New combo therapy shows promise for kids with aggressive leukemia
NCT ID NCT03591510
First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times
Summary
This study tests whether adding the drug midostaurin to standard chemotherapy helps children with a certain genetic type of acute myeloid leukemia (FLT3-mutated AML). About 22 children will receive the drug twice daily alongside chemo, then continue midostaurin alone for 12 more cycles. The goal is to see if the combination is safe and helps control the disease, but ongoing treatment may be needed.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Novartis Investigative Site
Prague, 150 06, Czechia
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Novartis Investigative Site
Berlin, 13353, Germany
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Novartis Investigative Site
Essen, 45147, Germany
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Novartis Investigative Site
Pavia, PV, 27100, Italy
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Novartis Investigative Site
Roma, RM, 00165, Italy
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Novartis Investigative Site
Torino, TO, 10126, Italy
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Novartis Investigative Site
Naples, 80122, Italy
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Novartis Investigative Site
Osaka, 5340021, Japan
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Novartis Investigative Site
Amman, 11941, Jordan
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Novartis Investigative Site
Krakow, 30-663, Poland
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Novartis Investigative Site
Moscow, 117198, Russia
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Novartis Investigative Site
Ljubljana, 1000, Slovenia
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Novartis Investigative Site
Seoul, 03080, South Korea
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Novartis Investigative Site
Seoul, 05505, South Korea
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Novartis Investigative Site
Adana, Adana, 1330, Turkey (Türkiye)
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