Major trial tests new drug combo against aggressive stomach cancers

NCT ID NCT05152147

Summary

This large Phase 3 study is testing whether a new drug combination works better than the current standard treatment for advanced HER2-positive stomach and esophageal cancers that cannot be removed by surgery. The trial will involve 920 patients and compares zanidatamab plus chemotherapy, with or without tislelizumab, against the standard treatment of trastuzumab plus chemotherapy. The main goals are to see if the new combinations help patients live longer without their cancer getting worse and improve overall survival.

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Contacts and locations

Locations

  • ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda

    Milan, 20162, Italy

  • Acibadem Adana Hospital

    Seyhan, 01130, Turkey (Türkiye)

  • Affiliated Hospital of Inner Mongolia Medical University

    Hohhot, 01000, China

  • Affiliated Hospital of Jiangnan University

    Wuxi, 214062, China

  • Agios Loucas Clinic SA

    Thessaloniki, 552 36, Greece

  • All India Institute of Medical Sciences, Bhubaneswar

    Bhubaneswar, 751019, India

  • Anhui Provincial Cancer Hospital

    Hefei, 230031, China

  • Arcispedale Santa Maria Nuova

    Reggio Emilia, 43100, Italy

  • Artemis Hospital

    Gūrgaon, 122003, India

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Attikon University General Hospital

    Athens, 124 64, Greece

  • Austin Health

    Heidelberg, 3084, Australia

  • Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi

    Bologna, 40138, Italy

  • Azienda Ospedaliero Universitaria Di Modena Policlinico

    Modena, 41124, Italy

  • Azienda ULSS 8 "Berica" - Ospedale San Bortolo

    Vicenza, 36100, Italy

  • BIOCINETIC SpA

    Santiago, 8330336, Chile

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Beijing Chao-Yang Hospital, Capital Medical University

    Beijing, 100020, China

  • Beijing Luhe Hospital, Capital Medical University

    Beijing, 101199, China

  • Bioclinic Thessaloniki Oncology Department

    Thessaloniki, 54622, Greece

  • Bristol Haematology and Oncology Centre

    Bristol, BS2 8ED, United Kingdom

  • CHA Bundang Medical Center, CHA University

    Seongnam-si, 13496, South Korea

  • CHRU de Brest - Hopital Morvan

    Saint-Priest-en-Jarez, 42270, France

  • CHRU de Poitiers La Miletrie

    Poitiers, 86021, France

  • CHU de Bordeaux - Hopital Haut Leveque

    Pessac, Gironde, 33600, France

  • CHU de Liège

    Liège, 4000, Belgium

  • Cancer Hospital Chinese Academy of Medical Sciences

    Beijing, 100021, China

  • Cancer Hospital affiliated to Xinjiang Medical University

    Ürümqi, 830026, China

  • Catharina Hospital

    Eindhoven, 5623 EJ, Netherlands

  • Cenantron - Centro Avancado de Tratamento Oncologico Ltda

    Belo Horizonte, 30130-090, Brazil

  • Centre Hospitalier Universitaire Grenoble Alpes - Hopital Albert Michallon

    Grenoble, 38043, France

  • Centre Léon Berard

    Lyon, 69008, France

  • Centro Hospitalar E Universitário de Coimbra EPE

    Coimbra, 3000-459, Portugal

  • Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria

    Lisbon, 1649-035, Portugal

  • Centro Hospitalar do Porto EPE

    Porto, 4099-001, Portugal

  • Centro Integrado de Pesquisa - CIP

    Barretos, 14784-400, Brazil

  • Centro Internacional de Estudios Clinicos CIEC

    Santiago, Region Metropolitan, 8420383, Chile

  • Centro Medico Integral de Cancerologia CEMIC

    Salcajá, 09002, Guatemala

  • Centro Médico Privado CEMAIC

    Córdoba, X5008HHW, Argentina

  • Centro Ricerche Cliniche Di Verona

    Verona, 37134, Italy

  • Centro de Estudios Clínicos SAGA SpA

    Providencia, 7500000, Chile

  • Centro de Investigacion Clinica de Oaxaca

    Oaxaca City, 68020, Mexico

  • Centro de Investigación Clínica - Clínica Viedma

    Viedma, R8500ACE, Argentina

  • Centro de Investigación Pergamino S.A.

    Pergamino, 2700, Argentina

  • Centro de Pesquisas Clínicas/Fundação Doutor Amaral Carvalho

    Brasília, 70840-901, Brazil

  • Centrum Onkologii Instytut im. Marii Sklodowskiej-Curie

    Warsaw, 02-034, Poland

  • Changzhi People's Hospital

    Changzhi, 046099, China

  • Changzhou First People's Hospital

    Changzhou, 213004, China

  • Chiba Cancer Center

    Chiba, Chiba, 260-0801, Japan

  • China Medical University Hospital

    Taichung, 404472, Taiwan

  • Chulaborn Hospital

    Lak Si, 10210, Thailand

  • Clinica Medica Especializada CELAN

    Guatemala City, 01010, Guatemala

  • Clinical Hospital Center Bezanijska Kosa

    Belgrade, 11070, Serbia

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Complejo Asistencial Universitario de Salamanca - H. Clinico

    Salamanca, 32911, Spain

  • Complejo Hospitalario de Navarra

    Pamplona, Navarre, 31008, Spain

  • Corporacio Sanitaria Parc Tauli

    Sabadell, Barcelona, 08208, Spain

  • Dokuz Eylul Universitesi

    Izmir, 35220, Turkey (Türkiye)

  • Dong-A University Hospital

    Busan, 49201, South Korea

  • Dr. Abdurrahman Yurtaslan Ankara Onkology Training and Research Hospital

    Yenimahalle, 06200, Turkey (Türkiye)

  • EDOG - Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer - PPDS

    Rennes, 35000, France

  • EDOG - Institut Bergonie - PPDS

    Bordeaux, 33000, France

  • EDOG Institut de Cancerologie de l'Ouest - PPDS

    Nantes, 44805, France

  • ETZ-Elisabeth

    Tilburg, 5042 AD, Netherlands

  • Edith Cavell Hospital

    Peterborough, PE3 9GZ, United Kingdom

  • Fiona Stanley Hospital

    Murdoch, 6150, Australia

  • First Affiliated Hospital of Xi 'an Jiaotong University

    Xi'an, 710061, China

  • Flinders Medical Centre

    Bedford Park, 5042, Australia

  • Fondazione Policlinico Universitario A Gemelli

    Rome, 00168, Italy

  • Fondazione del Piemonte per l'Oncologia (IRCCS)

    Candiolo, 10060, Italy

  • Fudan University Affiliated Zhongshan Hospital

    Shanghai, 200032, China

  • Fudan University Shanghai Cancer Center

    Shanghai, 200032, China

  • Fujian Cancer Hospital

    Fuzhou, 350014, China

  • Fundación Arturo López Pérez (FALP) - PPDS

    Providencia, Santiago Metropolitan, 7500000, Chile

  • Fundación Centro de Medicina Nuclear y Molecular ER

    Córdoba, X5000HXL, Argentina

  • Fundação Pio XII Hospital de Câncer de Barretos

    Barretos, 14784-400, Brazil

  • Fundeni Clinical Institute

    Bucharest, 022328, Romania

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Gangnam Severance Hospital, Yonsei University Health System

    Seoul, 06229, South Korea

  • Gansu Cancer Hospital

    Lanzhou, 730050, China

  • Gifu University Hospital

    Gifu, Gihu, 501-1112, Japan

  • Grupo Medico Angeles

    Guatemala City, 01015, Guatemala

  • Guangdong Provincial People's Hospital

    Guangzhou, 510055, China

  • Gunma Prefectural Cancer Center

    Ota-shi, Gunma, 373-8550, Japan

  • Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital

    London, SE1 9RT, United Kingdom

  • HCG City Cancer Center

    Vijayawada, 520002, India

  • Hacettepe Universitesi Kanser Enstitusu

    Ankara, 06230, Turkey (Türkiye)

  • Hainan General Hospital

    Haikou, 570311, China

  • Hallym University Sacred Heart Hospital

    Anyang-si, 14068, South Korea

  • Harbin Medical University Cancer Hospital

    Harbin, 150081, China

  • Health Pharma Professional Research S.A de C.V.

    Mexico City, 03100, Mexico

  • Henan Cancer Hospital

    Zhengzhou, 450003, China

  • High Technology Hospital MedCenter Ltd

    Tbilisi, 6000, Georgia

  • Hospital Garcia de Orta

    Almada, 2801-951, Portugal

  • Hospital Italiano de Buenos Aires

    Buenos Aires, C1181ACH, Argentina

  • Hospital Nossa Senhora Da Conceição

    Porto Alegre, 91350-200, Brazil

  • Hospital Pulau Pinang

    George Town, 10990, Malaysia

  • Hospital Regional Universitario de Malaga - Hospital General

    Málaga, 29010, Spain

  • Hospital Senhora da Oliveira - Guimaraes, E.P.E

    Guimarães, 4830-044, Portugal

  • Hospital Universitari de Girona Dr Josep Trueta

    Girona, 17007, Spain

  • Hospital Universitario Dr. Jose Eleuterio González

    Monterrey, 64460, Mexico

  • Hospital Universitario Germans Trias i Pujol

    Badalona, 8915, Spain

  • Hospital Universitario La Paz - PPDS

    Madrid, 28046, Spain

  • Hospital Universitario Marques de Valdecilla

    Santander, 39008, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Vall d'Hebron - PPDS

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital de Clinicas de Porto Alegre (HCPA) - PPDS

    Porto Alegre, 90050-170, Brazil

  • Hospital de Gastroenterología Dr Bonorino Udaondo

    Buenos Aires, 1264, Argentina

  • Hubei Cancer Hospital

    Wuhan, 430079, China

  • Hunan Cancer Hospital

    Changsha, 410031, China

  • Hyogo Cancer Center

    Akashi-shi, Hyôgo, 673-8558, Japan

  • Hôpital Saint Antoine

    Villejuif, 94800, France

  • Hôpital de Rangueil

    Toulouse, 69437, France

  • Ibaraki Prefectural Central Hospital

    Kasama-Shi, Ibaraki, 309-1793, Japan

  • Icegclinic

    Santiago, 8150513, Chile

  • Imelda VZW

    Bonheiden, 2820, Belgium

  • Indraprastha Apollo Hospitals

    New Delhi, 110076, India

  • Institut Català d'Oncologia (Hospital Duran y Reynals)

    L'Hospitalet de Llobregat, 08908, Spain

  • Institut für Klinisch-Onkologische Forschung

    Frankfurt am Main, Hesse, 60488, Germany

  • Instituto Do Câncer Do Ceará ICC

    Fortaleza, 60430-230, Brazil

  • Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS

    Porto, 4200-072, Portugal

  • Instituto de Investigaciones Metabólicas - IDIM

    Buenos Aires, C1012, Argentina

  • Instituto de Oncologia de Sorocaba

    Sorocaba, 18030-075, Brazil

  • Instituto do Cancer do Estado de São Paulo ICESP

    São Paulo, 01246-000, Brazil

  • Interbalkan Medical Center of Thessaloniki Oncology Department

    Thessaloniki, 57001, Greece

  • Irmandade Da Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, 90050-170, Brazil

  • Istituto Nazionale Dei Tumori

    Milan, 20133, Italy

  • Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS

    Meldola, 47014, Italy

  • Jinan Central Hospital

    Jinan, 250013, China

  • Kagawa University Hospital

    Kita-Gun Miki-Cho, Kagawa-ken, 761-0701, Japan

  • Kanagawa Cancer Center

    Yokohama-Shi Asahi-Ku, Kanagawa, 241-0815, Japan

  • Kangbuk Samsung Hospital

    Seoul, 03181, South Korea

  • Keio University Hospital

    Shinjuku-Ku, Tokyo, 160-8582, Japan

  • Kindai University Hospital

    Ōsaka-sayama, 589-0014, Japan

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Korea University Guro Hospital

    Seoul, 08308, South Korea

  • Kumamoto University Hospital - Honjo-Kuhonji Campus A

    Chuo-Ku, Kumamoto, 860-8556, Japan

  • Kurashiki Central Hospital

    Kurashiki-Shi, Okayama-ken, 710-0052, Japan

  • Kyoto University Hospital

    Sakyo-ku, Kyoto-shi, 606-8507, Japan

  • Kyungpook National University Chilgok Hospital

    Daegu, 41404, South Korea

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZA, Netherlands

  • Liaoning Cancer Hospital & Institute

    Shenyang, 110801, China

  • Liverpool Hospital

    Liverpool, 2170, Australia

  • MNJ Institute of Oncology and Regional Cancer Centre

    Hyderabad, 500004, India

  • Medical Park Trabzon Yildizli

    Trabzon, 61310, Turkey (Türkiye)

  • Medisprof SRL

    Cluj-Napoca, 400641, Romania

  • Nanjing Drum Tower Hospital ,The Affiliated Hospital of Nanjing University Medical School

    Nanjing, 210008, China

  • National Cancer Center

    Goyang-si, 10408, South Korea

  • National Cancer Center Hospital

    Chūōku, 104-0045, Japan

  • National Cancer Center Hospital East

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Cancer Center Singapore

    Singapore, 258500, Singapore

  • National Cancer Institute ( Institut Kanser Negara)

    Putrajaya, 62675, Malaysia

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395, Japan

  • North Estonia Medical Centre Foundation

    Tallinn, 13419, Estonia

  • Northern Jiangsu People's Hospital

    Yangzhou, 225001, China

  • Núcleo de Pesquisa Clínica da Rede São Camilo

    Santo André, 09060-650, Brazil

  • Oncology Center Sfantul Nectarie

    Craiova, 200347, Romania

  • Oncology Institute of Vojvodina

    Kamenitz, 21204, Serbia

  • Osaka International Cancer Institute

    Osaka, 540-0008, Japan

  • Osaka Medical and Pharmaceutical University Hospital

    Takatsuki-Shi, Osaka, 569-8686, Japan

  • Osaka University Hospital

    Suita-Shi, Osaka, 565-0871, Japan

  • Osaki Citizen Hospital

    Osaki-Shi, Miyagi, 989-6136, Japan

  • Ospedale Policlinico San Martino

    Genova, 16132, Italy

  • Ospedale San Raffaele S.r.l. - PPDS

    Milan, 20132, Italy

  • Peking University Third Hospital

    Beijing, 100191, China

  • Princess Margaret Cancer Centre

    Toronto, M5G 2C1, Canada

  • Prof Dr I Chiricuta Institute of Oncology - PPDS

    Cluj-Napoca, 400015, Romania

  • Regional Cancer Centre Indira Gandhi Institute of Medical Sciences

    Patna, 800014, India

  • Research Institute of Clinical Medicine

    Tbilisi, 0112, Georgia

  • Royal Marsden Hospital - London

    London, SW7 3RP, United Kingdom

  • Royal Marsden Hospital - Surrey

    London, SW7 3RP, United Kingdom

  • Ruijin hospital Shanghai Jiao Tong University School of Medicine

    Shanghai, 200025, China

  • Sainte-Catherine, Institut du Cancer Avignon Provence

    Avignon, 84000, France

  • Saitama Cancer Center

    Ina, 362-0806, Japan

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sarawak General Hospital

    Kuching, 93586, Malaysia

  • Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, 310017, China

  • Seoul National University Bundang Hospital

    Seongnam-si, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System - PPDS

    Seoul, 03686, South Korea

  • Shandong Cancer Hospital

    Jinan, 250000, China

  • Shanghai General Hospital

    Shanghai, 200080, China

  • Shikoku Cancer Center

    Matsuyama, 791-0245, Japan

  • Sichuan Cancer Hospital & Institute

    Chengdu, 610042, China

  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

    Hangzhou, 310016, China

  • Sociedad Oncovida S.A

    Santiago, 7500000, Chile

  • Sociedad de Investigaciones Medicas Limitada

    Temuco, 4810469, Chile

  • Songklanagarind Hospital

    Hat Yai, 90110, Thailand

  • Srinagarind Hospital, Khon Kaen University

    Khon Kaen, 40000, Thailand

  • St James University Hospital

    Leeds, LS9 7TF, United Kingdom

  • St James's Hospital

    Dublin, 8, Ireland

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • The Affiliated Hospital of Qingdao University

    Qingdao, 266003, China

  • The Cancer Institute Hospital of Japanese Foundation For Cancer Research

    Tokyo, 135-8550, Japan

  • The Catholic University of Korea, Seoul St. Mary's Hospital

    Seoul, 03080, South Korea

  • The First Affiliated Hospital of Bengbu Medical College

    Bengbu, 233004, China

  • The First Affiliated Hospital of Fujian Medical University

    Fuzhou, 350005, China

  • The First Affiliated Hospital of Nanchang University

    Nanchang, 330052, China

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, 325000, China

  • The First Affiliated Hospital of Xiamen University

    Xiamen, 361003, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, 450052, China

  • The First Affiliated Hospital, College of Medicine, Zhejiang University

    Hangzhou, 310003, China

  • The First Hospital of Lanzhou University

    Lanzhou, 730013, China

  • The Fourth Hospital of Hebei Medical University

    Shijiazhuang, 50011, China

  • The Municipal Enterprise Volyn Regional Medical Oncology Centre of the Volyn Regional Council

    Lutsk, 43018, Ukraine

  • The Second Affiliated Hospital of Anhui Medical University

    Hefei, 230601, China

  • The Sixth Affiliated Hospital of Sun Yat-sen University

    Guangzhou, 510655, China

  • The Tonghua Central Hospital

    Tonghua, 143099, China

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjin, 300060, China

  • Tianjin Medical University General Hospital

    Tianjin, 300041, China

  • Trakya University Medical Faculty

    Edirne, 22030, Turkey (Türkiye)

  • UZ Gent

    Ghent, 9000, Belgium

  • UZ Leuven

    Leuven, 3000, Belgium

  • Unidade Local de Saúde de Matosinhos SA

    Matosinhos Municipality, 4454-509, Portugal

  • Union Hospital Tongji Medical College HuaZhong University of Science and Technology

    Wuhan, 430023, China

  • Universite de Bourgogne - Faculte de Medecine - IN

    Dijon, 21079, France

  • University Clinical Center Nis

    Niš, 18000, Serbia

  • University Clinical Center of Serbia - PPDS

    Belgrade, 11000, Serbia

  • Weihai Municipal Hospital

    Weihai, 264200, China

  • Western General Hospital Edinburgh - PPDS

    Edinburgh, EH4 2XU, United Kingdom

  • Weston Park Cancer Centre

    Sheffield, S10 2SJ, United Kingdom

  • Wilgers Oncology Centre

    Pretoria, 0184, South Africa

  • Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi

    Lodz, 93-513, Poland

  • Yunnan Cancer Hospital

    Kunming, 650118, China

  • Zhejiang Cancer Hospital

    Hangzhou, 310022, China

Conditions

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