New hope for Tough-to-Treat leukemia: First-in-Human trial tests novel drug combo

NCT ID NCT06226571

Recruiting now Disease control Sponsor: Syndax Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing the safety and early effectiveness of a new oral drug, SNDX-5613, when given alongside standard intensive chemotherapy to adults newly diagnosed with a fast-growing blood cancer called acute myeloid leukemia (AML). The trial is specifically for people whose cancer has certain genetic changes (KMT2A, NPM1, or NUP98). Researchers will first find the safest dose of the new drug combination and then see how well it might work to control the disease.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AdventHealth Blood & Marrow Transplant Center
RECRUITING

Orlando, Florida, 32804, United States

Contact Email: •••••@•••••
Allina Health Cancer Institute
RECRUITING

Minneapolis, Minnesota, 55407, United States

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Atrium Health Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States

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Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States

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City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States

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East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States

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Emory Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

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Gordon and Leslie Diamond Health Care Center
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada

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Hammersmith Hospital
RECRUITING

London, London, City of, W12 0HS, United Kingdom

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Hospital Clinic de Barcelona
RECRUITING

Barcelona, 8036, Spain

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Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain

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Hospital San Pedro de Alcantara
RECRUITING

Cáceres, 10003, Spain

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Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain

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Hospital Universitario De Salamanca
RECRUITING

Salamanca, 37007, Spain

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Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain

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Hospital Universitario Virgen de Las Nieves
RECRUITING

Granada, 18014, Spain

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Hospital Universitario Virgen del Rocio - PPDS
RECRUITING

Seville, 41013, Spain

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Institution name: Northwell Health-Brany
RECRUITING

Lake Success, New York, 11042, United States

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LDS Hospital - Intermountain Healthcare
RECRUITING

Salt Lake City, Utah, 84143, United States

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MUSC Hollings Cancer Center (HCC)
RECRUITING

Charleston, South Carolina, 29425, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Northern Hospital, Victoria
RECRUITING

Epping, Victoria, 3076, Australia

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Norton Cancer Institute, St. Matthews Campus
RECRUITING

Louisville, Kentucky, 40207, United States

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Oregon Health and Science University- Center for Hematologic Malignancies
RECRUITING

Portland, Oregon, 97239, United States

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Royal Adelaide Hospital
RECRUITING

Adelaide, SA 5000, Australia

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Royal Perth Hospital
RECRUITING

Perth, Western Australia, 6000, Australia

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SUNY Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States

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Sir Charles Gairdner Hospital
RECRUITING

Nedlands, 6009, Australia

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Tampa General Hospital
RECRUITING

Tampa, Florida, 33606, United States

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The Alfred Hospital, Victoria
RECRUITING

Melbourne, 3004, Australia

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The Royal Marsden NHS
RECRUITING

Sutton, SM2 5PT, United Kingdom

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The Sir Mortimer B. Davis Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada

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The University of Texas, MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

Contact Email: •••••@•••••
UCLA Medical Hematology
RECRUITING

Burbank, California, 91505, United States

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UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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Universitat de Valencia
RECRUITING

Valencia, 46026, Spain

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University Medical Center Utrecht
RECRUITING

Utrecht, 3584, Netherlands

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University of Alberta Hospital
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada

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University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States

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University of Louisville Health Brown Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States

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University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

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University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States

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Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States

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Conditions

Explore the condition pages connected to this study.

ACUTE MYELOID LEUKEMIAS