New Two-Pronged cancer therapy aims to outsmart relapsed lymphoma

NCT ID NCT07188558

Recruiting now Disease control Sponsor: Lyell Immunopharma, Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing a new, experimental CAR T-cell therapy called ronde-cel against currently approved CAR T-cell therapies for patients with aggressive large B-cell lymphoma that has returned or not responded to initial chemotherapy. The new therapy is designed to target two markers (CD19 and CD20) on cancer cells instead of one, which researchers hope will make it more effective and longer-lasting. About 400 participants will be randomly assigned to receive either the new dual-targeting therapy or one of the current standard CAR T-cell treatments.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AdventHealth
NOT_YET_RECRUITING

Orlando, Florida, 32804, United States
Allegheny Health Network
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Atrium Health Wake Forest Baptist Comprehensive Cancer Center
NOT_YET_RECRUITING

Winston-Salem, North Carolina, 27157, United States
Banner MD Anderson Cancer Center
NOT_YET_RECRUITING

Gilbert, Arizona, 85234, United States
Cedars-Sinai Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90048, United States
Cleveland Clinical Taussig Cancer Center
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Corewell Health
NOT_YET_RECRUITING

Grand Rapids, Michigan, 49503, United States
Duke Cancer Institute
NOT_YET_RECRUITING

Durham, North Carolina, 27705, United States
Hackensack
NOT_YET_RECRUITING

Hackensack, New Jersey, 07601, United States
Honor Health
NOT_YET_RECRUITING

Scottsdale, Arizona, 85258, United States
Intermountain Healthcare
RECRUITING

Salt Lake City, Utah, 84143, United States
MD Anderson Cancer Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Mayo Clinic Arizona
NOT_YET_RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic Florida
NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
NOT_YET_RECRUITING

Rochester, Minnesota, 55905, United States
MedStar Georgetown University Hospital
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Moffitt Cancer Center
NOT_YET_RECRUITING

Tampa, Florida, 33612, United States
Northside Hospital
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30342, United States
Northwestern
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Oncology Hematology Care Clinical Trials
NOT_YET_RECRUITING

Cincinnati, Ohio, 45242, United States
Roswell Park Comprehensive Cancer Center
NOT_YET_RECRUITING

Buffalo, New York, 14263, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
St. David's South Austin Medical Center
RECRUITING

Austin, Texas, 78704, United States
Swedish Cancer Institute
NOT_YET_RECRUITING

Seattle, Washington, 98104, United States
Texas Transplant Institute
RECRUITING

San Antonio, Texas, 78229, United States
University of Arkansas
NOT_YET_RECRUITING

Little Rock, Arkansas, 72205, United States
University of California, Irvine
NOT_YET_RECRUITING

Orange, California, 92868, United States
University of California, Los Angeles (UCLA)
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
University of Chicago
NOT_YET_RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati
NOT_YET_RECRUITING

Cincinnati, Ohio, 45267, United States
University of Colorado
NOT_YET_RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa
NOT_YET_RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center
NOT_YET_RECRUITING

Westwood, Kansas, 66205, United States
University of Kentucky
NOT_YET_RECRUITING

Lexington, Kentucky, 40536, United States
University of Louisville Health
NOT_YET_RECRUITING

Louisville, Kentucky, 40202, United States
University of Nebraska Medical Center (UNMC)
NOT_YET_RECRUITING

Omaha, Nebraska, 68105, United States
University of Texas Southwestern Medical Center
NOT_YET_RECRUITING

Fort Worth, Texas, 76104, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States

Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B CELL LYMPHOMA (DLBCL) DIFFUSE LARGE B CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B CELL LYMPHOMA RELAPSED LARGE B-CELL LYMPHOMA LYMPHOMA, B-CELL NON-HODGKIN LYMPHOMA NON-HODGKIN LYMPHOMA REFRACTORY/ RELAPSED REFRACTORY NON-HODGKIN LYMPHOMA RELAPSED NON HODGKIN LYMPHOMA