New hope for kids with relapsed blood cancers: trial tests precision drug cocktail

NCT ID NCT05745714

Recruiting now Disease control Sponsor: Princess Maxima Center for Pediatric Oncology Source: ClinicalTrials.gov ↗

Summary

This trial is testing a new combination of targeted drugs (ruxolitinib and venetoclax) with standard chemotherapy for children and young adults whose leukemia or lymphoma has come back or not responded to prior treatment. It aims to see if this approach is safe and effective for patients whose cancer has specific genetic changes. The goal is to better control the disease and potentially prepare patients for a stem cell transplant.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Bristol Royal Hospital for Children
NOT_YET_RECRUITING

Bristol, B52 8BJ, United Kingdom

Contact Email: •••••@•••••
CHRU Lille - Hôpital Jeanne de Flandre
NOT_YET_RECRUITING

Lille, 59037, France

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CHU Nantes Hôpital Mère-Enfant
NOT_YET_RECRUITING

Nantes, 44093, France

Contact Email: •••••@•••••
Centre Léon Bérard
NOT_YET_RECRUITING

Lyon, 69 373, France

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Charité Universitätsmedizin Berlin
RECRUITING

Berlin, 13353, Germany

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Fondazione MBBM c/o Centro ML Verga
NOT_YET_RECRUITING

Monza, 20900, Italy

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Great North Children's Hospital
NOT_YET_RECRUITING

Newcastle, NE1 4LP, United Kingdom

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Great Ormond Street Hospital for Children NHS Trust
NOT_YET_RECRUITING

London, WC1N 2BH, United Kingdom

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Helsinki University Hospital, New Children's Hospital
NOT_YET_RECRUITING

Helsinki, FI00029, Finland

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Hopital La Timone - Enfants
NOT_YET_RECRUITING

Marseille, 13005, France

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Hospital Infantil Universitario Niño Jesús
NOT_YET_RECRUITING

Madrid, 28009, Spain

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Hospital Sant Joan de Déu de Barcelona
NOT_YET_RECRUITING

Barcelona, 08950, Spain

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Hôpital Robert Debré
NOT_YET_RECRUITING

Paris, 75019, France

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Hôpital des Enfants GH Pellegrin - CHU de Bordeaux
NOT_YET_RECRUITING

Bordeaux, 33076, France

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IRCCS Istituto Giannina Gaslini
NOT_YET_RECRUITING

Genova, 16147, Italy

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Karolinska university hospital
RECRUITING

Stockholm, 171 76, Sweden

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La Fe
NOT_YET_RECRUITING

Valencia, 46026, Spain

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Oslo University Hospital
NOT_YET_RECRUITING

Oslo, 0373, Norway

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Ospedale Infantile Regina Margherita
NOT_YET_RECRUITING

Turin, 10126, Italy

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Ospedale Pediatrico Bambino Gesù, IRCCS
NOT_YET_RECRUITING

Roma, 0165, Italy

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Our Lady's Hospital for Sick Children
NOT_YET_RECRUITING

Dublin, D12N512, Ireland

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Padova Azienda Ospedaliera
NOT_YET_RECRUITING

Padua, 35128, Italy

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Princess Máxima Center for Pediatric Oncology
NOT_YET_RECRUITING

Utrecht, Utrecht, 3584CS, Netherlands

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Rigshospitalet Copenhagen
RECRUITING

Copenhagen, DK-2100, Denmark

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Royal Marsden NHS Trust
NOT_YET_RECRUITING

Sutton, SM2 5PT, United Kingdom

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Schneider's Children's Medical Center
NOT_YET_RECRUITING

Petah Tikva, 4920235, Israel

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Sheba Medical Center Hospital
NOT_YET_RECRUITING

Ramat Gan, 52621, Israel

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St. Anna Kinderspital
NOT_YET_RECRUITING

Vienna, 1090, Austria

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Universitair Ziekenhuis Gent
NOT_YET_RECRUITING

Ghent, 9000, Belgium

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Universitätsklinikum Augsburg
NOT_YET_RECRUITING

Augsburg, 86156, Germany

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Universitätsklinikum Essen
NOT_YET_RECRUITING

Essen, 45147, Germany

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Universitätsklinikum Frankfurt
NOT_YET_RECRUITING

Frankfurt, 60590, Germany

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Universitätsklinikum Münster
NOT_YET_RECRUITING

Münster, 48149, Germany

Contact Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

ACUTE LYMPHOBLASTIC LEUKEMIA, IN RELAPSE LYMPHOBLASTIC LYMPHOMA (PRECURSOR B-LYMPHOBLASTIC LYMPHOMA/LEUKAEMIA) RECURRENT LYMPHOBLASTIC LYMPHOMA (PRECURSOR B-LYMPHOBLASTIC LYMPHOMA/LEUKAEMIA) REFRACTORY LYMPHOBLASTIC LYMPHOMA (PRECURSOR T-LYMPHOBLASTIC LYMPHOMA/LEUKAEMIA) RECURRENT LYMPHOBLASTIC LYMPHOMA (PRECURSOR T-LYMPHOBLASTIC LYMPHOMA/LEUKAEMIA) REFRACTORY