New hope for blood cancer patients: trial tests combo therapy for tough cases

NCT ID NCT04551053

Summary

This study tested whether adding a new drug called parsaclisib to the standard treatment (ruxolitinib) could help people with myelofibrosis, a serious bone marrow cancer, who weren't getting a good enough response from ruxolitinib alone. It involved 177 participants and compared the combination to just continuing ruxolitinib with a placebo. The main goals were to see if the combo could shrink enlarged spleens and reduce symptoms like fatigue and pain more effectively.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O. Universitaria Ospedale Di Circolo E Fondazione Macchi

    Varese, 21100, Italy

  • A.Z. St.-Jan A.V.

    Bruges, 08000, Belgium

  • AZ Delta

    Roeselare, 8800, Belgium

  • Advent Health Hendersonville Park Ridge Hospital Hendersonville

    Clyde, North Carolina, 28721, United States

  • Akershus University Hospital

    Lorenskog, 01478, Norway

  • Aou Policlinico Consorziale Di Bari

    Bari, 70124, Italy

  • Ap-Hp Groupe Hospitalier Saint-Louis Lariboisiere Fernand-Widal Site Saint Louis (Paris)

    Paris, 75010, France

  • Assuta Ramat Hahayal

    Tel Aviv, 69710, Israel

  • Augusta University - Medical College of Georgia

    Augusta, Georgia, 30912, United States

  • Azienda Ospedaliera Di Rilievo Nazionale E Di Alta Specializzazione Garibaldi

    Catania, 11111, Italy

  • Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello

    Palermo, 90146, Italy

  • Azienda Ospedaliera San Giuseppe Moscati

    Avellino, 83100, Italy

  • Azienda Ospedaliera San Giuseppe Moscati

    Taranto, 74123, Italy

  • Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria Alle Scotte

    Siena, 53100, Italy

  • Azienda Ospedaliero Universitaria Maggiore Della Carita Di Novara

    Novara, 28100, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126, Italy

  • Azienda Sanitaria Universitaria Friuli Centrale Asu Fc

    Udine, 33100, Italy

  • Baptist Cancer Center

    Memphis, Tennessee, 38120, United States

  • Baskent University Adana Hospital

    Adana, 01250, Turkey (Türkiye)

  • Baskent University Istanbul Hospital

    Istanbul, 34662, Turkey (Türkiye)

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • CCARE

    Fresno, California, 93720, United States

  • CHU Limoges - Hopital Duputren

    Limoges, 87042, France

  • California Research Institute (Cri)

    Los Angeles, California, 90027-6005, United States

  • Centre Hospitalier Universitaire Grenoble Alpes (Chu Grenoble Alpes) - Hopital Albert Michallon

    La Tronche, 38700, France

  • Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu

    Nantes, 44093, France

  • China Medical University Hospital

    Taichung, 00404, Taiwan

  • Chu Nimes

    Nîmes, 30900, France

  • Chu Ucl Namur University Hospital Mont-Godinne

    Yvoir, 05530, Belgium

  • Chu Vandoeuvre-Les-Nancy Hopital Brabois

    Vandœuvre-lès-Nancy, 54500, France

  • Chu de Limoges

    Limoges, 87042, France

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Coastal Integrated Cancer Care - Cicc

    San Luis Obispo, California, 93401, United States

  • Dokkyo Medical University Saitama Medical Center

    Saitama, 343-8555, Japan

  • Duke Cancer Center

    Durham, North Carolina, 27710, United States

  • Ege University Hospital

    Izmir, 35040, Turkey (Türkiye)

  • Emad Ibrahim Md Inc

    Redlands, California, 92373, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Fondazione Irccs Ca Granda Ospedale Maggiore

    Milan, 20122, Italy

  • Fujian Medical University Union Hospital

    Fuzhou, 350001, China

  • Fundacion Jimenez Diaz University Hospital

    Madrid, 28040, Spain

  • Gazi University Hospital Gazi University Faculty of Medicine

    Ankara, 06500, Turkey (Türkiye)

  • Georgetown University

    Washington D.C., District of Columbia, 20057, United States

  • Gloucestershire Royal Hospital

    Gloucester, GL1 3NN, United Kingdom

  • Grampian Health Board

    Aberdeen, AB15 6RE, United Kingdom

  • Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli

    Reggio Calabria, 89133, Italy

  • Hadassah Hebrew University Medical Center Ein Karem Hadassah

    Jerusalem, 91120, Israel

  • Hanusch-Krankenhaus Wiener Gebietskrankenkasse

    Vienna, 01140, Austria

  • Harbin Institute of Hematology and Oncology

    Harbin, 150010, China

  • Haukeland University Hospital

    Bergen, 05021, Norway

  • Helsinki University Central Hospital

    Helsinki, FI-00029, Finland

  • Henan Cancer Hostipal

    Zhengzhou, 450008, China

  • Henan Provincial Peoples Hospital

    Zhengzhou, 450003, China

  • Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • Hokuyukai Sapporo Hokuyu Hospital

    Sapporo, 003-0006, Japan

  • Hospices Civils de Lyon Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • Hospital Clinico Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hospital Del Mar

    Barcelona, 08003, Spain

  • Hospital General Universitario Morales Meseguer

    Murcia, 30008, Spain

  • Hospital General Universitario Vall D Hebron

    Barcelona, 08035, Spain

  • Hospital General Unviersitario de Alicante

    Alicante, 03010, Spain

  • Hospital Saint Antoine

    Paris, 75012, France

  • Hospital Universitari I Politecnic La Fe

    Valencia, 46000, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 24041, Spain

  • Hospital Universitario Doctor Peset

    Valencia, 46017, Spain

  • Hospital Universitario Insular de Gran Canaria

    Las Palmas de Gran Canaria, 35010, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • Hospital Universitario Virgen de La Arrixaca

    Murcia, 30120, Spain

  • Hospital of the University of Occupation and Environmental Health

    Kitakyushu-shi, 807-8556, Japan

  • Ico Hospital Germans Trias I Pujol

    Badalona, 08916, Spain

  • Indiana University Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana, 46202, United States

  • Institut Catala Doncologia Ico - Hospital Duran I Reynals Location

    Barcelona, 08908, Spain

  • Institut Universitaire Du Cancer de Toulouse Oncopole

    Toulouse, 31059, France

  • Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Pek

    Tianjin, 510080, China

  • Institute of Hematology and Transfusion Medicine

    Warsaw, 02-776, Poland

  • Irccs Azienda Ospedaliera Universitaria San Martino

    Genova, 16132, Italy

  • Istanbul Medipol Universitesi Ibagcilar Medipol Mega Universitesi Hastanesi

    Istanbul, 34214, Turkey (Türkiye)

  • James Cook University Hospital

    Middlesbrough, TS4 3BW, United Kingdom

  • Japanese Red Cross Nagoya Daini Hospital

    Nagoya, 453-8511, Japan

  • Japanese Red Cross Society Himeji Hospital

    Himeji-shi, 670-8540, Japan

  • Jessa Ziekenhuis

    Hasselt, 3500, Belgium

  • Jiangsu Province Hospital

    Nanjing, 210029, China

  • Jiangxi Provincial of People Hospital

    Nanchang, 330000, China

  • Jinan Central Hospital

    Jinan, 250013, China

  • Juntendo University Hospital

    Izunokuni, 410-2211, Japan

  • Juntendo University Hospital

    Tokyo, 113-8431, Japan

  • Kagoshima University Hospital

    Kagoshima, 890-8520, Japan

  • Kansai Medical University Hospital

    Hirakata, 573-1191, Japan

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301, Taiwan

  • Kaplan Medical Center

    Rehovot, 76100, Israel

  • Kelsey Seybold Clinic

    Houston, Texas, 77025, United States

  • Kobe City Medical Center General Hospital

    Kobe, 650-0047, Japan

  • Kumamoto Shinto General Hospital

    Kumamoto, 862-8655, Japan

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • Lanzhou University Second Hospital

    Lanzhou, 730030, China

  • Lstituto Di Ematologia Lorenzo Ea.Seragnoli Universita Degli Studi Di Bologna - Policlinico S. Or

    Bologna, 40138, Italy

  • Markhot Ferenc Korhaz

    Eger, 03300, Hungary

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Midamerica Cancer Care

    Kansas City, Missouri, 64114, United States

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • Morristown Medical Center - Atlantic Health System

    Morristown, New Jersey, 07960, United States

  • Mount Sinai School of Medicine

    New York, New York, 10029, United States

  • Nanfang Hospital

    Guangzhou, 510515, China

  • National Cheng Kung University (Ncku) Hospital

    Tainan, 00704, Taiwan

  • New Jersey Hematology Oncology Associates Llc

    Brick, New Jersey, 08724, United States

  • Nippon Medical School Hospital

    Tokyo, 113-8603, Japan

  • Ogaki Municipal Hospital

    Ōgaki, 5038502, Japan

  • Ondokuz Mayis University Medicine Faculty

    Samsun, 55200, Turkey (Türkiye)

  • Oregon Health & Science University

    Columbus, Ohio, 43210, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Osaka Metropolitan University Hospital

    Osaka, 545-8585, Japan

  • Ospedale S.Maria Della Misericordia

    Perugia, 06156, Italy

  • Ospedale S.Maria Della Misericordia

    Perugia, 6156, Italy

  • Ospedale Sant. Eugenio

    Roma, 144, Italy

  • Peking University People'S Hospital (Pkuph) - Institute of Hematology

    Beijing, 100044, China

  • Peking University Third Hospital

    Beijing, 100091, China

  • Peking University Third Hospital

    Beijing, 100191, China

  • Petz Aladar County Teaching Hospital

    Győr, 09024, Hungary

  • Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore

    Roma, 00168, Italy

  • Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore

    Rome, 00168, Italy

  • Pratia Hematologia Katowice

    Katowice, 40-040, Poland

  • Pratia Hematologia Katowice

    Katowice, 41-081, Poland

  • Presidio Ospedaliero Pescara

    Pescara, 65124, Italy

  • Providence Regional Medical Center Everett

    Everett, Washington, 98201, United States

  • Pusan National University Yangsan Hospital

    Busan, 49241, South Korea

  • Rambam Health Care Campus

    Haifa, 31999, Israel

  • Renovatio Clinical

    Houston, Texas, 77005, United States

  • Samodzielny Publiczny Szpital Kliniczny Nr 1

    Lublin, 20-081, Poland

  • Samodzielny Publiczny Zoz Szpital Uniwersytecki W Krakowie

    Krakow, 31-501, Poland

  • Samson Assuta Ashdod University Hospital

    Ashdod, 7747629, Israel

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Scripps Clinic

    San Diego, California, 92103, United States

  • Semmelweis Egyetem

    Budapest, 01088, Hungary

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Shenzhen University Hospital

    Shenzhen, 518055, China

  • Spitalul Clinic Coltea - Clinica Hematologie

    Bucharest, 30171, Romania

  • Spitalul Clinic Judetean de Urgenta Targu Mures

    Târgu Gânguleşti, 540139, Romania

  • Stamford Hospital - Medical Oncology Hematology

    Stamford, Connecticut, 06904, United States

  • Sutter Health Alta Bates Summit Medical Center Absmc Alta Bates Summit Comprehensive Cancer Center

    Berkeley, California, 94704, United States

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239, Israel

  • Texas Oncology - Baylor Sammons Cancer Center

    Dallas, Texas, 75246-2092, United States

  • Texas Oncology - Medical City Dallas

    Dallas, Texas, 75230, United States

  • The Affiliated Hospital of Inner Mongolia Medical University

    Hohhot, 10050, China

  • The Affiliated Hospital of Qingdao University

    Qingdao, 266003, China

  • The Catholic University of Korea Seoul St. Mary?S Hospital

    Seoul, 06591, South Korea

  • The First Affiliated Hospital of Nanchang University

    Nanchang, 330006, China

  • The First Affiliated Hospital of Zhejiang University

    Hangzhou, 310003, China

  • The First Hospital of China Medical University

    Shenyang, 110001, China

  • The First Hospital of Jilin University

    Changchun, 130021, China

  • The First Hospital of Lanzhou University

    Lanzhou, 730000, China

  • The First Peoples Hospital of Changzhou

    Changzhou, 213003, China

  • The Second Affiliated Hospital of Kunming Medical University

    Kunming, 650101, China

  • The Second Affiliated Hospital of Xi an Jiaotong University

    Xi'an, 710004, China

  • Tianjin Medical University General Hospital

    Tianjin, 300052, China

  • Tokai University Hospital

    Isehara, 2591193, Japan

  • Tongji Hospital Huazhong University of Science and Technology

    Wuhan, 430030, China

  • Tulane University

    New Orleans, Louisiana, 70112, United States

  • Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, 430022, China

  • United Lincolnshire Hospitals

    Boston, PE21 9QS, United Kingdom

  • Univ. Di Roma Facolta Di Armacia E Medicina

    Roma, 00161, Italy

  • Universita Di Napoli Federico Ii

    Napoli, 80131, Italy

  • Universitaetsmedizin Greifswald

    Greifswald, 17475, Germany

  • Universitaetsmedizin Rostock

    Rostock, 18057, Germany

  • Universitatsklinikum Bonn Aoer

    Bonn, 53127, Germany

  • Universitatsklinikum Halle (Saale)

    Halle, 06120, Germany

  • University College London Hospitals Nhs Foundation Trust

    London, NW1 2BU, United Kingdom

  • University of Florence

    Florence, 50134, Italy

  • University of Kansas Hospital Authority

    Westwood, Kansas, 66205, United States

  • University of Miyazaki Hospital

    Miyazaki, 889-1692, Japan

  • University of Science and Technology of China-First Affiliated Hospital (Anhui Provincial Hospital)

    Hefei, 230022, China

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390-8565, United States

  • University of Yamanashi Hospital

    Yamanashi, 409-3898, Japan

  • Westchester Medical Center Advanced Oncology

    Hawthorne, New York, 10532, United States

  • Xuanwu Hospital Capital Medical University

    Beijing, 100053, China

  • Yantai Yuhuangding Hospital

    Yantai, 264000, China

Conditions

Explore the condition pages connected to this study.