Promising drug may help kids with rare kidney disorder avoid dialysis

NCT ID NCT05001269

First seen Oct 31, 2025 · Last updated May 02, 2026 · Updated 22 times

Summary

This study tested a drug called nedosiran in 27 children from birth to 11 years old who have primary hyperoxaluria, a rare condition that causes harmful oxalate buildup and can lead to kidney failure. The goal was to see if the drug safely lowers oxalate levels in the urine, which could help control the disease. The treatment is not a cure, as ongoing management is still needed.

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Contacts and locations

Locations

  • Clinical Research Site

    Rochester, Minnesota, 55905, United States

  • Clinical Research Site

    Hamilton, Ontario, L8S 4K1, Canada

  • Clinical Research Site

    Heidelberg, 69120, Germany

  • Clinical Research Site

    Fukuoka, 830-0011, Japan

  • Clinical Research Site

    Nagoya, 467-8602, Japan

  • Clinical Research Site

    Beirut, 1100, Lebanon

  • Clinical Research Site

    Bialystok, 15-274, Poland

  • Clinical Research Site

    Barcelona, 08035, Spain

  • Clinical Research Site

    Yenimahalle, Ankara, 06506, Turkey (Türkiye)

  • Clinical Trial Site

    Bonn, 53127, Germany

  • Clinical Trial Site

    Roma, 00165, Italy

  • Clinical Trial Site

    Dubai, +971, United Arab Emirates

  • Clinical Trial Site

    London, WC1N 3JH, United Kingdom

Conditions

Explore the condition pages connected to this study.