New drug shows promise for Long-Term hot flash relief

NCT ID NCT03541200

Completed Symptom relief Sponsor: Tanabe Pharma America, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the long-term safety and effects of the drug MT-8554 in 190 postmenopausal women with moderate to severe hot flashes. All participants had completed a previous 12-week study of the same drug. Researchers monitored side effects, blood pressure, heart rate, and changes in the uterus lining. The goal was to see if MT-8554 remains safe and effective over a longer period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MT-8554 (oral drug)
What this could lead to: If successful, this could provide a long-term treatment option for reducing hot flashes in postmenopausal women.
What could go wrong: This is a small, early-phase extension study with no placebo group, so results may not confirm effectiveness or safety for wider use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VASOMOTOR SYMPTOMS (VMS)

Contacts and locations

Locations

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Birmingham, Alabama, 35209, United States
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Dothan, Alabama, 36303, United States
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Phoenix, Arizona, 85032, United States
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Norwalk, California, 90650, United States
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Sacramento, California, 94203, United States
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San Diego, California, 92111, United States
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Denver, Colorado, 80209, United States
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New London, Connecticut, 33176, United States
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Clearwater, Florida, 33759, United States
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Crystal River, Florida, 34429, United States
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Fort Myers, Florida, 33900, United States
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Hialeah, Florida, 33012, United States
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Hialeah, Florida, 33016, United States
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Jacksonville, Florida, 32256, United States
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Jupiter, Florida, 33458, United States
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Miami, Florida, 33176, United States
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Miami, Florida, 33185, United States
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Orlando, Florida, 32801, United States
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Orlando, Florida, 32806, United States
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Ponte Vedra, Florida, 32081, United States
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Port Saint Lucie, Florida, 34952, United States
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Sarasota, Florida, 34231, United States
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Wellington, Florida, 33414, United States
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West Palm Beach, Florida, 33409, United States
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Sandy Springs, Georgia, 30328, United States
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Idaho Falls, Idaho, 83404, United States
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Hutchinson, Kansas, 67501, United States
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Wichita, Kansas, 67226, United States
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Marrero, Louisiana, 70072, United States
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Metairie, Louisiana, 70001, United States
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Baltimore, Maryland, 21208, United States
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Kalamazoo, Michigan, 49009, United States
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Saginaw, Michigan, 48504, United States
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Kansas City, Missouri, 64114, United States
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Missoula, Montana, 59801, United States
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Las Vegas, Nevada, 89128, United States
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Lawrenceville, New Jersey, 08648, United States
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Morehead City, North Carolina, 28557, United States
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Winston-Salem, North Carolina, 27103, United States
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Cleveland, Ohio, 44101, United States
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Columbus, Ohio, 43213, United States
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Columbus, Ohio, 43231, United States
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Englewood, Ohio, 45322, United States
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Philadelphia, Pennsylvania, 19114, United States
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Bristol, Tennessee, 37620, United States
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Jackson, Tennessee, 38305, United States
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Memphis, Tennessee, 38119, United States
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Fort Worth, Texas, 76104, United States
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Schertz, Texas, 78154, United States
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Draper, Utah, 84020, United States
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Salt Lake City, Utah, 84107, United States
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Norfolk, Virginia, 23502, United States
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Seattle, Washington, 98101, United States

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