New nasal spray aims to tame Life-Threatening hunger in rare genetic disorder
NCT ID NCT06173531
Summary
This study is testing whether a carbetocin nasal spray can reduce the constant, extreme hunger (hyperphagia) that is the most challenging symptom of Prader-Willi syndrome (PWS). About 170 participants, aged 5 to 30, will use the spray or a placebo for 12 weeks. The main goal is to see if the spray helps caregivers report a meaningful decrease in food-seeking behaviors and overeating.
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Contacts and locations
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Locations
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Alberta Diabetes Institute
Edmonton, Alberta, T6G 2E1, Canada
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Barts Health NHS Trust - The Royal London Hospital
London, E1 1BB, United Kingdom
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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CHU Sainte Justine
Montreal, Quebec, H3T 1C5, Canada
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Centre Hospitalier Universitaire (CHU) de Toulouse - Hôpital des Enfants
Toulouse, 31059, France
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
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Children's of Alabama
Birmingham, Alabama, 35233, United States
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Christus Children's
San Antonio, Texas, 78207, United States
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Cook Children's Health Care System
Fort Worth, Texas, 79104, United States
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Hospital General Universitario Gregorio Marañón
Madrid, 28009, Spain
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Hospital Regional Universitario de Málaga
Málaga, 29010, Spain
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KJF Klinik Josefinum gGmbH
Augsburg, 86154, Germany
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Maimonides Medical Center
Brooklyn, New York, 11219, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Parc Taulí Hospital Universitari
Barcelona, 08208, Spain
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Phoenix Children's Hospital
Phoenix, Arizona, 85006, United States
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Rady Children's Hospital San Diego
San Diego, California, 92123, United States
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Royal Hospital for Children Glasgow Clinical Research Facility
Glasgow, G51 4TF, United Kingdom
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SSM Health/Saint Louis University
St Louis, Missouri, 63104, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Stanford University School of Medicine
Palo Alto, California, 94304, United States
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UPMC-Children's Hospital Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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University Hospitals Birmingham NHS Foundation Trust - Heartlands Hospital
Birmingham, B9 5SS, United Kingdom
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University of California Irvine
Orange, California, 92697, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Utah
Salt Lake City, Utah, 84108, United States
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Universitätsklinikum Essen
Essen, 45147, Germany
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Vanderbilt Clinical Research Center
Nashville, Tennessee, 37232, United States
Conditions
Explore the condition pages connected to this study.