First human tests begin for promising targeted cancer therapy

NCT ID NCT05067283

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

Summary

This early-stage study is testing a new drug called MK-1084 (calderasib) in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find safe doses and see how the body processes the drug, both when given alone and combined with other cancer treatments. Researchers will also look for early signs that the drug helps shrink tumors.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ankara City Hospital-oncology ( Site 0233)
RECRUITING

Ankara, 6800, Turkey (Türkiye)

Contact Phone: •••-•••-••••
Beijing Friendship Hospital Affiliate of Capital University-Oncology ( Site 0417)
RECRUITING

Beijing, Beijing Municipality, 100050, China

Contact Phone: •••-•••-••••
Bradfordhill ( Site 0042)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile

Contact Phone: •••-•••-••••
Cancer Institute Hospital of JFCR ( Site 0400)
RECRUITING

Koto, Tokyo, 135-8550, Japan

Contact Phone: •••-•••-••••
Cantonal Hospital St.Gallen ( Site 0224)
RECRUITING

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

Contact Phone: •••-•••-••••
Centro Hemato Oncológico Paitilla ( Site 0163)
COMPLETED

Panama City, 0832-00752, Panama
Centro Oncologico de Panama ( Site 0160)
RECRUITING

Panama City, 082410, Panama

Contact Phone: •••-•••-••••
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 0041)
RECRUITING

Santiago, Region M. de Santiago, 7500653, Chile

Contact Phone: •••-•••-••••
Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 0445)
RECRUITING

Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan

Contact Phone: •••-•••-••••
Chris O'Brien Lifehouse ( Site 0002)
RECRUITING

Camperdown, New South Wales, 2050, Australia

Contact Phone: •••-•••-••••
Clinica Universidad de Navarra ( Site 0213)
RECRUITING

Madrid, Madrid, Comunidad de, 28027, Spain

Contact Phone: •••-•••-••••
Communal Non-Commercial Enterprise Prykarpatski Clinical Onc-Chemotherapy department ( Site 0251)
RECRUITING

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine

Contact Phone: •••-•••-••••
Cross Cancer Institute ( Site 0033)
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada

Contact Phone: •••-•••-••••
Ege University Medicine of Faculty ( Site 0231)
COMPLETED

Bornova, İzmir, 35100, Turkey (Türkiye)
Erciyes University ( Site 0232)
COMPLETED

Talas, Kayseri, 38039, Turkey (Türkiye)
FALP-UIDO ( Site 0040)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile

Contact Phone: •••-•••-••••
Fujian Cancer Hospital ( Site 0419)
RECRUITING

Fuzhou, Fujian, 350014, China

Contact Phone: •••-•••-••••
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0438)
RECRUITING

La Rioja, F5300COE, Argentina

Contact Phone: •••-•••-••••
Hacettepe Universite Hastaneleri-oncology hospital ( Site 0234)
RECRUITING

Ankara, 06230, Turkey (Türkiye)

Contact Phone: •••-•••-••••
Hadassah Medical Center-Oncology ( Site 0094)
RECRUITING

Jerusalem, 9112001, Israel

Contact Phone: •••-•••-••••
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0030)
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada

Contact Phone: •••-•••-••••
Hospital Universitari Vall d'Hebron-Oncology ( Site 0212)
RECRUITING

Barcelona, 08035, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Fundación Jiménez Díaz-START Madrid-FJD ( Site 0211)
RECRUITING

Madrid, Madrid, Comunidad de, 28040, Spain

Contact Phone: •••-•••-••••
Hospital of Lithuanian University of Health Sciences Kauno klinikos ( Site 0121)
RECRUITING

Kaunas, Kaunas County, 45433, Lithuania

Contact Phone: •••-•••-••••
Humanitas ( Site 0113)
RECRUITING

Rozzano, Lombardy, 20089, Italy

Contact Phone: •••-•••-••••
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0110)
RECRUITING

Napoli, 80131, Italy

Contact Phone: •••-•••-••••
James Lind Centro de Investigacion del Cancer ( Site 0043)
COMPLETED

Temuco, Región de la Araucanía, 4800827, Chile
Jilin Cancer Hospital-oncology department ( Site 0412)
COMPLETED

Changchun, Jilin, 132000, China
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0260)
RECRUITING

Hackensack, New Jersey, 07601, United States

Contact Phone: •••-•••-••••
Kanagawa Cancer Center ( Site 0402)
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan

Contact Phone: •••-•••-••••
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0036)
RECRUITING

Kingston, Ontario, K7L 2V7, Canada

Contact Phone: •••-•••-••••
Laura and Isaac Perlmutter Cancer Center ( Site 0270)
COMPLETED

New York, New York, 10016, United States
Liverpool Hospital-Medical Oncology ( Site 0001)
RECRUITING

Liverpool, New South Wales, 2170, Australia

Contact Phone: •••-•••-••••
ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 0259)
RECRUITING

Rivne, Rivne Oblast, 33010, Ukraine

Contact Phone: •••-•••-••••
MEDICAL COLLEGE OF WISCONSIN-Cancer Center Clinical Trials Office ( Site 0262)
RECRUITING

Milwaukee, Wisconsin, 53226, United States

Contact Phone: •••-•••-••••
MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 0254)
RECRUITING

Cherkasy, Cherkasy Oblast, 18009, Ukraine

Contact Phone: •••-•••-••••
Meir Medical Center. ( Site 0091)
RECRUITING

Kfar Saba, 4428164, Israel

Contact Phone: •••-•••-••••
Moffitt Cancer Center ( Site 0261)
RECRUITING

Tampa, Florida, 33612, United States

Contact Phone: •••-•••-••••
Monash Health-Oncology Research ( Site 0003)
RECRUITING

Clayton, Victoria, 3168, Australia

Contact Phone: •••-•••-••••
NEXT Virginia ( Site 0271)
RECRUITING

Fairfax, Virginia, 22031, United States

Contact Phone: •••-•••-••••
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Oddzial Badan Wczesnych Faz ( Site 0170)
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland

Contact Phone: •••-•••-••••
National Cancer Center Hospital ( Site 0403)
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan

Contact Phone: •••-•••-••••
National Cancer Center Hospital East ( Site 0404)
RECRUITING

Kashiwa, Chiba, 277-8577, Japan

Contact Phone: •••-•••-••••
National Cheng Kung University Hospital ( Site 0444)
RECRUITING

Tainan, 704, Taiwan

Contact Phone: •••-•••-••••
National Taiwan University Hospital-Oncology ( Site 0443)
RECRUITING

Taipei, 10002, Taiwan

Contact Phone: •••-•••-••••
New Zealand Clinical Research (Christchurch) ( Site 0004)
COMPLETED

Christchurch, Canterbury, 8011, New Zealand
Oddzial Onkologii Klinicznej z Pododdzialem Chemioterapii Jednodniowej ( Site 0173)
RECRUITING

Koszalin, West Pomeranian Voivodeship, 75-581, Poland

Contact Phone: •••-•••-••••
Odense Universitetshospital-Department of oncology ( Site 0421)
RECRUITING

Odense, Region Syddanmark, 5000, Denmark

Contact Phone: •••-•••-••••
Ospedale Regionale Bellinzona e Valli ( Site 0220)
RECRUITING

Bellinzona, Canton Ticino, 6500, Switzerland

Contact Phone: •••-•••-••••
Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0032)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

Contact Phone: •••-•••-••••
Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 0255)
RECRUITING

Kropyvnytskyi, Kirovohrad Oblast, 25006, Ukraine

Contact Phone: •••-•••-••••
Rambam Health Care Campus-Oncology ( Site 0090)
RECRUITING

Haifa, 3109601, Israel

Contact Phone: •••-•••-••••
Rivne Regional Clinical Hospital ( Site 0257)
COMPLETED

Rivne, Rivne Oblast, 33007, Ukraine
START Midwest ( Site 0267)
RECRUITING

Grand Rapids, Michigan, 49546, United States

Contact Phone: •••-•••-••••
Samsung Medical Center-Division of Hematology/Oncology ( Site 0193)
RECRUITING

Seoul, 06351, South Korea

Contact Phone: •••-•••-••••
Sarawak General Hospital ( Site 0453)
RECRUITING

Kuching, Sarawak, 93586, Malaysia

Contact Phone: •••-•••-••••
Seoul National University Hospital ( Site 0191)
RECRUITING

Seoul, 03080, South Korea

Contact Phone: •••-•••-••••
Shaare Zedek Medical Center-Oncology ( Site 0092)
RECRUITING

Jerusalem, 9103102, Israel

Contact Phone: •••-•••-••••
Shanghai Chest Hospital-Oncology department ( Site 0410)
RECRUITING

Shanghai, Shanghai Municipality, 200030, China

Contact Phone: •••-•••-••••
Shanghai East Hospital ( Site 0416)
RECRUITING

Shanghai, Shanghai Municipality, 200120, China

Contact Phone: •••-•••-••••
Sheba Medical Center-ONCOLOGY ( Site 0093)
RECRUITING

Ramat Gan, 5265601, Israel

Contact Phone: •••-•••-••••
Shizuoka Cancer Center ( Site 0401)
RECRUITING

Nakatogari, Shizuoka, 411-8777, Japan

Contact Phone: •••-•••-••••
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 0413)
RECRUITING

Guangzhou, Guangdong, 510515, China

Contact Phone: •••-•••-••••
Sun Yat-sen University Cancer Center-Internal medicine ( Site 0415)
RECRUITING

Guangzhou, Guangdong, 511400, China

Contact Phone: •••-•••-••••
The Moncton Hospital ( Site 0037)
RECRUITING

Moncton, New Brunswick, E1C 6Z8, Canada

Contact Phone: •••-•••-••••
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0418)
RECRUITING

Wuhan, Hubei, 430048, China

Contact Phone: •••-•••-••••
Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 0172)
RECRUITING

Poznan, Greater Poland Voivodeship, 60-569, Poland

Contact Phone: •••-•••-••••
Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 0171)
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-952, Poland

Contact Phone: •••-•••-••••
Uzhhorod Multispecialty City Clinical Hospital ( Site 0258)
RECRUITING

Uzhhorod, Zakarpattia Oblast, 88000, Ukraine

Contact Phone: •••-•••-••••
Vilnius University Hospital Santaros Clinics Affiliate - National Cancer Center ( Site 0120)
RECRUITING

Vilnius, LT-08406, Lithuania

Contact Phone: •••-•••-••••
Westmead Hospital ( Site 0006)
RECRUITING

Westmead, New South Wales, 2145, Australia

Contact Phone: •••-•••-••••
Zhejiang Cancer Hospital-Thoracic oncology ( Site 0411)
RECRUITING

Hangzhou, Zhejiang, 310022, China

Contact Phone: •••-•••-••••
ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 0111)
RECRUITING

Siena, Tuscany, 53100, Italy

Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.

ADVANCED SOLID TUMORS