New 'Immune Mobilizer' drug enters human trials for Tough-to-Treat cancers
NCT ID NCT04262466
Summary
This study is testing a new type of cancer drug called brenetafusp (IMC-F106C) in adults with advanced solid tumors that have a specific marker called PRAME. The first part of the study aims to find a safe and effective dose, and the second part will see how well the drug works to control the cancer. Participants must have a specific genetic tissue type (HLA-A*02:01) and have cancer that has not responded well to standard treatments.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Angeles Clinic and Research Institute
Los Angeles, California, 90025, United States
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CHU de Liege
Liège, Luik, 4000, Belgium
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CHUM Centre de Recherche
Montreal, Quebec, H2X 0A9, Canada
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Centre Hospitalier Universitaire Vaudois Lausanne
Lausanne, Switzerland
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Centrum Medyczne Pratia Poznan - Skorzewo
Skórzewo, 60-185, Poland
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Columbia University Medical Center
New York, New York, 10032, United States
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D'Or Institute for Research and Education
Rio de Janeiro, Brazil
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di Medicina Interna e Scienze Mediche
Rome, Roma, 00168, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Patologia Ostetrica e Ginecologica
Seriate, Roma, 00168, Italy
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Georgetown University Medical Center
Washington D.C., District of Columbia, 20057, United States
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Gustave Roussy (Institut de Cancerologie Gustave-Roussy)
Villejuif, Val De Marne, 94805, France
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Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
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Hopital Saint-Louis - Centre d'Onco-Dermatologie
Paris, 75010, France
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Hospital Duran i Reynals
Barcelona, 08908, Spain
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Hospital Israelita Albert Einstein
São Paulo, Brazil
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Hospital Nossa Senhora da Conceicao
Porto Alegre, 91350-200, Brazil
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario Vall dHebron
Barcelona, 08035, Spain
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Houston Lee Moffitt Cancer Center & Research Institute
Tampa, Florida, 33612, United States
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Institut Bergonie - Nouvelle-Aquitaine
Bordeaux, Gironde, France
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Institut Curie
Paris, France
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Institut Jules Bordet
Brussels, 1070, Belgium
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Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale
Naples, 80131, Italy
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John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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LKH - Universitätsklinikum der PMU Salzburg
Salzburg, 5020, Austria
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Leiden UMC
Leiden, ZA, 2333, Netherlands
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Linear Clinical Research
Nedlands, Western Australia, 6009, Australia
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Melanoma Institute Australia (MIA) - The Poche Centre
Wollstonecraft, New South Wales, 2065, Australia
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Memorial Sloan Kettering
New York, New York, 10065, United States
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NEXT Barcelona
Barcelona, 08023, Spain
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Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
Warsaw, 02-781, Poland
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National Cancer Institute
Rio de Janeiro, Brazil
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Netherlands Cancer Institute
Amsterdam, CX, 1066, Netherlands
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New Zealand Clinical Research-Auckland
Auckland, 92697, New Zealand
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2C4, Canada
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Prisma Health
Greenville, South Carolina, 92697, United States
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Royal Marsden Hospital
Surrey Quays, SM25PT, United Kingdom
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Samsung Medical Center
Seoul, 06351, South Korea
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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Sarah Cannon Research Institute UK
London, City of London, W1G6AD, United Kingdom
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Scientia Clinical Research
Randwick, New South Wales, 2031, Australia
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Seoul National University Hospital
Seoul, 03080, South Korea
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St Vincents University Hospital
Dublin, Ireland
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The Alfred Hospital
Melbourne, Victoria, 3004, Australia
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The Beatson West of Scotland Cancer Centre
Glasgow, Scotland, G12 0YN, United Kingdom
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The Christie NHS Foundation Trust
Manchester, United Kingdom
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The University of Chicago Medical Center
Chicago, Illinois, 60637, United States
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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UMC Groningen Comprehensive Cancer Center
Groningen, GZ, 9713, Netherlands
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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UZ Leuven
Leuven, 3000, Belgium
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UZA
Edegem, 2650, Belgium
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Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Madrid
Madrid, 28022, Spain
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Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Pamplona
Pamplona, Navarre, 31008, Spain
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Universitaetsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitair Ziekenhuis Brussel
Jette, Brussels Capital, 1090, Belgium
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Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
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Universite Claude Bernard Lyon Est
Lyon, Villeurbanne, 69100, France
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University College Hospital London
London, W1T7HA, United Kingdom
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University Hospital of Zurich
Zurich, 8058, Switzerland
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University Hospital, Basel Switzerland
Basel, 4031, Switzerland
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University of California - San Diego
La Jolla, California, 92093, United States
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University of California Davis Comprehensive Center
Sacramento, California, 95817, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Liverpool
Liverpool, L69 3BX, United Kingdom
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University of Oklahoma Peggy and Charles Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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University of Oxford
Oxford, Oxfordshire, OX3 7LI, United Kingdom
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University of Ulsan College of Medicine
Seoul, 05505, South Korea
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University of Utah - Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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University of Washington - Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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University of Wisconsin
Madison, Wisconsin, 53705, United States
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Yonsei University College of Medicine
Seoul, 03722, South Korea
Conditions
Explore the condition pages connected to this study.