New immune weapons tested against tough colon cancers

NCT ID NCT05608044

Summary

This study is testing whether new immunotherapy drugs called botensilimab and balstilimab can help control advanced colon cancer that has spread and stopped responding to standard chemotherapy. The trial will compare these drugs given alone or together against current standard treatments in about 234 patients. Researchers want to see if these immune-based treatments can shrink tumors and help patients live longer with manageable side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • "Clinical Hospital "RZD-Medicine" of Saint Petersburg"

    Saint Petersburg, 195271, Russia

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Antwerp University Hospital (UZA)

    Edegem, 2650, Belgium

  • Atlantic Health System - Morristown Medical Center

    Morristown, New Jersey, 07960, United States

  • BHI of the Omsk region "Clinical oncological dispensary"

    Omsk, 644013, Russia

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Branch office of " Hadassah Medical Ltd"

    Moscow, 121205, Russia

  • CHU Poitiers - Pole Regional de Cancerologie de Poitiers (PRC)

    Poitiers, 86000, France

  • Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa

    Porto Alegre, 90110-270, Brazil

  • Centro Paulista de Oncologia

    São Paulo, 04538-132, Brazil

  • Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho

    Jaú, São Paulo, 17210-080, Brazil

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Closed Joint Stock Company Medical Center "AVICENNA"

    Novosibirsk, 630099, Russia

  • Clínica Universidad de Navarra - Sede Madrid

    Madrid, 28027, Spain

  • Clínica Universidad de Navarra - Sede Pamplona

    Pamplona, 31008, Spain

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Earle A. Chiles Research Institute - Robert W. Franz Cancer Center - Providence Cancer Institute

    Portland, Oregon, 97213, United States

  • Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

    Moscow, 119991, Russia

  • Federal State Budgetary Institution "National Medical Research Center of Oncology named after N.N.Petrov" of the Ministry of Health of the Russian Federation

    Saint Petersburg, 197758, Russia

  • Florida Cancer Specialists and Research Institute - Lake Mary

    Lake Mary, Florida, 32746, United States

  • Fondazione IRCCS Instituto Nazionale dei Tumori

    Milan, 20133, Italy

  • High Technology Hospital Medcenter Ltd

    Batumi, 0144, Georgia

  • HonorHealth Research Institute

    Scottsdale, Arizona, 85258, United States

  • Hospital A.C. Camargo Cancer Center

    São Paulo, 01509-010, Brazil

  • Hospital Sirio Libanes Brasilia

    Brasília, 70200-730, Brazil

  • Hospital Universitario Marques de Valdecilla

    Santander, 39008, Spain

  • Hôpital Saint Antoine/AP-HP Hopital Saint Antoine (Pierre and Marie Curie University)

    Paris, 75012, France

  • Innova LLC

    Tbilisi, 0159, Georgia

  • Institut Paoli-Calmettes

    Marseille, 13009, France

  • Instituto Americas

    Rio de Janeiro, 22775-001, Brazil

  • Instituto Sul Mineiro de Oncologia - ONCOMINAS

    Pouso Alegre, 37554-216, Brazil

  • Istituto Oncologico Veneto-I.R.C.C.S. - Ospedale Busonera

    Padua, 35128, Italy

  • Keck School of Medicine of the University of Southern California

    Los Angeles, California, 90033, United States

  • Lifespan Clinical Research Center/Cancer Institute (Providence Rhode Island)

    East Providence, Rhode Island, 02915, United States

  • Limited Liability Company "EVIMED"

    Chelyabinsk, 454048, Russia

  • MDACC

    Houston, Texas, 77030, United States

  • Medical Oncology Hematology Consultants

    Newark, Delaware, 19713, United States

  • Memorial Sloan Kettering

    New York, New York, 10065, United States

  • Mount Sinai Hospital - New York

    New York, New York, 10029, United States

  • Napalkov SBHI "Saint-Petersburg clinical scientific and practical center for specialised types of medical care (oncological)

    Saint Petersburg, 197758, Russia

  • Northwest Cancer Center Specialists - Vancouver Cancer Center - Compass Oncology Vancouver

    Vancouver, Washington, 98684, United States

  • Oncosite - Centro de Pesquisa Clinica Em Oncologia

    Ijuí, 98700-000, Brazil

  • Oregon Health & Science University (OHSU)

    Portland, Oregon, 97239, United States

  • Regional Budgetary Healthcare Institution "Kursk Oncological Research and Clinical Center named after G. E. Ostroverkhov"

    Kursk, 305524, Russia

  • Regional State Budgetary Institution of Healthcare"Altai Regional Oncology Dispensary"

    Barnaul, 656045, Russia

  • Rocky Mountain Cancer Center - Aurora

    Aurora, Colorado, 80012, United States

  • Saint-Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology)

    Saint Petersburg, Russia

  • Service d'Oncologie Medicale - CHRU Besancon

    Besançon, 25000, France

  • Siberian State Medical University

    Tomsk, 634028, Russia

  • State Budgetary Institution of Health Care "Clinical Oncological Dispensary No. 1" of the Ministry of Health of the Krasnodar region

    Krasnodar, 350040, Russia

  • State Budgetary Institution of Healthcare of the City of Moscow "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Health of the City of Moscow"

    Moscow, 111123, Russia

  • Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • Tbilisi Central Hospital Ltd

    Tbilisi, 0159, Georgia

  • Tennessee Oncology Nashville (Sarah Cannon)

    Nashville, Tennessee, 37203, United States

  • Texas Oncology - Austin Midtown

    Austin, Texas, 78705, United States

  • Texas Oncology - Baylor Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • Universitair Ziekenhuis Leuven

    Leuven, 3000, Belgium

  • University of Colorado

    Denver, Colorado, 80220, United States

  • University of Michigan

    Ann Arbor, Michigan, 48084, United States

  • Unversite Paris-Saclay Gustave Roussy Cancer Center Campus Paris

    Villejuif, 94805, France

  • Vall d'Hebron Institute of Oncology (VHIO)

    Barcelona, 8035, Spain

  • Vanderbilt University School of Medicine

    Nashville, Tennessee, 37215, United States

  • Virginia Cancer Specialists/NEXT Virginia

    Fairfax, Virginia, 22031, United States

  • Weill Cornell Medicine

    New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.