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Nanotech patch aims to slash opioid use after wisdom tooth surgery

NCT ID NCT07461506

Symptom relief Sponsor: nCap Medical Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new nanotechnology patch, called NeuroCuple, placed on the skin for two days after wisdom tooth extraction. The goal is to see if it reduces pain and the need for opioid painkillers. 120 healthy adults aged 18–50 will be randomly assigned to get either the active patch or a sham patch. The main measure is how much opioid medication they use in the first 48 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NeuroCuple patch (a non-drug device using nanotechnology)
What this could lead to
If it works, this could offer a drug-free way to manage dental pain and lower the risk of opioid addiction after wisdom tooth extraction.
What could go wrong
This is an early feasibility study with only 120 people. The patch may not work better than a placebo, and results may not apply to other types of surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Males and females of all races and ethnicity 2. \>18 to 50 years 3. Healthy based on medical history 4. Scheduled for elective extraction of one or more partially or fully impacted mandibular third molars 5. Able to understand and sign the informed consent form 6. Willing and able to comply with all study procedures 7. Available for the duration of the study 8. Able to understand the directions for data gathering instruments Exclusion Criteria: 1. Children (\< 18 years of age) 2. T-score ≥ 60 in any of the three PROMIS measures (i.e., sleep, anxiety, and depression) 3. Other concomitant surgery being performed in addition to third molar extraction 4. History of gastrointestinal bleeding and/or peptic ulcer, renal disease (excluding kidney stones), hepatic disease, bleeding disorder, respiratory depression 5. History of respiratory depression with opioids or other anesthetic drugs that required postoperative ventilatory support or naloxone 6. Active or untreated asthma 7. Known allergy to ibuprofen, acetaminophen, oxycodone, hydrocodone, and/or anesthesia 8. Currently taking CYP3A4 inhibitors, azole-antifungal agents, protease inhibitors, or CNS depressants 9. Consumes three or more alcoholic drinks per day 10. Active alcoholism or illicit drug abuse (defined as daily use of illicit drugs) 11. History of substance or alcohol abuse 12. History of substance or alcohol abuse in a first-degree relative 13. No more than one opioid prescription filled within the past 12 months (self-report and PDMP) 14. Pregnant or lactating women Sex, race, and ethnicity will not be used as exclusion criteria.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Wisdom teeth Wisdom teeth extraction or jaw implant

How to take part

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  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

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    Open the record ↗

  4. A doctor treating you

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Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • University of Pittsburgh School of Dental Medicine

    Pittsburgh, Pennsylvania, 15261, United States