New 'Immune Mobilizer' drug enters human trials for Tough-to-Treat cancers

NCT ID NCT04262466

Summary

This study is testing a new type of cancer drug called brenetafusp (IMC-F106C) in adults with advanced solid tumors that have a specific marker called PRAME. The first part of the study aims to find a safe and effective dose, and the second part will see how well the drug works to control the cancer. Participants must have a specific genetic tissue type (HLA-A*02:01) and have cancer that has not responded well to standard treatments.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Abramson Cancer Center of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Angeles Clinic and Research Institute

    Los Angeles, California, 90025, United States

  • CHU de Liege

    Liège, Luik, 4000, Belgium

  • CHUM Centre de Recherche

    Montreal, Quebec, H2X 0A9, Canada

  • Centre Hospitalier Universitaire Vaudois Lausanne

    Lausanne, Switzerland

  • Centrum Medyczne Pratia Poznan - Skorzewo

    Skórzewo, 60-185, Poland

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • D'Or Institute for Research and Education

    Rio de Janeiro, Brazil

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di Medicina Interna e Scienze Mediche

    Rome, Roma, 00168, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Patologia Ostetrica e Ginecologica

    Seriate, Roma, 00168, Italy

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20057, United States

  • Gustave Roussy (Institut de Cancerologie Gustave-Roussy)

    Villejuif, Val De Marne, 94805, France

  • Guy's and St Thomas' NHS Foundation Trust

    London, United Kingdom

  • Hopital Saint-Louis - Centre d'Onco-Dermatologie

    Paris, 75010, France

  • Hospital Duran i Reynals

    Barcelona, 08908, Spain

  • Hospital Israelita Albert Einstein

    São Paulo, Brazil

  • Hospital Nossa Senhora da Conceicao

    Porto Alegre, 91350-200, Brazil

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Hospital Universitario Vall dHebron

    Barcelona, 08035, Spain

  • Houston Lee Moffitt Cancer Center & Research Institute

    Tampa, Florida, 33612, United States

  • Institut Bergonie - Nouvelle-Aquitaine

    Bordeaux, Gironde, France

  • Institut Curie

    Paris, France

  • Institut Jules Bordet

    Brussels, 1070, Belgium

  • Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale

    Naples, 80131, Italy

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • LKH - Universitätsklinikum der PMU Salzburg

    Salzburg, 5020, Austria

  • Leiden UMC

    Leiden, ZA, 2333, Netherlands

  • Linear Clinical Research

    Nedlands, Western Australia, 6009, Australia

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Melanoma Institute Australia (MIA) - The Poche Centre

    Wollstonecraft, New South Wales, 2065, Australia

  • Memorial Sloan Kettering

    New York, New York, 10065, United States

  • NEXT Barcelona

    Barcelona, 08023, Spain

  • Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

    Warsaw, 02-781, Poland

  • National Cancer Institute

    Rio de Janeiro, Brazil

  • Netherlands Cancer Institute

    Amsterdam, CX, 1066, Netherlands

  • New Zealand Clinical Research-Auckland

    Auckland, 92697, New Zealand

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2C4, Canada

  • Prisma Health

    Greenville, South Carolina, 92697, United States

  • Royal Marsden Hospital

    Surrey Quays, SM25PT, United Kingdom

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Sarah Cannon Research Institute UK

    London, City of London, W1G6AD, United Kingdom

  • Scientia Clinical Research

    Randwick, New South Wales, 2031, Australia

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • St Vincents University Hospital

    Dublin, Ireland

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The Beatson West of Scotland Cancer Centre

    Glasgow, Scotland, G12 0YN, United Kingdom

  • The Christie NHS Foundation Trust

    Manchester, United Kingdom

  • The University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • UMC Groningen Comprehensive Cancer Center

    Groningen, GZ, 9713, Netherlands

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • UZ Leuven

    Leuven, 3000, Belgium

  • UZA

    Edegem, 2650, Belgium

  • Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Madrid

    Madrid, 28022, Spain

  • Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Pamplona

    Pamplona, Navarre, 31008, Spain

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitair Ziekenhuis Brussel

    Jette, Brussels Capital, 1090, Belgium

  • Universitair Ziekenhuis Gent

    Ghent, 9000, Belgium

  • Universite Claude Bernard Lyon Est

    Lyon, Villeurbanne, 69100, France

  • University College Hospital London

    London, W1T7HA, United Kingdom

  • University Hospital of Zurich

    Zurich, 8058, Switzerland

  • University Hospital, Basel Switzerland

    Basel, 4031, Switzerland

  • University of California - San Diego

    La Jolla, California, 92093, United States

  • University of California Davis Comprehensive Center

    Sacramento, California, 95817, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Liverpool

    Liverpool, L69 3BX, United Kingdom

  • University of Oklahoma Peggy and Charles Stephenson Cancer Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Oxford

    Oxford, Oxfordshire, OX3 7LI, United Kingdom

  • University of Ulsan College of Medicine

    Seoul, 05505, South Korea

  • University of Utah - Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • University of Washington - Fred Hutchinson Cancer Center

    Seattle, Washington, 98109, United States

  • University of Wisconsin

    Madison, Wisconsin, 53705, United States

  • Yonsei University College of Medicine

    Seoul, 03722, South Korea

Conditions

Explore the condition pages connected to this study.