New drug combo tested in major breast cancer trial

NCT ID NCT06435429

Recruiting now Disease control Sponsor: Jazz Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial is testing whether a new drug, zanidatamab, combined with standard chemotherapy works better than the current standard treatment (trastuzumab plus chemotherapy) for people with advanced HER2-positive breast cancer that has worsened after a specific prior therapy. It will enroll about 550 adults to compare how long the cancer is controlled and the safety of the two treatment approaches. The goal is to find a new effective option for patients who have run out of other treatments.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AP HM Hopital de La Timone
RECRUITING

Marseille, 13005, France
AZ Delta- Campus Rumbeke
RECRUITING

Roeselare, 8800, Belgium
Abramson Cancer Center of The University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Aichi Cancer Center
RECRUITING

Nagoya, 464-8681, Japan
Aretaieio Hospital
RECRUITING

Athens, 11528, Greece
Arizona Oncology Tucson - Wilmot
WITHDRAWN

Tucson, Arizona, 85711, United States
Asst Papa Giovanni Xxiii
RECRUITING

Bergamo, 24127, Italy
Athens Medical Center
RECRUITING

Athens, 15125, Greece
Azienda Ospedaliero Universitaria Di Bologna Policlinico S Orsola Malpighi Via Massarenti
RECRUITING

Bologna, 40138, Italy
Azienda Ospedaliero Universitaria di Modena
RECRUITING

Modena, 41124, Italy
BC Cancer-Vancouver Center
RECRUITING

Vancouver, V5Z 4E6, Canada
Beatson West Of Scotland Cancer Centre
RECRUITING

Glasgow, G12 0YN, United Kingdom
Białostockie Centrum Onkologii im. Marii Skłodowskiej-Curie w Białymstoku
RECRUITING

Bialystok, 15-027, Poland
Blue Ridge Cancer Care
RECRUITING

Roanoke, Virginia, 24014, United States
Box Hill Hospital
RECRUITING

Melbourne, Victoria, 3128, Australia
CHU UCL Namur - Site Sainte-Elisabeth
RECRUITING

Namur, 5000, Belgium
CHU de Québec Université Laval Hôpital du Saint Sacrement
RECRUITING

Québec, G1S 4L8, Canada
CHUVI - H.U. Alvaro Cunqueiro
RECRUITING

Vigo, 36312, Spain
Catarina Pesquisa Clinica
RECRUITING

Itajaí, 88301-220, Brazil
Centre François Baclesse
RECRUITING

Caen, 14000, France
Centre Georges François Leclerc
RECRUITING

Dijon, 21000, France
Centre Oscar Lambret
RECRUITING

Lille, 59020, France
Centro Regional Integrado de Oncologia
RECRUITING

Ceará, 60336-232, Brazil
Ceon Pesquisas Ltda
RECRUITING

São Caetano do Sul, 09541-270, Brazil
Charring Cross Hospital
RECRUITING

London, W6 8RF, United Kingdom
Chiba Cancer Center
RECRUITING

Chiba, 260-8717, Japan
Churchill Hospital
RECRUITING

Oxford, OX3 7LJ, United Kingdom
Columbia University Medical Center 161 Fort Washington
RECRUITING

New York, New York, 10032-3729, United States
DASA Hospital Brasilia
RECRUITING

Brasília, 71.635-610, Brazil
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215-5418, United States
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27710-2000, United States
European Interbalkan Medical Center
RECRUITING

Thessaloniki, 57001, Greece
Florida Cancer Specialists Research East
RECRUITING

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists Research North
RECRUITING

St. Petersburg, Florida, 33705, United States
Florida Cancer Specialists Research South
RECRUITING

Fort Myers, Florida, 33901, United States
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
Fondazione IRCCS San Gerardo dei Tintori
RECRUITING

Monza, 20900, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS
RECRUITING

Rome, 00136, Italy
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Froedtert and The Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Fukushima Medical University Hospital
RECRUITING

Fukushima, 960-1295, Japan
Gachon University Gil Medical Center
RECRUITING

Namdong-gu, 21565, South Korea
Gangnam Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 06273, South Korea
Grand Hôpital de Charleroi
RECRUITING

Gilly, 6060, Belgium
Gustave Roussy
RECRUITING

Villejuif, 94800, France
Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
HPS Pharmacies - Adelaide
RECRUITING

Adelaide, 5000, Australia
Hackensack Meridian Health
RECRUITING

Hackensack, New Jersey, 07601, United States
Helios Klinikum Berlin Buch GmbH Klinik für Gynäkologie und Geburtshilfe
RECRUITING

Berlin, 13125, Germany
Hospital Beata Maria Ana
RECRUITING

Madrid, 28007, Spain
Hospital Beneficiencia Portuguesa
RECRUITING

São Paulo, 01323-030, Brazil
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital General Universitario de Elche
RECRUITING

Elche, 03203, Spain
Hospital Nossa Senhora Da Conceição
RECRUITING

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul PUCRS
RECRUITING

Porto Alegre, 90610-001, Brazil
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario A Coruña
RECRUITING

A Coruña, 15006, Spain
Hospital Universitario Clinico San Cecilio
RECRUITING

Granada, 18016, Spain
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario de Badajoz
RECRUITING

Badajoz, 06006, Spain
Hospital Universitario de Canarias
RECRUITING

San Cristóbal de La Laguna, 38320, Spain
ICANS - Institut de cancérologie Strasbourg Europe
RECRUITING

Strasbourg, 67000, France
ICO Badalona-H.U. Germans Trias i Pujol
RECRUITING

Barcelona, 08916, Spain
IEPE Unimed Sorocaba
RECRUITING

Sorocaba, São Paulo, 18060-105, Brazil
IRCCS Centro di Riferimento Oncologico di Aviano CRO
RECRUITING

Aviano, 33081, Italy
IRCCS Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Institut Bergonie
RECRUITING

Bordeaux, 33076, France
Institut Paoli Calmettes
RECRUITING

Marseille, 13009, France
Institute Jules Bordet
RECRUITING

Anderlecht, 1070, Belgium
Irmandade Da Santa Casa de Misericordia de Porto Alegre
RECRUITING

Portalegre, 90050-170, Brazil
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Oncologico Veneto - I.R.C.C.S.
RECRUITING

Padua, 35128, Italy
Jewish General Hospital
RECRUITING

Montreal, H3T 1E2, Canada
Juntendo University Hospital
RECRUITING

Tokyo, 113-8431, Japan
Kanagawa Cancer Center
RECRUITING

Yokohama, 241-8515, Japan
Klinikum Wels-Grieskirchen GmbH - Abteilung für Innere Medizin IV
RECRUITING

Wels, 4600, Austria
Kyoto University Hospital
RECRUITING

Kyoto, 606-8507, Japan
LMU Klinikum - Apotheke
RECRUITING

München, 81377, Germany
Leicester Royal Infirmary
RECRUITING

Leicester, LE2 7LX, United Kingdom
Los Angeles Hematology Oncology Medical Group Glendale
RECRUITING

Glendale, California, 91204, United States
MD Anderson Cancer Center
RECRUITING

Madrid, 28033, Spain
Marienhospital Bottrop gGmbH
RECRUITING

Dortmund, 44263, Germany
Maryland Oncology Hematology Healing Way - USOR
RECRUITING

Irving, Texas, 75063, United States
Mayo Clinic - PPDS
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Jacksonville - PPDS
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Scottsdale - PPDS
RECRUITING

Phoenix, Arizona, 85054, United States
Medical Oncology Hematology Consultants
RECRUITING

Irving, Texas, 75063, United States
Medizinische Universitat Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Medizinische Universitat Wien
RECRUITING

Vienna, 1090, Austria
Medstar Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Memorial Sloan Kettering
RECRUITING

Long Island City, New York, 11101, United States
Messino Cancer Center
RECRUITING

Asheville, North Carolina, 28806, United States
Millennium Research and Clinical Development
WITHDRAWN

Houston, Texas, 77090, United States
Minnesota Oncology Hematology
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Nagoya City University Hospital
RECRUITING

Nagoya, 467-8602, Japan
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy w Warszawie
RECRUITING

Warsaw, 02-781, Poland
National Cancer Center Hospital
RECRUITING

Chūōku, 104-0045, Japan
National Hospital Organization Hokkaido Cancer Center
RECRUITING

Sapporo, 003-0804, Japan
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan
National Hospital Organization Osaka National Hospital
RECRUITING

Osaka, 540-0006, Japan
New Cross Hospital
RECRUITING

Wolverhampton, WV10 0QP, United Kingdom
Nexus Health
RECRUITING

Irving, Texas, 75063, United States
Nucleo de Oncologia Da Bahia
RECRUITING

Salvador, 40.170-070, Brazil
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Onco Star Sp Oncologia LTDA
RECRUITING

São Paulo, 04062-001, Brazil
Oncology Hematology Care (OHC)
RECRUITING

Cincinnati, Ohio, 45226, United States
Oncopôle Claudius Regaud Pharmacie
RECRUITING

Toulouse, 31059, France
Ordensklinikum Barmherzige Schwestern
RECRUITING

Linz, 4010, Austria
Osaka International Cancer Institute
RECRUITING

Chūōku, 541-8567, Japan
Ospedale San Raffaele S.r.l PPDS
RECRUITING

Milan, 20132, Italy
Peninsula and South Eastern Haematology and Oncology Group
RECRUITING

Mount Waverly, Victoria, 3149, Australia
Perlmutter Cancer Center 160 E 34th St
RECRUITING

New York, New York, 10016-4744, United States
Pharmacie Centre de Cancerologie de la Sarthe
RECRUITING

Le Mans, 72000, France
Pharmacie ICM Val d'Aurelle
RECRUITING

Montpellier, 34298, France
Pratia MCM Kraków
RECRUITING

Krakow, 30-727, Poland
Pratia Poznan
RECRUITING

Poznan, 60-192, Poland
Real Hospital Portugues de Beneficiencia Em Pernambuco
RECRUITING

Recife, 52.010-075, Brazil
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States
Royal United Hospital
RECRUITING

Bath, BA1 3NG, United Kingdom
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sagara Hospital
RECRUITING

Kagoshima, 892-0833, Japan
Saint Luke's Cancer Institute
RECRUITING

Kansas City, Missouri, 64111, United States
Saitama Medical University International Medical Center
RECRUITING

Hidaka-shi, 350-1298, Japan
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sansum Clinic 540 W - USOR
RECRUITING

Irving, Texas, 75063, United States
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, 13605, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Showa University Hospital
RECRUITING

Tokyo, 142-8666, Japan
Soon Chun Hyang University Cheonan Hospital
RECRUITING

Cheonan-si, 330721, South Korea
St John of God Hospital Subiaco
RECRUITING

Subiaco, 6008, Australia
Sunnybrook Research Institute
RECRUITING

Toronto, M4N 3M5, Canada
Sunshine Coast University Private Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
Texas Oncology - Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
Texas Oncology Gulf Coast
RECRUITING

Irving, Texas, 75063, United States
Texas Oncology West
RECRUITING

Irving, Texas, 75063, United States
The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITING

Seoul, 137-701, South Korea
The Christie - PPDS
RECRUITING

Manchester, M20 4BX, United Kingdom
The Kinghorn Cancer Centre
RECRUITING

Mount Kuring-Gai, 2080, Australia
The Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
The Oncology Institute Of Hope And Innovation
RECRUITING

Cerritos, California, 90703, United States
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, K1H 8L6, Canada
Tokai University Hospital
RECRUITING

Isesaki-shi, 259-1193, Japan
U.T. MD Anderson Cancer Center, Investigational Pharmacy Services
RECRUITING

Houston, Texas, 77030, United States
UCSF at Mission Bay MB
RECRUITING

San Francisco, California, 94158, United States
UNC Central Investigational Drug Services
RECRUITING

Morrisville, North Carolina, 27560, United States
USC-Norris Comprehensive Cancer Center - Investigational Drug Service IDS
RECRUITING

Los Angeles, California, 90033, United States
UZ Antwerpen
RECRUITING

Edegem, 2650, Belgium
University General Hospital of Patras
RECRUITING

Pátrai, 26504, Greece
University Hospitals Cleveland Medical Center 11100 Euclid Ave
WITHDRAWN

Cleveland, Ohio, 44106-1716, United States
University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85719, United States
University of Colorado-Cancer Center-PPDS
RECRUITING

Aurora, Colorado, 80045-2517, United States
Universitätsklinikum Carl Gustav Carus an der TU
RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, 60-569, Poland
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates, Sentara Health
RECRUITING

Norfolk, Virginia, 23502, United States
Washington Cancer Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Wojewódzki Szpital Specjalistyczny W Białej Podlaskiej
RECRUITING

Biała Podlaska, 21-500, Poland

Conditions

Explore the condition pages connected to this study.

METASTATIC HER2-POSITIVE BREAST CANCER