Drug combo tested to reverse scarring in advanced fatty liver disease

NCT ID NCT04971785

Completed Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

Summary

This study tested whether two different drug combinations could improve liver scarring and reduce inflammation in people with advanced liver disease caused by NASH, a serious form of fatty liver disease. It involved 457 participants with compensated cirrhosis. The goal was to see if the treatments could lead to measurable improvement in liver health over 72 weeks.

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Contacts and locations

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Locations

(G.I.R.I.) Gastrointestinal Research Institute

Vancouver, V6Z 2K5, Canada
ARCare Center for Clinical Research

Little Rock, Arkansas, 72205, United States
Adobe Clinical Research, LLC

Tucson, Arizona, 85712, United States
Advanced Medical Research Center

Port Orange, Florida, 32127, United States
Advanced Pharma CR, LLC

Miami, Florida, 33147, United States
Advanced Research Institute, Inc.

New Port Richey, Florida, 34653, United States
Allied Health Clinical Research Organization, LLC

Freehold, New Jersey, 07728, United States
American Research Corporation at the Texas Liver Institute

San Antonio, Texas, 78215, United States
Arizona Health Research

Chandler, Arizona, 85225, United States
Arkansas Diagnostic Center

Little Rock, Arkansas, 72204, United States
Arkansas Gastroenterology

North Little Rock, Arkansas, 72117, United States
Asheville Gastroenterology, a Division of Digestive Health Partners, PA

Asheville, North Carolina, 28801, United States
Atrium Health Transplant and Center for Liver Disease

Charlotte, North Carolina, 28204, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
BioStar Clinical Research Group Inc.

Katy, Texas, 77494, United States
Biopharma Informatic, LLC

Los Angeles, California, 90035, United States
Biopharma Informatic, LLC

Houston, Texas, 77043, United States
Biopharma Informatic, LLC

Houston, Texas, 77084, United States
Biopharma Informatic, LLC

McAllen, Texas, 78503, United States
Bon Secours Richmond Community Hospital, Inc. d/b/a Bon Secours Liver Institute of Richmond

Richmond, Virginia, 23226, United States
CHU Amiens Picardie

Amiens, 80054, France
CHU Rennes Pontchaillou

Rennes, 35000, France
CHU de Grenoble

Grenoble, 38043, France
Cadena Care Institute, LLC

Poway, California, 92064, United States
California Liver Research Institute

Pasadena, California, 91105, United States
Carolina's GI Research, LLC

Raleigh, North Carolina, 27607, United States
Center for Research at Southwest Gastroenterology Associates, PC

Albuquerque, New Mexico, 87109, United States
Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau

Chambray-lès-Tours, 37170, France
Centre Hospitalier Universitaire Limoges

Limoges, 87042, France
Centre Hospitalier Universitaire de Nice - Hopital L'archet

Nice, 06202, France
Centre Hospitalier Universitarie de Montpellier - Hospital Saint-Eloi

Montpellier, 34295, France
Centre Hosptitalier Universitaire d'Angers

Angers, 49033, France
Centre de Recherche du Centre Hospitalier de I'Universite de Montreal (CRCHUM)

Montreal, H2X 0A9, Canada
Century Research, LLC

Miami, Florida, 33173, United States
Charlotte Gastroenterology & Hepatology, PLLC

Charlotte, North Carolina, 28207, United States
Charter Research

Winter Park, Florida, 32792, United States
Chronic Viral Illness Service, Royal Victoria Hospital, McGill University Health Centre (MUHC)

Montreal, H4A 3J1, Canada
Clinical Research Institute of Michigan, LLC

Chesterfield, Michigan, 48047, United States
Clinical Research Institute of Ohio, LLC

Westlake, Ohio, 44145, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Coastal Research Institute

Fayetteville, North Carolina, 28304, United States
Columbia Digestive Health Research

Columbia, South Carolina, 29204, United States
Combined Gastro Research, LLC

Lafayette, Louisiana, 70503, United States
Complejo Hospitalario de Pontevedra

Pontevedra, 36071, Spain
Consorcio Hospital General Universitario de Valencia

Valencia, 46014, Spain
Covenant Metabolic Specialists, LLC

Sarasota, Florida, 34240, United States
DHR Health Institute for Research and Development Cancer Research Center

Edinburg, Texas, 78539, United States
DSI Research

Springboro, Ohio, 45066, United States
Delta Research Partners

Monroe, Louisiana, 71201, United States
Diabetes and Glandular Disease Clinic, P.A.

San Antonio, Texas, 78229, United States
Digestive Disease Research

Florham Park, New Jersey, 07932, United States
Digestive Disease Research Center

Greenwood, South Carolina, 29646, United States
Digestive Health Research of North Texas

Wichita Falls, Texas, 07960, United States
Digestive Health Research of Southern California

Long Beach, California, 90808, United States
Digestive Health Specialists

Dothan, Alabama, 36305, United States
Digestive Research Alliance of Michigan

South Bend, Indiana, 44635, United States
Digestive System Healthcare

Pasadena, Texas, 77505, United States
Digestive and Liver Disease Specialists

Norfolk, Virginia, 23502, United States
Eastern Health, Box Hill Hospital

Box Hill, Victoria, 3128, Australia
Ehime University Hospital

Toon-Shi, 791-0295, Japan
Encore Borland-Groover Clinical Research

Jacksonville, Florida, 32256, United States
Evolution Clinical Research, INC

Hialeah Gardens, Florida, 33016, United States
Excel Medical Clinical Trials, LLC

Boca Raton, Florida, 33434, United States
FDI Clinical Research

San Juan, 00927, Puerto Rico
Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital

Tokyo, 105-8470, Japan
Flinders Medical Centre

Adelaide, South Australia, 5042, Australia
Florida Medical Clinic, LLC

Zephyrhills, Florida, 33542, United States
Florida Research Institute

Lakewood Rch, Florida, 34211, United States
Fukui-ken Saiseikai Hospital

Fukui, 918-8503, Japan
G+C Research Group

Miami, Florida, 33126, United States
GI Alliance

Baton Rouge, Louisiana, 70809, United States
GI Alliance

Flowood, Mississippi, 39232, United States
GI Alliance

Cedar Park, Texas, 78613, United States
GI Alliance

Dallas, Texas, 75246, United States
GI Alliance

Fort Worth, Texas, 76104, United States
GI Alliance

Garland, Texas, 75044, United States
GI Alliance

Lubbock, Texas, 79410, United States
GI Alliance

Webster, Texas, 77598, United States
GI Alliance (Patients Seen, IP Shipment & Fibroscan)

San Marcos, Texas, 78666, United States
GI Associates Research

Columbia, Missouri, 65201, United States
Gastro Care Institute (Fibroscan)

Lancaster, California, 93534, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center

Wyoming, Michigan, 49519, United States
Gastroenterology Group of Naples

Naples, Florida, 34102, United States
Gastroenterology Health Partners, PLLC

New Albany, Indiana, 47150, United States
Gastrointestinal (GI) Specialists of Georgia

Marietta, Georgia, 30060, United States
Gastrointestinal Alliance - Sun City

Sun City, Arizona, 85351, United States
Gastrointestinal Associates of Northeast Tennessee

Johnson City, Tennessee, 37604, United States
Gordon and Leslie Diamond Health Care Centre, Vancouver General Hospital, UBC Division of Gastroenterology

Vancouver, V5Z 1M9, Canada
Greater Boston Gastroenterology

Framingham, Massachusetts, 01702, United States
Hawthorn Medical Associates

South Dartmouth, Massachusetts, 02747, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Hopital Beaujon

Pessac, 33600, France
Hopital Brabois Adultes - CHU de Nancy

Vandœuvre-lès-Nancy, 54500, France
Hopital Claude Huriez

Lille, 59 037, France
Hopital Haut Leveque

Pessac, 33604, France
Hopital Henri Mondor

Créteil, 94010, France
Hopital Rangueil

Toulouse, 31300, France
Hopital Saint Joseph

Marseille, 13008, France
Hopital Universitaire Pitie Salpetriere

Paris, 75013, France
Hopital de la Croix-Rousse

Lyon, 69004, France
Hopitaux de Paris - Hopital Cochin

Paris, 75014, France
Hospital Clinic De Barcelona

Barcelona, 8036, Spain
Hospital Clinico Universitario de Santiago

Santiago de Compostela, 15706, Spain
Hospital Clinico Universitario de Valladolid

Valladolid, 47010, Spain
Hospital General Universiatrio Gregorio Maranon

Madrid, 28007, Spain
Hospital Germans Trias i Pujol

Badalona, Barcelona, 08916, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario La Paz Edificio de Malemidad

Madrid, 28046, Spain
Hospital Universitario Marques de Valdecilla

Santander, 39008, Spain
Hospital Universitario Puerta de Hierro-Majadahonda

Majadahonda, 28222, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Torrecardenas

Almería, 04009, Spain
Hospital Universitario Virgin del Rocio

Seville, 41013, Spain
Hospital Universitario y Politecnlo la Fe

Valencia, 46026, Spain
Hospital del Mar

Barcelona, 08003, Spain
Houston Methodist Hospital

Houston, Texas, 77030, United States
Houston Research Institute

Houston, Texas, 77079, United States
Huron Gastroenterology Associates

Ypsilanti, Michigan, 48197, United States
Impact Research Institute

Waco, Texas, 76710, United States
Indago Research and Health Center, Inc.

Hialeah, Florida, 33012, United States
Indiana University Health Enterprise Clinical Research Operations

Indianapolis, Indiana, 46202, United States
Inland Empire Clinical Trials

Rialto, California, 92377, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Internal Medicine Digestive and Liver Diseases Clinical Trials

Dallas, Texas, 75390, United States
International Medical Investigational Centers, Inc.

Miami, Florida, 33176, United States
Iowa Digestive Disease Center, PC

Clive, Iowa, 50325, United States
Japanese Red Cross Masashino Hospital

Musashino, 1808610, Japan
Juntendo University Shizouka Hospital

Izunokuni, 410-2295, Japan
Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Kansas City Research Institute

Kansas City, Missouri, 64131, United States
Kansas Medical Clinic PA

Topeka, Kansas, 66606, United States
Keck Medical Center of USC Healthcare Consultation II

Los Angeles, California, 90033, United States
Knowledge Research Center

Orange, California, 92868, United States
Latin Clinical Trial Center

San Juan, 00909, Puerto Rico
Liver Associates of Texas, P.A.

Houston, Texas, 77030, United States
Liver Clinic (study visits, Fibroscan): Columbia University Irving Medical Center / NewYork Presbyterian Hospital

New York, New York, 10032, United States
Liver Institute Northwest

Seattle, Washington, 98105, United States
Liver Specialists of Texas

Houston, Texas, 77030, United States
Liverpool Hospital

Liverpool, New South Wales, 2170, Australia
London Health Sciences Centre - University Hospital

London, N6A 5A5, Canada
Louisiana Research Center, LLC

Shreveport, Louisiana, 71105, United States
Lucas Research, Inc.

Morehead City, North Carolina, 28557, United States
Manassas Clinical Research Center

Manassas, Virginia, 20110, United States
Maya Research Center

Hialeah, Florida, 33016, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
McMaster University Medical Center

Hamilton, L8N 3Z5, Canada
Medical Associates Research Group

San Diego, California, 92123, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Mercy Medical Center

Baltimore, Maryland, 21202, United States
Michigan Medicine - University of Michigan

Ann Arbor, Michigan, 48109, United States
Monash Health, Monash Medical Centre (Clayton)

Clayton, Victoria, 3168, Australia
Mount Sinai Medical Center

New York, New York, 10029, United States
Nature Coast Clinical Research

Inverness, Florida, 34452, United States
New Generation of Medical Research

Hialeah, Florida, 33016, United States
New York University Langone Health

New York, New York, 10016, United States
North Alabama Health Research, LLC

Madison, Alabama, 35758, United States
Northeast GI Research Division

Concord, North Carolina, 28027, United States
Northwell Health Center for Liver Diseases

Manhasset, New York, 11030, United States
Ocala GI Research

Ocala, Florida, 34471, United States
Ocean Blue Medical Research Center, Inc

Miami Springs, Florida, 33166, United States
Optimed Research

Columbus, Ohio, 43235, United States
Options Health Research, LLC

Tulsa, Oklahoma, 74104, United States
Osaka City University Hospital

Osaka, 5458586, Japan
Oschner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Palmtree Clinical Research, Inc.

Palm Springs, California, 92262, United States
Pinnacle Clinical Research

Austin, Texas, 78757, United States
Pinnacle Clinical Research

Georgetown, Texas, 78626, United States
Pinnacle Clinical Research, LLC

San Antonio, Texas, 78229, United States
Precision Research Institute

San Diego, California, 92114, United States
ProLive Medical Research, Corp

Miami, Florida, 33175, United States
Progressive Medical Research

Port Orange, Florida, 32127, United States
Quality Medical Research, PLLC

Nashville, Tennessee, 37211, United States
Quest Clinical Research

San Francisco, California, 94115, United States
Research and Education Inc.

San Diego, California, 92105, United States
Royal Brisbane and Women's Hospital

Herston, Queensland, 4029, Australia
Royal Perth Hospital

Perth, Western Australia, 6000, Australia
Rush University Medical Group - Department of Hepatology

Chicago, Illinois, 60612, United States
Rutgers New Jersey Medical School

Newark, New Jersey, 07103, United States
Saga University Hospital

Saga, 849-0937, Japan
Saiseikai Suita Hospital

Suita, 564-0013, Japan
San Jose Gastroenterology at One Health

San Jose, California, 95128, United States
Sapporo-Kosei General Hospital

Sapporo, 060-0033, Japan
Schiff Center for Liver Diseases/ University of Miami

Miami, Florida, 33136, United States
Sierra Clinical Research

Las Vegas, Nevada, 89106, United States
Soma Clinical Trials, LLC

Denison, Texas, 75020, United States
South Denver Gastroenterology

Englewood, Colorado, 80113, United States
South Texas Research Institute

Brownsville, Texas, 78520, United States
South Texas Research Institute

Edinburg, Texas, 78539, United States
Southeast Clinical Research LLC

Dalton, Georgia, 30720, United States
Southern California Research Center

Coronado, California, 92118, United States
Southern Therapy and Advanced Research

Jackson, Mississippi, 39216, United States
Southwest General Healthcare Center

Fort Myers, Florida, 33907, United States
Stanford Medicine Outpatient Center

Redwood City, California, 94063, United States
Sunbright Health Medical Center

Homestead, Florida, 33032, United States
Synergy Healthcare

Bradenton, Florida, 34208, United States
Tandem Clinical Research GI, LLC

Marrero, Louisiana, 70072, United States
Texas Clinical Research Institute

Arlington, Texas, 76012, United States
Texas Digestive Specialists

Harlingen, Texas, 78550, United States
The Institute for Liver Health DBA Arizona Liver Health

Peoria, Arizona, 85381, United States
The Institution For Liver Health dba Arizona Liver Health

Chandler, Arizona, 85224, United States
The Institution For Liver Health dba Arizona Liver Health

Tucson, Arizona, 85712, United States
The Liver Institute at Methodist Dallas Medical Center

Dallas, Texas, 75203, United States
The New York - Presbyterian Hospital

New York, New York, 10065, United States
The University Of Vermont Medical Center

Burlington, Vermont, 05401, United States
Toronto Digestive Disease Associates Specialty Research

Vanghan, L4L 4Y7, Canada
Toronto General Hospital - University Health Network

Toronto, M5G 2C4, Canada
Toronto Liver Centre

Toronto, M6H 3M1, Canada
TriWest Research Associates, LLC

San Diego, California, 92108, United States
Tulane University Health Sciences Center

New Orleans, Louisiana, 70112, United States
UF Health Jacksonville-Gastroenterology Emerson

Jacksonville, Florida, 32224, United States
United Medical Doctors

Murrieta, California, 92563, United States
University Gastroenterology

Providence, Rhode Island, 02905, United States
University Hospital, Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan
University of Alabama at Birmingham Hospital

Birmingham, Alabama, 35233, United States
University of Calgary Liver Unit - Heritage Medical Research Clinic

Calgary, T2N 4Z6, Canada
University of California, Davis Medical Center

Sacramento, California, 95817, United States
University of California, San Diego - Altman Clinical and Translational Research Institute

La Jolla, California, 92037, United States
University of California, San Francisco - Fresno

Fresno, California, 93701, United States
University of California, San Francisco - Liver Clinic

San Francisco, California, 94143, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Florida Hepatology Research at the Clinical and Translational Research Building

Gainesville, Florida, 32610, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Utah Hospital

Salt Lake City, Utah, 84132, United States
University of Virginia Medical Center

Charlottesville, Virginia, 22908, United States
VA Caribbean Healthcare System

San Juan, 00921, Puerto Rico
Velocity Clinical Research - Providence

East Greenwich, Rhode Island, 02818, United States
Velocity Clinical Research, Hallandale Beach

Hallandale, Florida, 33009, United States
Velocity Clinical Research, Salt Lake City

West Jordan, Utah, 84088, United States
Velocity Clinical Research, Spartanburg

Spartanburg, South Carolina, 29303, United States
Virginia Commonwealth University Health Clinical Research Services Unit

Richmond, Virginia, 23298, United States
Virginia Mason

Seattle, Washington, 98101, United States
Wake Research - ClinsSearch, LLC

Chattanooga, Tennessee, 37421, United States
Walter Reed National Military Medical Center

Bethesda, Maryland, 20889, United States
Westmead Hospital

Westmead, New South Wales, 2145, Australia
Wlliam Osler Health System - Brampton Civic Hospital

Brampton, L6R 3J7, Canada
Woodholme Gastroenterology Associates

Glen Burnie, Maryland, 21061, United States
Yale Center for Clinical Investigation, Church Street Research Unit

New Haven, Connecticut, 06519, United States
Yamagata University Hospital

Yamagata, 9909585, Japan
Yokohama City University Hospital

Yokohama, 2360004, Japan

Conditions

Explore the condition pages connected to this study.

NONALCOHOLIC STEATOHEPATITIS