Liver study tests how body handles experimental drug
NCT ID NCT06442436
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study looks at how the experimental drug nemtabrutinib is processed in people with moderate liver impairment compared to healthy volunteers. About 32 adults will receive a single oral dose, and researchers will measure drug levels in the blood over time. The goal is to gather safety and dosing information, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nemtabrutinib (a drug taken by mouth)
What this could lead to
If successful, this study could help doctors understand how to dose nemtabrutinib safely for patients with liver problems.
What could go wrong
This is a very early, small Phase 1 study with only 32 participants. It is not designed to test whether the drug works for any disease, only how the body handles it.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Clinical Pharmacology of Miami ( Site 0003)
RECRUITINGMiami, Florida, 33172, United States
Contact Phone: •••-•••-••••
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Orlando Clinical Research Center ( Site 0001)
RECRUITINGOrlando, Florida, 32809, United States
Contact Phone: •••-•••-••••
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Texas Liver Institute ( Site 0002)
RECRUITINGSan Antonio, Texas, 78215, United States
Contact Phone: •••-•••-••••