Inhaled antibiotic tested to fight stubborn lung infection

NCT ID NCT04677569

Completed Disease control Sponsor: Insmed Incorporated Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding a new inhaled antibiotic (ALIS) to standard oral medications works better than the standard medications alone for adults newly diagnosed with a MAC lung infection. It involved 425 adults and measured whether the combination improved breathing symptoms and cleared the bacteria over 13 months. The goal was to see if this inhaled treatment could better control this difficult-to-treat, chronic lung disease.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

ARG001

Rosario, Santa Fe Province, S2000DTC, Argentina
ARG002

Córdoba, CArdoba, 5000, Argentina
ARG003

CArdoba, CArdoba, X5003DCE, Argentina
ARG004

Ciudad autAnoma de Buenos Aires, Buenos Aires, C1426ABP, Argentina
ARG005

Quilmes, Buenos Aires, B1878FNR, Argentina
ARG006

Villa Vatteone, Buenos Aires, B1853AIK, Argentina
ARG007

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
AUS001

South Brisbane, Queensland, 4101, Australia
AUS002

Westmead, New South Wales, 2145, Australia
AUS003

Greenslopes, Queensland, 4120, Australia
AUS004

New Lambton Heights, New South Wales, 2305, Australia
AUS005

Perth, 5000, Australia
AUS006

Concord, New South Wales, 2139, Australia
AUS007

Clayton, Victoria, 3168, Australia
AUS008

Adelaide, South Australia, 5000, Australia
AUS009

Melbourne, Victoria, 3001, Australia
AUS010

Chermside, Queensland, 4032, Australia
AUS011

Woolloongabba, Queensland, 4102, Australia
AUS012

Birtinya, Queensland, 4575, Australia
AUS013

Douglas, Queensland, 4814, Australia
AUS014

Meadowbrook, Queensland, 4131, Australia
AUS015

Spearwood, Western Australia, 6163, Australia
AUS016

Herston, Queensland, 4029, Australia
AUT001

Linz, Upper Austria, 4040, Austria
AUT003

Wels, OberAsterreich, 4600, Austria
BEL001

Leuven, 3000, Belgium
BEL002

Ghent, 9000, Belgium
BEL003

Brussels, Brussels Capital, 1000, Belgium
CAN002

Toronto, Ontario, M5T 2S8, Canada
CAN003

Winnepeg, Manitoba, R2H 2A6, Canada
CAN004

Windsor, Ontario, N8X-5A6, Canada
CHL001

Curicó, Maule Region, 3440000, Chile
CHL002

Quillota, 2260000, Chile
CHL003

Valparaíso, 2340000, Chile
CHL004

Talca, Chile
DNK001

Roskilde, Zeeland, 4000, Denmark
DNK002

Aarhus N, 8200, Denmark
DNK003

Odensa C, 5000, Denmark
DNK004

Aalborg, 9000, Denmark
DNK005

Vejle, Region Syddanmark, 7100, Denmark
ESP001

Madrid, 28034, Spain
ESP002

Barcelona, 08003, Spain
ESP003

Barcelona, 8035, Spain
ESP004

Madrid, 28046, Spain
ESP005

Girona, 17007, Spain
ESP006

Pontevedra, 36001, Spain
ESP007

Vigo, Pontevedra, 36312, Spain
ESP008

Barcelona, 8025, Spain
ESP009

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
ESP010

Madrid, 28007, Spain
ESP011

Pamplona, 31008, Spain
ESP012

Seville, 41013, Spain
FRA001

Marseille, 13285, France
FRA002

Créteil, 94000, France
FRA003

Saint-Pierre, 97448, France
FRA004

Saint-Denis, 97405, France
FRA005

Brest, 29609, France
FRA006

Amiens, 80054, France
FRA007

Caen, 14033, France
FRA008

Nantes, Loire-Atlantique, 44000, France
FRA009

Paris, 75018, France
FRA010

Suresnes, Hauts-de-Seine, 92151, France
FRA011

Toulouse, 31400, France
FRA012

Nice, Alpes-Maritimes, 6000, France
FRA013

Paris, 75020, France
FRA014

Paris, 75013, France
FRA015

Pessac, Gironde, 33064, France
FRA016

Strasbourg, Bas-Rhin, 67091, France
GBR001

Cambridge, CB2 OAY, United Kingdom
GBR002

Dundee, DD1 9SY, United Kingdom
GBR003

London, SW3 6NP, United Kingdom
GBR004

Liverpool, L14 3PE, United Kingdom
GBR005

Aberdeen, AB25 2ZN, United Kingdom
GBR007

London, EC1A 7BE, United Kingdom
GBR008

Birmingham, West Midlands, B9 5SS, United Kingdom
GBR009

Plymouth, Devon, PL6 8BQ, United Kingdom
GBR010

London, NW32QG, United Kingdom
GBR012

Salford, Lancashire, M6 8HD, United Kingdom
GBR013

Swansea, West Glamorgan, SA6 6NL, United Kingdom
GER001

Donaustauf, Bavaria, 93093, Germany
GER002

Frankfurt, 69590, Germany
GER003

Borstel, Lower Saxony, 23845, Germany
GER004

Freiburg im Breisgau, 79106, Germany
GER005

München, Bavaria, 80335, Germany
GER006

Dresden, 1307, Germany
GER007

Hanover, 30625, Germany
GER008

Berlin, 13125, Germany
GER009

Essen, 45127, Germany
GER010

Immenhausen, Hesse, 34376, Germany
GER011

Cologne, North Rhine-Westphalia, 51109, Germany
GER012

Potsdam, Brandenburg, 14467, Germany
GER013

Gauting, Bavaria, 82131, Germany
GER014

Cologne, North Rhine-Westphalia, 50678, Germany
GRC001

Heraklion, 71110, Greece
GRC002

Athens, Attica, 11527, Greece
GRC003

Alexandroupoli, 681 00, Greece
HUN001

Törökbálint, 2045, Hungary
HUN002

Budapest, 1121, Hungary
ISR001

Ashkelon, 78100, Israel
ISR002

Beer-Yaakov, 70300, Israel
ISR003

Petah Tikva, 4910000, Israel
ISR004

Ramat Gan, 52621, Israel
ISR005

Jerusalem, 91120, Israel
ISR007

Haifa, 34362, Israel
ISR008

Tel Aviv, Tel Aviv, 64239, Israel
ITA001

Milan, 20122, Italy
ITA002

Milan, Milano, 20162, Italy
ITA003

Pavia, 27100, Italy
ITA004

Florence, 50134, Italy
ITA005

Roma, 00168, Italy
ITA006

Modena, Emilia-Romagna, 41124, Italy
ITA007

Monza, 20900, Italy
ITA008

Siena, Tuscany, 53100, Italy
ITA009

Milan, 20123, Italy
ITA010

Genoa, Liguria, 16128, Italy
ITA011

Reggio Emilia, Emilia-Romagna, 42123, Italy
JPN001

Fukui, 910-8526, Japan
JPN002

Sakaishi, 591-8555, Japan
JPN003

Jonan-ku, Japan
JPN004

Fukuoka, 819-8555, Japan
JPN005

Tokyo, Japan
JPN006

Nagano, 380-0928, Japan
JPN008

Shinjuku-ku, Tokyo, 1628655, Japan
JPN009

Shimonoseki, 750-8520, Japan
JPN010

Kiyose, 204-8522, Japan
JPN011

Nagoya, Aiti, 465-0065, Japan
JPN012

Naka-gun, 319-1113, Japan
JPN014

Hamamatsu, Shizuoka, 434-8511, Japan
JPN015

Kiyose-Shi, Tokyo, 204-0023, Japan
JPN016

Toyonaka-Shi, Ôsaka, 560-0045, Japan
JPN017

Matsusaka-Shi, Mie-ken, 515-0073, Japan
JPN018

Nagasaki, Nagasaki, 852-8501, Japan
JPN019

Izumo-Shi, Shimane, 693-0021, Japan
JPN020

Kita Kyushu-shi, Hukuoka, 807-8556, Japan
JPN021

Ōta-ku, Tokyo, 143-8541, Japan
JPN022

Yokohama-Shi Tsuzuki-Ku, Kanagawa, 224-0032, Japan
JPN023

Kurashiki-Shi, Okayama-ken, 710-0052, Japan
KOR001

Seoul, South Korea
KOR002

Seoul, 05505, South Korea
KOR003

Seoul, 06973, South Korea
KOR004

Seoul, 03722, South Korea
KOR005

Seongnam-si, Gyeonggido, 13620, South Korea
KOR006

Incheon, 22332, South Korea
KOR007

Seongbuk-Gu, Seoul Teugbyeolsi, 02841, South Korea
KOR008

Ansan-si, Gyeonggido, 15355, South Korea
KOR009

Seoul, 06591, South Korea
NZL001

Christchurch, 8461, New Zealand
NZL002

Hamilton, Waikato Region, 3204, New Zealand
NZL003

Hastings, Hawkes's Bay, 4122, New Zealand
NZL004

Auckland, 1051, New Zealand
POL003

Kielce, Świętokrzyskie Voivodeship, 25-751, Poland
PRT002

Braga, 4710-243, Portugal
PRT003

Lisbon, 1796-001, Portugal
TUR002

Kocaeli, 41380, Turkey (Türkiye)
TUR003

Izmir, 35110, Turkey (Türkiye)
TUR004

Maltepe, Istanbul, 34844, Turkey (Türkiye)
TWN001

Douliu, 640, Taiwan
TWN002

Taipei, 116, Taiwan
TWN003

Kaohsiung City, 813, Taiwan
TWN004

Chiayi City, Chiayi, 613, Taiwan
TWN005

Kaohsiung City, 807, Taiwan
TWN006

Taipei, 10002, Taiwan
TWN007

New Taipei City, 23561, Taiwan
TWN008

Taipei, 11217, Taiwan
TWN009

Taipei, 11490, Taiwan
TWN010

Taipei, 110, Taiwan
TWN011

Taipei, 10002, Taiwan
TWN012

Hsinchu, 300, Taiwan
USA001

Denver, Colorado, 80206, United States
USA002

New Orleans, Louisiana, 70112, United States
USA003

Clearwater, Florida, 33765, United States
USA004

Lawrenceville, Georgia, 30046-3325, United States
USA006

San Antonio, Texas, 78258, United States
USA007

Winston-Salem, North Carolina, 27103, United States
USA008

Birmingham, Alabama, 35233-1711, United States
USA009

Omaha, Nebraska, 68198, United States
USA011

New York, New York, 10017, United States
USA012

Rock Hill, South Carolina, 29732, United States
USA013

Rochester, Minnesota, 55905, United States
USA014

St. Petersburg, Florida, 33707, United States
USA015

DuBois, Pennsylvania, 15801, United States
USA016

Dallas, Texas, 75246, United States
USA017

Baltimore, Maryland, 21224-3057, United States
USA018

Cleveland, Ohio, 44195, United States
USA019

Leesburg, Florida, 34748, United States
USA020

Charleston, South Carolina, 29425, United States
USA021

McKinney, Texas, 75069-8085, United States
USA022

Franklin, Tennessee, 37067, United States
USA023

Washington D.C., District of Columbia, 20007, United States
USA024

Charleston, South Carolina, 29414, United States
USA025

Portland, Oregon, 97239, United States
USA026

Sebring, Florida, 33870, United States
USA028

Brandon, Florida, 33511-5719, United States
USA029

Rincon, Georgia, 31326, United States
USA030

Springfield, Illinois, 62702, United States
USA031

Chicago, Illinois, 60611, United States
USA032

Toms River, New Jersey, 08755-8000, United States
USA033

Charlotte, North Carolina, 28277-8915, United States
USA034

Mooresville, North Carolina, 28117, United States
USA035

Charlotte, North Carolina, 28273, United States
USA037

Kansas City, Kansas, 66160, United States
USA038

Atlanta, Georgia, 30342-2147, United States
USA039

Naples, Florida, 34102-5444, United States
USA040

Philadelphia, Pennsylvania, 19104, United States
USA041

Hendersonville, Tennessee, 37075, United States
USA042

Kissimmee, Florida, 34746, United States
USA043

Jacksonville, Florida, 32204, United States
USA044

Anderson, South Carolina, 29621, United States
USA045

Omaha, Nebraska, 68124, United States
USA046

New Port Richey, Florida, 34652, United States
USA047

Jacksonville, Florida, 32224, United States
USA048

San Diego, California, 92103, United States
USA050

Stanford, California, 94305, United States
USA051

Durham, North Carolina, 27710-0001, United States
USA052

Tyler, Texas, 75708, United States
USA053

Weston, Florida, 33331, United States
USA054

Sarasota, Florida, 34239-2913, United States
USA055

Santa Barbara, California, 93105, United States
USA058

Sacramento, California, 95817, United States
USA059

The Bronx, New York, 10461, United States
USA060

Los Angeles, California, 90033-5313, United States
USA061

St Louis, Missouri, 63110, United States
USA062

Fresno, California, 93701, United States
USA063

Columbus, Ohio, 43210-1240, United States
USA064

Cincinnati, Ohio, 45267, United States
USA065

Bayside, New York, 11361, United States
USA066

Augusta, Georgia, 30912, United States
USA067

Tampa, Florida, 33606, United States
USA068

Tampa, Florida, 33614-7101, United States
USA069

Hillsborough, New Jersey, 08844, United States
USA070

St. Petersburg, Florida, 33704-2733, United States
USA071

Portland, Oregon, 97213-2982, United States
USA072

Jacksonville, Florida, 32207-8567, United States
USA073

Springfield, Illinois, 62702-4968, United States
USA074

Iowa City, Iowa, 52242-1081, United States
USA075

Cincinnati, Ohio, 45242-4402, United States
USA076

Charlotte, North Carolina, 28204, United States
USA077

Springfield, Massachusetts, 01107, United States
USA078

Nashville, Tennessee, 37232, United States
USA079

Coeur d'Alene, Idaho, 83814, United States
USA080

Bradenton, Florida, 34209, United States
USA081

San Francisco, California, 94143, United States
USA082

Columbia, Missouri, 65212-1000, United States
USA083

Charlottesville, Virginia, 22903, United States
USA084

Sebastian, Florida, 32958, United States
USA085

Jacksonville, Florida, 32209-6511, United States
USA086

Houston, Texas, 77070-1190, United States
USA087

Madison, Wisconsin, 53792-0001, United States
USA088

East Syracuse, New York, 13057, United States
USA089

Temple, Texas, 76508, United States
USA090

Newport Beach, California, 92663, United States
USA091

Denison, Texas, 75020, United States
USA092

Providence, Rhode Island, 02906, United States
USA093

Philadelphia, Pennsylvania, 19107, United States
USA096

Naples, Florida, 34102, United States
USA097

Naples, Florida, 34102, United States
USA099

Lexington, Massachusetts, 02421, United States
USA100

Dallas, Texas, 75246, United States

Conditions

Explore the condition pages connected to this study.

MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS