    RECRUITING

    Toulouse, 31059, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Ospedale Santa Maria Delle Croci

    RECRUITING

    Ravenna, 48121, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Rigshospitalet

    RECRUITING

    Copenhagen, 2100, Denmark

  • Royal North Shore Hospital

    RECRUITING

    St Leonards, New South Wales, 2065, Australia

  • Samsung Medical Center

    RECRUITING

    Seoul, Gangnam-gu, 06351, South Korea

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam-si, Gyeonggido, 13620, South Korea

  • Seoul St. Mary's Hospital, The Catholic University of Korea

    RECRUITING

    Seoul, Seocho-gu, 06591, South Korea

  • Severance Hospital

    RECRUITING

    Seoul, Seodaemun-Gu, 03722, South Korea

  • Stanford University - Stanford Cancer Institute

    RECRUITING

    Stanford, California, 94305, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Taichung Veterans General Hospital

    RECRUITING

    Taichung, 40705, Taiwan

  • Taipei Municipal Wanfang Hospital

    RECRUITING

    Taipei, Wenshan Dist, 116, Taiwan

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 11217, Taiwan

  • Tennessee Oncology

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • The Netherlands Cancer Institute (NKI)

    RECRUITING

    Amsterdam, 1066, Netherlands

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Thoracic General Hospital of Athens "I SOTIRIA"

    RECRUITING

    Athens, 11527, Greece

  • Thoraxklinik Heidelberg gGmbH - Universitätsklinikum Heidelberg

    RECRUITING

    Heidelberg, 69126, Germany

    Contact Email: •••••@•••••

  • UC Davis, Davis Comprehensive Cancer Center

    RECRUITING

    Sacramento, California, 95817, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UCSF Medical Center - Mission Bay

    RECRUITING

    San Francisco, California, 94158, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

    Contact Email: •••••@•••••

  • Uniklinik Köln

    RECRUITING

    Cologne, 50937, Germany

    Contact Email: •••••@•••••

  • University Hospitals Cleveland Medical Center

    RECRUITING

    Cleveland, Ohio, 44106, United States

    Contact Phone: •••-•••-••••

  • University Medical Center Utrecht

    RECRUITING

    Utrecht, 3584, Netherlands

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University Medical Centre Groningen

    RECRUITING

    Groningen, 9713, Netherlands

  • University of California, San Diego Moores Cancer Center

    RECRUITING

    San Diego, California, 92037, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Universitätsklinikum Carl Gustav Carus an der TU Dresden

    RECRUITING

    Dresden, 01307, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Universitätsklinikum Frankfurt

    RECRUITING

    Frankfurt am Main, 60590, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

KRAS G12C-MUTATED SOLID TUMORS, LUNG CANCER KRAS, NRAS, HRAS-MUTATED NSCLC LUNG CANCER STAGE IV, ADVANCED SOLID TUMOR, CANCER NON-SMALL CELL LUNG CANCER (NSCLC) RAS G12D-MUTATED NSCLC