Could a forearm shot of naloxone save more lives?
NCT ID NCT07180420
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether injecting naloxone into the forearm works as well as the standard injection into the buttocks. Twelve healthy volunteers received the forearm injection to measure how the drug behaves in the body. The goal is to make naloxone easier to give quickly during an opioid overdose.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- naloxone hydrochloride
- What this could lead to
- If successful, this could allow faster and easier naloxone administration during an opioid overdose, potentially saving more lives.
- What could go wrong
- This is a very early, small study in healthy volunteers, not people experiencing an overdose. Results may not translate to real-world emergency use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
12 people
The number who actually took part.
- Started
-
Mar 2024
- Finished
-
Apr 2024
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 55 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18 to 55 years of age * Body mass index (BMI) 18 to 30 kg/m2 * Subjects who do not take prescribed or OTC medications on a regular basis. In the case of recent sporadic use for minor illness, the subject may be enrolled if the investigator deems the use insignificant to study. * Nonsmokers and subjects who smoked 10 or fewer cigarettes per day. * Be willing to spend at least 12 hours in the study facility. Exclusion Criteria: * Subjects who do not fulfill criteria as described in Inclusion Criteria above * Abnormal wrist or forearm anatomy (or history of prior wrist/forearm surgery). * Difficult venous access for blood draws * Active infection in including respiratory tract infection * Used opioid analgesics for pain relief within the previous 14 days, or, in the judgment of the investigator, had significant acute or chronic medical conditions. * Known previous or concomitant serious illness or medical condition such as malignancy, HIV, significant gastrointestinal or hepatic disease or cardiovascular event or hepatitis that in the opinion of the investigator may interfere with participation in the study * Previous Substance Use Disorder (SUD) with injectable drugs. * Compromised cardiovascular system (history of myocardial infarction- MI, angina, etc., at discretion of principal investigator- PI).
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
JCCT
Lenexa, Kansas, 66219, United States