New cocktail of cancer drugs aims to wipe out myeloma before transplant
NCT ID NCT05558319
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests three different drug combinations for people with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The goal is to see which combination leads to the deepest remission (measured by minimal residual disease negativity) after 18 cycles of treatment plus transplant. About 480 participants will be randomly assigned to one of three arms: standard VRD (bortezomib, lenalidomide, dexamethasone) with early rescue, isatuximab plus VRD, or isatuximab plus iberdomide and dexamethasone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Isatuximab, Iberdomide, Bortezomib, Lenalidomide, Dexamethasone
What this could lead to
If successful, this could lead to more effective treatment combinations for multiple myeloma, helping patients achieve deeper remission and potentially longer disease control.
What could go wrong
This is an early-stage Phase 3 trial, and the new combinations may not prove better than standard therapy. Side effects from the drugs, including infections and nerve damage, are possible.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Clinica Universidad Navarra (CUN)
RECRUITINGPamplona, Navarre, 31008, Spain
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RECRUITINGLeón, Spain
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RECRUITINGLugo, Spain
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RECRUITINGSantiago de Compostela, Spain
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RECRUITINGSanta Cruz de Tenerife, Spain
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COMPLETEDOurense, Spain
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RECRUITINGCáceres, Spain
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RECRUITINGPamplona, Spain
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RECRUITINGToledo, Spain
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RECRUITINGMadrid, Spain
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RECRUITINGBarcelona, Spain
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RECRUITINGValencia, Spain
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RECRUITINGMálaga, Spain
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RECRUITINGMadrid, Spain
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COMPLETEDMurcia, Spain
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RECRUITINGAlbacete, Spain
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RECRUITINGLogroño, Spain
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RECRUITINGPalma de Mallorca, Spain
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RECRUITINGMálaga, Spain
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RECRUITINGGirona, Spain
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RECRUITINGTerrassa, Spain
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RECRUITINGPalma de Mallorca, Spain
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RECRUITINGBarcelona, Spain
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RECRUITINGValencia, Spain
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RECRUITINGValencia, Spain
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RECRUITINGPozuelo de Alarcón, Madrid, 28223, Spain
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RECRUITINGMóstoles, Spain
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RECRUITINGGranada, Spain
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