Major trial tests Triple-Threat attack on deadly esophageal cancer

NCT ID NCT04949256

Summary

This large, late-stage study is testing whether adding the drug lenvatinib to a standard immunotherapy and chemotherapy combination helps people with advanced esophageal cancer that has spread. The main goal is to see if this three-drug approach helps patients live longer compared to the standard two-drug treatment. The study is no longer enrolling new participants and is in its final close-out phase.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O. Universitaria di Modena ( Site 1307)

    Modena, 41124, Italy

  • A.O.U. Santa Maria della Misericordia di Udine ( Site 1302)

    Udine, Friuli Venezia Giulia, 33100, Italy

  • A.O.U. Universita degli Studi della Campania-Luigi Vanvitelli ( Site 1305)

    Napoli, 80131, Italy

  • AHN Allegheny General Hospital ( Site 0164)

    Pittsburgh, Pennsylvania, 15212, United States

  • Academician I.P. Pavlov First St. Petersburg State Medical University ( Site 1519)

    Saint Petersburg, Sankt-Peterburg, 197022, Russia

  • Acibadem Universitesi Atakent Hastanesi-Medical Oncology ( Site 1716)

    Istanbul, 34303, Turkey (Türkiye)

  • Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 1714)

    Adana, 01140, Turkey (Türkiye)

  • Affiliated Hospital of Chengde Medical Univeristy ( Site 8053)

    Chengde, Hebei, 067055, China

  • Affiliated Hospital of Jining Medical University ( Site 8017)

    Jining, Shandong, 272000, China

  • Affiliated hospital of Jiangnan university ( Site 8049)

    Wuxi, Jiangsu, 214122, China

  • Aichi Cancer Center Hospital ( Site 9006)

    Nagoya, Aichi-ken, 464-8681, Japan

  • Anhui Provincial Cancer Hospital ( Site 8058)

    Hefei, Anhui, 230031, China

  • Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1715)

    Ankara, 06800, Turkey (Türkiye)

  • Anyang Cancer Hospital ( Site 8006)

    Anyang, Henan, 455000, China

  • Asan Medical Center ( Site 5002)

    Songpagu, Seoul, 05505, South Korea

  • Atatürk Üniversitesi-onkoloji ( Site 1712)

    Erzurum, 25070, Turkey (Türkiye)

  • Azienda Ospedaliera Mater Domini-Translational Oncology Unit ( Site 1314)

    Catanzaro, 88100, Italy

  • Azienda Ospedaliera Universitaria Pisana ( Site 1312)

    Pisa, Tuscany, 56126, Italy

  • Azienda Ospedaliero Universitaria Careggi ( Site 1301)

    Florence, 50134, Italy

  • Beijing Cancer Hospital ( Site 8001)

    Beijing, Beijing Municipality, 100142, China

  • Bradford Hill Centro de Investigaciones Clinicas ( Site 0404)

    Santiago, Region M. de Santiago, 8420383, Chile

  • C.H. regional Unv. de Brest - Hopital La Cavale Blanche - Institut de Cancerologie et d Imagerie ( S

    Brest, Finistere, 29200, France

  • CHRU de Tours - Hopital Bretonneau ( Site 1018)

    Tours, Indre-et-Loire, 37044, France

  • CHU Besançon ( Site 1015)

    Besançon, Franche-Comte, 25000, France

  • CHU Bordeaux Haut-Leveque ( Site 1012)

    Pessac, Gironde, 33604, France

  • CIMCA Centro de Investigacion y Manejo del Cancer ( Site 0902)

    San José, 10103, Costa Rica

  • Cambridge University Hospitals NHSFT ( Site 1908)

    Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom

  • CancerCare Manitoba ( Site 0001)

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Capital Health Medical Center - Hopewell ( Site 0189)

    Pennington, New Jersey, 08534, United States

  • Cardiomed SRL Cluj-Napoca-Medical Oncology ( Site 2207)

    Cluj-Napoca, Cluj, 400015, Romania

  • Centre François Baclesse ( Site 1009)

    Caen, Calvados, 14076, France

  • Centre Georges Francois Leclerc ( Site 1008)

    Dijon, Cote-d Or, 21000, France

  • Centro Regional de Sub Especialidades Medicas SA ( Site 0604)

    Guatemala, Departamento de Quetzaltenango, 09001, Guatemala

  • Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 0401)

    Temuco, Región de la Araucanía, 4810218, Chile

  • Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0203)

    Berazategui, Buenos Aires, B1884BBF, Argentina

  • Chang Gung Med Foundation. Kaohsiung Branch ( Site 6005)

    Kaohsiung City, 833, Taiwan

  • Chernihiv Medical Center of Modern Oncology ( Site 1811)

    Chernihiv, Chernihiv Oblast, 14029, Ukraine

  • Chi Mei Hospital - Liouying Branch-Clinical Trial Center ( Site 6007)

    Tainan, Tainan, 73657, Taiwan

  • Chiba Cancer Center ( Site 9023)

    Chiba, Chiba, 260-8717, Japan

  • China Medical University Hospital ( Site 6003)

    Taichung, 40447, Taiwan

  • City of Hope ( Site 0102)

    Duarte, California, 91010, United States

  • Clínica San Carlos de Apoquindo Red Salud UC Christus ( Site 0407)

    Santiago, Region M. de Santiago, 7550000, Chile

  • Communal nonprofit enterprise "Kherson Regional Oncology Dispensary" of Kherson Regional Council (

    Antonivka Village, Kherson Oblast, 73000, Ukraine

  • Complexo Hospitalario Universitario de Ourense-MEDICAL ONCOLOGY ( Site 1609)

    Ourense, Orense, 32005, Spain

  • FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 1510)

    Moscow, Moscow, 115478, Russia

  • Faculty of Medicine Siriraj Hospital ( Site 7002)

    Bangkok, Bangkok, 10700, Thailand

  • Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1306)

    Milan, 20133, Italy

  • Fujian Provincial Cancer Hospital ( Site 8029)

    Fuzhou, Fujian, 350014, China

  • Fundacion Arturo Lopez Perez FALP ( Site 0403)

    Santiago, Region M. de Santiago, 7500836, Chile

  • Fundacion Estudios Clinicos-Oncology ( Site 0215)

    Rosario, Santa Fe Province, S2000DEJ, Argentina

  • Fundacion Favaloro ( Site 0201)

    Buenos Aires, C1093AAS, Argentina

  • Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0221)

    La Rioja, F5300COE, Argentina

  • Fundación Respirar ( Site 0216)

    Buenos Aires, C1426ABP, Argentina

  • GBUZ LOKB ( Site 1502)

    Saint-Petersburg, Leningradskaya Oblast', 194291, Russia

  • Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1701)

    Ankara, 06230, Turkey (Türkiye)

  • Harbin Medical University Cancer Hospital ( Site 8009)

    Harbin, Heilongjiang, China

  • Hematology-Oncology Associates of CNY ( Site 0173)

    East Syracuse, New York, 13057, United States

  • Hopital Henri Mondor ( Site 1007)

    Créteil, Val-de-Marne, 94010, France

  • Hopital Saint Louis ( Site 1029)

    Paris, 75010, France

  • Hospital General Universitari Vall d Hebron ( Site 1607)

    Barcelona, 08035, Spain

  • Hospital General Universitario Gregorio Maranon ( Site 1604)

    Madrid, 28007, Spain

  • Hospital Italiano de Córdoba ( Site 0218)

    Córdoba, X5004BAL, Argentina

  • Hospital Kuala Lumpur ( Site 9104)

    Kuala Lumpur, 50586, Malaysia

  • Hospital Provincial del Centenario ( Site 0217)

    Rosario, Santa Fe Province, S2002KDS, Argentina

  • Hospital Universitario General de Asturias ( Site 1601)

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Universitario Marques de Valdecilla ( Site 1602)

    Santander, Cantabria, 39008, Spain

  • Hospital Virgen del Rocio ( Site 1606)

    Seville, 41013, Spain

  • Hotel-Dieu de Levis ( Site 0013)

    Lévis, Quebec, G6V 3Z1, Canada

  • Hubei Cancer Hospital ( Site 8014)

    Wuhan, Hubei, 430079, China

  • Humanitas Research Hospital ( Site 1309)

    Rozzano, Lombardy, 20089, Italy

  • Hyogo Cancer Center ( Site 9014)

    Akashi, Hyōgo, 673-8558, Japan

  • Hôpital Claude Huriez ( Site 1030)

    Lille, Nord, 59000, France

  • ICIMED-Oncology Research Unit ( Site 0903)

    San José, Provincia de San José, 10108, Costa Rica

  • IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 0202)

    CABA, Buenos Aires, C1012AAR, Argentina

  • IRCCS Ospedale San Raffaele di Milano ( Site 1304)

    Milan, 20132, Italy

  • Ibaraki Prefectural Central Hospital ( Site 9007)

    Kasama, Ibaraki, 309-1793, Japan

  • Institut De Cancerologie De L Ouest ( Site 1003)

    Saint-Herblain, Loire-Atlantique, 44805, France

  • Institut De Cancerologie De Lorraine ( Site 1010)

    Vandœuvre-lès-Nancy, Ain, 54519, France

  • Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1014)

    Strasbourg, Alsace, 67200, France

  • Institut du Cancer de Montpellier ( Site 1002)

    Montpellier, Herault, 34298, France

  • Institute of General and Emergency Surgery n.a Zaitsev NAMS of Ukraine ( Site 1813)

    Kharkiv, Kharkivs’ka Oblast’, 61103, Ukraine

  • Instituto San Marcos ( Site 0213)

    San Juan, J5400EBB, Argentina

  • Instituto de Investigaciones Clinicas Mar del Plata ( Site 0205)

    Mar del Plata, Buenos Aires, B7600FZO, Argentina

  • Istanbul Okmeydanı Egitim ve Arastirma Hastanesi ( Site 1711)

    Istanbul, 34384, Turkey (Türkiye)

  • Istituto Oncologico Veneto IRCCS-Oncologia Medica 1 ( Site 1311)

    Padua, Veneto, 35128, Italy

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 1313)

    Meldola, Emilia-Romagna, 47014, Italy

  • James Graham Brown Cancer Center ( Site 0117)

    Louisville, Kentucky, 40202, United States

  • James Lind Centro de Investigacion del Cancer ( Site 0412)

    Temuco, Región de la Araucanía, 4800827, Chile

  • Jilin Cancer Hospital ( Site 8016)

    Changchun, Jilin, 130012, China

  • Jinan Central Hospital ( Site 8052)

    Jinan, Shandong, 250013, China

  • Johns Hopkins Bayview Medical Center ( Site 0152)

    Baltimore, Maryland, 21224, United States

  • Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1203)

    Szolnok, Jász-Nagykun-Szolnok, 5000, Hungary

  • Kagawa University Hospital ( Site 9015)

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Kanagawa Cancer Center ( Site 9004)

    Yokohama, Kanagawa, 241-8515, Japan

  • Keio University Hospital ( Site 9020)

    Tokyo, 160-8582, Japan

  • Kharkiv Regional Clinical Oncology Center ( Site 1812)

    Kharkiv, Kharkivs’ka Oblast’, 61000, Ukraine

  • Kindai University Hospital ( Site 9017)

    Sayama, Osaka, 589-8511, Japan

  • Korea University Guro Hospital ( Site 5001)

    Seoul, 08308, South Korea

  • Kyoto University Hospital ( Site 9011)

    Kyoto, Japan

  • Linyi Cancer Hospital- Medical Oncology Department ( Site 8051)

    Linyi, Shandong, 276000, China

  • MEDI-K ( Site 0601)

    Guatemala City, 01009, Guatemala

  • MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2201)

    Bucharest, București, 013812, Romania

  • MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council ( Site 1804)

    Kryviy Rih, Dnipropetrovsk Oblast, 50048, Ukraine

  • MedStar Washington Hospital Center ( Site 0186)

    Washington D.C., District of Columbia, 20010, United States

  • Medeniyet Universitesi Tip Fakultesi ( Site 1703)

    Istanbul, 34732, Turkey (Türkiye)

  • Medical University of South Carolina-Hollings Cancer Center ( Site 0177)

    Charleston, South Carolina, 29425, United States

  • Memorial Ankara Hastanesi ( Site 1702)

    Ankara, 06520, Turkey (Türkiye)

  • Memorial Sloan Kettering Cancer Center ( Site 0132)

    New York, New York, 10065, United States

  • National Cancer Center Hospital ( Site 9001)

    Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East ( Site 9002)

    Kashiwa, Chiba, 277-8577, Japan

  • National Cancer Centre Singapore ( Site 9201)

    Singapore, Central Singapore, 168583, Singapore

  • National Cheng Kung University Hospital ( Site 6004)

    Tainan, 704, Taiwan

  • National Hospital Organization Kyushu Cancer Center ( Site 9010)

    Fukuoka, 811-1395, Japan

  • National Hospital Organization Shikoku Cancer Center ( Site 9019)

    Matsuyama, Ehime, 791-0280, Japan

  • National Taiwan University Hospital ( Site 6001)

    Taipei, 10002, Taiwan

  • Niigata Cancer Center Hospital ( Site 9022)

    Niigata, Niigata, 951-8566, Japan

  • Ninewells Hospital and Medical School ( Site 1907)

    Dundee, Dundee City, DD2 1SG, United Kingdom

  • Norton Cancer Institute ( Site 0116)

    Louisville, Kentucky, 40217, United States

  • Nottingham University Hospital NHS Trust ( Site 1910)

    Nottingham, England, NG5 1PF, United Kingdom

  • Odense University Hospital ( Site 2101)

    Odense, Region Syddanmark, 5000, Denmark

  • Okayama University Hospital ( Site 9024)

    Okayama, 700-8558, Japan

  • Onco Tech S A ( Site 0901)

    San José, 10103, Costa Rica

  • Oncomedica ( Site 0602)

    Guatemala City, 01010, Guatemala

  • Oncovida ( Site 0413)

    Santiago, Region M. de Santiago, 7510032, Chile

  • Orszagos Onkologiai Intezet ( Site 1207)

    Budapest, 1122, Hungary

  • Osaka General Medical Center ( Site 9018)

    Osaka, 558-8558, Japan

  • Osaka International Cancer Institute ( Site 9009)

    Osaka, 541-8567, Japan

  • Osaka Medical and Pharmaceutical University Hospital ( Site 9008)

    Takatsuki, Osaka, 569-8686, Japan

  • Osaka University Hospital ( Site 9021)

    Suita, Osaka, 565-0871, Japan

  • Ovidius Clinical Hospital OCH-Oncology and Hematology ( Site 2203)

    Ovidiu, Constanța County, 905900, Romania

  • PROCLINICAL Pharma ( Site 0904)

    San José, Provincia de San José, 11303, Costa Rica

  • Pecsi Tudomanyegyetem AOK ( Site 1204)

    Pécs, Baranya, 7624, Hungary

  • Petz Aladar Egyetemi Oktato Korhaz ( Site 1210)

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Podillya Regional Center of Oncology ( Site 1809)

    Vinnytsia, Vinnytsia Oblast, 21029, Ukraine

  • Policlinica Oncomed SRL ( Site 2206)

    Timișoara, Timiș County, 300239, Romania

  • Princess Margaret Cancer Centre ( Site 0004)

    Toronto, Ontario, M5G 2M9, Canada

  • Queen Elizabeth Hospital. ( Site 4004)

    Kowloon, Hong Kong

  • Queen Mary Hospital ( Site 4001)

    Hong Kong, Hong Kong

  • Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 1819)

    Chernivtsi, Chernivetska Oblast, 58013, Ukraine

  • Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1507)

    Ufa, Baskortostan, Respublika, 450054, Russia

  • Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 150

    Kazan', Tatarstan, Respublika, 420029, Russia

  • Rigshospitalet ( Site 2102)

    Copenhagen, Capital Region, 2100, Denmark

  • Rivne Regional Clinical Hospital ( Site 1817)

    Rivne, Rivne Oblast, 33007, Ukraine

  • Royal Marsden NHS Foundation Trust ( Site 1905)

    London, London, City of, SW3 6JJ, United Kingdom

  • Royal Marsden NHS Trust. ( Site 1906)

    Sutton, London, City of, SM2 5PT, United Kingdom

  • S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2204)

    Craiova, Dolj, 200542, Romania

  • SAIH of Tyumen reg "Multifield clinical medical center "Medical city" ( Site 1520)

    Tyumen, Tyumen Oblast, 625041, Russia

  • SC Radiotherapy Center Cluj SRL ( Site 2202)

    Comuna Floresti, Cluj, 407280, Romania

  • SNPE National Cancer Institute ( Site 1806)

    Kyiv, Kyivska Oblast, 03022, Ukraine

  • Saitama Prefectural Cancer Center ( Site 9003)

    Kitaadachi-gun, Saitama, 362-0806, Japan

  • Samsung Medical Center ( Site 5005)

    Seoul, 06351, South Korea

  • Sanatorio Parque ( Site 0206)

    Rosario, Santa Fe Province, S2000DSV, Argentina

  • Sarawak General Hospital-Radiotherapy Unit ( Site 9100)

    Kuching, Sarawak, 93586, Malaysia

  • Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1503)

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • Seattle Cancer Care Alliance ( Site 0145)

    Seattle, Washington, 98109, United States

  • Seoul National University Bundang Hospital ( Site 5006)

    Seongnam-si, Kyonggi-do, 13605, South Korea

  • Severance Hospital ( Site 5003)

    Seoul, 03722, South Korea

  • Shalimov Institute of Surgery and Transplantation ( Site 1818)

    Kyiv, 03126, Ukraine

  • Shandong Cancer Hospital ( Site 8060)

    Jinan, Shandong, 250117, China

  • Shanxi Provincial Cancer Hospital ( Site 8019)

    Taiyuan, Shanxi, 030000, China

  • Shizuoka Cancer Center ( Site 9016)

    Nakatogari, Shizuoka, 411-8777, Japan

  • Showa University Hospital ( Site 9025)

    Shinagawa, Tokyo, 142-8666, Japan

  • Sir Run Run Shaw Hospital ( Site 8021)

    Hangzhou, Zhejiang, 310016, China

  • Soluciones Gastrointestinales S.A. ( Site 0607)

    Guatemala City, 01010, Guatemala

  • Songklanagarind hospital ( Site 7001)

    Hat Yai, Changwat Songkhla, 90110, Thailand

  • Southern Medical University Nanfang Hospital ( Site 8031)

    Guangzhou, Guangdong, 510515, China

  • St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1915)

    London, London, City of, EC1A 7BE, United Kingdom

  • St. Luke's University Health Network ( Site 0185)

    Bethlehem, Pennsylvania, 18015, United States

  • Taipei Veterans General Hospital ( Site 6006)

    Taipei, 11217, Taiwan

  • The Affiliated Cancer Hospital of Xinjiang Medical University. ( Site 8041)

    Ürümqi, Xinjiang, 830000, China

  • The Affiliated Hospital of Xuzhou Medical University ( Site 8015)

    Xuzhou, Jiangsu, 221000, China

  • The Cancer Institute Hospital of JFCR ( Site 9005)

    Tokyo, 135-8550, Japan

  • The Christie NHS Foundation Trust ( Site 1909)

    Manchester, M20 4BX, United Kingdom

  • The First Affiliated Hospital of Hainan Medical University ( Site 8042)

    Haikou, Hainan, 570102, China

  • The First Affiliated Hospital of Henan University of Science &Technology-Tumor ( Site 8036)

    Luoyang, Henan, 471003, China

  • The First Affiliated Hospital of Xiamen University ( Site 8003)

    Xiamen City, Fujian Province, Fujian, 361003, China

  • The First Affiliated Hospital of Xinxiang Medical University ( Site 8018)

    Xinxiang, Henan, 453100, China

  • The First Affiliated Hospital.Sun Yat-sen University ( Site 8047)

    Guangzhou, Guangdong, 510080, China

  • The Oncology Centre ( Site 9505)

    Durban, KwaZulu-Natal, 4091, South Africa

  • The Second Affiliated Hospital of Anhui Medical University ( Site 8026)

    Hefei, Anhui, 230031, China

  • The Third Xiangya Hospital of Central South University ( Site 8046)

    Changsha, Hainan, 410013, China

  • Tianjin Medical University Cancer Institute & Hospital ( Site 8035)

    Tianjin, Tianjin Municipality, 300060, China

  • Tohoku University Hospital ( Site 9013)

    Sendai, Miyagi, 980-8574, Japan

  • Tokyo Metropolitan Komagome Hospital ( Site 9028)

    Bunkyo Ku, Tokyo, 113-8677, Japan

  • Tongji Medical College Huazhong Uinversity Of Science and Technology ( Site 8025)

    Wuhan, Hubei, 430030, China

  • Toranomon Hospital ( Site 9026)

    Minato-ku, Tokyo, 105-8470, Japan

  • UMASS Memorial Medical Center ( Site 0120)

    Worcester, Massachusetts, 01655, United States

  • Universita Cattolica del Sacro Cuore - Policlinico Gemelli ( Site 1310)

    Roma, 00168, Italy

  • University College London Hospitals NHS Foundation Trust ( Site 1901)

    London, London, City of, NW1 2BU, United Kingdom

  • University Hospital,Kyoto Prefectural University of Medicine ( Site 9027)

    Kyoto, 602-8566, Japan

  • University Malaya Medical Centre ( Site 9101)

    Lembah Pantai, Kuala Lumpur, 59100, Malaysia

  • VCU Health Adult Outpatient Pavillion ( Site 0160)

    Richmond, Virginia, 23219, United States

  • Volyn Regional Oncological Dispensary ( Site 1816)

    Lutsk, Volyn Oblast, 43018, Ukraine

  • Weill Cornell Medical College ( Site 0133)

    New York, New York, 10065, United States

  • West China Hospital of Sichuan University ( Site 8048)

    Chengdu, Sichuan, 610041, China

  • Western General Hospital ( Site 1912)

    Edinburgh, Midlothian, EH4 2XU, United Kingdom

  • Wits Clinical Research ( Site 9502)

    Johannesburg, Gauteng, 2193, South Africa

  • Zhongshan Hospital Affiliated to Xiamen University ( Site 8055)

    Xiamen, Fujian, 361004, China

Conditions

Explore the condition pages connected to this study.