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New drug shows promise for Long-Term hot flash relief

NCT ID NCT03541200

Completed Symptom relief Sponsor: Tanabe Pharma America, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the long-term safety and effects of the drug MT-8554 in 190 postmenopausal women with moderate to severe hot flashes. All participants had completed a previous 12-week study of the same drug. Researchers monitored side effects, blood pressure, heart rate, and changes in the uterus lining. The goal was to see if MT-8554 remains safe and effective over a longer period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

MT-8554 (oral drug)

What this could lead to

If successful, this could provide a long-term treatment option for reducing hot flashes in postmenopausal women.

What could go wrong

This is a small, early-phase extension study with no placebo group, so results may not confirm effectiveness or safety for wider use.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VASOMOTOR SYMPTOMS (VMS)

Contacts and locations

Locations

  • Research Site

    Birmingham, Alabama, 35209, United States

  • Research Site

    Dothan, Alabama, 36303, United States

  • Research Site

    Phoenix, Arizona, 85032, United States

  • Research Site

    Norwalk, California, 90650, United States

  • Research Site

    Sacramento, California, 94203, United States

  • Research Site

    San Diego, California, 92111, United States

  • Research Site

    Denver, Colorado, 80209, United States

  • Research Site

    New London, Connecticut, 33176, United States

  • Research Site

    Clearwater, Florida, 33759, United States

  • Research Site

    Crystal River, Florida, 34429, United States

  • Research Site

    Fort Myers, Florida, 33900, United States

  • Research Site

    Hialeah, Florida, 33012, United States

  • Research Site

    Hialeah, Florida, 33016, United States

  • Research Site

    Jacksonville, Florida, 32256, United States

  • Research Site

    Jupiter, Florida, 33458, United States

  • Research Site

    Miami, Florida, 33176, United States

  • Research Site

    Miami, Florida, 33185, United States

  • Research Site

    Orlando, Florida, 32801, United States

  • Research Site

    Orlando, Florida, 32806, United States

  • Research Site

    Ponte Vedra, Florida, 32081, United States

  • Research Site

    Port Saint Lucie, Florida, 34952, United States

  • Research Site

    Sarasota, Florida, 34231, United States

  • Research Site

    Wellington, Florida, 33414, United States

  • Research Site

    West Palm Beach, Florida, 33409, United States

  • Research Site

    Sandy Springs, Georgia, 30328, United States

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    Idaho Falls, Idaho, 83404, United States

  • Research Site

    Hutchinson, Kansas, 67501, United States

  • Research Site

    Wichita, Kansas, 67226, United States

  • Research Site

    Marrero, Louisiana, 70072, United States

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    Metairie, Louisiana, 70001, United States

  • Research Site

    Baltimore, Maryland, 21208, United States

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    Kalamazoo, Michigan, 49009, United States

  • Research Site

    Saginaw, Michigan, 48504, United States

  • Research Site

    Kansas City, Missouri, 64114, United States

  • Research Site

    Missoula, Montana, 59801, United States

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    Las Vegas, Nevada, 89128, United States

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    Lawrenceville, New Jersey, 08648, United States

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    Morehead City, North Carolina, 28557, United States

  • Research Site

    Winston-Salem, North Carolina, 27103, United States

  • Research Site

    Cleveland, Ohio, 44101, United States

  • Research Site

    Columbus, Ohio, 43213, United States

  • Research Site

    Columbus, Ohio, 43231, United States

  • Research Site

    Englewood, Ohio, 45322, United States

  • Research Site

    Philadelphia, Pennsylvania, 19114, United States

  • Research Site

    Bristol, Tennessee, 37620, United States

  • Research Site

    Jackson, Tennessee, 38305, United States

  • Research Site

    Memphis, Tennessee, 38119, United States

  • Research Site

    Fort Worth, Texas, 76104, United States

  • Research Site

    Schertz, Texas, 78154, United States

  • Research Site

    Draper, Utah, 84020, United States

  • Research Site

    Salt Lake City, Utah, 84107, United States

  • Research Site

    Norfolk, Virginia, 23502, United States

  • Research Site

    Seattle, Washington, 98101, United States