Targeted drug combo challenges chemo in advanced breast cancer fight

NCT ID NCT05063786

Summary

This study is for people with advanced HER2-positive breast cancer that has a specific gene change called PIK3CA and has worsened after previous treatments. It aims to see if a combination of targeted drugs (trastuzumab with alpelisib, plus fulvestrant for some) can control the cancer better and for longer than the standard approach of trastuzumab with chemotherapy. About 300 participants worldwide will be randomly assigned to receive one of these two treatment strategies.

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Contacts and locations

Locations

  • A.O. "SS Antonio e Biagio e Cesare Arrigo"

    Alessandria, Italy

  • AOU Maggiore della Caritá

    Novara, Italy

  • ASST Cremona

    Cremona, Italy

  • ASST-Mantova- Hospital Carlo Poma

    Mantova, Italy

  • AUSL Romagna/Oncology Department

    Rimini, Italy

  • Adrz Medisch Centrum

    Goes, Netherlands

  • Althaia Xarxa Assistencial de Manresa

    Manresa, Spain

  • Azienda Ospedaliero-Universitaria Careggi, University of Florence

    Florence, Italy

  • Azienda Ospedaliero-Universitaria di Parma

    Parma, Italy

  • Cannizzaro Hospital

    Catania, Italy

  • Casa di Cura La Maddalena S.P.A.

    Palermo, Italy

  • Centre Jean Perrin

    Clermont-Ferrand, France

  • Centre Régional De Lutte Contre Le Cancer Georges-François Leclerc

    Dijon, France

  • Centre d'Oncologie et Radiothérapie 37

    Chambray-lès-Tours, France

  • Centre du sein Fribourg

    Fribourg, Switzerland

  • Centre hospitalier universitaire de Poitiers

    Poitiers, France

  • Centre hospitalier universitaire à Limoges

    Limoges, France

  • Centro Oncoloxico de Galicia

    A Coruña, Spain

  • Clinica Oncologica, AOU Riuniti

    Ancona, Italy

  • Complejo Hospitalario Universitario de Albacete

    Albacete, Spain

  • Complejo Hospitalario de Navarra

    Pamplona, Spain

  • Complexo Hospitalario Universitario A Coruña

    A Coruña, Spain

  • Consorcio Hospital General Universitario de Valencia

    Valencia, Spain

  • Corporació Sanitaria Parc Taulí

    Sabadell, Spain

  • Department of Oncology, ASUFC, PO Sm Misericordia

    Udine, Italy

  • Diakonessenhuis Utrecht

    Utrecht, Netherlands

  • HagaZiekenhuis

    The Hague, Netherlands

  • Hospital Clinico Universitario Virgen de La Arrixaca

    Murcia, Spain

  • Hospital Clínic de Barcelona

    Barcelona, Spain

  • Hospital Clínico San Carlos

    Madrid, Spain

  • Hospital Clínico Universitario de Santiago CHUS

    A Coruña, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, Spain

  • Hospital Galdakao-Usansolo

    Bilbao, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, Spain

  • Hospital General Universitario de Alicante

    Alicante, Spain

  • Hospital General Universitario de Elche

    Elche, Spain

  • Hospital Provincial de Zamora (Complejo Asistencial de Zamora)

    Zamora, Spain

  • Hospital San Pedro de Alcántara

    Cáceres, Spain

  • Hospital Universitario Arnau de Vilanova de Lleida

    Lleida, Spain

  • Hospital Universitario Arnau de Vilanova de Valencia

    Valencia, Spain

  • Hospital Universitario Basurto

    Bilbao, 48013, Spain

  • Hospital Universitario Clínico San Cecilio

    Granada, Spain

  • Hospital Universitario Donostia

    Donostia / San Sebastian, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Hospital Universitario HM Sanchinarro - CIOCC Clara Campal

    Madrid, Spain

  • Hospital Universitario Juan Ramón Jiménez

    Huelva, Spain

  • Hospital Universitario Lucus Augusti

    Lugo, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, Spain

  • Hospital Universitario Nuestra Señora de la Candelaria

    Santa Cruz de Tenerife, Spain

  • Hospital Universitario Puerta de Hierro Majadahonda

    Madrid, Spain

  • Hospital Universitario Puerta del Mar

    Cadiz, Spain

  • Hospital Universitario Ramon Y Cajal

    Madrid, Spain

  • Hospital Universitario Regional de Malaga

    Málaga, Spain

  • Hospital Universitario Sant Joan de Reus

    Tarragona, Spain

  • Hospital Universitario Severo Ochoa

    Madrid, Spain

  • Hospital Universitario Son Espases

    Palma de Mallorca, Spain

  • Hospital Universitario Son Llatzer

    Palma de Mallorca, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, Spain

  • Hospital Universitario Virgen Macarena

    Seville, Spain

  • Hospital Universitario Virgen de Valme

    Seville, Spain

  • Hospital Universitario Virgen de las Nieves

    Granada, Spain

  • Hospital Universitario de Badajoz

    Badajoz, Spain

  • Hospital Universitario de Canarias

    Santa Cruz de Tenerife, Spain

  • Hospital Universitario de Cruces

    Bilbao, Spain

  • Hospital Universitario de Fuenlabrada

    Madrid, Spain

  • Hospital Universitario de Jaen

    Jaén, Spain

  • Hospital Universitario de Jerez de la Frontera

    Jerez de la Frontera, Spain

  • Hospital Virgen de la Salud

    Toledo, Spain

  • Hospital de La Santa Creu I Sant Pau

    Barcelona, Spain

  • Hospital de Mataró

    Mataró, Spain

  • Hospital de Terrassa - Consorci Sanitari de Terrassa

    Terrassa, Spain

  • Hospital del Mar

    Barcelona, Spain

  • ICO Badalona - Hospital Universitario Germans Trias i Pujol

    Badalona, Spain

  • ICO de Girona - Hospital Josep Trueta

    Girona, Spain

  • IEO - Istituto Europeo di Oncologia

    Milan, Italy

  • IRCCS Ospedale San Raffaele

    Milan, Italy

  • IRCCS Policlinico San Martino

    Genoa, Italy

  • Inselspital, Universitätsspital Bern

    Bern, Switzerland

  • Institut Curie Hospital

    Paris, France

  • Institute Curie - Site Saint-Cloud

    Saint-Cloud, 92210, France

  • Istituti Clinici Scientifici Maugeri SpA-SB

    Pavia, Italy

  • Istituti Fisioterapici ospitaliersi - IFO - Istituti Regina Elena

    Roma, Italy

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei tumori

    Meldola, Italy

  • Klinik Hietzing Wien

    Vienna, Austria

  • Klinik Ottakring

    Vienna, Austria

  • LKH Hochsteiermark - Leoben

    Leoben, Austria

  • Maastricht UMC

    Maastricht, Netherlands

  • Martini Ziekenhuis

    Groningen, Netherlands

  • Mater Salutis Hospital

    Legnago, Italy

  • Meander Medisch Centrum

    Amersfoort, Netherlands

  • Medizinische Universität Innsbruck - Univ.Klinik f. Frauenheilkunde Innsbruck

    Innsbruck, Austria

  • Medizinische Universität Wien - Univ.klinikum AKH Wien

    Vienna, Austria

  • Ordensklinikum Linz GmbH - BHS

    Linz, Austria

  • Ospedale MultiMedica Castellanza

    Castellanza, Italy

  • Ospedale di Bolzano Azienda Sanitaria Alto Adige

    Bolzano, Italy

  • Ospedali Riuniti Monselice Padova

    Monselice, Italy

  • Policlinico Umberto I

    Roma, Italy

  • Pyhrn - Eisenwurzen Klinikum Steyr

    Steyr, Austria

  • Radboud Medical Center

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Sant'Anna Hospital - Città della salute e della scienza

    Turin, Italy

  • Santa Chiara Hospital

    Trento, Italy

  • Tumor Zentrum Aarau

    Aarau, Switzerland

  • UOSD AUSL Modena

    Sassuolo, Italy

  • Universitätsklinikum St. Pölten

    Pölten, Austria

  • VieCuri Medisch Centrum

    Venlo, Netherlands

  • ZorgSaam Ziekenhuis

    Terneuzen, Netherlands

Conditions

Explore the condition pages connected to this study.