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Which Root-End filling technique heals better?

NCT ID NCT07808424

Disease control Sponsor: Postgraduate Institute of Dental Sciences Rohtak Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests two methods of placing a mineral trioxide aggregate (MTA) plug during apical surgery for people with persistent apical periodontitis in back teeth. One method fills the root end from the outside (retrograde), the other from the inside (orthograde). Researchers will compare healing on X-rays and 3D scans, pain levels, and quality of life over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mineral trioxide aggregate (MTA) used as a root-end filling material during endodontic micro-surgery, applied either orthograde (from within the root canal) or retrograde (from the root tip).
What this could lead to
If one method proves better, it could improve healing rates and reduce pain for people with persistent root infections after standard treatment.
What could go wrong
This is a small, early-stage trial, so results may not apply to all cases. Surgery carries risks like pain, swelling, or damage to nearby teeth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients in which non-surgical retreatment is unfeasible (anatomical complexity, iatrogenic errors) or previously failed treatment in cases of persistent symptomatic apical periodontitis involving posteriors. * Tooth with a peri-radicular lesion of endodontic origin (chronic apical periodontitis) or endo-perio origin with the size of lesion ≥5mm. * Teeth with less than 10 degree root curvature. * Patients between 18-55 years of age. * No general medical contraindications for oral surgical procedures (ASA-1 according to the classification of the American Society of Anesthesiologists) * Tooth with adequate final restoration without clinical evidence of coronal leakage. * Good periodontal health condition at tooth level. * Able to completely understand and sign an informed consent form. Exclusion Criteria: * • Patients with systemic diseases (diabetes mellitus, uncontrolled hypertension grade III, hepatic/renal disease, or systemic bleeding disorders) (Bharathi et al 2021). * Patients on anticoagulant/ antiplatelet drugs. * Fractured/perforated teeth. * Presence of vertical root fracture. * Pregnancy.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non vital teeth Persistent symptomatic apical periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • PGIDS

    RECRUITING

    Rohtak, Haryana, 124001, India