Major trial aims to extend lives in advanced stomach cancer

NCT ID NCT04662710

Summary

This large, late-stage study is testing whether adding two newer drugs (lenvatinib and pembrolizumab) to standard chemotherapy works better than chemotherapy alone for people with advanced stomach or esophageal cancer that has spread. The main goal is to see if the three-drug combination helps patients live longer and keeps the cancer from growing for a longer time compared to the current standard treatment. The study will also closely monitor side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O.U. Universita degli Studi della Campania-Luigi Vanvitelli ( Site 1604)

    Naples, 80131, Italy

  • AHN West Penn Hospital-AHN Esophageal and Lung Institute ( Site 0058)

    Pittsburgh, Pennsylvania, 15224, United States

  • AULSS8 Berica-Ospedale S.Bortolo ( Site 1607)

    Vicenza, Veneto, 36100, Italy

  • AZ Delta ( Site 1006)

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Addenbrooke's Hospital ( Site 2200)

    Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom

  • Aichi Cancer Center Hospital ( Site 2603)

    Nagoya, Aichi-ken, 464-8681, Japan

  • Anhui Provincial Hospital ( Site 2415)

    Hefei, Anhui, 230001, China

  • Asan Medical Center ( Site 2802)

    Songpagu, Seoul, 05505, South Korea

  • Ataturk Universitesi Tip Fakultesi Hastanesi ( Site 2005)

    Erzurum, 25240, Turkey (Türkiye)

  • Azienda Ospedaliera Mater Domini-Translational Oncology Unit ( Site 1611)

    Catanzaro, 88100, Italy

  • Beaumont Hospital ( Site 1402)

    Dublin, Dublin 9, Ireland

  • Beijing Cancer Hospital ( Site 2453)

    Beijing, Beijing Municipality, 100035, China

  • Blokhin National Medical Oncology ( Site 1800)

    Moscow, Moscow, 115478, Russia

  • Bradfordhill ( Site 0404)

    Santiago, Region M. de Santiago, 8420383, Chile

  • CEMIC ( Site 0209)

    Buenos Aires, C1431FWO, Argentina

  • CHU Bordeaux Haut-Leveque ( Site 1110)

    Pessac, Gironde, 33604, France

  • CHU Hopital Saint Antoine ( Site 1102)

    Paris, 75012, France

  • CHU Hotel Dieu Nantes ( Site 1101)

    Nantes, Pays de la Loire Region, 44093, France

  • CHU UCL Namur Site de Godinne ( Site 1005)

    Yvoir, Namur, 5530, Belgium

  • CIMCA-Hemato-Oncology ( Site 0601)

    San José, Provincia de San José, 10103, Costa Rica

  • CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0103)

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Cancer Hospital Affiliated to Xinjiang Medical University ( Site 2428)

    Ürümqi, Xinjiang, 830011, China

  • Cancer Hospital Chinese Academy of Medical Sciences ( Site 2403)

    Beijing, Beijing Municipality, 100021, China

  • Cancer and Hematology Centers of Western Michigan ( Site 0025)

    Grand Rapids, Michigan, 49503, United States

  • Central Clinical Hospital with Polyclinic ( Site 1801)

    Moscow, Moscow, 121359, Russia

  • Centre Francois Baclesse ( Site 1107)

    Caen, Calvados, 14076, France

  • Centre Georges Francois Leclerc ( Site 1106)

    Dijon, Cote-d Or, 21079, France

  • Centre Hospitalier Annecy Genevois ( Site 1117)

    Epagny Metz-Tessy, Haute-Savoie, 74370, France

  • Centro Investigación del Cáncer James Lind ( Site 0414)

    Temuco, Región de la Araucanía, Temuco, Chile

  • Chang Gung Medical Foundation. Linkou ( Site 2902)

    Taoyuan District, 333, Taiwan

  • Changzhou Cancer Hospital-Department of Oncology ( Site 2458)

    Changzhou, Jiangsu, 213000, China

  • Charite Berlin Campus Virchow-Klinikum ( Site 1202)

    Berlin, 13353, Germany

  • Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1816)

    Chelyabinsk, Chelyabinsk Oblast, 454087, Russia

  • China Medical University Hospital ( Site 2903)

    Taichung, 40447, Taiwan

  • Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 0501)

    Bogotá, Bogota D.C., 111321, Colombia

  • Clinica Privada Dr Rixci Ramirez Fallas ( Site 0702)

    Guatemala City, 01010, Guatemala

  • Clinica Universidad Catolica del Maule ( Site 0411)

    Talca, Maule Region, 3460000, Chile

  • Clinica de la Costa S.A.S. ( Site 0502)

    Barranquilla, Atlántico, 080020, Colombia

  • Clínica San Carlos de Apoquindo Red Salud UC Christus ( Site 0407)

    Santiago, Region M. de Santiago, 7550000, Chile

  • Dana Farber Cancer Center ( Site 0019)

    Boston, Massachusetts, 02215, United States

  • Dolnoslaskie Centrum Onkologii. ( Site 1712)

    Wroclaw, Lower Silesian Voivodeship, 53-413, Poland

  • Ege Universitesi Tip Fakultesi Hastanesi ( Site 2001)

    Izmir, 35040, Turkey (Türkiye)

  • Facharztzentrum Eppendorf ( Site 1201)

    Hamburg, 20249, Germany

  • First Hospital of Lanzhou University ( Site 2417)

    Lanzhou, Gansu, 730000, China

  • Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1610)

    Milan, Lombardy, 20133, Italy

  • Fourth Hospital Of Hebei Medical University ( Site 2441)

    Shijiazhuang, Hebei, 050011, China

  • Fujian Provincial Cancer Hospital ( Site 2408)

    Fuzhou, Fujian, 350014, China

  • Fundacion Arturo Lopez Perez FALP ( Site 0403)

    Santiago, Region M. de Santiago, 7500836, Chile

  • Fundacion Favaloro ( Site 0201)

    Buenos Aires, C1093AAS, Argentina

  • Gangnam Severance Hospital ( Site 2805)

    Seoul, 06273, South Korea

  • Georgetown University Medical Center ( Site 0009)

    Washington D.C., District of Columbia, 20007, United States

  • Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 2003)

    Ankara, 06100, Turkey (Türkiye)

  • Hadassah Ein Kerem Medical Center ( Site 1501)

    Jerusalem, 9112001, Israel

  • Hallym University Sacred Heart Hospital ( Site 2806)

    Anyang-si, Kyonggi-do, 14068, South Korea

  • Hamilton Health Sciences - Juravinski Site ( Site 0106)

    Hamilton, Ontario, L8V 5C2, Canada

  • Harbin Medical University Cancer Hospital ( Site 2410)

    Harbin, Heilongjiang, 150081, China

  • Henan Cancer Hospital ( Site 2443)

    Zhengzhou, Henan, 450008, China

  • Henry Ford Health System ( Site 0023)

    Detroit, Michigan, 48202, United States

  • Hillel Yaffe Medical Center ( Site 1503)

    Hadera, 3810004, Israel

  • Hiroshima City Hiroshima Citizens Hospital ( Site 2612)

    Hiroshima, 730-8518, Japan

  • Hollywood Private Hospital-Medical Oncology ( Site 2308)

    Nedlands, Western Australia, 6009, Australia

  • Hopital Henri Mondor ( Site 1105)

    Créteil, Val-de-Marne, 94010, France

  • Hopital Saint Louis ( Site 1100)

    Paris, 75010, France

  • Hospital Aleman ( Site 0210)

    Buenos Aires, C1118AAT, Argentina

  • Hospital General Gregorio Maranon de Madrid ( Site 1904)

    Madrid, 28007, Spain

  • Hospital General Universitari Vall d Hebron ( Site 1907)

    Barcelona, 08035, Spain

  • Hospital Metropolitano - Sede Lindora-Metropolitano Research Institute Sede Lindora ( Site 0602)

    Santa Ana, Provincia de San José, 10903, Costa Rica

  • Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0207)

    Buenos Aires, C1264AAA, Argentina

  • Hospital Privado de Cordoba ( Site 0204)

    Córdoba, X5016KEH, Argentina

  • Hospital Universitario General de Asturias ( Site 1901)

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Universitario Marques de Valdecilla ( Site 1902)

    Santander, Cantabria, 39008, Spain

  • Hubei Cancer Hospital ( Site 2429)

    Wuhan, Hubei, 430079, China

  • Humanitas Research Hospital ( Site 1600)

    Rozzano, Lombardy, 20089, Italy

  • Hunan Cancer Hospital ( Site 2440)

    Changsha, Hunan, 410006, China

  • Hyogo Cancer Center ( Site 2621)

    Akashi, Hyōgo, 673-8558, Japan

  • Hôpital Edouard Herriot ( Site 1116)

    Lyon, Auvergne-Rhône-Alpes, 69003, France

  • IC La Serena Research ( Site 0410)

    La Serena, Coquimbo Region, 1720430, Chile

  • IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 0202)

    Caba, Buenos Aires, C1012AAR, Argentina

  • IRCCS Ospedale San Raffaele di Milano ( Site 1603)

    Milan, 20132, Italy

  • Ibaraki Prefectural Central Hospital ( Site 2618)

    Kasama, Ibaraki, 309-1793, Japan

  • Institut du Cancer Avignon-Provence ( Site 1103)

    Avignon, Vaucluse, 84918, France

  • Instituto Cancerologico de Narino Ltda ( Site 0504)

    Pasto, Departamento de Nariño, 520001, Colombia

  • Instituto Medico Alexander Fleming ( Site 0208)

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

  • Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 2002)

    Istanbul, 34098, Turkey (Türkiye)

  • Istituto Scientifico Romagnolo per Studio e Cura Tumori IRST ( Site 1608)

    Meldola, Abruzzo, 47014, Italy

  • James Graham Brown Cancer Center ( Site 0017)

    Louisville, Kentucky, 40202, United States

  • Jilin Cancer Hospital ( Site 2438)

    Changchun, Jilin, 130012, China

  • Johns Hopkins University ( Site 0052)

    Baltimore, Maryland, 21224, United States

  • Kagawa University Hospital ( Site 2611)

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Kanagawa Cancer Center ( Site 2608)

    Yokohama, Kanagawa, 241-8515, Japan

  • Kansai Medical University Hospital ( Site 2622)

    Hirakata, Osaka, 573-1191, Japan

  • Kindai University Hospital ( Site 2600)

    Sayama, Osaka, 5898511, Japan

  • Klinikum Rechts der Isar der TU Muenchen ( Site 1200)

    Muechen, Bavaria, 81675, Germany

  • Kobe City Medical Center General Hospital ( Site 2606)

    Kobe, Hyōgo, 650-0047, Japan

  • Konyang University ( Site 2807)

    Daejeon, Taejon-Kwangyokshi, 35365, South Korea

  • Korea University Guro Hospital ( Site 2808)

    Seoul, 08308, South Korea

  • Krankenhaus Nordwest ( Site 1205)

    Frankfurt am Main, Hesse, 60488, Germany

  • Leningrad Regional Oncology Center ( Site 1810)

    Saint Petersburg, Sankt-Peterburg, 188663, Russia

  • LinYi Cancer Hospital-Gastrology department ( Site 2463)

    Linyi, Shandong, 276000, China

  • Medi-K Cayala ( Site 0700)

    Guatemala City, 01016, Guatemala

  • Medical University REAVIZ ( Site 1814)

    Samara, Samara Oblast, 443011, Russia

  • Medizinische Hochschule Hannover ( Site 1210)

    Hanover, Lower Saxony, 30625, Germany

  • Meir Medical Center ( Site 1504)

    Kfar Saba, 4428164, Israel

  • Memorial Ankara Hastanesi ( Site 2004)

    Ankara, 06520, Turkey (Türkiye)

  • Memorial Sloan Kettering Cancer Center ( Site 0032)

    New York, New York, 10065, United States

  • Mount Sinai Hospital ( Site 0051)

    New York, New York, 10029, United States

  • Nanfang Hospital ( Site 2456)

    Guangzhou, Guangdong, 510000, China

  • Nanjing Drum Tower Hospital ( Site 2419)

    Nanjing, Jiangsu, 210008, China

  • Nantong Tumor Hospital-Digestive Oncology ( Site 2464)

    Nantong, Jiangsu, 226361, China

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 1704)

    Warsaw, Masovian Voivodeship, 02-034, Poland

  • National Cancer Center Hospital ( Site 2602)

    Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East ( Site 2601)

    Kashiwa, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital ( Site 2904)

    Tainan, 704, Taiwan

  • National Hospital Organization Kyushu Cancer Center ( Site 2609)

    Fukuoka, 811-1395, Japan

  • National Hospital Organization Shikoku Cancer Center ( Site 2610)

    Matsuyama, Ehime, 791-0280, Japan

  • National Medical and Surgical Center n.a.N.I.Pirogov ( Site 1805)

    Moscow, Moscow, 105203, Russia

  • National Taiwan University Hospital ( Site 2901)

    Taipei, 10048, Taiwan

  • Nepean Hospital ( Site 2305)

    Kingswood, New South Wales, 2747, Australia

  • Ninewells Hospital and Medical School ( Site 2207)

    Dundee, Dundee City, DD1 9SY, United Kingdom

  • Oncologika S.A. ( Site 0704)

    Guatemala City, 01010, Guatemala

  • Oncologos del Occidente S.A. ( Site 0525)

    Pereira, Risaralda Department, 660001, Colombia

  • Oncomedica ( Site 0701)

    Guatemala City, 01010, Guatemala

  • Oncomedica S.A. ( Site 0507)

    Montería, Departamento de Córdoba, 230002, Colombia

  • Osaka International Cancer Institute ( Site 2607)

    Osaka, 5418567, Japan

  • Presidio Ospedaliero Universitario Santa Maria della Misericordia ( Site 1609)

    Udine, Friuli Venezia Giulia, 33100, Italy

  • Prince of Wales Hospital ( Site 2503)

    Hong Kong, Hong Kong

  • Princess Margaret Hospital. ( Site 2502)

    Hong Kong, Hong Kong

  • Przychodnia Lekarska KOMED ( Site 1701)

    Konin, Greater Poland Voivodeship, 62-500, Poland

  • Queen Elizabeth II Health Sciences Centre ( Site 0101)

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Queen Mary Hospital ( Site 2501)

    Hong Kong, Hong Kong

  • Rabin Medical Center ( Site 1506)

    Petah Tikva, 4941492, Israel

  • Rambam Health Care Campus-Oncology Division ( Site 1502)

    Haifa, 3109601, Israel

  • Royal Brisbane and Women s Hospital ( Site 2304)

    Herston, Queensland, 4029, Australia

  • Royal Marsden NHS Foundation Trust ( Site 2202)

    London, London, City of, SW3 6JJ, United Kingdom

  • Royal Marsden NHS Trust ( Site 2203)

    Sutton, Surrey, SM2 5PT, United Kingdom

  • Saitama Cancer Center ( Site 2604)

    Kitaadachi-gun, Saitama, 362-0806, Japan

  • Sakarya Universitesi Tip Fakultesi ( Site 2007)

    Sakarya, Istanbul, 54290, Turkey (Türkiye)

  • Samsung Medical Center ( Site 2801)

    Seoul, 06351, South Korea

  • Sanatorio Nuestra Senora del Pilar ( Site 0705)

    Guatemala City, 01015, Guatemala

  • Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1809)

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • Seoul National University Bundang Hospital ( Site 2804)

    Seongnam-si, Kyonggi-do, 13620, South Korea

  • Seoul National University Hospital ( Site 2803)

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System ( Site 2800)

    Seoul, 03722, South Korea

  • Shanghai East Hospital ( Site 2455)

    Shanghai, Shanghai Municipality, 200120, China

  • Shanghai General Hospital ( Site 2424)

    Shanghai, Shanghai Municipality, 200080, China

  • Sir Run Run Shaw Hospital ( Site 2412)

    Hangzhou, Zhejiang, 310016, China

  • Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0508)

    Valledupar, Cesar Department, 200001, Colombia

  • Soluciones Gastrointestinales S.A. ( Site 0706)

    Guatemala City, 01010, Guatemala

  • Soroka Medical Center ( Site 1507)

    Beersheba, 8410101, Israel

  • Sourasky Medical Center ( Site 1500)

    Tel Aviv, 6423906, Israel

  • St James Hospital ( Site 1400)

    Dublin, Leinster, Dublin 8, Ireland

  • St Petersburg City Clinical Oncology Dispensary ( Site 1808)

    Saint Petersburg, Sankt-Peterburg, 198255, Russia

  • Szpital Kliniczny im. Heliodora Swiecickiego Uniwers Medyczn ( Site 1703)

    Poznan, Greater Poland Voivodeship, 60-780, Poland

  • Tang Du Hospital ( Site 2432)

    Xi'an, Shaanxi, 710038, China

  • The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army ( Si

    Fuzhou, Fujian, 350025, China

  • The Affiliated Hospital Of Hainan Medical University-Cancer rehabilitation and palliative treatment

    Haikou, Hainan, 570102, China

  • The Beatson West of Scotland Cancer Centre ( Site 2204)

    Glasgow, Glasgow City, G12 0YN, United Kingdom

  • The Cancer Institute Hospital of JFCR ( Site 2605)

    Tokyo, 135-8550, Japan

  • The Christie NHS Foundation Trust ( Site 2209)

    Manchester, M20 4BX, United Kingdom

  • The First Affiliated Hospital of Xiamen University ( Site 2420)

    Xiamen, Fujian, 361003, China

  • The First Affiliated Hospital of Xiamen University ( Site 2446)

    Xiamen, Fujian, 361003, China

  • The First Affiliated Hospital of Zhejiang University ( Site 2414)

    Hangzhou, Zhejiang, 310009, China

  • Tianjin Medical University Cancer Institute & Hospital ( Site 2447)

    Tianjin, Tianjin Municipality, 300060, China

  • Trakya Universitesi Tip Fakultesi ( Site 2000)

    Edirne, 22030, Turkey (Türkiye)

  • UCLA Hematology/Oncology - Santa Monica ( Site 0003)

    Los Angeles, California, 90404, United States

  • UMASS Memorial Medical Center ( Site 0020)

    Worcester, Massachusetts, 01655, United States

  • UZ Gent ( Site 1002)

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • UZ Leuven ( Site 1004)

    Leuven, Vlaams-Brabant, 3000, Belgium

  • Universitaetsklinikum Leipzig ( Site 1211)

    Leipzig, Saxony, 04103, Germany

  • Universitaetsklinikum Regensburg ( Site 1203)

    Regensburg, Bavaria, 93053, Germany

  • University College London Hospitals NHS Foundation Trust ( Site 2201)

    London, London, City of, NW1 2BU, United Kingdom

  • University Hospital Coventry and Warwickshire NHS Trust ( Site 2205)

    Coventry, Warwickshire, CV2 2DX, United Kingdom

  • Washington University School of Medicine ( Site 0027)

    St Louis, Missouri, 63110, United States

  • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1702)

    Przemyśl, Podkarpackie Voivodeship, 37-700, Poland

  • Wollongong Hospital ( Site 2307)

    Wollongong, New South Wales, 2500, Australia

  • Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1821)

    Yaroslavl, Yaroslavl Oblast, 150054, Russia

  • Zhongshan Hospital Affiliated to Xiamen University ( Site 2421)

    Xiamen, Fujian, 361004, China

Conditions

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