Promising new combo therapy targets Hard-to-Treat gut tumors

NCT ID NCT06784752

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a radioactive drug (177Lu-DOTA-TATE) to standard therapy (octreotide) helps control advanced neuroendocrine tumors of the gut or pancreas better than standard therapy alone. About 240 newly diagnosed patients with slow-growing but high-burden tumors will participate. The goal is to see if the combination delays tumor growth and maintains quality of life.

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Conditions

The condition(s) this trial relates to.

digestive system neuroendocrine neoplasm digestive system neuroendocrine tumor, grade 1/2 follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROENTEROPANCREATIC NEUROENDOCRINE TUMOR (GEP-NET) SOMATOSTATIN RECEPTOR POSITIVE (SSTR+)

Contacts and locations

Locations

Blue Ridge Cancer Center
RECRUITING

Wytheville, Virginia, 24382, United States
Hartford Hospital
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Hartford, Connecticut, 06102, United States
Henry Ford Hospital
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Detroit, Michigan, 48202-2689, United States
Highlands Oncology Group
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Fayetteville, Arkansas, 72703, United States
LSU Medical Center
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New Orleans, Louisiana, 70112, United States
Mayo Clinic Arizona
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Scottsdale, Arizona, 85259, United States
Mayo Clinic Jacksonville
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Jacksonville, Florida, 32224, United States
Mount Sinai Medical Center
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New York, New York, 10029-6574, United States
Northwest Medical Specialties
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Tacoma, Washington, 98405, United States
Novartis Investigative Site
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Edmonton, Alberta, T6G 1Z2, Canada
Novartis Investigative Site
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London, Ontario, N6A 5W9, Canada
Novartis Investigative Site
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Toronto, Ontario, M4N 3M5, Canada
Novartis Investigative Site
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Montreal, Quebec, H3T 1E2, Canada
Novartis Investigative Site
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Beijing, 100036, China
Novartis Investigative Site
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Beijing, 100730, China
Novartis Investigative Site
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Beijing, 102200, China
Novartis Investigative Site
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Shanghai, 200032, China
Novartis Investigative Site
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Bron, 69677, France
Novartis Investigative Site
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Clichy, 92110, France
Novartis Investigative Site
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Montpellier, 34298, France
Novartis Investigative Site
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Nantes, 44093, France
Novartis Investigative Site
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Pessac, 33604, France
Novartis Investigative Site
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Toulouse, 31059, France
Novartis Investigative Site
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Erlangen, 91054, Germany
Novartis Investigative Site
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Essen, 45147, Germany
Novartis Investigative Site
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München, 80377, Germany
Novartis Investigative Site
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Budapest, H-1083, Hungary
Novartis Investigative Site
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Szeged, 6725, Hungary
Novartis Investigative Site
RECRUITING

Cona, FE, 44124, Italy
Novartis Investigative Site
RECRUITING

Genova, GE, 16132, Italy
Novartis Investigative Site
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Milan, MI, 20133, Italy
Novartis Investigative Site
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Rozzano, MI, 20089, Italy
Novartis Investigative Site
RECRUITING

Pisa, PI, 56126, Italy
Novartis Investigative Site
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Roma, RM, 00168, Italy
Novartis Investigative Site
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Roma, RM, 00189, Italy
Novartis Investigative Site
RECRUITING

Milan, 20141, Italy
Novartis Investigative Site
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Rotterdam, South Holland, 3015 GD, Netherlands
Novartis Investigative Site
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Utrecht, 3584 CX, Netherlands
Novartis Investigative Site
RECRUITING

Gdansk, 80-214, Poland
Novartis Investigative Site
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Gliwice, 44 101, Poland
Novartis Investigative Site
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Krakow, 30-688, Poland
Novartis Investigative Site
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Poznan, 60-355, Poland
Novartis Investigative Site
RECRUITING

Warsaw, 02-351, Poland
Novartis Investigative Site
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Warsaw, 04-141, Poland
Novartis Investigative Site
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Seoul, 03080, South Korea
Novartis Investigative Site
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Seoul, 03722, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 05505, South Korea
Novartis Investigative Site
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Novartis Investigative Site
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Oviedo, Principality of Asturias, 33011, Spain
Novartis Investigative Site
RECRUITING

Barcelona, 08035, Spain
Novartis Investigative Site
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Madrid, 28034, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28040, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28041, Spain
Novartis Investigative Site
RECRUITING

Salamanca, 37007, Spain
Novartis Investigative Site
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London, SE5 9RS, United Kingdom
Piedmont Healthcare
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Winston-Salem, North Carolina, 27103, United States
Rocky Mountain Cancer Centers
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Denver, Colorado, 80218, United States
St Elizabeth Healthcare
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Edgewood, Kentucky, 41017, United States
Tennessee Oncology
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Nashville, Tennessee, 37203, United States
Texas Oncology
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Dallas, Texas, 75251, United States
TxO Austin Midtown
ACTIVE_NOT_RECRUITING

Austin, Texas, 78705, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 06520, United States