New hope for tough lymphomas? early trial of NB02 begins

NCT ID NCT07114367

Recruiting now Disease control Sponsor: NOBO Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing a new drug called NB02 (posseltinib) in 9 adults with certain types of Non-Hodgkin lymphoma (follicular, mantle cell, or marginal zone) that have returned or not responded to at least two prior treatments. The main goals are to find a safe dose and check for side effects, while also looking for signs that the drug might fight the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NB02 (posseltinib)
What this could lead to: If this works, it could point toward a new treatment option for people with certain types of Non-Hodgkin lymphoma that have not responded to other therapies.
What could go wrong: This is a very early, small Phase 1 trial with only 9 participants, so it is mainly checking safety and dosing. It is too soon to know if the drug will effectively shrink tumors or help patients feel better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma lymphoma mantle cell lymphoma marginal zone lymphoma non-Hodgkin lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON HODGKIN LYMPHOMA (NHL)

Contacts and locations

Locations

Catholic univ of Yeouido St Mary's Hospital
RECRUITING

Seoul, South Korea
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, South Korea
Samsung Medical Center
RECRUITING

Seoul, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam, South Korea
Seoul National University Hospital
RECRUITING

Seoul, South Korea
Ulsan University Hospital
RECRUITING

Ulsan, South Korea

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