New cocktail of cancer drugs aims to wipe out myeloma before transplant

NCT ID NCT05558319

Recruiting now Disease control Sponsor: PETHEMA Foundation Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests three different drug combinations for people with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The goal is to see which combination leads to the deepest remission (measured by minimal residual disease negativity) after 18 cycles of treatment plus transplant. About 480 participants will be randomly assigned to one of three arms: standard VRD (bortezomib, lenalidomide, dexamethasone) with early rescue, isatuximab plus VRD, or isatuximab plus iberdomide and dexamethasone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Isatuximab, Iberdomide, Bortezomib, Lenalidomide, Dexamethasone
What this could lead to: If successful, this could lead to more effective treatment combinations for multiple myeloma, helping patients achieve deeper remission and potentially longer disease control.
What could go wrong: This is an early-stage Phase 3 trial, and the new combinations may not prove better than standard therapy. Side effects from the drugs, including infections and nerve damage, are possible.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEWLY DIAGNOSED MULTIPLE MYELOMA

Contacts and locations

Locations

Clinica Universidad Navarra (CUN)
RECRUITING

Pamplona, Navarre, 31008, Spain
Complejo Asistencial Universitario de León
RECRUITING

León, Spain
Complejo Hospitalario Lucus Augusti
RECRUITING

Lugo, Spain
Complejo Hospitalario Regional Virgen Del Rocío
RECRUITING

Seville, Spain
Complejo Hospitalario Santiago (CHUS)
RECRUITING

Santiago de Compostela, Spain
Complejo Hospitalario Universitario Nuestra Señora de la Candelaria
RECRUITING

Santa Cruz de Tenerife, Spain
Complejo Hospitalario Universitario de Ourense
COMPLETED

Ourense, Spain
Complejo Hospitalario de Cáceres
RECRUITING

Cáceres, Spain
Complejo Hospitalario de Navarra
RECRUITING

Pamplona, Spain
Complejo Hospitalario de Pontevedra
RECRUITING

Pontevedra, Spain
Complejo Hospitalario de Toledo (Virgen de la Salud)
RECRUITING

Toledo, Spain
Fundación Jiménez Díaz-Ute
RECRUITING

Madrid, Spain
H. Morales Meseguer
RECRUITING

Murcia, Spain
H. U. Txagorritxu
RECRUITING

Vitoria-Gasteiz, Spain
H. Un. Virgen de la Arrixaca
RECRUITING

Murcia, Spain
H. Universitario Marqués de Valdecilla
RECRUITING

Santander, Spain
H. Universitario de Valme
RECRUITING

Seville, Spain
H.Universitario de Jerez de la Frontera
RECRUITING

Jerez de la Frontera, Spain
Hospital Arnau de Vilanova (Lleida)
RECRUITING

Lleida, Spain
Hospital Clinic i Provincial de Barcelona
RECRUITING

Barcelona, Spain
Hospital Clinico Universitario Lozano Blesa
RECRUITING

Zaragoza, Spain
Hospital Clinico Universitario Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Spain
Hospital Costa del Sol
RECRUITING

Málaga, Spain
Hospital General Universitario Gregorio Marañón
RECRUITING

Madrid, Spain
Hospital General Universitario Santa Lucía
COMPLETED

Murcia, Spain
Hospital General Universitario de Albacete
RECRUITING

Albacete, Spain
Hospital General de Segovia
RECRUITING

Segovia, Spain
Hospital Germans Trias i Pujol (ICO BADALONA)
RECRUITING

Badalona, Spain
Hospital HLA Universitario Moncloa
RECRUITING

Madrid, Spain
Hospital Principe de Asturias
RECRUITING

Alcalá de Henares, Madrid, Spain
Hospital Regional de Málaga
RECRUITING

Málaga, Spain
Hospital San Pedro
RECRUITING

Logroño, Spain
Hospital Son Llatzer
RECRUITING

Palma de Mallorca, Spain
Hospital U Niversitario Virgen de La Victoria
RECRUITING

Málaga, Spain
Hospital Universitari Dr. Josep Trueta (ICO Girona)
RECRUITING

Girona, Spain
Hospital Universitari Mutua Terrassa
RECRUITING

Terrassa, Spain
Hospital Universitari Son Espases
RECRUITING

Palma de Mallorca, Spain
Hospital Universitari Vall d´Hebron
RECRUITING

Barcelona, Spain
Hospital Universitari de Tarragona Joan XXIII
RECRUITING

Tarragona, Spain
Hospital Universitari i Politecnic la Fe
RECRUITING

Valencia, Spain
Hospital Universitario 12 de octubre
RECRUITING

Madrid, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, Spain
Hospital Universitario Clínico San Carlos
RECRUITING

Madrid, Spain
Hospital Universitario Dr. Peset Aleixandre
RECRUITING

Valencia, Spain
Hospital Universitario Fundación Alcorcón
COMPLETED

Madrid, Spain
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, Spain
Hospital Universitario Infanta Leonor
RECRUITING

Madrid, Spain
Hospital Universitario Infanta Sofía
RECRUITING

San Sebastián de los Reyes, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Spain
Hospital Universitario La Zarzuela
RECRUITING

Madrid, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, Spain
Hospital Universitario Puerta del Hierro
RECRUITING

Madrid, Spain
Hospital Universitario Quirón Salud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Spain
Hospital Universitario Reina Sofía
RECRUITING

Seville, Spain
Hospital Universitario Rey Juan Carlos
RECRUITING

Móstoles, Spain
Hospital Universitario Virgen de las Nieves
RECRUITING

Granada, Spain
Hospital Universitario de Burgos
RECRUITING

Burgos, 09006, Spain
Hospital Universitario de Cabueñes
RECRUITING

Gijón, Spain
Hospital Universitario de Canarias
RECRUITING

San Cristóbal de La Laguna, Spain
Hospital Universitario de Cruces
RECRUITING

Bilbao, Spain
Hospital Universitario de Donostia
RECRUITING

San Sebastián, Spain
Hospital Universitario de Fuenlabrada
RECRUITING

Madrid, Spain
Hospital Universitario de Guadalajara
RECRUITING

Guadalajara, Spain
Hospital Universitario de la Princesa
RECRUITING

Madrid, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, Spain
ICO L´Hospitalet
RECRUITING

Barcelona, Spain

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