Tailored radiation aims to shrink tumors, spare healthy tissue in nasopharyngeal cancer
NCT ID NCT07661771
First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times
Summary
This phase 3 trial tests whether a personalized radiation plan, which expands the treatment area based on each patient's tumor margins, can control nasopharyngeal cancer as well as the standard approach. The study includes 568 adults with newly diagnosed, non-metastatic disease. Participants receive standard therapy (chemotherapy, immunotherapy, or radiation alone depending on tumor stage) but with either the individualized or standard radiation targeting. The goal is to see if the personalized method maintains local tumor control while possibly reducing complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Individualized radiation therapy (IMRT with personalized target volume)
- What this could lead to
- If successful, this approach could offer a more precise radiation treatment for nasopharyngeal cancer, potentially reducing side effects while maintaining disease control.
- What could go wrong
- This is a non-inferiority trial, meaning it aims to show the new method is not worse than the standard. There is a risk it may not be as effective, or benefits may be small.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen
NOT_YET_RECRUITINGShenzhen, Guangdong, 518116, China
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Dongguan People's Hospital
NOT_YET_RECRUITINGDongguan, Guangdong, China
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Hunan Cancer Hospital
NOT_YET_RECRUITINGChangsha, Hunan, China
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Sun Yat-Sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, China
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Xiangya Hospital Central South University
NOT_YET_RECRUITINGChangsha, Hunan, China
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