Major trial aims to boost survival for aggressive blood cancer

NCT ID NCT04824092

Ongoing Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding two newer drugs (tafasitamab and lenalidomide) to the standard R-CHOP chemotherapy helps people with newly diagnosed, high-risk diffuse large B-cell lymphoma (DLBCL) live longer without their cancer getting worse. It will compare the new combination against the standard treatment alone in about 900 patients. The main goal is to see if the new approach prevents the cancer from progressing or returning.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Daphne, Alabama, 36526, United States
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Anaheim, California, 92801, United States
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Clovis, California, 93611, United States
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Fullerton, California, 92834-4138, United States
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Harbor City, California, 90710, United States
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Los Angeles, California, 90017, United States
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San Diego, California, 92123, United States
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Whittier, California, 90603, United States
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Aurora, Colorado, 80012, United States
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Jacksonville, Florida, 32224, United States
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Honolulu, Hawaii, 96813, United States
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Wichita, Kansas, 67214, United States
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Lexington, Kentucky, 40536-0293, United States
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Louisville, Kentucky, 40241, United States
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Baltimore, Maryland, 21237, United States
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Bethesda, Maryland, 20817-7847, United States
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Columbia, Maryland, 21044, United States
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Detroit, Michigan, 48202, United States
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Minneapolis, Minnesota, 55426, United States
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Rochester, Minnesota, 55905, United States
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Kansas City, Missouri, 64132, United States
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Lebanon, New Hampshire, 03755, United States
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Florham Park, New Jersey, 07932, United States
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Buffalo, New York, 14263, United States
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Rochester, New York, 14642, United States
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Canton, Ohio, 44718, United States
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Cincinnati, Ohio, 45242, United States
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Eugene, Oregon, 97401, United States
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Danville, Pennsylvania, 17822-4910, United States
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Chattanooga, Tennessee, 37404, United States
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Germantown, Tennessee, 38138, United States
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Nashville, Tennessee, 37203, United States
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Austin, Texas, 78745, United States
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Bedford, Texas, 76022, United States
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Denison, Texas, 75020, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77030, United States
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McAllen, Texas, 78503, United States
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Tyler, Texas, 75702, United States
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Ogden, Utah, 84405, United States
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Salt Lake City, Utah, 84112, United States
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Gainesville, Virginia, 20155, United States
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Roanoke, Virginia, 24014, United States
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Virginia Beach, Virginia, 23456, United States
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Olympia, Washington, 98502, United States
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Tacoma, Washington, 98405, United States
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Marshfield, Wisconsin, 54449, United States
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Buenos Aires, C1118AAT, Argentina
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Buenos Aires, C1181ACH, Argentina
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Cipolletti, 8324, Argentina
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Rosario, 2000, Argentina
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San Miguel de Tucumán, T4000IVL, Argentina
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Adelaide, 5000, Australia
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Ballarat, 3353, Australia
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Birtinya, 4575, Australia
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Brisbane, 4101, Australia
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Canberra, 2605, Australia
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Clayton, 3168, Australia
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Frankston, VIC 3199, Australia
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Geelong, 3220, Australia
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Gold Coast, QLD 4217, Australia
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Gosford, 2250, Australia
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Greenslopes, 4120, Australia
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Hobart, 7000, Australia
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Kingswood, 2747, Australia
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Kogarah, 2217, Australia
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Launceston, TAS 7250, Australia
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Malvern, 3144, Australia
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Melbourne, 3065, Australia
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Melbourne, 3084, Australia
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Nedlands, 6009, Australia
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Perth, 6000, Australia
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Perth, 6150, Australia
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Richmond, 3121, Australia
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St Albans, 3021, Australia
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Sydney, 2050, Australia
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Sydney, 2145, Australia
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Townsville, 4817, Australia
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Wahroonga, 8833, Australia
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Waratah, 2298, Australia
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Wollongong, 2500, Australia
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Innsbruck, 6020, Austria
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Linz, 4010, Austria
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Linz, 4021, Austria
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Rankweil, 6830, Austria
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Sankt Pölten, 3100, Austria
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Vienna, 1090, Austria
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Vienna, 1140, Austria
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Halifax, B3H 2A7, Canada
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London, N6A 5W9, Canada
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Montreal, H3T 1E2, Canada
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Saskatoon, S7N 4H4, Canada
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Sherbrooke, J1G 2E8, Canada
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Medellín, 050034, Colombia
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Valledupar, 20001, Colombia
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Olomouc, 775 20, Czechia
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Ostrava, 708 52, Czechia
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Prague, 100 34, Czechia
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Prague, 110 00, Czechia
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Prague, 150 06, Czechia
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Amiens, 14033, France
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Bordeaux, 33074, France
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Bordeaux, 33076, France
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La Tronche, 38700, France
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Le Mans, 72037, France
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Lille, 59020, France
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Limoges, 87042, France
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Marseille, 13385, France
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Nantes, 44093, France
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Poitiers, 86021, France
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Quimper, 29107, France
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Saint-Priest-en-Jarez, 42270, France
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Vandœuvre-lès-Nancy, France
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Vannes, 56017, France
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Aachen, 52074, Germany
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Augsburg, 86156, Germany
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Berlin, 10967, Germany
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Berlin, 13353, Germany
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Bonn, 53127, Germany
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Chemnitz, 09116, Germany
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Cottbus, 03048, Germany
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Göttingen, 37075, Germany
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Halle, 06120, Germany
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Heilbronn, D-74078, Germany
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Jena, 07747, Germany
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Kassel, 34125, Germany
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Lübeck, 23538, Germany
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Magdeburg, 39120, Germany
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Mainz, 55131, Germany
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Marburg, 35043, Germany
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Munich, 81675, Germany
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Munich, 81737, Germany
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Münster, 48149, Germany
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Paderborn, 33098, Germany
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Tübingen, 65199, Germany
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Wiesbaden, 65191, Germany
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Wuppertal, 42283, Germany
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Würzburg, 97080, Germany
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Budapest, 1085, Hungary
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Budapest, H-1122, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Pécs, H-7624, Hungary
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Dublin, Ireland
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Limerick, Ireland
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Beersheba, 8410101, Israel
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Haifa, 31096, Israel
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Jerusalem, 9112001, Israel
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Petah Tikva, 49100, Israel
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Tel Aviv, 6423906, Israel
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Bergamo, 24127, Italy
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Brescia, 25123, Italy
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Candiolo, 10060, Italy
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Catania, 95123, Italy
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Forlì, 47014, Italy
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Genoa, 16132, Italy
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Lecce, 73100, Italy
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Milan, 20141, Italy
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Novara, 28100, Italy
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Orbassano, 10043, Italy
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Padua, 35128, Italy
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Palermo, 90146, Italy
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Pavia, 27100, Italy
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Ravenna, 48121, Italy
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Rimini, 47923, Italy
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Rozzano, 20089, Italy
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Siena, 15121, Italy
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Siena, 53100, Italy
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Terni, 05100, Italy
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Tricase, 73039, Italy
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Trieste, 34129, Italy
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Turin, 10126, Italy
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Fukuoka, 810-8563, Japan
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Gifu, 500-8513, Japan
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Ibaraki, 311-3193, Japan
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Isehara, 259-1193, Japan
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Kagoshima, 890-8520, Japan
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Nagoya, 466-8650, Japan
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Narita-shi, 286-8520, Japan
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Okayama, 701-1192, Japan
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Osaka, 565-0871, Japan
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Osakasayama-shi, 589-8511, Japan
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Sapporo, 003-0804, Japan
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Tachikawa, 190-0014, Japan
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Tokyo, 113-8603, Japan
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Tokyo, 142-8666, Japan
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Tokyo, 162-8666, Japan
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Tsu, 514-8507, Japan
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Alor Star, 05460, Malaysia
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Ampang, 68000, Malaysia
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George Town, 10990, Malaysia
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Ipoh, 30450, Malaysia
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Johor Bahru, 80100, Malaysia
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Kota Bharu, 16150, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuantan, 25100, Malaysia
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Kuching, 93586, Malaysia
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Petaling Jaya, 47500, Malaysia
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Subang Jaya, 47500, Malaysia
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Auckland, 1023, New Zealand
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Manila, 1000, Philippines
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Pasig, 1605, Philippines
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Quezon City, 1112, Philippines
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Warsaw, 02-781, Poland
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Brasov, 500366, Romania
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Bucharest, 050098, Romania
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Iași, 700483, Romania
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Kazan', 420029, Russia
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Novosibirsk, 630087, Russia
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Saint Petersburg, 197341, Russia
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Saint Petersburg, 197758, Russia
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Belgrade, 11 000, Serbia
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Belgrade, 11 080, Serbia
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Kamenitz, 21204, Serbia
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Bratislava, 83310, Slovakia
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Košice, 04166, Slovakia
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Busan, 47392, South Korea
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Busan, 49201, South Korea
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Busan, 4924, South Korea
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Busan, 49267, South Korea
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Daegu, 42415, South Korea
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Daegu, 42472, South Korea
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Daegu, 42601, South Korea
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Goyang-si, 10408, South Korea
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Incheon, South Korea
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Jeonju, 561-712, South Korea
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Jinju, South Korea
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Seoul, 03080, South Korea
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Seoul, 03181, South Korea
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Seoul, 037222, South Korea
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Seoul, 05505, South Korea
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Seoul, 07345, South Korea
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Seoul, 07985, South Korea
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Yangsan, 50612, South Korea
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Badalona, 08916, Spain
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Barcelona, 08035, Spain
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Barcelona, 08908, Spain
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Girona, 17007, Spain
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Jerez de la Frontera, 11407, Spain
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Lugo, 27003, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Madrid, 28050, Spain
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Madrid, 28223, Spain
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Pamplona, 31008, Spain
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Salamanca, 37007, Spain
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Seville, 41009, Spain
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Seville, 41013, Spain
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Seville, 41014, Spain
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Valencia, 46017, Spain
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Vitoria-Gasteiz, 01009, Spain
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Kaohsiung City, 833401, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 71004, Taiwan
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Taipei, 100226, Taiwan
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Bangkok, 10400, Thailand
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Pathum Thani, 12120, Thailand
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Ankara, 06590, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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İzmit, 41380, Turkey (Türkiye)
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Malatya, 44280, Turkey (Türkiye)
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Mersin, 33343, Turkey (Türkiye)
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Kyiv, 03115, Ukraine
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Aberdeen, AB25 2ZN, United Kingdom
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Bath, BA1 3NG, United Kingdom
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Birmingham, B15 2TH, United Kingdom
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Bristol, BS2 8ED, United Kingdom
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London, EC1M 6BQ, United Kingdom
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London, SM2 5PT, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Sutton, SW17 0QT, United Kingdom
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Wolverhampton, WV10 0QP, United Kingdom
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Caen, Cedex 9, France
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Bordeau, Pessac Cedax, France
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Le Chesnay, France
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Berlin, Germany
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Nyíregyháza, Hungary
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Ramat Gan, Israel
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Lodz, Poland
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Bucharest, Romania
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Cluj-Napoca, Romania
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Craiova, Romania
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Moscow, Russia
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Petrozavodsk, Russia
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Saint Petersburg, Russia
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Novi Sad, Serbia
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Chang-hua, Taiwan
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Chiayi City, 613, Taiwan
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Hualien City, Taiwan
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Kaohsiung City, Taiwan
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New Taipei City, Taiwan
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Taichung, 40447, Taiwan
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Bangkok, 10500, Thailand
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Chiang Mai, 50200, Thailand
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Khon Kaen, 40000, Thailand
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Cherkasy, 18009, Ukraine
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Chernihiv, 14029, Ukraine
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Kharkiv, 61070, Ukraine
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Kyiv, 03022, Ukraine
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Kyiv, 03680, Ukraine
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London, SW3 6JJ, United Kingdom
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Ufa, Russia
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Taoyuan District, Taiwan

Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B-CELL LYMPHOMA