New hope for MS patients when standard drugs stop working

NCT ID NCT04353492

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study tested whether switching to the drug ofatumumab could better control multiple sclerosis in patients whose current treatments were no longer working effectively. It followed 562 adults with relapsing MS for 96 weeks after they switched from specific older medications. The main goal was to see if the new treatment reduced the frequency of MS flare-ups (relapses) and to monitor side effects.

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Contacts and locations

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Locations

Ascension St Francis Center

Milwaukee, Wisconsin, 53215, United States
Atlanta Neuroscience Institute

Atlanta, Georgia, 30327, United States
Axiom Clinical Research of Florida

Tampa, Florida, 33609, United States
Baylor College of Medicine

Houston, Texas, 77030, United States
CU Anschutz Med Campus

Aurora, Colorado, 80045, United States
Christiana Care Health Services

Newark, Delaware, 19713, United States
Cleveland Clinic Foundation

Las Vegas, Nevada, 89106, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Columbus Neuroscience

Westerville, Ohio, 43082, United States
Five Towns Neuroscience Research

Woodmere, New York, 11598, United States
Fullerton Neuro and Headache Ctr

Fullerton, California, 92835, United States
Georgia Neurology and Sleep Medicine Assoc

Suwanee, Georgia, 30024, United States
Homestead Assoc In Research Inc

Homestead, Florida, 33033, United States
INOVA Medical Group

Fairfax, Virginia, 22030, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Memorial Healthcare System

Hollywood, Florida, 33021, United States
Multiple Sclerosis Center of Excellence of OMRF

Oklahoma City, Oklahoma, 73104, United States
Negroski Neurology

Sarasota, Florida, 34233, United States
Neurology Associates PA

Maitland, Florida, 32751, United States
Novartis Investigative Site

Rosario, Santa Fe Province, S2000BZL, Argentina
Novartis Investigative Site

Rosario, Santa Fe Province, S2000DSW, Argentina
Novartis Investigative Site

Buenos Aires, C1424BYD, Argentina
Novartis Investigative Site

San Miguel de Tucumán, 4000, Argentina
Novartis Investigative Site

New Lambton Heights, New South Wales, 2305, Australia
Novartis Investigative Site

Woolloongabba, Queensland, 4102, Australia
Novartis Investigative Site

Parkville, Victoria, 3050, Australia
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Linz, Upper Austria, A 4020, Austria
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Vienna, Vienna, 1010, Austria
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Linz, 4020, Austria
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Vienna, 1090, Austria
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Bruges, 8000, Belgium
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Brussels, 1200, Belgium
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Edegem, 2650, Belgium
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Pleven, Bulgaria, 5800, Bulgaria
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Sofia, Bulgaria, 1431, Bulgaria
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Pleven, 5800, Bulgaria
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Sofia, 1113, Bulgaria
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Sofia, 1431, Bulgaria
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Toronto, Ontario, M4N 3M5, Canada
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Brno, 602 00, Czechia
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Havířov, 736 01, Czechia
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Hradec Králové, 500 05, Czechia
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Prague, 128 08, Czechia
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Teplice, 415 29, Czechia
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Tallinn, 11315, Estonia
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Tartu, 50406, Estonia
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Munich, Bavaria, 81377, Germany
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Cottbus, Brandenburg, 03048, Germany
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Osnabrück, Lower Saxony, 49076, Germany
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Cologne, North Rhine-Westphalia, 50935, Germany
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Bielefeld, 33647, Germany
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Heidelberg, 69120, Germany
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Leipzig, 04275, Germany
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Potsdam, 14471, Germany
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Siegen, 57076, Germany
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Ulm, 89073, Germany
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Ulm, 89081, Germany
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Westerstede Olden, 26655, Germany
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Larissa, 411 10, Greece
Novartis Investigative Site

Thessaloniki, 53246, Greece
Novartis Investigative Site

Thessaloniki, GR 54636, Greece
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Budapest, HUN, 1135, Hungary
Novartis Investigative Site

Budapest, 1138, Hungary
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Budapest, 1204, Hungary
Novartis Investigative Site

Pécs, 7623, Hungary
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Florence, FI, 50134, Italy
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Pavia, PV, 27100, Italy
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Roma, RM, 00152, Italy
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Verona, VR, 37134, Italy
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Riga, LV, LV-1005, Latvia
Novartis Investigative Site

Riga, LV 1002, Latvia
Novartis Investigative Site

Beirut, 113-0236, Lebanon
Novartis Investigative Site

Beirut, 166830, Lebanon
Novartis Investigative Site

Beirut, 8610, Lebanon
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Mexico City, Mexico City, 03100, Mexico
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Mexico City, Mexico City, 06700, Mexico
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Morelia, Michoacán, 58260, Mexico
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Oslo, NO-0407, Norway
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Katowice, 40-571, Poland
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Kielce, 25 726, Poland
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Lodz, 90-153, Poland
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Wroclaw, 51-685, Poland
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Braga, 4710243, Portugal
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Lisbon, 1349-019, Portugal
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Loures, 2674-514, Portugal
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Porto, 4099-001, Portugal
Novartis Investigative Site

Moscow, 115516, Russia
Novartis Investigative Site

Moscow, 127015, Russia
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Saint Petersburg, 190000, Russia
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Riyadh, SAU, 11525, Saudi Arabia
Novartis Investigative Site

Jeddah, 21499, Saudi Arabia
Novartis Investigative Site

Banská Bystrica, Slovakia, 975 17, Slovakia
Novartis Investigative Site

Bratislava, Slovakia, 813 69, Slovakia
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Bratislava, Slovakia, 826 06, Slovakia
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Bratislava, Slovakia, 833 05, Slovakia
Novartis Investigative Site

Košice, Slovakia, 041 90, Slovakia
Novartis Investigative Site

Nitra, Slovakia, 950 01, Slovakia
Novartis Investigative Site

Trnava, Slovakia, 917 02, Slovakia
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Maribor, Slovenia, 2000, Slovenia
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Ljubljana, 1000, Slovenia
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Seville, Andalusia, 41009, Spain
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El Palmar, Murcia, 30120, Spain
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Santa Cruz, Santa Cruz de Tenerife, 38009, Spain
Novartis Investigative Site

Barakaldo, Vizcaya, 48903, Spain
Novartis Investigative Site

Barcelona, 08041, Spain
Novartis Investigative Site

Madrid, 28040, Spain
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Valencia, 46010, Spain
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Valencia, 46026, Spain
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Basel, 4031, Switzerland
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Samsun, Atakum, 55200, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, Fatih, 34098, Turkey (Türkiye)
Novartis Investigative Site

Trabzon, Ortahisar, 61080, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, Sancaktepe, 34785, Turkey (Türkiye)
Novartis Investigative Site

Izmir, 35100, Turkey (Türkiye)
Novartis Investigative Site

Cardiff, CF14 4XW, United Kingdom
Novartis Investigative Site

Swansea, SA2 8QA, United Kingdom
Premiere Research Institute

West Palm Beach, Florida, 33407, United States
Saturn Research Solutions LLC

Plano, Texas, 75024, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107-5098, United States
UM Department Of Neurology

Miami, Florida, 33136, United States
University Of South Florida

Tampa, Florida, 33612, United States
University of New Mexico

Albuquerque, New Mexico, 87131-0001, United States

Conditions

Explore the condition pages connected to this study.

RELAPSING MULTIPLE SCLEROSIS