New hope for older leukemia patients: major trial tests promising drug combo

NCT ID NCT06852222

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding a new drug called bleximenib to a standard two-drug treatment works better for older adults with a specific type of acute myeloid leukemia (AML) who are too frail for intensive chemotherapy. It will involve about 600 participants and compare the new three-drug combination against the standard two-drug treatment. The main goals are to see if more people achieve complete remission and if they live longer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

A O U Sant Orsola Malpighi
RECRUITING

Bologna, 40138, Italy
ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
ASST Papa Giovanni XXIII Bergamo
RECRUITING

Bergamo, 24127, Italy
AST Pesaro e Urbino Ospedale San Salvatore
RECRUITING

Pesaro, 61121, Italy
AZ Sint-Jan
RECRUITING

Bruges, 8000, Belgium
Aalborg University Hospital
RECRUITING

Aalborg, 9000, Denmark
Addenbrookes Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Ahepa University General Hospital of Thessaloniki
RECRUITING

Thessaloniki, 54636, Greece
Aiiku Hospital
RECRUITING

Sapporo, 064 0804, Japan
Algemeen Ziekenhuis Delta
RECRUITING

Roeselare, 8800, Belgium
Ankara Etlik Sehir Hastanesi
RECRUITING

Ankara, 06170, Turkey (Türkiye)
Ankara University School of Medicine Cebeci Hospital
RECRUITING

Ankara, 06590, Turkey (Türkiye)
Arthur J E Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Atrium Health
RECRUITING

Charlotte, North Carolina, 28204, United States
Atrium Health Wake Forest Baptist Comprehensive Cancer Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Azienda Ospedaliera Spedali Civili di Brescia
RECRUITING

Brescia, 25123, Italy
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino
RECRUITING

Torino, 10126, Italy
Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia
RECRUITING

Perugia, 06132, Italy
Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
CHRU de Nancy - Hopitaux de Brabois
RECRUITING

Vandœuvre Ies-Nancy, 54500, France
CHU De Nice Hopital De l'Archet
RECRUITING

Nice, 06202, France
CHU Lyon Sud
RECRUITING

Pierre-Bénite, 69310, France
CHU Reims Hopital Robert Debre
RECRUITING

Reims, 51100, France
CHU d'Angers
RECRUITING

Angers, 49933, France
CHU de Clermont Ferrand - Site Estaing
RECRUITING

Clermont-Ferrand, 63100, France
CHU de Montpellier Hopital Saint Eloi
RECRUITING

Montpellier, 34295, France
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Cancer Treatment Center of America Phoenix
RECRUITING

Goodyear, Arizona, 85338, United States
Cancercare Manitoba
RECRUITING

Winnipeg, Manitoba, R3E 0V9, Canada
Carmel Medical Center
RECRUITING

Haifa, 3436212, Israel
Casa Sollievo Della Sofferenza IRCCS
RECRUITING

San Giovanni Rotondo, 71013, Italy
Centro de Investigacion Clinica Chapultepec
RECRUITING

Mexico City, 04100, Mexico
Chaim Sheba Medical Center
RECRUITING

Ramat Gan, 5262000, Israel
Chi Mei Medical Center Liouying Branch
RECRUITING

Tainan, 736, Taiwan
Chu Helora Hospital La Louviere Site Jolimont
RECRUITING

La Louvière, 7100, Belgium
Chu Rennes Hopital Pontchaillou
RECRUITING

Rennes, 35000, France
Chungnam National University Hospital
RECRUITING

Daejeon, 35015, South Korea
City of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Florida
RECRUITING

Weston, Florida, 33331, United States
Clinica Univ. de Navarra
RECRUITING

Pamplona, 31008, Spain
Clinica Univ. de Navarra Madrid
RECRUITING

Madrid, 28027, Spain
Clinique Saint Pierre
RECRUITING

Ottignies, 1340, Belgium
Colchester Hospital University NHS
RECRUITING

Colchester, CO4 5JL, United Kingdom
DF Star Rede D or
RECRUITING

Brasília, 70390 140, Brazil
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
Dartmouth Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Derriford Hospital
RECRUITING

Plymouth, PL6 8DH, United Kingdom
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Einstein-Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Evaggelismos Hospital
RECRUITING

Athens, 106 76, Greece
Fakultni Nemocnice Ostrava
RECRUITING

Ostrava - Poruba, 708 52, Czechia
Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika
RECRUITING

Brno, 625 00, Czechia
Fakultni nemocnice Hradec Kralove
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Kralovske Vinohrady
RECRUITING

Prague, 100 00, Czechia
Fakultni nemocnice Plzen
RECRUITING

Pilsen, 304 60, Czechia
First Affiliated Hospital SooChow University
RECRUITING

Suzhou, 215005, China
Flinders Medical Centre
RECRUITING

Bedford Park, 5042, Australia
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, 20122, Italy
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Fukushima Medical University Hospital
RECRUITING

Fukushima, 960 1295, Japan
Fundacao Pio XII
RECRUITING

Barretos, 14780 070, Brazil
Gabrail Cancer Center
RECRUITING

Canton, Ohio, 44718, United States
General University Hospital of Patras
RECRUITING

Rio, 265 04, Greece
Geniko Nosokomeio Thessalonikis George Papanikolaou
RECRUITING

Thessaloniki, 570 10, Greece
Ghent University Hospital
RECRUITING

Ghent, 9000, Belgium
Gifu Municipal Hospital
RECRUITING

Gifu, 500-8513, Japan
Grande Ospedale Metropolitano 'Bianchi-Melacrino-Morelli' Reggio Calabria
RECRUITING

Reggio Calabria, 89124, Italy
Gunmaken Saiseikai Maebashi Hospital
RECRUITING

Maebashi, 371-0821, Japan
Guys' and St Thomas' NHS Trust
RECRUITING

London, SE1 9RT, United Kingdom
Hadassah University Hospita Ein Kerem
RECRUITING

Jerusalem, 9112001, Israel
Henan Cancer Hospital
RECRUITING

Zhengzhou, 450008, China
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Hopital Saint Louis
RECRUITING

Paris, 75010, France
Hopital Saint Vincent de Paul
RECRUITING

Lille, 59020, France
Hosp Clinico Univ de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hosp Univ A Coruna
RECRUITING

A Coruña, 15006, Spain
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 08035, Spain
Hosp. Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hosp. Quiron Madrid Pozuelo
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Hosp. San Pedro de Alcantara
RECRUITING

Cáceres, 10003, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. I Politecni La Fe
RECRUITING

Valencia, 46026, Spain
Hosp. Univ. Marques de Valdecilla
RECRUITING

Santander, 39008, Spain
Hosp. Univ. Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hosp. Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hosp. de Jerez de La Frontera
RECRUITING

Jerez de la Frontera, 11407, Spain
Hosp. de La Santa Creu I Sant Pau
RECRUITING

Barcelona, 08041, Spain
IRCCS Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Inst. Cat. Doncologia-H Duran I Reynals
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France
Institut Paoli Calmettes
RECRUITING

Marseille, 13273, France
Institut Universitaire du Cancer Toulouse Oncopole
RECRUITING

Toulouse, 31100, France
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
RECRUITING

Tijian, 3000200, China
Instituto D Or de Pesquisa e Ensino
RECRUITING

São Paulo, 01401 002, Brazil
Instituto Nacional de Cancerologia
RECRUITING

Mexico City, 14080, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
RECRUITING

Mexico City, 14080, Mexico
Instituto Portugues de Oncologia Porto
RECRUITING

Porto, 4200 072, Portugal
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)
RECRUITING

Rio de Janeiro, 22775 001, Brazil
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
RECRUITING

Meldola, 47014, Italy
Japanese Red Cross Osaka Hospital
RECRUITING

Osaka, 543 8555, Japan
Jupiter Research
RECRUITING

Jupiter, Florida, 33458, United States
Juravinski Cancer Centre
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kanazawa University Hospital
RECRUITING

Kanazawa, 920-8641, Japan
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 833, Taiwan
Kent and Canterbury Hospital
RECRUITING

Canterbury, CT1 3NG, United Kingdom
Kepler Universitatsklinikum GmbH
RECRUITING

Linz, 4020, Austria
Klinikum Augsburg
RECRUITING

Augsburg, 86156, Germany
Klinikum Wels Grieskirchen
RECRUITING

Wels, 4600, Austria
Kobe City Medical Center General Hospital
RECRUITING

Kobe, 650 0047, Japan
Koc University Medical Faculty
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
Kyushu University Hospital
RECRUITING

Fukuoka, 812 8582, Japan
Liga Norte Riograndense Contra O Cancer
RECRUITING

Natal, 59062 000, Brazil
Liga Paranaense de Combate ao Cancer
RECRUITING

Curitiba, 81520 060, Brazil
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan District, 333, Taiwan
London Health Sciences Centre Victoria Hospital
RECRUITING

London, Ontario, N6A 5W9, Canada
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Mary Bird Perkins Cancer Center
RECRUITING

Baton Rouge, Louisiana, 70809, United States
Medical University of Vienna Universitatsklinik fur Innere Medizin I
RECRUITING

Vienna, 1090, Austria
Memorial Antalya Hospital
RECRUITING

Antalya, 07025, Turkey (Türkiye)
Memorial Regional Hospital
COMPLETED

Hollywood, Florida, 33021 5421, United States
Ministerio da Saude Instituto Nacional do Cancer
RECRUITING

Rio de Janeiro, 20230 130, Brazil
Moffit Cancer center
RECRUITING

Tampa, Florida, 33612, United States
Nagoya University Hospital
RECRUITING

Nagoya, 466 8560, Japan
National Cancer Center
RECRUITING

Goyang-si, 10408, South Korea
National Hospital Organization Kumamoto Medical Center
RECRUITING

Kumamoto, 860-0008, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
New York Presbyterian - Weill Cornell
RECRUITING

New York, New York, 10065, United States
Nippon Medical School Hospital
RECRUITING

Tokyo, 113 8603, Japan
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Novant Health Charlotte
RECRUITING

Charlotte, North Carolina, 28204, United States
Novant Health Winston Salem
RECRUITING

Winston-Salem, North Carolina, 27106, United States
Odense University Hospital
RECRUITING

Odense, 5000, Denmark
Okayama University Hospital
RECRUITING

Okayama, 700 8558, Japan
Ondokuz Mayis University
RECRUITING

Samsun, 55139, Turkey (Türkiye)
Ordensklinikum Linz GmbH Elisabethinen
RECRUITING

Linz, 4020, Austria
Orlando Health Cancer Institute
RECRUITING

Orlando, Florida, 32806, United States
Ospedale S. Maria Delle Croci
RECRUITING

Ravenna, 48121, Italy
Peking University First Hospital
RECRUITING

Beijing, 100020, China
Peking University People's Hospital
RECRUITING

Beijing, 100044, China
Peking University Third Hospital
RECRUITING

Beijing, 100191, China
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, 3000, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, 4102, Australia
Princess Margaret Cancer Centre University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Providence Oncology and Hematology Care Clinic Westside
RECRUITING

Portland, Oregon, 97225, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Qilu Hospital of Shandong University
RECRUITING

Jinan, 250012, China
Queen Elizabeth II Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Queen Mary Hospital
RECRUITING

Hong Kong, Hong Kong
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
Real e Benemerita Associacao Portuguesa de Beneficencia
RECRUITING

São Paulo, 01323 010, Brazil
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14263, United States
Royal Prince Alfred Hospital
RECRUITING

Camperdown, 2050, Australia
Sakarya University Training and Research Hospital
RECRUITING

Sakarya, 54100, Turkey (Türkiye)
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Shamir Medical Center Assaf Harofeh
RECRUITING

Beer Yaakov, 7033001, Israel
Shengjing Hospital Of China Medical University
RECRUITING

Shenyang, 110055, China
Sichuan Provincial Peoples Hospital
RECRUITING

Chengdu, 610032, China
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
RECRUITING

São Paulo, 05652 900, Brazil
St George Hospital
RECRUITING

Kogarah, 2217, Australia
St Vincents Hospital Melbourne
RECRUITING

Fitzroy, 3065, Australia
Sun Yat Sen University Cancer Center
RECRUITING

Guangzhou, 510060, China
Swedish Cancer Institute
RECRUITING

Seattle, Washington, 98104, United States
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach
RECRUITING

Kielce, 25 734, Poland
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
The Catholic University of Korea Seoul St Marys Hospital
RECRUITING

Seoul, 137 701, South Korea
The Clatterbridge Cancer Centre
RECRUITING

Liverpool, L7 8YA, United Kingdom
The First Affiliated Hospital Zhejiang University College of Medicine
RECRUITING

Hangzhou, 310003, China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, 401147, China
The First Affiliated Hospital of Guangxi Medical University
RECRUITING

Nanning, 530021, China
The First Affiliated Hospital of NanChang University
RECRUITING

Nanchang, 330006, China
The First Affiliated Hospital of USTC Anhui Provincial Hospital
RECRUITING

Hefei, 230001, China
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, 325000, China
The Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, 710004, China
The Second Hospital & Clinical Medical School Lanzhou University
RECRUITING

Lanzhou, 730030, China
The Second People's Hospital of Shenzhen
RECRUITING

Shenzhen, 518035, China
The first Affiliated Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The first affiliated hospital of xiamen university
RECRUITING

Xiamen, 361003, China
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tohoku University Hospital
RECRUITING

Sendai, 980 8574, Japan
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
RECRUITING

Bunkyō City, 113 8677, Japan
TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology
RECRUITING

Wuhan, 430030, China
UZ Antwerpen
RECRUITING

Edegem, 2650, Belgium
Uls Santa Maria Hosp. Santa Maria
RECRUITING

Lisbon, 1649 028, Portugal
Uls Santo Antonio - Hosp. Santo Antonio
RECRUITING

Porto, 4099 001, Portugal
Uls Sao Joao - Hosp. Sao Joao
RECRUITING

Porto, 4200 319, Portugal
Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos
RECRUITING

Lisbon, 1169 050, Portugal
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
RECRUITING

Wuhan, 430022, China
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Frankfurt
RECRUITING

Frankfurt, 60590, Germany
Universitaetsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, 79106, Germany
Universitaetsklinikum Hamburg Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Koeln
RECRUITING

Cologne, 50937, Germany
Universitaetsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitaetsklinikum Salzburg Landeskrankenhaus
RECRUITING

Salzburg, 5020, Austria
Universitaetsklinikum Schleswig Holstein Campus Kiel
RECRUITING

Kiel, 24105, Germany
Universitaetsklinikum Wuerzburg
RECRUITING

Würzburg, 97080, Germany
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 3000, Belgium
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
RECRUITING

Chaïdári, 124 62, Greece
University General Hospital of Ioannina
RECRUITING

Ioannina, 455 00Q, Greece
University Hospital of Alexandroupolis
RECRUITING

Alexandroupoli, 68100, Greece
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Hospitals Sussex NHS Foundation Trust
RECRUITING

Worthing, BN11 2DH, United Kingdom
University Hospitals Sussex NHS Foundation Trust
RECRUITING

Brighton, BN2 5BE, United Kingdom
University of Arkansas at Little Rock
RECRUITING

Little Rock, Arkansas, 72204, United States
University of Chicago Medicine
RECRUITING

Chicago, Illinois, 60637, United States
University of Fukui Hospital
RECRUITING

Yoshida, 910-1193, Japan
University of Kentucky Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15260, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Tennessee
RECRUITING

Knoxville, Tennessee, 37920, United States
Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu
RECRUITING

Wroclaw, 50 367, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
RECRUITING

Bialystok, 15 276, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80 211, Poland
UofL Health Brown Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States
Ustav Hematologie A Krevni Transfuze
RECRUITING

Prague, 128 00, Czechia
VM Medical Park Mersin Hospital
RECRUITING

Mersin, 33200, Turkey (Türkiye)
Vancouver General Hospital
RECRUITING

Vancouver, British Columbia, V5Z 1N1, Canada
Vanderbilt Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University - Massey Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vseobecna Fakultní Nemocnice
RECRUITING

Prague, 128 08, Czechia
Washington University in St Louis
RECRUITING

St Louis, Missouri, 63130, United States
West China Hospital Si Chuan University
RECRUITING

Chengdu, 610041, China
Western General Hospital
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Wiener Gesundheitsverbund Klinik Hietzing
RECRUITING

Vienna, 1130, Austria
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi
RECRUITING

Lodz, 93 513, Poland
Yamagata University Hospital
RECRUITING

Yamagata, 990 2331, Japan
Zealand University Hospital
RECRUITING

Roskilde, 4000, Denmark
Zhongda Hospital Southeast University
RECRUITING

Nanjing, 210009, China
Ziekenhuis Oost-Limburg
RECRUITING

Genk, 3600, Belgium

Conditions

Explore the condition pages connected to this study.

LEUKEMIA, MYELOID, ACUTE