New blood cancer combo aims to outperform standard treatment

NCT ID NCT06073821

Summary

This study tests whether a new two-drug combination (sonrotoclax plus zanubrutinib) works better than the current standard treatment (venetoclax plus obinutuzumab) for people newly diagnosed with chronic lymphocytic leukemia (CLL), a type of blood cancer. About 652 participants worldwide will be randomly assigned to receive one of the two treatment combinations. The main goal is to see which treatment helps patients live longer without their cancer getting worse.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Affiliated Hospital of Nantong University

    Nantong, Jiangsu, 201203, China

  • Aichi Cancer Center Hospital Clinical Oncology

    Nagoya, Aichi-ken, 464-8681, Japan

  • Aiiku Hospital

    Sapporo, Hokkaido, 064-0804, Japan

  • Alaska Oncology and Hematology, Llc

    Anchorage, Alaska, 99508-2974, United States

  • Albert Schweitzer Ziekenhuis

    Dordrecht, 3318 AT, Netherlands

  • Amsterdam Umc Vu Mc

    Amsterdam, 1081 HV, Netherlands

  • Ankara University Medical Faculty

    Ankara, 06620, Turkey (Türkiye)

  • Aomori Prefectural Central Hospital

    Aomori, 030-8553, Japan

  • Aou Maggiore Della Carita

    Novara, 28100, Italy

  • Arthur Je Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • Asan Medical Center

    SongpaGu, Seoul Teugbyeolsi, 05505, South Korea

  • Assuta Ashdod Medical Center

    Ashdod, 7747629, Israel

  • Assuta Medical Center

    Tel Aviv, 60000, Israel

  • Atrium Health Levine Cancer Institute (Lci)

    Charlotte, North Carolina, 28204-2990, United States

  • Auckland City Hospital

    Auckland, 1023, New Zealand

  • Austin Health

    Heidelberg, Victoria, VIC 3084, Australia

  • Auxilio Mutuo Cancer Center

    San Juan, 00917, Puerto Rico

  • Azienda Ospedaliera Di Padova

    Padua, 35128, Italy

  • Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi

    Bologna, 40138, Italy

  • Azienda Ospedaliero Universitaria Di Ferrara

    Ferrara, 44124, Italy

  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Cabrini Hospital Malvern

    Malvern East, Victoria, VIC 3144, Australia

  • Cancercare Manitoba

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Carmel Medical Center

    Haifa, 3365409, Israel

  • Centralny Szpital Kliniczny Uck Wum

    Warsaw, 02-097, Poland

  • Centre Henri Becquerel

    Rouen, 76038, France

  • Centre Hospitalier Le Mans

    Le Mans, 72037, France

  • Centre Hospitalier Universitaire Nantes Hotel Dieu

    Nantes, 44000, France

  • Centre Hospitalier de Luniversite de Montreal (Chum)

    Montreal, Quebec, H2X 0C1, Canada

  • Centre Integre de Sante Et de Services Sociaux de La Monteregie Centre

    Greenfield Park, Quebec, J4V 2H1, Canada

  • Centre Leon Berard

    Lyon, 69373, France

  • Centre de Lutte Contre Le Cancer Institut Bergonie

    Bordeaux, 33000, France

  • Centro Gaucho Integrado de Oncologia Hospital Mae de Deus

    Porto Alegre, 90110-270, Brazil

  • Centrum Fur Haematologie Und Onkologie Bethanien

    Frankfurt am Main, 60389, Germany

  • Chao Family Comprehensive Cancer Center

    Orange, California, 92868-3201, United States

  • Chiba Cancer Center

    Chiba, Chiba, 260-8717, Japan

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing Municipality, 400030, China

  • Christchurch Hospital

    Christchurch, 8011, New Zealand

  • Chu Clermont Ferrand Therapie Cellulaire and Hematolo

    Clermontferrand, 63100, France

  • Chu Lille

    Lille, 59037, France

  • Chu Nancy Hopital Brabois

    VandoeuvrelesNancy, 54511, France

  • Chu Rennes

    Rennes Cedes, 35000, France

  • Chu Tours Hopital Bretonneau

    Tours, 37000, France

  • Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)

    Québec, G1J 1Z4, Canada

  • City of Hope National Medical Center

    Duarte, California, 91010-3012, United States

  • Ciusss de Lestrie Chus

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195-0001, United States

  • Clinical Research Alliance, Inc

    Westbury, New York, 11590-5119, United States

  • Clinique Louis Pasteur

    Esseylesnancy, 54270, France

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Concord Repatriation General Hospital

    Concord, New South Wales, NSW 2139, Australia

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Duke University Medical Center

    Durham, North Carolina, 27705-3976, United States

  • Dunedin Hospital

    Dunedin, 9016, New Zealand

  • Erciyes University School of Medicine

    Kayseri, 38039, Turkey (Türkiye)

  • Fakultni Nemocnice Brno

    Brno, 625 00, Czechia

  • Fakultni Nemocnice Hradec Kralove

    Hradec Králové, 500 03, Czechia

  • Fakultni Nemocnice Olomouc

    Olomouc, 77900, Czechia

  • Fakultni Nemocnice Ostrava

    Ostrava, 708 00, Czechia

  • Fakultni Nemocnice Plzen

    PLZE, 323 00, Czechia

  • Flevoziekenhuis

    Almere Stad, 1315 RA, Netherlands

  • Flinders Medical Centre

    Bedford PK, South Australia, SA 5042, Australia

  • Fort Wayne Medical Oncology and Hematology

    Fort Wayne, Indiana, 46804, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111-2434, United States

  • Franciscus Gasthuis and Vlietland

    Schiedam, 3318 JH, Netherlands

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington, 98109-4433, United States

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, 350001, China

  • Gazi University

    Ankara, 6500, Turkey (Türkiye)

  • Genesiscare North Shore

    St Leonards, New South Wales, NSW 2065, Australia

  • Gunderson Health System

    La Crosse, Wisconsin, 54601-5467, United States

  • Hadassah University Hospital Ein Kerem

    Jerusalem, 91120, Israel

  • Hagaziekenhuis

    Sgravenhage, 2545 AA, Netherlands

  • Hanusch Krankenhaus

    Vienna, 1140, Austria

  • Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular

    São Paulo, 05402-000, Brazil

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450000, China

  • Hollywood Private Hospital

    Nedlands, Western Australia, WA 6009, Australia

  • Hopital Prive Du Confluent

    Nantes, 44200, France

  • Hopital de La Pitie Salpetriere

    Paris, 75013, France

  • Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp

    Ribeirão Preto, 14051-140, Brazil

  • Hospital Erasto Gaertner

    Curitiba, 81520-060, Brazil

  • Hospital La Candelaria

    Santa Cruz de Tenerife, 38010, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Ramon Y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario de Burgos

    Burgos, 09006, Spain

  • Hospital Universitario de Gran Canaria Dr Negrin

    Las Palmas de Gran Canaria, 35010, Spain

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112-5550, United States

  • Hyogo Prefectural Amagasaki General Medical Center

    AmagasakiCity, Hyōgo, 660-8550, Japan

  • Ikazia Ziekenhuis

    Rotterdam, 3083 AN, Netherlands

  • Illinois Cancercare, Pc

    Peoria, Illinois, 61615-7822, United States

  • Institut Catala Doncologia Hospital Duran I Reynals

    L'Hospitalet de Llobregat, 8908, Spain

  • Institute of Hematology and Hospital of Blood Disease

    Tianjin, Tianjin Municipality, 300020, China

  • Instytut Hematologii I Transfuzjologii

    Warsaw, 02-776, Poland

  • Istituto Europeo Di Oncologia

    Milan, 20141, Italy

  • Jiangsu Province Hospital

    Nanjing, Jiangsu, 210029, China

  • Jieyang Peoples Hospital (Jieyang Affiliated Hospital, Sun Yat Sen University )

    Jieyang, Guangdong, 522000, China

  • Jining No1 Peoples Hospital West Branch

    Jining, Shandong, 272000, China

  • John Theurer Cancer Center Hackensack University Medical Center

    Hackensack, New Jersey, 07601-2191, United States

  • Kagoshima University Hospital

    Kagoshima, Kagoshima-ken, 890-8520, Japan

  • Kansai Medical University Hospital

    Hirakata, Osaka, 573-1191, Japan

  • Karolinska Universitetssjukhuset Solna

    Stockholm, 171 76, Sweden

  • Kent and Canterbury Hospital

    Canterbury, CT1 3NG, United Kingdom

  • Kindai University Hospital

    Sakai, Osaka, 590-0197, Japan

  • Kings College

    London, SE5 9RS, United Kingdom

  • Kocaeli Universitesi Tip Fakultesi

    Kocaeli, 41380, Turkey (Türkiye)

  • Kumamoto University Hospital

    Kumamoto, 860-8556, Japan

  • Kurashiki Central Hospital

    Kurashikishi, Okayama-ken, 710-8602, Japan

  • Lakeridge Health

    Oshawa, Ontario, L1G 2B9, Canada

  • Martini Ziekenhuis

    Groningen, 9728 NT, Netherlands

  • Md Anderson Cancer Center Madrid Spain

    Madrid, 28033, Spain

  • Meander Medisch Centrum

    Amersfoort, 3813 TZ, Netherlands

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226-1222, United States

  • Medizinische Universitatsklinik Innsbruck

    Innsbruck, 6020, Austria

  • Medstar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007-2113, United States

  • Mission Cancer and Blood

    Waukee, Iowa, 50263, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612-9496, United States

  • Monash Health

    Clayton, Victoria, VIC 3168, Australia

  • Mount Sinai Comprehensive Cancer Center

    Miami Beach, Florida, 33140-2840, United States

  • Nanfang Hospital of Southern Medical University

    Guangzhou, Guangdong, 510515, China

  • Nanyang Central Hospital

    Nanyang, Henan, 473000, China

  • National Cancer Center (Korea)

    IlsandongGu GoyangSi, Gyeonggi-do, 10408, South Korea

  • National Cancer Center Hospital

    ChuoKu, Tokyo, 104-0045, Japan

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192, Japan

  • Nho Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280, Japan

  • Niigata University Medical and Dental Hospital

    Niigata, Niigata, 951-8520, Japan

  • Noordwest Ziekenhuisgroep

    Alkmaar, 1815 JD, Netherlands

  • Norfolk and Norwich University Hospitals Nhs Foundation Trust

    Norwich, NR4 7UY, United Kingdom

  • North Shore Hospital

    Auckland, 0622, New Zealand

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Norton Cancer Institute Pavilion

    Louisville, Kentucky, 40207-4700, United States

  • Ochsner Clinic Foundation

    New Orleans, Louisiana, 70121-2429, United States

  • Oncology Associates of Oregon Willamette Valley Cancer Center

    Eugene, Oregon, 97401, United States

  • Osaka Metropolitan University Hospital

    Osaka, 545-8586, Japan

  • Ospedale Santa Maria Della Misericordia

    Perugia, 6129, Italy

  • Oxford University Hospitals Nhs Trust Churchill Hospital

    Headington, OX3 7LE, United Kingdom

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 100000, China

  • Pindara Private Hospital

    Benowa, Queensland, QLD 4217, Australia

  • Praxis Am Volkspark

    Berlin, 10715, Germany

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, QLD 4102, Australia

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • Royal Marsden Nhs Foundation Royal Marsden Hospital

    Sutton, SM2 5PT, United Kingdom

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08901-1914, United States

  • Scri Tennessee Oncology Chattanooga

    Chattanooga, Tennessee, 37404-1130, United States

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea

  • Shaare Zedek Medical Center

    Jerusalem, 9103102, Israel

  • Shandong Provincial Hospital

    Jinan, Shandong, 250021, China

  • Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital

    Chengdu, Sichuan, 610071, China

  • Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

    São Paulo, 05652-900, Brazil

  • Southampton General Hospital

    Southampton, SO16 6YD, United Kingdom

  • Southeastern Regional Medical Center

    Newnan, Georgia, 30265-8001, United States

  • St Jamess University Hospital

    Leeds, LS9 7TF, United Kingdom

  • St Vincents Hospital Melbourne

    Fitzroy, Victoria, VIC 3065, Australia

  • Stanford Medicine

    Palo Alto, California, 94304-2205, United States

  • Sunshine Coast Hospital and Health Service

    Birtinya, Queensland, QLD 4575, Australia

  • Tauranga Hospital

    Tauranga, 3112, New Zealand

  • The Affiliated Hospital of Xuzhou Medical University

    Xuzhou, Jiangsu, 221000, China

  • The Alfred Hospital

    Melbourne, Victoria, VIC 3004, Australia

  • The Catholic University of Korea, Seoul St Marys Hospital

    SeochoGu, Seoul Teugbyeolsi, 06591, South Korea

  • The Clatterbridge Cancer Centre Liverpool

    Liverpool, L7 8YA, United Kingdom

  • The First Affiliated Hospital of Anhui Medical University

    Hefei, Anhui, 230000, China

  • The First Affiliated Hospital of Guangxi Medical University

    Nanning, Guangxi, 530021, China

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, 325000, China

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310003, China

  • The First Hospital of China Medical University

    Shenyang, Liaoning, 110001, China

  • The First Peoples Hospital of Changzhou

    Changzhou, Jiangsu, 213000, China

  • The James Cancer Hospital and Solove Research Institute At Ohio State University

    Columbus, Ohio, 43210-1240, United States

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006, China

  • The Second Affiliated Hospital of Xian Jiaotong University

    Xi'an, Shaanxi, 710004, China

  • The University of Kansas Cancer Center

    Westwood, Kansas, 66205-2003, United States

  • Tohoku University Hospital

    Sendai, Miyagi, 980-8574, Japan

  • Tokai University Hospital

    Iseharashi, Kanagawa, 259-1193, Japan

  • Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, 430030, China

  • UCLA Department of Medicine Hematologyoncology

    Los Angeles, California, 90095-3075, United States

  • Unesp Faculdade de Medicina Da Universidade Estadual Paulista Campus Botucatu

    Botucatu, 18618687, Brazil

  • Unite de Recherche Clinique Du Cisss Des Laurentides

    SaintJerome, Quebec, J7Z 5T3, Canada

  • Universitaetsklinikum Schleswig Holstein Campus Luebeck

    Lübeck, 23538, Germany

  • Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg

    Salzburg, 5020, Austria

  • University College Hospital

    London, NW1 2PG, United Kingdom

  • University Hospitals Dorset Royal Bournemouth Hospital

    Bournemouth, BH7 7DW, United Kingdom

  • University of California San Diego (Ucsd) Moores Cancer Center

    La Jolla, California, 92093-1503, United States

  • University of Colorado Cancer Center

    Aurora, Colorado, 80045-2517, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242-1009, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455-0341, United States

  • University of North Carolina At Chapel Hill

    Chapel Hill, North Carolina, 27514-4220, United States

  • Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu

    Wroclaw, 50-367, Poland

  • Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie

    Lublin, 20-090, Poland

  • Uniwersytecki Szpital Kliniczny W Poznaniu

    Poznan, 61-131, Poland

  • Valkyrie Clinical Trials

    Los Angeles, California, 90067-2011, United States

  • Vcu Health Systemmassey Comprehensive Cancer Center

    Richmond, Virginia, 23298-5004, United States

  • Virginia Cancer Institute

    Richmond, Virginia, 23229-8605, United States

  • Vseobecna Fakultni Nemocnice V Praze

    Prague, 10000, Czechia

  • Washington University School of Medicine

    St Louis, Missouri, 63110-1010, United States

  • Wellington Regional Hospital (Ccdhb)

    Wellington, 6021, New Zealand

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041, China

  • Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi

    Lodz, 93-513, Poland

  • Yamagata University Hospital

    Yamagata, Yamagata, 990-9585, Japan

  • Yantai Yuhuangding Hospital

    Yantai, Shandong, 264000, China

  • Yichang Central Peoples Hospitaljiangnan Branch

    Yichang, Hubei, 443001, China

  • Yokohama Municipal Citizens Hospital

    Yokohama, 221-0855, Japan

Conditions

Explore the condition pages connected to this study.