Shock therapy for sex? nerve zaps may help premature ejaculation
NCT ID NCT04207723
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a mild electrical nerve stimulation (TENS) on the ankle could help men with premature ejaculation. 120 men were split into three groups: TENS alone, standard drug (paroxetine) alone, or both together. The goal was to see if the nerve zap could improve ejaculation timing and satisfaction, possibly offering a drug-free alternative.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Transcutaneous posterior tibial nerve stimulation (TENS) and paroxetine
- What this could lead to
- If it works, this could offer a non-drug treatment option for premature ejaculation, either alone or combined with standard medication.
- What could go wrong
- This is a completed trial, but results are not yet widely reported. The nerve stimulation approach is still experimental and may not work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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120 people
The number who actually took part.
- Started
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Jul 2020
- Finished
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Apr 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Primary premature ejaculation as defined by the International Society for Sexual Medicine (ISSM-International Society for Sexual Medicine) (30): a) ejaculation occurs always or almost always within the first minute after penetration, b) disability to delay ejaculation in all or almost all penetrations, c) negative personal consequences are generated, such as stress, discomfort, frustration and / or avoidance of sexual intimacy. * Age equal to or greater than 18 years. * PEDT score greater than 11. * Stable heterosexual relationship of at least 6 months with the interest of maintaining it for at least the duration of the study. * Sexual activity at least once a week. * Minimum chronicity of PE of 6 months. * Voluntary participation in the study. * Signature of informed consent prior to participation in the study. Exclusion Criteria: * IIEF-EF score greater than 25. * Clinically significant comorbidity: cardiovascular, hepatic, thromboembolic, neurological, locomotive, endocrine, oncological, renal or rheumatologic. * History of retroperitoneal surgery, radiotherapy or multiple sclerosis. * History of mental illness: depression, anxiety, suicidal behavior, bipolar disorder, agoraphobia, dysthymia, social phobia, obsessive compulsive disorder, post-traumatic stress, psychiatric disorder, referred by the patient or by the use of a medication for one of these terms. * Consumption of medications that affect ejaculatory control such as psychiatric medications, opioid analgesics, alpha blockers. * Treatment for PD in the last 3 months. * Treatment for epileptic syndromes or Parkinson's disease. * Use of pacemaker or cardiac defibrillator. * Skin lesions in the electrode placement area. * Abuse or dependence on piscoactive substances: alcohol, hallucinogenic drugs. * Couple in a state of pregnancy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Boston Medical Group
Bogotá, 110111, Colombia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Exercise may be a new weapon against ED and premature ejaculation